LOCUS       NM_019814               1682 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus HIG1 domain family, member 1A (Higd1a), transcript
            variant 5, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_019814
VERSION     NM_019814.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1682)
  AUTHORS   Li,B.Y., Peng,W.Q., Liu,Y., Guo,L. and Tang,Q.Q.
  TITLE     HIGD1A links SIRT1 activity to adipose browning by inhibiting the
            ROS/DNA damage pathway
  JOURNAL   Cell Rep 42 (7), 112731 (2023)
   PUBMED   37393616
  REMARK    GeneRIF: HIGD1A links SIRT1 activity to adipose browning by
            inhibiting the ROS/DNA damage pathway.
REFERENCE   2  (bases 1 to 1682)
  AUTHORS   Xie,Z., Shen,S., Huang,K., Wang,W., Liu,Z., Zhang,H., Lu,M.,
            Sun,J., Hou,J., Liu,H., Guo,H. and Zhang,X.
  TITLE     Mitochondrial HIGD1A inhibits hepatitis B virus transcription and
            replication through the cellular PNKD-NF-kappaB-NR2F1 nexus
  JOURNAL   J Med Virol 95 (4), e28749 (2023)
   PUBMED   37185850
  REMARK    GeneRIF: Mitochondrial HIGD1A inhibits hepatitis B virus
            transcription and replication through the cellular
            PNKD-NF-kappaB-NR2F1 nexus.
REFERENCE   3  (bases 1 to 1682)
  AUTHORS   Zhu,J.Y., Chen,M., Mu,W.J., Luo,H.Y. and Guo,L.
  TITLE     Higd1a facilitates exercise-mediated alleviation of fatty liver in
            diet-induced obese mice
  JOURNAL   Metabolism 134, 155241 (2022)
   PUBMED   35750235
  REMARK    GeneRIF: Higd1a facilitates exercise-mediated alleviation of fatty
            liver in diet-induced obese mice.
REFERENCE   4  (bases 1 to 1682)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1682)
  AUTHORS   Li,T., Xian,W.J., Gao,Y., Jiang,S., Yu,Q.H., Zheng,Q.C. and
            Zhang,Y.
  TITLE     Higd1a Protects Cells from Lipotoxicity under High-Fat Exposure
  JOURNAL   Oxid Med Cell Longev 2019, 6051262 (2019)
   PUBMED   31089410
  REMARK    GeneRIF: Higd1a plays positive roles in protecting cells from
            oxidative stress, and reactive oxygen species could induce Higd1a
            expression by upregulating PGC-1a and HIF-1a expressions.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1682)
  AUTHORS   Ameri,K., Rajah,A.M., Nguyen,V., Sanders,T.A., Jahangiri,A.,
            Delay,M., Donne,M., Choi,H.J., Tormos,K.V., Yeghiazarians,Y.,
            Jeffrey,S.S., Rinaudo,P.F., Rowitch,D.H., Aghi,M. and Maltepe,E.
  TITLE     Nuclear localization of the mitochondrial factor HIGD1A during
            metabolic stress
  JOURNAL   PLoS One 8 (4), e62758 (2013)
   PUBMED   23646141
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1682)
  AUTHORS   Chen,Y.C., Taylor,E.B., Dephoure,N., Heo,J.M., Tonhato,A.,
            Papandreou,I., Nath,N., Denko,N.C., Gygi,S.P. and Rutter,J.
  TITLE     Identification of a protein mediating respiratory supercomplex
            stability
  JOURNAL   Cell Metab 15 (3), 348-360 (2012)
   PUBMED   22405070
REFERENCE   8  (bases 1 to 1682)
  AUTHORS   An,H.J., Shin,H., Jo,S.G., Kim,Y.J., Lee,J.O., Paik,S.G. and Lee,H.
  TITLE     The survival effect of mitochondrial Higd-1a is associated with
            suppression of cytochrome C release and prevention of caspase
            activation
  JOURNAL   Biochim Biophys Acta 1813 (12), 2088-2098 (2011)
   PUBMED   21856340
REFERENCE   9  (bases 1 to 1682)
  AUTHORS   Miyata,K., Yasukawa,T., Fukuda,M., Takeuchi,T., Yamazaki,K.,
            Sakumi,K., Tamamori-Adachi,M., Ohnishi,Y., Ohtsuki,Y.,
            Nakabeppu,Y., Kitajima,S., Onishi,S. and Aso,T.
  TITLE     Induction of apoptosis and cellular senescence in mice lacking
            transcription elongation factor, Elongin A
  JOURNAL   Cell Death Differ 14 (4), 716-726 (2007)
   PUBMED   17170753
REFERENCE   10 (bases 1 to 1682)
  AUTHORS   Wang,J., Cao,Y., Chen,Y., Chen,Y., Gardner,P. and Steiner,D.F.
  TITLE     Pancreatic beta cells lack a low glucose and O2-inducible
            mitochondrial protein that augments cell survival
  JOURNAL   Proc Natl Acad Sci U S A 103 (28), 10636-10641 (2006)
   PUBMED   16815968
  REMARK    GeneRIF: Important role in stress protective programs in
            mitochondria.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE457620.1, AK018360.1 and AI303276.1.
            
            On Nov 10, 2017 this sequence version replaced NM_019814.4.
            
            Transcript Variant: This variant (5) differs in the 5' UTR compared
            to variant 1. All six variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008756.1, AY028386.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               BE457620.1         1-225
            226-1486            AK018360.1         58-1318
            1487-1682           AI303276.1         1-196               c
FEATURES             Location/Qualifiers
     source          1..1682
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 72.67 cM"
     gene            1..1682
                     /gene="Higd1a"
                     /gene_synonym="2210020B17Rik; 7420700H20Rik; Hig1; HIMP1"
                     /note="HIG1 domain family, member 1A"
                     /db_xref="GeneID:56295"
                     /db_xref="MGI:MGI:1930666"
     exon            1..285
                     /gene="Higd1a"
                     /gene_synonym="2210020B17Rik; 7420700H20Rik; Hig1; HIMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            286..404
                     /gene="Higd1a"
                     /gene_synonym="2210020B17Rik; 7420700H20Rik; Hig1; HIMP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             308..595
                     /gene="Higd1a"
                     /gene_synonym="2210020B17Rik; 7420700H20Rik; Hig1; HIMP1"
                     /note="hypoxia induced gene 1; hypoxia-inducible gene 1
                     protein"
                     /codon_start=1
                     /product="HIG1 domain family member 1A, mitochondrial"
                     /protein_id="NP_062788.1"
                     /db_xref="CCDS:CCDS40812.1"
                     /db_xref="GeneID:56295"
                     /db_xref="MGI:MGI:1930666"
                     /translation="MSTNTDLSLSSYDEGQGSKFIRKAKETPFVPIGMAGFAAIVAYG
                     LYKLKSRGNTKMSIHLIHMRVAAQGFVVGAMTLGMGYSMYQEFWANPKPKP"
     exon            405..539
                     /gene="Higd1a"
                     /gene_synonym="2210020B17Rik; 7420700H20Rik; Hig1; HIMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            540..1672
                     /gene="Higd1a"
                     /gene_synonym="2210020B17Rik; 7420700H20Rik; Hig1; HIMP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      667..672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Higd1a"
                     /gene_synonym="2210020B17Rik; 7420700H20Rik; Hig1; HIMP1"
                     /note="hexamer: AATAAA"
     polyA_site      706
                     /gene="Higd1a"
                     /gene_synonym="2210020B17Rik; 7420700H20Rik; Hig1; HIMP1"
     regulatory      1649..1654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Higd1a"
                     /gene_synonym="2210020B17Rik; 7420700H20Rik; Hig1; HIMP1"
                     /note="hexamer: ATTAAA"
     polyA_site      1669
                     /gene="Higd1a"
                     /gene_synonym="2210020B17Rik; 7420700H20Rik; Hig1; HIMP1"
                     /note="major polyA site"
ORIGIN      
        1 gcggccgcca ggcggcaccg cgccagcact gccgcccagg cctcacgtct gacacgaaca
       61 gcgcgcgccg ccacgaaccg ggccggcccc ccagccaatg ggcgccgcgc tacaagtgac
      121 cacgcccacc gcccctcgca cgtaaaggga gtctctggcc cggcctcgcc ggctgctggc
      181 ttctgattgg ctggggcgag cagtggccgc agcaggcgaa gccggtgttc tcgcactcgg
      241 gtggcggcca gaaaccggca ggactggaag ggaccccgcg tctcggaaga ctcttcaaga
      301 aatcacaatg tcaaccaaca cagacctttc tctctcttca tacgatgaag gtcaggggtc
      361 taagtttatt cggaaagcta aggagacacc gtttgtcccc attggaatgg cgggctttgc
      421 agcgattgtt gcctatgggt tgtacaagct gaagagcaga ggaaatacaa agatgtccat
      481 tcacttgatc cacatgcgtg tagcagccca gggctttgtt gtgggggcca tgactcttgg
      541 tatgggctac tccatgtatc aggaattctg ggccaaccct aagcctaagc cttagaagag
      601 ctggtggcat gggaagtgct tgctttagtt agacgtctca tattgaggtt acgtgtttgt
      661 atctacaata aataacatgt gggtttagac aaaacacggt attgaatatt ggtttacttt
      721 cttgccagct tgatttgcca aattgttagt gactgattcg ctaactaggt cactcatggg
      781 ggttaaggta acacagaaga aatctgtcac ctgaaagtag ttgggtacag tgttttcctc
      841 acacccttgt gatgaaagtc attgtaagaa gggcagctga caatgcagat acacacacaa
      901 tatgtgcaga ctaggccatg ctttgggagg gtgtcaggaa agaatcctgt ttgctctggt
      961 tcgtttattt tgtctgcttg tgggctgact tcagaacttc aggttttaag gtttgttggc
     1021 ttctgaaaac actttccaaa gagtccacaa aatataacta gcttataaat cccctataac
     1081 taagtaggag ggagagagag aaagagattg tgtgtgtgtg tgtgtgtgcg tgtgtgcatg
     1141 cgtgcgtgcg tgcacgtaca gcaacttgga aagctgataa gagctgcaga aaggcagtgt
     1201 ttattaaaat cacacttaga aactggttgt gggttctggt taagctcttt tataattgca
     1261 aagttctatt tttgctgctt ggtagtagga taattcttaa acatcttaaa ctataggttt
     1321 ttgtttcttt tttgtggtac taggcattac gtgcagggtc tcacataggc caagcaagtg
     1381 ctgtaccatg gagttgaacc ccggcagcag taggtactgt atgttgtaac acaaggataa
     1441 aggaaataca tggcctagta caggcagtgt gtctacttcg taagagccgt gtctatccag
     1501 gtaccaaaag tgagaggtca gcagtgggtg ggctggtgtt ttgagacatt acacacatac
     1561 ttggacatac agaatgttaa gtgcactttg aaatccatgt ccaacccaaa ctaatattcc
     1621 atagagacaa ggtgtcatat gtattgttat taaaataact ctgaacatat caaaaaaaaa
     1681 aa
//
