LOCUS       NM_001162950            6916 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus hypoxia inducible factor 3, alpha subunit (Hif3a),
            transcript variant 1, mRNA.
ACCESSION   NM_001162950
VERSION     NM_001162950.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6916)
  AUTHORS   Lou,S., Miao,Z., Li,X., Ma,L., Li,D., Du,M., Wang,L. and Pan,Y.
  TITLE     Functional variant at 19q13.3 confers nonsyndromic cleft palate
            susceptibility by regulating HIF3A
  JOURNAL   iScience 28 (2), 111829 (2025)
   PUBMED   39967876
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6916)
  AUTHORS   Kawahata,T., Tanaka,K., Oyama,K., Ueda,J., Okamoto,K. and Makino,Y.
  TITLE     HIF3A gene disruption causes abnormal alveoli structure and early
            neonatal death
  JOURNAL   PLoS One 19 (5), e0300751 (2024)
   PUBMED   38717999
  REMARK    GeneRIF: HIF3A gene disruption causes abnormal alveoli structure
            and early neonatal death.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6916)
  AUTHORS   Mikec,S., Simon,M., Morton,N.M., Atanur,S.S., Konc,J., Dovc,P.,
            Horvat,S. and Kunej,T.
  TITLE     Genetic variants of the hypoxia-inducible factor 3 alpha subunit
            (Hif3a) gene in the Fat and Lean mouse selection lines
  JOURNAL   Mol Biol Rep 49 (6), 4619-4631 (2022)
   PUBMED   35347545
  REMARK    GeneRIF: Genetic variants of the hypoxia-inducible factor 3 alpha
            subunit (Hif3a) gene in the Fat and Lean mouse selection lines.
REFERENCE   4  (bases 1 to 6916)
  AUTHORS   Kirschner,K.M., Kelterborn,S., Stehr,H., Penzlin,J.L.T.,
            Jacobi,C.L.J., Endesfelder,S., Sieg,M., Kruppa,J., Dame,C. and
            Sciesielski,L.K.
  TITLE     Adaptation of the Oxygen Sensing System during Lung Development
  JOURNAL   Oxid Med Cell Longev 2022, 9714669 (2022)
   PUBMED   35242281
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6916)
  AUTHORS   Li,Z.F., Meng,D.D., Liu,Y.Y., Bi,F.G., Tian,K., Xu,J.Z., Sun,J.G.,
            Gu,C.X. and Li,Y.
  TITLE     Hypoxia inducible factor-3alpha promotes osteosarcoma progression
            by activating KDM3A-mediated demethylation of SOX9
  JOURNAL   Chem Biol Interact 351, 109759 (2022)
   PUBMED   34826399
  REMARK    GeneRIF: Hypoxia inducible factor-3alpha promotes osteosarcoma
            progression by activating KDM3A-mediated demethylation of SOX9.
REFERENCE   6  (bases 1 to 6916)
  AUTHORS   Heidbreder,M., Qadri,F., Johren,O., Dendorfer,A., Depping,R.,
            Frohlich,F., Wagner,K.F. and Dominiak,P.
  TITLE     Non-hypoxic induction of HIF-3alpha by 2-deoxy-D-glucose and
            insulin
  JOURNAL   Biochem Biophys Res Commun 352 (2), 437-443 (2007)
   PUBMED   17125738
  REMARK    GeneRIF: These data suggest an involvement of the HIF system in
            metabolic derangements as for instance caused by diabetes.
REFERENCE   7  (bases 1 to 6916)
  AUTHORS   Takeda,K., Ho,V.C., Takeda,H., Duan,L.J., Nagy,A. and Fong,G.H.
  TITLE     Placental but not heart defects are associated with elevated
            hypoxia-inducible factor alpha levels in mice lacking prolyl
            hydroxylase domain protein 2
  JOURNAL   Mol Cell Biol 26 (22), 8336-8346 (2006)
   PUBMED   16966370
REFERENCE   8  (bases 1 to 6916)
  AUTHORS   Makino,Y., Kanopka,A., Wilson,W.J., Tanaka,H. and Poellinger,L.
  TITLE     Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible
            splicing variant of the hypoxia-inducible factor-3alpha locus
  JOURNAL   J Biol Chem 277 (36), 32405-32408 (2002)
   PUBMED   12119283
  REMARK    GeneRIF: alternative splicing and expression of IPAS is induced by
            hypoxia.
REFERENCE   9  (bases 1 to 6916)
  AUTHORS   Makino,Y., Cao,R., Svensson,K., Bertilsson,G., Asman,M., Tanaka,H.,
            Cao,Y., Berkenstam,A. and Poellinger,L.
  TITLE     Inhibitory PAS domain protein is a negative regulator of
            hypoxia-inducible gene expression
  JOURNAL   Nature 414 (6863), 550-554 (2001)
   PUBMED   11734856
REFERENCE   10 (bases 1 to 6916)
  AUTHORS   Gu,Y.Z., Moran,S.M., Hogenesch,J.B., Wartman,L. and Bradfield,C.A.
  TITLE     Molecular characterization and chromosomal localization of a third
            alpha-class hypoxia inducible factor subunit, HIF3alpha
  JOURNAL   Gene Expr 7 (3), 205-213 (1998)
   PUBMED   9840812
  REMARK    GeneRIF: Identity of third HIF alpha class member, HIF-3alpha. mRNA
            expression information by mouse MTN. Experimental proof of
            dimerization with ARNT/HIF-1beta.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC148976.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB289606.1, SRR7345562.4804524.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AC148976.3         124360-124431       c
            73-263              AC148976.3         118264-118454       c
            264-409             AC148976.3         116686-116831       c
            410-494             AC148976.3         113926-114010       c
            495-607             AC148976.3         113137-113249       c
            608-816             AC148976.3         112553-112761       c
            817-923             AC148976.3         111004-111110       c
            924-1071            AC148976.3         110618-110765       c
            1072-1184           AC148976.3         106859-106971       c
            1185-1375           AC148976.3         106381-106571       c
            1376-1477           AC148976.3         104593-104694       c
            1478-1749           AC148976.3         102973-103244       c
            1750-1861           AC148976.3         101562-101673       c
            1862-1943           AC148976.3         99138-99219         c
            1944-6916           AC148976.3         92997-97969         c
FEATURES             Location/Qualifiers
     source          1..6916
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.15 cM"
     gene            1..6916
                     /gene="Hif3a"
                     /gene_synonym="bHLHe17; Ipas; MOP7; NEPAS"
                     /note="hypoxia inducible factor 3, alpha subunit"
                     /db_xref="GeneID:53417"
                     /db_xref="MGI:MGI:1859778"
     exon            1..72
                     /gene="Hif3a"
                     /gene_synonym="bHLHe17; Ipas; MOP7; NEPAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..2041
                     /gene="Hif3a"
                     /gene_synonym="bHLHe17; Ipas; MOP7; NEPAS"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hypoxia inducible factor three alpha; hypoxia-inducible
                     factor 3-alpha; inhibitory PAS domain protein; HIF3-alpha;
                     HIF-3-alpha; HIF3-alpha-1; member of PAS protein 7;
                     basic-helix-loop-helix-PAS protein MOP7; neonatal and
                     embryonic PAS protein"
                     /codon_start=1
                     /product="hypoxia-inducible factor 3-alpha isoform 1"
                     /protein_id="NP_001156422.1"
                     /db_xref="CCDS:CCDS52045.1"
                     /db_xref="GeneID:53417"
                     /db_xref="MGI:MGI:1859778"
                     /translation="MALGLQRVRSNTELRKEKSRDAARSRRSQETEVLYQLAHTLPFA
                     RGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQVEKGGEPLDACYLKALEGFVMVLTA
                     EGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPRPNLSKKKLEAPT
                     ERHFSLRMKSTLTSRGRTLNLKAATWKVLHCSGHMRAYKPPAQTSPAGSPRSEPPLQC
                     LVLICEAIPHPASLEPPLGRGAFLSRHSLDMKFTYCDERIAEVAGYSPDDLIGCSAYE
                     YIHALDSDAVSRSIHTLLSKGQAVTGQYRFLARTGGYLWTQTQATVVSGGRGPQSESI
                     ICVHFLISRVEETGVVLSLEQTEQHTRRPPRLSASSQKGIPGNSVDSPAPRILAFLHP
                     PALSEASLAADPRRFCSPDLRRLMAPILDGPPPAATPSTPQATRRPQSPLPADLPDKL
                     TVGLENAHRLSTAQKNKTVETDLDIAQDPDTLDLEMLAPYISMDDDFQLNSSEQLPKV
                     HRRPPRVARRPRARSFHGLSPPIPEPSLLPRWGSDPRLNCSSPSRGDRPTASLMPGTR
                     KRALAQSSEDKGLELLETKPPKRSPRLEPGSFLLPPLSLSFLLQGRQLPGNQQDPRAP
                     LVHSHEPLGLAPSLLSLCQHEETVQPRNRFPPAAGLGQTH"
     exon            73..263
                     /gene="Hif3a"
                     /gene_synonym="bHLHe17; Ipas; MOP7; NEPAS"
                     /inference="alignment:Splign:2.1.0"
     exon            264..409
                     /gene="Hif3a"
                     /gene_synonym="bHLHe17; Ipas; MOP7; NEPAS"
                     /inference="alignment:Splign:2.1.0"
     exon            410..494
                     /gene="Hif3a"
                     /gene_synonym="bHLHe17; Ipas; MOP7; NEPAS"
                     /inference="alignment:Splign:2.1.0"
     exon            495..607
                     /gene="Hif3a"
                     /gene_synonym="bHLHe17; Ipas; MOP7; NEPAS"
                     /inference="alignment:Splign:2.1.0"
     exon            608..816
                     /gene="Hif3a"
                     /gene_synonym="bHLHe17; Ipas; MOP7; NEPAS"
                     /inference="alignment:Splign:2.1.0"
     exon            817..923
                     /gene="Hif3a"
                     /gene_synonym="bHLHe17; Ipas; MOP7; NEPAS"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1071
                     /gene="Hif3a"
                     /gene_synonym="bHLHe17; Ipas; MOP7; NEPAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1184
                     /gene="Hif3a"
                     /gene_synonym="bHLHe17; Ipas; MOP7; NEPAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1375
                     /gene="Hif3a"
                     /gene_synonym="bHLHe17; Ipas; MOP7; NEPAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1477
                     /gene="Hif3a"
                     /gene_synonym="bHLHe17; Ipas; MOP7; NEPAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1749
                     /gene="Hif3a"
                     /gene_synonym="bHLHe17; Ipas; MOP7; NEPAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1861
                     /gene="Hif3a"
                     /gene_synonym="bHLHe17; Ipas; MOP7; NEPAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1943
                     /gene="Hif3a"
                     /gene_synonym="bHLHe17; Ipas; MOP7; NEPAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..6916
                     /gene="Hif3a"
                     /gene_synonym="bHLHe17; Ipas; MOP7; NEPAS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6373..6378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hif3a"
                     /gene_synonym="bHLHe17; Ipas; MOP7; NEPAS"
                     /note="hexamer: CATAAA"
     polyA_site      6402
                     /gene="Hif3a"
                     /gene_synonym="bHLHe17; Ipas; MOP7; NEPAS"
                     /note="major polyA site"
ORIGIN      
        1 gggggacgct gggcatcgag ggctctggaa ccgcgaaggg cgagccatgg cgttggggct
       61 gcagcgcgtg aggtcgaaca ccgagctgcg gaaggagaag tcgcgggacg cggcccgcag
      121 ccggcgcagc caggagacgg aggtgctgta ccagctggcg cacactctgc cctttgcgcg
      181 cggcgtcagc gcgcacctgg acaaggcctc catcatgcgc ctcacaatca gctacctgcg
      241 catgcaccgc ctctgcgcag caggggagtg gaaccaggtg gaaaaagggg gagagccact
      301 ggacgcctgc tacctgaagg ccctggaggg tttcgtcatg gtactcaccg ccgagggaga
      361 catggcttac ctgtcggaaa atgtcagcaa gcacctgggc ctcagtcagc tggagctcat
      421 tggacacagt atctttgatt ttatccatcc ctgtgaccaa gaggaacttc aagacgccct
      481 gacccccagg ccgaacctgt caaagaagaa gctggaagcc ccaacagagc gccacttttc
      541 cctgcgaatg aagagcacgc tcaccagcag agggcgcacg ctcaacctca aagcggccac
      601 ctggaaggtg ctgcactgct caggacatat gagggcctac aagccccctg cacagacttc
      661 ccctgccggg agccctcgct ccgagcctcc cctgcaatgc ctggtgctta tctgtgaagc
      721 catcccccac ccagccagtc tggagccccc gctgggccga ggggcctttc tcagtcgcca
      781 cagcctggac atgaagttca catactgcga cgagaggatt gcagaagttg ctggctacag
      841 tcctgatgac ctgattggct gttctgccta tgaatacatc cacgctttgg actctgatgc
      901 ggtcagcagg agcatccaca ctttgttgag caagggccag gcagtaacgg ggcagtatcg
      961 cttcctggcc cggactggag gctatctgtg gactcagact caggctacag tggtgtcagg
     1021 ggggcggggc ccccagtcgg aaagtatcat ctgcgtccac ttcctgatca gccgtgtaga
     1081 agagaccgga gtggtgctgt ctctggaaca aacggagcaa catactcgca gaccccctcg
     1141 gctgagtgcc tcctcgcaga agggtatccc tggcaacagt gtagactctc ctgctccgcg
     1201 gatcctggcc ttcctgcacc ctccggccct gagtgaggcc tccctggctg ctgaccctcg
     1261 ccgtttctgt agtccagacc tgcgccgcct catggcaccc atcctggatg gacctccccc
     1321 agctgccacg cccagcaccc cacaagctac acggagaccc caaagtcctc ttccggctga
     1381 tctcccagat aagttgacag tgggcttgga aaatgcgcac agactctcca ctgcccagaa
     1441 aaacaagacc gtggagacag atctagatat agctcaggac cctgacactc tggacttgga
     1501 gatgctggcc ccctacatct ccatggatga tgacttccag ctcaactcca gcgagcaatt
     1561 gcccaaagtc caccgcagac ctcccagggt ggcccgcagg ccccgtgctc ggagcttcca
     1621 tggcctgtcg cctcctatcc ctgagccctc cctactaccc cgctggggga gtgatccacg
     1681 actgaactgt tccagtcctt ccaggggcga tcgccccaca gcctccctga tgcctggaac
     1741 tcggaagagg gccttggccc agagctcaga ggacaaaggg ttggagctgc tggaaactaa
     1801 gccgcccaag cggtccccaa gactagaacc tggaagcttc ctgctgcctc cgctcagcct
     1861 gagtttcctt ctgcaaggtc gacaactccc ggggaaccag caggatccca gagcccccct
     1921 cgtgcattct catgagccct tgggcctagc tccctcgctg ctctctctct gccagcatga
     1981 ggaaactgtc cagcccagga accgcttccc gccagcagca ggcttgggcc agacccactg
     2041 agtcagcctt cctctcagcc ctcttcttct atcccagaaa ggactcagcc acactccaca
     2101 ccagcagcct acacccagga tggggcctct ctcctctgag tgtgcccccc ccagccagcc
     2161 acagtcctac ctcagccccc caaccttctg ctgcccccag tcggaggctt cttgggtatt
     2221 ctcagctcag tgacctttgg gaggggtgtg tgaccctccc cacctcctct caggacttcc
     2281 tttggggttc tccacagttc tccatacctc aatacccctt tttctgactc tctttgcttt
     2341 atttgggaga atgaggggtt gggagaatcg gagatccatc tctgatcctg gccccatgga
     2401 gcttagacaa ctgtaatcac attttttggt tgttgttttg gtttttttgt ttgttttttg
     2461 ttttctccct gttcctcttc tatcggcttg actttgtcct tttcacaata gggcattcag
     2521 tcactctgca ttgcacagat ccacagcaat tgtgagactc tggtcttccc cctcttccgt
     2581 ggcaaatgtg ggaagactct gggtcagatt tcacctcaaa caacttatgg agtctcagcc
     2641 ttccaactgc cccccagctc tgcttgccat gtctgctcct gacttcatgc tggccccaga
     2701 cgctgcctaa ataatgactt catttgtgat cttcctgtgt tagggggagc cagcgacttc
     2761 ctccactcca cagacctata atctctggat cttgaatact tgactcccac ctttactgtt
     2821 tgtagactgt gcaacttcta gccttccctg gacctaggct ataccacttt ctctcttcct
     2881 tgcacctaga catgtagctc ctggtctttg ttggctctag actgaaaacc cttgggcctt
     2941 ctctggttct agagatctct gggttctctg attctagact ttctacttct tggttctaaa
     3001 acatacaatc catggctttt ccctggctct ctgactccat atttctcatc ttttttctgt
     3061 ttctagaatg tgaaacctgt gagcttcatt ggctgtagac tgtaccacca gtggtctcct
     3121 ctagtttgtg actcatgacc tctggccttc ccttgttcta gacactgtgg cctctggcct
     3181 ccatggttct aaactgtgtt gttcctgcct tcttttgttc tagactgttc aatctctgac
     3241 attctctagt tctagtctgt acagtctcca gtcttttacc tgactctaga ctgcaggcct
     3301 ttggacctgg ctctggttct agaccatgcc acttctctgg ccttttctct gattctagac
     3361 tttaggccct ctggttttct gtggttctag aacaggggtt ctcaaccttc ctaatgctgc
     3421 aaccctctaa tacagtttct catgttgtag tgaccactga ctataaattt atttcattgc
     3481 tgcttcataa ctgtaatttt gcatctgtta tgaatcataa tgtaaatatc tggtatgcag
     3541 gatatctgat atctgatcct caaagtggtc acagcccaca gattgagagc tgctgttcta
     3601 gactctacag cctatgagct tctttgattc taggttatgc tgcctctggt cttcactggt
     3661 tctaaactag atgaccacta gccttctctg gcattccctg gttctagact gtgctgtcat
     3721 tgacttcccc ctggttctac actgtgttat cattggcttc ccccctggtt ctagacagca
     3781 tcatttccaa catggtctgt taaagacctc aatttcttca aacccctcta cttccacatc
     3841 tcatactctt tagttctttc ttgggctgga tctcacagct cccaatctgc cattttaaag
     3901 tggggtttga attacataat ctgtaaagct ctctggatct aaagcctaca accaccaaga
     3961 atcctctagc ttcaaggctt attctgtaat ttcctctggt tctaggcctc ttcttaaaaa
     4021 tcctctggtt ctcatgccct ctgctgcctg tcattgcaga ccattggtgt gtgtagtagc
     4081 aaggattaaa cctcaggcct tgcacgtgct aggcaagcac tctaccacgg agctttcccc
     4141 agtcctgtct tatgtcttat tttgagacag gatctttatt ggttgcacag actaaccttg
     4201 aactcaagtc tgttcagata gaccctgaac tcatcctgct tcagcctccc gagtagctgg
     4261 gaattacagg cctttgagac tggggccagc taatcttata attggcgatc tcctcttgtt
     4321 tctggattcc ccaactccaa gcttcttatt agctccggtc tttctaatct gtaagacagt
     4381 tggtttcaaa tccagacctg atttctagat cattttggtt ccaaacctca tgatgtcgag
     4441 tttattgttc ttcagacccc tgtgctttcc cccagtaagg aggagtggag tgagttttat
     4501 gtcttgaact tggatctggc ctttctggaa ccacatacca cgtgcccatt cttttgggtt
     4561 ctggatttca ttacctttaa tcattaccca tgttttagat tatgtaaact ctagaccccg
     4621 aaacttccag gatcctctgt tctcagatgc tctggtgatc tgcctattac tgagcttcaa
     4681 atatcaaggt gggcagtggt ggtgcacgtc tctgatccta gcacttagga agcagaagga
     4741 ggcaaatctc taagtttgag gccagctgat ctatcgagca agttccagga tgccagggct
     4801 acatggagaa accctgtctc aaaatcaaca aaacagaaca aaacaaacag caaatatctt
     4861 ctggggtttg ttactgtttt gagacagtgt cttaaattca ttgaccataa aattgctatg
     4921 tagccaaatg attttaaatc cgtgataccc cttcacccac cccaccaagt gctggggtta
     4981 cagacatgcc tagttgtatg tggtgttgga gactgaagcc agagcttcat gcatgctagg
     5041 caagtactct accaactgag ctacacccag cctctataaa tgtcttctgc atctagacct
     5101 atcccatgag tttctttggt tctagacccc acaattgccc agtcctcttt acttcagatc
     5161 ttaacaactc aaagtaccct gaatctagaa cagagtttga aaatatcagc ggatatcttg
     5221 ccttctatat ttctctagtt ctaagcctta gaaccccaat cttgattcta gatttaagat
     5281 cctaaaatcc ctgtggattc tagaccttgg tttgggggct tttctttccc caggaatggg
     5341 ctggatgaca tgcagctctg actggcctcc agctcactat agagccagag atgaccttga
     5401 acttgtgacc ctcttccctc tgcctctcaa atgctgcgat tgcaggtgtc cagcagcttg
     5461 ctcactttgt gtggtgccag ggatgaaccc cagctttgtg cgtgacaatc aagcactcta
     5521 ccagcagaga cacatccctc tcctacgctt tgtctaattc tgtctctctg ggttccttgg
     5581 ggttctaggc ctcatagttt ccagttgcct ctggcttctg cttctccttc ctcaggctct
     5641 agtatgtagc cttcaaatgt ctctcgttgt agaatctaga actcaccatg tagatgtcct
     5701 tgatctaaga tctcgcaccc cttgactccc tgggttcaaa tctgatcctt ctagctccgt
     5761 ctgggcttcc cagccctcac tgaacttgtc tcagttctta accctccagt cttctcctcc
     5821 cagatgttct gctcatgaag ttcacgctca agcccctcct gtctcatagc cctaaaaatt
     5881 ctctacccta gaacctcttt cacacctcac cccaagcctc caggcatgca ttcaacctta
     5941 actctactcc aggtatctag ggacctgggg ctccttctcc ttcctaggag ctccataatc
     6001 cagccgcaca caggcacacg cacagcccta tctgcatatc ttggggtggg gaaagagggc
     6061 aggacccctc cactgtctcc caccagctat gcatcttcct aacccccagc tccccttcca
     6121 cgatggtgct actctgggtc ttccacagga gaagactccc atctctacct tattcacccc
     6181 tctttggaag gcactacttt gtcttgtcaa gaggtggcct gttcaggtgc tacaggggaa
     6241 agggactgaa tcctctctcc cctcatgggt gttgtgggcc cttaaccgga aaaattgtcc
     6301 tggctaggag ggagggaagg acatggccca gctatcctta gcccagaaac ccacaaatgt
     6361 ctccaaaacc accataaaga cctctccttg ttaggcacca gagagaccgg tgttgactca
     6421 tctgtggggt tgctttggag gttgtgggta cactgtgtag ctgggattcc ttgttttttt
     6481 atggagaatg tgacaaagcc tattgtaaac caggctagcc tcaaattcac tgtgtagcca
     6541 aggatgacct gtaactttga tcagcctgcc tccacctctt aagtgctggt ataacagggg
     6601 tgtgccacta ccactacatt tggctttcat aatactttct ggtgctgtgt gtgtgtgtgt
     6661 gtgtgtctct gtgtgtgtat gagtctctgt gtatgctgat gttgctattt tgtggaaaca
     6721 tgtgggtctt tgtaccatgc ttctgtggtg ggaggattgt gattctttct gcacattgat
     6781 gttagtttct ggatattttt ctgtactttc ttgttgcaaa cattgtgatt ttttttttca
     6841 ttttatttgt tttgtgtgca tgagtttggg tgtgtgtgca tactatatgt gtgcatatta
     6901 aaggacaact tgcagg
//
