LOCUS       NM_001313919            4788 bp    mRNA    linear   ROD 29-MAY-2023
DEFINITION  Mus musculus hypoxia inducible factor 1, alpha subunit (Hif1a),
            transcript variant 1, mRNA.
ACCESSION   NM_001313919 XM_006515477
VERSION     NM_001313919.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4788)
  AUTHORS   Sha JF, Xie QM, Chen N, Song SM, Ruan Y, Zhao CC, Liu Q, Shi RH,
            Jiang XQ, Fei GH and Wu HM.
  TITLE     TLR2-hif1alpha-mediated glycolysis contributes to pyroptosis and
            oxidative stress in allergic airway inflammation
  JOURNAL   Free Radic Biol Med 200, 102-116 (2023)
   PUBMED   36907255
  REMARK    GeneRIF: TLR2-hif1alpha-mediated glycolysis contributes to
            pyroptosis and oxidative stress in allergic airway inflammation.
REFERENCE   2  (bases 1 to 4788)
  AUTHORS   Kou K, Li S, Qiu W, Fan Z, Li M and Lv G.
  TITLE     Hypoxia-inducible factor 1alpha/IL-6 axis in activated hepatic
            stellate cells aggravates liver fibrosis
  JOURNAL   Biochem Biophys Res Commun 653, 21-30 (2023)
   PUBMED   36848821
  REMARK    GeneRIF: Hypoxia-inducible factor 1alpha/IL-6 axis in activated
            hepatic stellate cells aggravates liver fibrosis.
REFERENCE   3  (bases 1 to 4788)
  AUTHORS   Shi C, Zhang Z, Xu R, Zhang Y and Wang Z.
  TITLE     Contribution of HIF-1alpha/BNIP3-mediated autophagy to lipid
            accumulation during irinotecan-induced liver injury
  JOURNAL   Sci Rep 13 (1), 6528 (2023)
   PUBMED   37085612
  REMARK    GeneRIF: Contribution of HIF-1alpha/BNIP3-mediated autophagy to
            lipid accumulation during irinotecan-induced liver injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4788)
  AUTHORS   Hrabalova P, Bohuslavova R, Matejkova K, Papousek F, Sedmera D,
            Abaffy P, Kolar F and Pavlinkova G.
  TITLE     Dysregulation of hypoxia-inducible factor 1alpha in the sympathetic
            nervous system accelerates diabetic cardiomyopathy
  JOURNAL   Cardiovasc Diabetol 22 (1), 88 (2023)
   PUBMED   37072781
  REMARK    GeneRIF: Dysregulation of hypoxia-inducible factor 1alpha in the
            sympathetic nervous system accelerates diabetic cardiomyopathy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4788)
  AUTHORS   Chen X, Liu L, Kang S, Gnanaprakasam JR and Wang R.
  TITLE     The lactate dehydrogenase (LDH) isoenzyme spectrum enables
            optimally controlling T cell glycolysis and differentiation
  JOURNAL   Sci Adv 9 (12), eadd9554 (2023)
   PUBMED   36961904
REFERENCE   6  (bases 1 to 4788)
  AUTHORS   Li H, Ko HP and Whitlock JP.
  TITLE     Induction of phosphoglycerate kinase 1 gene expression by hypoxia.
            Roles of Arnt and HIF1alpha
  JOURNAL   J Biol Chem 271 (35), 21262-21267 (1996)
   PUBMED   8702901
REFERENCE   7  (bases 1 to 4788)
  AUTHORS   Wood SM, Gleadle JM, Pugh CW, Hankinson O and Ratcliffe PJ.
  TITLE     The role of the aryl hydrocarbon receptor nuclear translocator
            (ARNT) in hypoxic induction of gene expression. Studies in
            ARNT-deficient cells
  JOURNAL   J Biol Chem 271 (25), 15117-15123 (1996)
   PUBMED   8662957
REFERENCE   8  (bases 1 to 4788)
  AUTHORS   Semenza GL, Rue EA, Iyer NV, Pang MG and Kearns WG.
  TITLE     Assignment of the hypoxia-inducible factor 1alpha gene to a region
            of conserved synteny on mouse chromosome 12 and human chromosome
            14q
  JOURNAL   Genomics 34 (3), 437-439 (1996)
   PUBMED   8786149
REFERENCE   9  (bases 1 to 4788)
  AUTHORS   Wenger RH, Rolfs A, Marti HH, Guenet JL and Gassmann M.
  TITLE     Nucleotide sequence, chromosomal assignment and mRNA expression of
            mouse hypoxia-inducible factor-1 alpha
  JOURNAL   Biochem Biophys Res Commun 223 (1), 54-59 (1996)
   PUBMED   8660378
REFERENCE   10 (bases 1 to 4788)
  AUTHORS   Obara N and Takeda M.
  TITLE     Expression of neural cell adhesion molecule (NCAM) during the first
            molar development in the mouse
  JOURNAL   Anat Embryol (Berl) 187 (3), 209-219 (1993)
   PUBMED   8470821
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124712.5 and AK034087.1.
            
            [WARNING] On Jun 6, 2023 this sequence was replaced by
            NM_001313919.2.
            
            On Sep 11, 2015 this sequence version replaced XM_006515477.2.
            
            Summary: This gene encodes the alpha subunit which, along with the
            beta subunit, forms a heterodimeric transcription factor that
            regulates the cellular and developmental response to reduced oxygen
            tension. The transcription factor has been shown to regulate genes
            involved in several biological processes, including erythropoiesis
            and angiogenesis which aid in increased delivery of oxygen to
            hypoxic regions. The transcription factor also plays a role in the
            induction of genes involved in cell proliferation and survival,
            energy metabolism, apoptosis, and glucose and iron metabolism.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034087.1, SRR1660821.151734.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC124712.5         89412-89448
            38-125              AK034087.1         1-88
            126-128             AC124712.5         89537-89539
            129-1615            AK034087.1         92-1578
            1616-1616           AC124712.5         121235-121235
            1617-2131           AK034087.1         1580-2094
            2132-2132           AC124712.5         123513-123513
            2133-4334           AK034087.1         2096-4297
            4335-4788           AK034087.1         4299-4752
FEATURES             Location/Qualifiers
     source          1..4788
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 31.99 cM"
     gene            1..4788
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /note="hypoxia inducible factor 1, alpha subunit"
                     /db_xref="GeneID:15251"
                     /db_xref="MGI:MGI:106918"
     exon            1..458
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             424..2937
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hypoxia-inducible factor 1-alpha; ARNT-interacting
                     protein"
                     /codon_start=1
                     /product="hypoxia-inducible factor 1-alpha isoform 1"
                     /protein_id="NP_001300848.1"
                     /db_xref="GeneID:15251"
                     /db_xref="MGI:MGI:106918"
                     /translation="MEGAGGENEKKNRMSSERRKEKSRDAARSRRSKESEVFYELAHQ
                     LPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGGLDSEDEMKAQMDCFYLKALDGFVM
                     VLTDDGDMVYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGPVRKGK
                     ELNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPM
                     TCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSI
                     YEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQ
                     CIVCVNYVVSGIIQHDLIFSLQQTESVLKPVESSDMKMTQLFTKVESEDTSCLFDKLK
                     KEPDALTLLAPAAGDTIISLDFGSDDTETEDQQLEDVPLYNDVMFPSSNEKLNINLAM
                     SPLPSSETPKPLRSSADPALNQEVALKLESSPESLGLSFTMPQIQDQPASPSDGSTRQ
                     SSPERLLQENVNTPNFSQPNSPSEYCFDVDSDMVNVFKLELVEKLFAEDTEAKNPFST
                     QDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESNSPSPPSMSTVTGFQQTQLQKPTIT
                     ATATTTATTDESKTETKDNKEDIKILIASPSSTQVPQETTTAKASAYSGTHSRTASPD
                     RAGKRVIEQTDKAHPRSLNLSATLNQRNTVPEEELNPKTIASQNAQRKRKMEHDGSLF
                     QAAGIGTLLQQPGDCAPTMSLSWKRVKGFISSEQNGTEQKTIILIPSDLACRLLGQSM
                     DESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN"
     exon            459..652
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..798
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            799..883
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..996
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1199
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1306
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1454
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1675
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1959
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2124
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2549
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2658
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2785
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..4788
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtgaggcg ggcccgcggg cgcgcgcgtt gggtgctgag cgggcgcgcg cacccctcgg
       61 cttttccctc ccctcgccgc gcgcccgagc gcgcctccgc ccttgcccgc cccctgccgc
      121 tgcttcagcg cctcagtgca cagagcctcc tcggctgagg ggacgcgagg actgtcctcg
      181 ccgccgtcgc gggcagtgtc tagccaggcc ttgacaagct agccggagga gcgcctagga
      241 acccgagccg gagctcagcg agcgcagcct gcagctcccg cctcgccgtc ccggggggcg
      301 tcccgcctcc caccccgcct ctggacttgt ctctttctcc gcgcgcgcgg acagagccgg
      361 cgtttaggcc cgagcgagcc cgggggccgc cggccgggaa gacaacgcgg gcaccgattc
      421 gccatggagg gcgccggcgg cgagaacgag aagaaaaata ggatgagttc tgaacgtcga
      481 aaagaaaagt ctagagatgc agcaagatct cggcgaagca aagagtctga agttttttat
      541 gagcttgctc atcagttgcc acttccccac aatgtgagct cacatcttga taaagcttct
      601 gttatgaggc tcaccatcag ttatttacgt gtgagaaaac ttctggatgc cggtggtcta
      661 gacagtgaag atgagatgaa ggcacagatg gactgttttt atctgaaagc cctagatggc
      721 tttgtgatgg tgctaacaga tgacggcgac atggtttaca tttctgataa cgtgaacaaa
      781 tacatggggt taactcagtt tgaactaact ggacacagtg tgtttgattt tactcatcca
      841 tgtgaccatg aggaaatgag agaaatgctt acacacagaa atggcccagt gagaaaaggg
      901 aaagaactaa acacacagcg gagctttttt ctcagaatga agtgcaccct aacaagccgg
      961 gggaggacga tgaacatcaa gtcagcaacg tggaaggtgc ttcactgcac gggccatatt
     1021 catgtctatg ataccaacag taaccaacct cagtgtgggt acaagaaacc acccatgacg
     1081 tgcttggtgc tgatttgtga acccattcct catccgtcaa atattgaaat tcctttagat
     1141 agcaagacat ttctcagtcg acacagcctc gatatgaaat tttcttactg tgatgaaaga
     1201 attactgagt tgatgggtta tgagccggaa gaacttttgg gccgctcaat ttatgaatat
     1261 tatcatgctt tggattctga tcatctgacc aaaactcacc atgatatgtt tactaaagga
     1321 caagtcacca caggacagta caggatgctt gccaaaagag gtggatatgt ctgggttgaa
     1381 actcaagcaa ctgtcatata taatacgaag aactcccagc cacagtgcat tgtgtgtgtg
     1441 aattatgttg taagtggtat tattcagcac gacttgattt tctcccttca acaaacagaa
     1501 tctgtgctca aaccagttga atcttcagat atgaagatga ctcagctgtt caccaaagtt
     1561 gaatcagagg atacaagctg cctttttgat aagcttaaga aggagcctga tgctctcact
     1621 ctgctggctc cagctgccgg cgacaccatc atctctctgg attttggcag cgatgacaca
     1681 gaaactgaag atcaacaact tgaagatgtt ccattatata atgatgtaat gtttccctct
     1741 tctaatgaaa aattaaatat aaacctggca atgtctcctt taccttcatc ggaaactcca
     1801 aagccacttc gaagtagtgc tgatcctgca ctgaatcaag aggttgcatt aaaattagaa
     1861 tcaagtccag agtcactggg actttctttt accatgcccc agattcaaga tcagccagca
     1921 agtccttctg atggaagcac tagacaaagt tcacctgaga gacttcttca ggaaaacgta
     1981 aacactccta acttttccca gcctaacagt cccagtgaat attgctttga tgtggatagc
     2041 gatatggtca atgtattcaa gttggaactg gtggaaaaac tgtttgctga agacacagag
     2101 gcaaagaatc cattttcaac tcaggacact gatttagatt tggagatgct ggctccctat
     2161 atcccaatgg atgatgattt ccagttacgt tcctttgatc agttgtcacc attagagagc
     2221 aattctccaa gccctccaag tatgagcaca gttactgggt tccagcagac ccagttacag
     2281 aaacctacca tcactgccac tgccaccaca actgccacca ctgatgaatc aaaaacagag
     2341 acgaaggaca ataaagaaga tattaaaata ctgattgcat ctccatcttc tacccaagta
     2401 cctcaagaaa cgaccactgc taaggcatca gcatacagtg gcactcacag tcggacagcc
     2461 tcaccagaca gagcaggaaa gagagtcata gaacagacag acaaagctca tccaaggagc
     2521 cttaacctgt ctgccacttt gaatcaaaga aatactgttc ctgaggaaga attaaaccca
     2581 aagacaatag cttcgcagaa tgctcagagg aagcgaaaaa tggaacatga tggctccctt
     2641 tttcaagcag caggaattgg aacattattg cagcaaccag gtgactgtgc acctactatg
     2701 tcactttcct ggaaacgagt gaaaggattc atatctagtg aacagaatgg aacggagcaa
     2761 aagactatta ttttaatacc ctccgattta gcatgcagac tgctggggca gtcaatggat
     2821 gagagtggat taccacagct gaccagttac gattgtgaag ttaatgctcc catacaaggc
     2881 agcagaaacc tactgcaggg tgaagaatta ctcagagctt tggatcaagt taactgagcg
     2941 tttcctaatc tcattccttt tgattgttaa tgtttttgtt cagttgttgt tgtttgttgg
     3001 gtttttgttt ctgttggtta tttttggaca ctggtggctc agcagtctat ttatattttc
     3061 tatatctaat tttagaagcc tggctacaat actgcacaaa ctcagatagt ttagttttca
     3121 tcccctttct acttaatttt cattaatgct ctttttaata tgttctttta atgccagatc
     3181 acagcacatt cacagctcct cagcatttca ccattgcatt gctgtagtgt catttaaaat
     3241 gcaccttttt atttatttat ttttggtgag ggagtttgtc ccttattgaa ttatttttaa
     3301 tgaaatgcca atataatttt ttaagaaagc agtaaattct catcatgatc ataggcagtt
     3361 gaaaactttt tactcatttt tttcatgttt tacatgaaaa taatgctttg tcagcagtac
     3421 atggtagcca caattgcaca atatattttc tttaaaaaac cagcagttac tcatgcaata
     3481 tattctgcat ttataaaact agtttttaag aaattttttt tggcctatgg aattgttaag
     3541 cctggatcat gaagctgttg atcttataat gattcttaaa ctgtatggtt tctttatatg
     3601 ggtaaagcca tttacatgat ataaagaaat atgcttatat ctggaaggta tgtggcattt
     3661 atttggataa aattctcaat tcagagaagt tatctggtgt ttcttgactt taccaactca
     3721 aaacagtccc tctgtagttg tggaagctta tgctaatatt gtgtaattga ttatgaaaca
     3781 taaatgttct gcccaccctg ttggtataaa gacattttga gcatactgta aacaaacaaa
     3841 caaaaaatca tgctttgtta gtaaaattgc ctagtatgtt gatttgttga aaatatgatg
     3901 tttggtttta tgcactttgt cgctattaac atcctttttt catatagatt tcaataagtg
     3961 agtaatttta gaagcattat tttaggaata tagagttgtc atagtaaaca tcttgttttt
     4021 tctatgtata ctgtataaat ttttcgttcc cttgctcttt gtggttgggt ctaacactaa
     4081 ctgtactgtt ttgttatatc aaataaacat cttctgtgga ccaggccccc tgggtcagcg
     4141 cttacgttta aataacattt gtctcaacat ttctagctca taaaacgatt tctcaaaaat
     4201 ttaagttctt tataaaaatt agattgtaca tttctacatt cattttattg ccattttcta
     4261 atgtatgatg tgtccctaaa tgtcatgtta aataatgaca tcataatatt gcattgtaaa
     4321 gagaattttt ttttagaatt ttgccattat aaatgtatga gtctattaaa atataaagta
     4381 caaaccttca gtatttgcag tatgaatgga gtaagtgaaa cagttcatga aacatgatca
     4441 tactgttttg agggctcagg ctcctgcgtg catgtctaat ctgttcccat tagcaggtga
     4501 aggaagctag ggctgaaaca agagttttcc gcgctctcag ggagctatgt ggcatgtcag
     4561 aatcttaggt ctcagaacat accttgtttg gttttgatat tggtttggtt tgattctggt
     4621 acatggcaca ttaatatgca gatacattat atagataatc atatattacc tgatgtttct
     4681 ttactttgcc agctttaaaa aagtatctta tgcaattgtg aattttagaa acttccaaat
     4741 aaacaccaca aaccttccag cttatatgca tatctttcta gttcatgt
//
