LOCUS       NM_001346774            3290 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus HID1 domain containing (Hid1), transcript variant 2,
            mRNA.
ACCESSION   NM_001346774 XM_006533077
VERSION     NM_001346774.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3290)
  AUTHORS   Du,W., Zhou,M., Zhao,W., Cheng,D., Wang,L., Lu,J., Song,E.,
            Feng,W., Xue,Y., Xu,P. and Xu,T.
  TITLE     HID-1 is required for homotypic fusion of immature secretory
            granules during maturation
  JOURNAL   Elife 5, e18134 (2016)
   PUBMED   27751232
  REMARK    GeneRIF: The authors demonstrate that HID-1 deficiency prevented
            secretory granule maturation by blocking homotypic fusion of
            immature secretory granules.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3290)
  AUTHORS   Kikkawa,Y., Shitara,H., Wakana,S., Kohara,Y., Takada,T.,
            Okamoto,M., Taya,C., Kamiya,K., Yoshikawa,Y., Tokano,H.,
            Kitamura,K., Shimizu,K., Wakabayashi,Y., Shiroishi,T., Kominami,R.
            and Yonekawa,H.
  TITLE     Mutations in a new scaffold protein Sans cause deafness in Jackson
            shaker mice
  JOURNAL   Hum Mol Genet 12 (5), 453-461 (2003)
   PUBMED   12588793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ153052.1, AK138882.1, AL603828.9 and AW047036.1.
            
            On Oct 30, 2016 this sequence version replaced XM_006533077.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044395.1, AK138882.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                CJ153052.1         1-30
            31-3229             AK138882.1         1-3199
            3230-3230           AL603828.9         148666-148666       c
            3231-3270           AK138882.1         3201-3240
            3271-3290           AW047036.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..3290
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.84 cM"
     gene            1..3290
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /note="HID1 domain containing"
                     /db_xref="GeneID:217310"
                     /db_xref="MGI:MGI:2445087"
     exon            1..213
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..2511
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     UPF0663 transmembrane protein C17orf28 homolog; protein
                     hid-1 homolog; HID1 domain-containing protein; protein
                     HID1"
                     /codon_start=1
                     /product="protein HID1 isoform 2"
                     /protein_id="NP_001333703.1"
                     /db_xref="CCDS:CCDS83927.1"
                     /db_xref="GeneID:217310"
                     /db_xref="MGI:MGI:2445087"
                     /translation="MGSADSKLNFRKAVIQLTTKTQPVEATDNAFWDQFWADTATSVQ
                     DVFALVPAAEIRAVREESPSNLATLCYKAVEKLVQGAEGGCHSEKEKQVVLNCSRLLT
                     RVLPYIFEDPDWRGFFWSTVPGAGRGGGEEEDENARPLAESLLLAIADLLFCPDFTVQ
                     NHRRNDVDSAEDVHSLDSCEYIWEAGVGFAHSPQPNYIHDMNRMELLKLLLTCFSEAM
                     YLPPSPESGSTNPWVQFFCSTENRHALPLFTSLLNTVCAYDPVGYGIPYNHLLFSDYR
                     EPLVEEAAQVLIVTLDHDSATSTSPTVDGTTTGTAMDDADPPGPENLFVNYLSRIHRE
                     EDFQFILKGIARLLSNPLLQTYLPNSTKKIQFHQELLVLFWKLCDFNKKFLFFVLKSS
                     DVLDILVPILYFLNDARADQSRVGLMHIGVFILLLLSGERNFGVRLNKPYSVRVPMDI
                     PVFTGTHADLLIVVFHKIITSGHQRLQPLFDCLLTIVVNVSPYLKSLSMVTANKLLHL
                     LEAFSTTWFLFSASQNHHLVFFLLEVFNNIIQYQFDGNSNLVYAIIRKRAVFHQLANL
                     PTDPPSIHKALQRRRRTPEPLSRTGSQEGTSMEGSRPAAPAEPGTLKTSLVATPGIDK
                     LTEKSQVSEDGTLRSLEPESQQSSAENSPSDGESSQTWREQRRLSNASASGQWSPTSD
                     WILSWKSKLPLQTIMRLLQVLVPQVEKICIDKGLTDESEILRFLQHGTLVGLLPVPHP
                     ILIRKYQANSGTAMWFRTYMWGVIYLRNVDPPIWYDTDVKLFEIQRV"
     exon            214..363
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            364..534
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            535..648
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            649..755
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            756..872
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1095
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1152
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1293
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1384
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1536
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1615
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1780
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..2008
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2115
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2196
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2288
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2447
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..3273
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3254..3259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3271
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggggcgggg ccgacgcctg cggcaggcgg ggttcgcagc ttcgctcccc agagagcagc
       61 cggggctgcg gagctggagc tggagtcaca gccggagccc gcggcagagt cggaatccgg
      121 ggtcgggctg gagcggggtc catcgacatg ggatccgcag actccaagct gaacttccgg
      181 aaggcggtga tccagctgac caccaagacg cagcccgtgg aagccaccga caatgctttc
      241 tgggaccagt tctgggcaga caccgctacc tcggtgcagg atgtctttgc gttggtgccg
      301 gcagcagaga tccgggctgt gcgagaggag tcaccctcta acctggccac gctgtgctac
      361 aaggctgtgg agaagctggt gcaaggagca gagggtggct gccactctga gaaggagaaa
      421 caggtcgtcc tgaactgcag ccggctactc acccgagtgc tgccttacat cttcgaggac
      481 cccgactgga ggggcttctt ctggtccaca gtgcccgggg cagggcgtgg agggggtgag
      541 gaagaggatg agaacgctcg tcccttggct gagtccttgc tcctggccat tgccgatttg
      601 ctcttctgcc cagacttcac tgtgcagaac caccggagga acgacgtgga ctcagcagaa
      661 gatgtccatt ccctggacag ctgtgaatat atctgggagg ctggtgtggg ctttgctcat
      721 tccccacagc ccaactacat ccatgacatg aaccggatgg agctgctgaa gttactgctc
      781 acgtgcttct cagaggccat gtacctgccc ccatctccag agagtggcag caccaacccc
      841 tgggttcagt tcttttgttc cacggagaac agacacgcgc tgcccctctt cacttcactc
      901 ctcaacaccg tgtgtgccta tgaccctgtg ggctacggga tcccctacaa ccacctgctc
      961 ttctcggact accgggagcc cctggtggag gaggctgctc aggtgcttat tgtcaccttg
     1021 gaccatgaca gtgctaccag caccagcccc accgtggacg gcaccaccac gggcacagct
     1081 atggatgatg ctgatcctcc agggcccgag aacctgtttg tgaactacct gtcccgaatt
     1141 catcgtgagg aggacttcca gttcatcctc aaggggatcg ctcggctgct gtccaatccc
     1201 ctgctccaga cctaccttcc caactccacc aagaagatcc agtttcacca ggagttgctt
     1261 gttctcttct ggaaactctg tgacttcaac aagaaattcc tcttctttgt actgaagagc
     1321 agtgacgtgc tggatatcct ggttcctatc ctctattttc tcaacgacgc ccgggcagat
     1381 caatctcggg tgggcttgat gcacatcggg gtcttcatcc tgctgctcct gagtggggag
     1441 aggaactttg gggtacggct gaacaagccc tactcagtgc gcgtgcccat ggacatcccg
     1501 gtcttcacag gcacacatgc agatttgctc attgtggtat tccacaaaat catcaccagc
     1561 ggtcatcagc ggttgcaacc cctcttcgac tgcctgctca ccattgtggt caacgtgtct
     1621 ccctacctca agagcctgtc catggtgact gccaacaagc tcctgcatct gctcgaggcc
     1681 ttctcgacca cctggttcct cttctcggca tctcagaacc accatctggt cttcttcctt
     1741 ctggaggtct tcaacaacat tatccagtac cagtttgatg gcaattccaa cctggtctat
     1801 gccatcatcc gtaaacgtgc ggtcttccac cagctggcca acctgcccac tgacccaccc
     1861 tccatccaca aggcacttca gcggcggcgg aggacaccag agcccctgtc ccgtactggt
     1921 tcccaggagg gaacgtccat ggagggatcc cgccctgctg cccctgcaga accaggcacc
     1981 cttaagacta gcctggtggc cactccaggc atcgacaagc tgacagagaa atcccaggta
     2041 tcagaggacg gcaccttgag gtctctagag cccgaatccc agcaaagctc agcagaaaac
     2101 agcccatctg atggggagtc cagccaaaca tggagagagc aacggagatt gtccaatgca
     2161 tcagccagtg gccagtggag cccaacatca gattggatct tgtcctggaa gtcaaagctg
     2221 ccgctgcaga ccatcatgcg cctgctgcag gtcctggttc cccaggtgga gaagatctgc
     2281 attgacaagg gtctgacgga tgagtctgag atcctgagat tcctgcagca cggtacccta
     2341 gtggggcttc tgcctgtgcc ccaccccatc cttatccgaa agtaccaggc gaactcgggg
     2401 actgccatgt ggttccgtac ctacatgtgg ggcgttatct atttgaggaa tgtggaccca
     2461 cctatctggt atgacactga cgtgaagctg tttgagatcc agcgggtgtg aggatgtcga
     2521 cttgagggaa tagggccgga agagctggtt ctagtcccca gtgctcccaa acccattgtt
     2581 ctgagcttaa agatccatta tcagggtgtg gggcgagcag agtagttggt cctggatggc
     2641 aggtcccagg tgcccattgt ggctggagac acagggattt aaaaaaaaaa gtgcccctct
     2701 gccctccagg ctgttctagg agcctcttgt ctcctccaga gatacaaccc catcagaacc
     2761 cctgcccact ctggctcctc ctccaagacc tgcccttgtg ctgcctgctc ccagaagctg
     2821 tcaggtcact gtgccctaat gggttgtctc aaaaaggagc catgtgctgc cccgtgaggg
     2881 cacctggtca tggtaaaggg agttctggct acctagtctg agacttctgt tccaggcgtc
     2941 ccttttgcca gcgccctggt tgggaagagc gactcagccg ctagtgaaga aggctggagg
     3001 ctgacgcttg tgaagcagga ccgtggagtg tgctttaggg gcttggagta gggtatcgag
     3061 agtgccctgt tactgtccgg ggtcggggga atctgcctgg ctggtggagc ctgaaggatg
     3121 tcggtgtccc tgccttatct gcggcctggg tggtgggagt tacactctat gagccccagc
     3181 tctggcctcc cggtcgccct tgcctcccct gtgtcagtac aatctttgct ctgtacaatc
     3241 ggccacttta cacaataaaa tgtccctccc agtaaaaaaa aaaaaaaaaa
//
