LOCUS       NP_001333703             787 aa            linear   ROD 27-APR-2025
DEFINITION  protein HID1 isoform 2 [Mus musculus].
ACCESSION   NP_001333703 XP_006533140
VERSION     NP_001333703.1
DBSOURCE    REFSEQ: accession NM_001346774.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 787)
  AUTHORS   Du,W., Zhou,M., Zhao,W., Cheng,D., Wang,L., Lu,J., Song,E.,
            Feng,W., Xue,Y., Xu,P. and Xu,T.
  TITLE     HID-1 is required for homotypic fusion of immature secretory
            granules during maturation
  JOURNAL   Elife 5, e18134 (2016)
   PUBMED   27751232
  REMARK    GeneRIF: The authors demonstrate that HID-1 deficiency prevented
            secretory granule maturation by blocking homotypic fusion of
            immature secretory granules.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 787)
  AUTHORS   Kikkawa,Y., Shitara,H., Wakana,S., Kohara,Y., Takada,T.,
            Okamoto,M., Taya,C., Kamiya,K., Yoshikawa,Y., Tokano,H.,
            Kitamura,K., Shimizu,K., Wakabayashi,Y., Shiroishi,T., Kominami,R.
            and Yonekawa,H.
  TITLE     Mutations in a new scaffold protein Sans cause deafness in Jackson
            shaker mice
  JOURNAL   Hum Mol Genet 12 (5), 453-461 (2003)
   PUBMED   12588793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ153052.1, AK138882.1, AL603828.9 and AW047036.1.
            
            On Oct 30, 2016 this sequence version replaced XP_006533140.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044395.1, AK138882.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..787
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.84 cM"
     Protein         1..787
                     /product="protein HID1 isoform 2"
                     /note="UPF0663 transmembrane protein C17orf28 homolog;
                     protein hid-1 homolog; HID1 domain-containing protein;
                     protein HID1"
                     /calculated_mol_wt=88520
     Region          1..784
                     /region_name="Hid1"
                     /note="High-temperature-induced dauer-formation protein;
                     pfam12722"
                     /db_xref="CDD:463680"
     Region          296..315
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R1F6.1)"
     Region          570..679
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R1F6.1)"
     Site            652
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8IV36; propagated from
                     UniProtKB/Swiss-Prot (Q8R1F6.1)"
     Site            669
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8R1F6.1)"
     CDS             1..787
                     /gene="Hid1"
                     /gene_synonym="C630004H02Rik"
                     /coded_by="NM_001346774.1:148..2511"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS83927.1"
                     /db_xref="GeneID:217310"
                     /db_xref="MGI:MGI:2445087"
ORIGIN      
        1 mgsadsklnf rkaviqlttk tqpveatdna fwdqfwadta tsvqdvfalv paaeiravre
       61 espsnlatlc ykaveklvqg aeggchseke kqvvlncsrl ltrvlpyife dpdwrgffws
      121 tvpgagrggg eeedenarpl aeslllaiad llfcpdftvq nhrrndvdsa edvhsldsce
      181 yiweagvgfa hspqpnyihd mnrmellkll ltcfseamyl ppspesgstn pwvqffcste
      241 nrhalplfts llntvcaydp vgygipynhl lfsdyreplv eeaaqvlivt ldhdsatsts
      301 ptvdgtttgt amddadppgp enlfvnylsr ihreedfqfi lkgiarllsn pllqtylpns
      361 tkkiqfhqel lvlfwklcdf nkkflffvlk ssdvldilvp ilyflndara dqsrvglmhi
      421 gvfillllsg ernfgvrlnk pysvrvpmdi pvftgthadl livvfhkiit sghqrlqplf
      481 dclltivvnv spylkslsmv tankllhlle afsttwflfs asqnhhlvff llevfnniiq
      541 yqfdgnsnlv yaiirkravf hqlanlptdp psihkalqrr rrtpeplsrt gsqegtsmeg
      601 srpaapaepg tlktslvatp gidklteksq vsedgtlrsl epesqqssae nspsdgessq
      661 twreqrrlsn asasgqwspt sdwilswksk lplqtimrll qvlvpqveki cidkgltdes
      721 eilrflqhgt lvgllpvphp ilirkyqans gtamwfrtym wgviylrnvd ppiwydtdvk
      781 lfeiqrv
//
