LOCUS       NM_178922               6360 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus hypermethylated in cancer 2 (Hic2), mRNA.
ACCESSION   NM_178922
VERSION     NM_178922.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6360)
  AUTHORS   Medeiros de Araujo,J.A., Barao,S., Mateos-White,I., Espinosa,A.,
            Costa,M.R., Gil-Sanz,C. and Muller,U.
  TITLE     ZBTB20 is crucial for the specification of a subset of callosal
            projection neurons and astrocytes in the mammalian neocortex
  JOURNAL   Development 148 (16) (2021)
   PUBMED   34351428
REFERENCE   2  (bases 1 to 6360)
  AUTHORS   Song,J.Y., Lee,S.H., Kim,M.K., Jeon,B.N., Cho,S.Y., Lee,S.H.,
            Kim,K.S. and Hur,M.W.
  TITLE     HIC2, a new transcription activator of SIRT1
  JOURNAL   FEBS Lett 593 (14), 1763-1776 (2019)
   PUBMED   31127867
  REMARK    GeneRIF: HIC2 is a pivotal transcriptional activator of SIRT1
REFERENCE   3  (bases 1 to 6360)
  AUTHORS   Dykes,I.M., van Bueren,K.L. and Scambler,P.J.
  TITLE     HIC2 regulates isoform switching during maturation of the
            cardiovascular system
  JOURNAL   J Mol Cell Cardiol 114, 29-37 (2018)
   PUBMED   29061339
  REMARK    GeneRIF: HIC2 regulates a switching event within both the
            contractile machinery of cardiomyocytes and the oxygen carrying
            systems during the developmental period.
            Erratum:[J Mol Cell Cardiol. 2023 Oct;183:102. doi:
            10.1016/j.yjmcc.2023.07.010.. PMID: 37517876]
REFERENCE   4  (bases 1 to 6360)
  AUTHORS   Dykes,I.M., van Bueren,K.L., Ashmore,R.J., Floss,T., Wurst,W.,
            Szumska,D., Bhattacharya,S. and Scambler,P.J.
  TITLE     HIC2 is a novel dosage-dependent regulator of cardiac development
            located within the distal 22q11 deletion syndrome region
  JOURNAL   Circ Res 115 (1), 23-31 (2014)
   PUBMED   24748541
  REMARK    GeneRIF: data suggest that HIC2 haploinsufficiency likely
            contributes to the cardiac defects seen in distal 22q11 deletion
            syndrome
REFERENCE   5  (bases 1 to 6360)
  AUTHORS   Gurtan,A.M., Ravi,A., Rahl,P.B., Bosson,A.D., JnBaptiste,C.K.,
            Bhutkar,A., Whittaker,C.A., Young,R.A. and Sharp,P.A.
  TITLE     Let-7 represses Nr6a1 and a mid-gestation developmental program in
            adult fibroblasts
  JOURNAL   Genes Dev 27 (8), 941-954 (2013)
   PUBMED   23630078
REFERENCE   6  (bases 1 to 6360)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 6360)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (bases 1 to 6360)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 6360)
  AUTHORS   Mannan,A., Lucke,K., Dixkens,C., Neesen,J., Kamper,M., Engel,W. and
            Burfeind,P.
  TITLE     Alternative splicing, chromosome assignment and subcellular
            localization of the testicular haploid expressed gene (THEG)
  JOURNAL   Cytogenet Cell Genet 91 (1-4), 171-179 (2000)
   PUBMED   11173852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ965108.1, AK129266.1, BQ954078.1 and BC050867.1.
            
            On Jul 15, 2005 this sequence version replaced NM_178922.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156332.1, AK157276.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BQ965108.1         8-21
            15-4504             AK129266.1         1-4490
            4505-5062           BQ954078.1         105-662
            5063-6360           BC050867.1         744-2041
FEATURES             Location/Qualifiers
     source          1..6360
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 10.68 cM"
     gene            1..6360
                     /gene="Hic2"
                     /gene_synonym="HRG22; mKIAA1020"
                     /note="hypermethylated in cancer 2"
                     /db_xref="GeneID:58180"
                     /db_xref="MGI:MGI:1929869"
     exon            1..144
                     /gene="Hic2"
                     /gene_synonym="HRG22; mKIAA1020"
                     /inference="alignment:Splign:2.1.0"
     exon            145..243
                     /gene="Hic2"
                     /gene_synonym="HRG22; mKIAA1020"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..2077
                     /gene="Hic2"
                     /gene_synonym="HRG22; mKIAA1020"
                     /note="hic-2"
                     /codon_start=1
                     /product="hypermethylated in cancer 2 protein"
                     /protein_id="NP_849253.2"
                     /db_xref="CCDS:CCDS27999.1"
                     /db_xref="GeneID:58180"
                     /db_xref="MGI:MGI:1929869"
                     /translation="MVSGPLALRWCPWAGHRDMGPDMELPSHSKQLLLQLNQQRAKGF
                     LCDVIIMVENSIFRAHKNVLAASSIYFKSLVLHDNLINLDTDMVSSTVFQQILDFIYT
                     GKLLPSDQPSEPNFSTLLTAASYLQLPELAALCRRKLKRAGKPFGPGRVGTAGIGRPT
                     RSQRLSTASVIQARFPGLVDVRKGHPAPQELPQAKGSDDELFLGTSTQESTHGLGLGG
                     PAGGEMGLGGCSTSTNGSSGGCEQELGLDLSKKSPPLPPTTPGPHLTPEDPAQLSDSQ
                     RESPAPTSTSALPVGNSASFVELGATPEEPMDVEGAEENHLSLLEGQGGQPRKSLRHS
                     ARKKDWNKKEPVAGSPFDRRETGSKGSCPGEEGEGTGDRVPNGVLASSAGGGGPSASY
                     GEQSFPCKEEEENGKDGSEDSGQSGSEGGSGHTGAHYVYRQEGYETVSYGDNVYVCIP
                     CAKGFPSSEQLNAHVETHTEEELFIKEEGAYETGSGGAEEEAEDLSTPSAAYTADSRP
                     FKCSVCEKTYKDPATLRQHEKTHWLTRPFPCNICGKMFTQRGTMTRHMRSHLGLKPFA
                     CDECGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLISHLRMHTSPS"
     exon            244..6339
                     /gene="Hic2"
                     /gene_synonym="HRG22; mKIAA1020"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6316..6321
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hic2"
                     /gene_synonym="HRG22; mKIAA1020"
                     /note="hexamer: ATTAAA"
     polyA_site      6330
                     /gene="Hic2"
                     /gene_synonym="HRG22; mKIAA1020"
     polyA_site      6339
                     /gene="Hic2"
                     /gene_synonym="HRG22; mKIAA1020"
                     /note="major polyA site"
ORIGIN      
        1 gatggcgcgg agcgggcggc tgtgagcagc gctctgggcg cgctgggcgg agagccgagc
       61 gggggccggc ggagggcgga cagggcgggc gcgtgcagct caggtcgggc gcccaagacg
      121 aggggcctct ggcaggcacc tgaggtaacc aggctttgat gcaccctcag gaagtctgtg
      181 cactcgagga ggccaccccc cgccggctgc tgctcacatg gtttctgggc ccctggcact
      241 ccggtggtgc ccgtgggcag ggcacaggga catggggcca gacatggagc ttcccagcca
      301 ttcaaaacag ctcctgctac agctgaacca gcagagggcc aagggcttcc tgtgtgacgt
      361 catcatcatg gtggagaact ctatcttccg ggcccacaag aatgtcctgg ctgctagcag
      421 catctacttc aagtccctgg tcctgcatga taacctcatc aacttagaca cagacatggt
      481 cagctccact gtgttccagc agatcctgga cttcatctac acaggcaagc tcctgcccag
      541 tgaccagcca tctgagccaa acttcagcac tctactcact gctgccagct acctccagct
      601 gcctgagttg gcagccctct gtcgccgcaa actgaagcga gctggcaagc cctttggccc
      661 tggacgagtg ggtactgctg gcatagggcg accaacccgc agtcagcggc tgtccacagc
      721 ctctgtcatc caggctcgat ttccagggct tgtagatgtg cgtaaaggac accctgctcc
      781 ccaggagctc cctcaggcca aaggctcaga tgatgagctt tttctgggca cctccactca
      841 ggagagcaca cacggcctgg gcttgggggg tccagctggt ggggagatgg gcttgggggg
      901 ctgcagcacc agcaccaatg ggagtagtgg gggctgtgag caggagctgg gcttggacct
      961 gtccaagaag agcccaccct tacctcctac aacccctggc ccccacctca cacccgagga
     1021 cccagcccag ctgagtgaca gccagcgaga gtcacccgca cccacatcga cctctgccct
     1081 gcctgtcggc aatagtgcct catttgttga gctgggggcc actcctgagg agcccatgga
     1141 tgtggaaggg gctgaggaaa accacctgag tctgctggaa ggacagggtg ggcagcctcg
     1201 caagagcctc cggcattcag cccgcaaaaa agattggaac aaaaaggaac ctgtggctgg
     1261 gtcccccttt gataggagag aaacaggatc taagggttcc tgcccagggg aagaaggtga
     1321 agggactggg gacagggttc ccaatggcgt tctggctagc agtgctggtg gaggtggccc
     1381 cagtgcatcg tatggggagc agtcattccc ctgcaaggag gaggaggaga atggcaaaga
     1441 tgggagtgag gacagtgggc agagtgggag tgaggggggc agcggccata ctggcgccca
     1501 ctatgtatac cggcaggaag gctatgagac agtgtcatat ggggacaatg tttatgtgtg
     1561 catcccctgt gccaagggct tccccagctc tgagcagctc aatgctcacg tggagacaca
     1621 cacggaggag gagttattca tcaaggaaga aggggcttat gagaccggca gtgggggtgc
     1681 cgaggaggag gctgaggacc tgtcaacacc tagtgcagcc tacacagctg actctcgtcc
     1741 tttcaagtgc tcagtttgtg agaagaccta caaggaccca gccacactgc ggcaacacga
     1801 gaagacacac tggttgaccc gtccgttccc ctgcaacatt tgtggaaaga tgttcacaca
     1861 gcgaggcact atgacacgcc acatgcggag ccacctgggc ctgaagccct ttgcctgtga
     1921 tgagtgtggt atgcgtttca ctcgccagta ccgcctcaca gagcacatgc gtgtgcactc
     1981 aggtgagaag ccctatgagt gccagctctg tggaggcaag ttcacccaac agcgcaacct
     2041 catcagccac ctgcgcatgc acacttcccc ttcctagaag ccaaagaccc gtgggagccc
     2101 tctacagact tgccacttgg gaacccacgg aagcatggtg ggagggttga gccccaaagt
     2161 ctgacatgag gctcctggca gcccctctgg cccagcctcc tcacgcccag agctttaatc
     2221 aacagtatac caagggaagc caagagagaa gctgaccagt ctagccctat gcatgtggtg
     2281 ctggtgacta ttctacctcc ctgggcccac tgggctttcc agctccctga aggagctgct
     2341 gaagagccgg tgggagtcca tcatgtgggt gccagtgggg cctggttggt tcctttcctg
     2401 caggttgggc tgggccacag ggtttcctgt ggccaaaagt ggtgcctgga gcaggcctag
     2461 ctggcaggga cctcggctgt gtgtgtgcat gtgtgcttgt gtctttgcag tgcagtgtga
     2521 ctctggtgtt ggggtgctgg tgctgggtgg cagttccttt ctctgtgagc tggggtggca
     2581 actgctagct ggcactggaa cagtcagggt gacccattgc ctacctctct gcaactaaag
     2641 agccctctgg gcctatattg ctgttattcc tactgagctg ttcctatttc ttttttacag
     2701 tttttaaaaa ttctttttta aaaccaaaat gaacaatatt ttcctcctgc ctctttgggg
     2761 ttgagcctgg gtctgcagac tgaatgtaac cggggcagct gcccctccct atcattttcc
     2821 ctagtcctgg tgcttgggca tggttgaacc tgcctctcca aggcccagaa gcccttcttg
     2881 cccaaaggct tccctgattc tgagccctgc ctgcctgggc ttcctcagga gaatatgctt
     2941 ttccataatt tccaaggaat gtcccttgtt agaggtactt atttttattg agaaccacac
     3001 cctcccccat ataccttttt gagatgtgga actggaaggt ctgaagtttc agagggtgga
     3061 ggggaggcta gattcggtgc cagagccatc ggtactcttg ctctcgtgtg cacacgcatc
     3121 tgtgtgtgcg tgcgcgcgcg cgcgcgcgcg cgcgtgtgtg tgtgtgtgtg tgtgtgtgtg
     3181 tgtgtgcgcg cgcatgtgcg tgtgtgttgc ttatgcacag atgcttcact tccttgctca
     3241 ctgaacatgg tggggagcct tctgaccttt gctacctctt gaattcaata cccagtacag
     3301 ttgaggctga gccacttgct tttgtttttc tgtagtggga gtaacctggg cttgggctgg
     3361 cccaagcccc ttgtgggacc cagtgttctc tgaagagatg tctgctgctc agggcatgct
     3421 gtgtgtgggg caggtgctgg gcatctgagt aacaggcaga agccattagg aaggagcagc
     3481 tcccttttat gagccagggt caggtggaag tgagcccacc ccatcctgtc ccctccagag
     3541 ctcaggtatg tctggtaacc tacagcagag ccagaggtaa tggttgaccc ctacctatac
     3601 tgactcagta cagggtcaag ctaacccttc catgggtgtg tcagccagcc tcagatgttt
     3661 gcatgggctt ctgcaagggg caaggcaaga ccaagagtgt ctgtgttctg tcccagatgg
     3721 gcctatagac cttatcatgt tgcttcatgg cttttcattt tccttttgat ttttacttca
     3781 gaccaaaaaa ttccagagtc atcccctgct tgcctccacc cctcagagac cctggagcct
     3841 acattcagta cccagagagt gttgggtgtg ggagtgaggg cacctggcca aacctccaca
     3901 tagtgcctgt gtactgagcc agctctccat cagccctcac tgggaatctt agttctctga
     3961 ctgagcatct gagtgcagcc caggcactat tctacccagt gaaatagcag ggcatgctgg
     4021 cctctgctcc ccacccaccc acctaccagc acttaaggcc taggacacaa ggtctgtgtg
     4081 gcctcccagg ctgtaggtac cctcatctgc agaaaatcag ggactaggag cagagcccct
     4141 cactgagcat gtctgtgcga cagagtattg tacccacctt agtgttgtac caagcctttt
     4201 ctgtgtttta atgagaaagc aaaacactag tttcctattt gagatttaag ggttgttggg
     4261 atgggtggga tccacacttg gattctcttt cctttgttct cactgctgca tgcctatgag
     4321 tgtgtctctg tgtgtgtctg tgtgtgtgtg cagatagaag agcctcatgg aaaccaggcc
     4381 ataggaggcc aaggcagcga acagttctct gttttagtca tttaattcct gaatgttttg
     4441 gggaaacagg aaacagaaaa tagcagatgt catgtagaga aaaaaaaaag ttaaaaaaaa
     4501 aatcaaaaga aaaaaaaaaa aagctcatac ccaaattcac aaaacctatt ttttaaacca
     4561 aagcacattt tgaatgagtg tggaacctca gtgggctcag aaaaaaatac taatatattt
     4621 atctcattgt ttacataaac ttatacagtt tcagacctca gcagctacaa cagtcccagg
     4681 gaagctctcc cctcccacct gggtccttct gaggcgaccc ttgagcagct caagggcaga
     4741 ggcagccctg ggtgctgggt aaggactcga agtcccccta gcttcacctg agccctcatc
     4801 cccatttttt ggggcctctt caagctcagc tgccaccaaa gagcatgcac caagctgacc
     4861 agcccccagg cttcctagct gaacccaagg ggtggatttg gccctgccca tgagccttgt
     4921 gttactttga gagtcactca agccaaaaaa gcaggtagct ttatgaagct cagtggactc
     4981 cgtcatgcac gtaccctacc ccgggcagca gaagggtctg actggagtct ggtccttact
     5041 aacaaatggt gcagacactc tcaacagtgt tgtttttgta tcaatgtttg tgcagtgatg
     5101 aatgtattta tttctcagac ttagggcaat ccagtggagc aggcctggct ctgccagtgc
     5161 ccatttccac cggaccgagc tactgcaagg gctcttccaa ggttgcaaaa aggaaaagat
     5221 gaacttatga acacataaga atctcagact tgcagcatag ccatacacct caactgtgac
     5281 tcctgacctc atgtggccca ggaagtgtgt tttccgtcca tcaacactga ggggagccag
     5341 gtccccacct gctgtccaca ctatcagtat tcactggacc tcaggtcctt gtgcaggagt
     5401 gcgatctgcc gggcaatctg tcagcaggca gactgctgcc ttcctgagta ggggaaaccc
     5461 tgggcagccg ggagggcagg cctcagggag caagcgctat gagtaaaggt ggaagccaag
     5521 ggcaaggcct gtaaagactg gacaggctct cgaaaccctg ctgtgctcga tgaaagggac
     5581 caaggtcttc ctttccccag tcacgatggg gccaatgtta ctgaacctat gaaatggatg
     5641 ccaggaatga gggatagaga gggacccgac ctcagtctga cattccagcc caggaaaggg
     5701 tgggagctgt ggatccgtgc tgcccaggac cccttcctag gaaacctgca gcttcagtca
     5761 ccttacttta actttctacc agggacccct cccctacctc accttgctat ttattgctgt
     5821 aatttattga cctcaaaaat gctgcataac agacctcact tgggtcaggg agagttccca
     5881 gggtcctccc ctccacttgg tggggcccca tgggggccag gtgctgagag gaaccccctg
     5941 tacccaccca tcactcgttt tcctccagga gccccaggtt gggctctatc catcccattt
     6001 gcaaatacct caggagggat ggggtatctg tttcatttaa ttggaactgg aagagggatc
     6061 atgacgtcct ttatgccctt ccccgagcag gggagggatg ctgggatcgc actcctgtac
     6121 tggtcacccc tattaccacg catcacattg atttgagttt acttccctaa agagtttgga
     6181 tggatgcatt caggtcagag ctgcagctct gcagccctcc gatgttagag tgatttatcc
     6241 atgactaatc tctccattca aaagcgtgca gtcttaatgt acagtgatga gaaactgtta
     6301 ttttatgatc ttttcattaa aagcttgatt gaaaactgaa aaaaaaaaaa aaaaaaaaaa
//
