LOCUS       NM_010430               3122 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus hypermethylated in cancer 1 (Hic1), transcript variant
            1, mRNA.
ACCESSION   NM_010430 XM_001000715
VERSION     NM_010430.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3122)
  AUTHORS   Wang,L., Mishra,S., Fan,K.K., Quon,S., Li,G., Yu,B., Liao,W.,
            Liu,Y., Zhang,X., Qiu,Y., Li,Y., Goldrath,A.W., Ma,C. and Zhang,N.
  TITLE     T-bet deficiency and Hic1 induction override TGF-beta-dependency in
            the formation of CD103+ intestine-resident memory CD8+ T cells
  JOURNAL   Cell Rep 43 (6), 114258 (2024)
   PUBMED   38781073
  REMARK    GeneRIF: T-bet deficiency and Hic1 induction override
            TGF-beta-dependency in the formation of CD103[+] intestine-resident
            memory CD8[+] T cells.
REFERENCE   2  (bases 1 to 3122)
  AUTHORS   Hasegawa,K., Tamaki,M., Sakamaki,Y. and Wakino,S.
  TITLE     Nmnat1 Deficiency Causes Mitoribosome Excess in Diabetic
            Nephropathy Mediated by Transcriptional Repressor HIC1
  JOURNAL   Int J Mol Sci 25 (12), 6384 (2024)
   PUBMED   38928090
  REMARK    GeneRIF: Nmnat1 Deficiency Causes Mitoribosome Excess in Diabetic
            Nephropathy Mediated by Transcriptional Repressor HIC1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3122)
  AUTHORS   Tung,L.W., Groppa,E., Soliman,H., Lin,B., Chang,C., Cheung,C.W.,
            Ritso,M., Guo,D., Rempel,L., Sinha,S., Eisner,C., Brassard,J.,
            McNagny,K., Biernaskie,J. and Rossi,F.
  TITLE     Spatiotemporal signaling underlies progressive vascular rarefaction
            in myocardial infarction
  JOURNAL   Nat Commun 14 (1), 8498 (2023)
   PUBMED   38129410
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3122)
  AUTHORS   Lotto,J., Cullum,R., Drissler,S., Arostegui,M., Garside,V.C.,
            Fuglerud,B.M., Clement-Ranney,M., Thakur,A., Underhill,T.M. and
            Hoodless,P.A.
  TITLE     Cell diversity and plasticity during atrioventricular heart valve
            EMTs
  JOURNAL   Nat Commun 14 (1), 5567 (2023)
   PUBMED   37689753
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3122)
  AUTHORS   Arostegui,M., Scott,R.W. and Underhill,T.M.
  TITLE     Hic1 identifies a specialized mesenchymal progenitor population in
            the embryonic limb responsible for bone superstructure formation
  JOURNAL   Cell Rep 42 (4), 112325 (2023)
   PUBMED   37002923
REFERENCE   6  (bases 1 to 3122)
  AUTHORS   Guerardel,C., Deltour,S., Pinte,S., Monte,D., Begue,A., Godwin,A.K.
            and Leprince,D.
  TITLE     Identification in the human candidate tumor suppressor gene HIC-1
            of a new major alternative TATA-less promoter positively regulated
            by p53
  JOURNAL   J Biol Chem 276 (5), 3078-3089 (2001)
   PUBMED   11073960
REFERENCE   7  (bases 1 to 3122)
  AUTHORS   Carter,M.G., Johns,M.A., Zeng,X., Zhou,L., Zink,M.C.,
            Mankowski,J.L., Donovan,D.M. and Baylin,S.B.
  TITLE     Mice deficient in the candidate tumor suppressor gene Hic1 exhibit
            developmental defects of structures affected in the Miller-Dieker
            syndrome
  JOURNAL   Hum Mol Genet 9 (3), 413-419 (2000)
   PUBMED   10655551
REFERENCE   8  (bases 1 to 3122)
  AUTHORS   Guerardel,C., Deltour,S. and Leprince,D.
  TITLE     Evolutionary divergence in the broad complex, tramtrack and bric a
            brac/poxviruses and zinc finger domain from the candidate tumor
            suppressor gene hypermethylated in cancer
  JOURNAL   FEBS Lett 451 (3), 253-256 (1999)
   PUBMED   10371200
REFERENCE   9  (bases 1 to 3122)
  AUTHORS   Grimm,C., Sporle,R., Schmid,T.E., Adler,I.D., Adamski,J.,
            Schughart,K. and Graw,J.
  TITLE     Isolation and embryonic expression of the novel mouse gene Hic1,
            the homologue of HIC1, a candidate gene for the Miller-Dieker
            syndrome
  JOURNAL   Hum Mol Genet 8 (4), 697-710 (1999)
   PUBMED   10072440
REFERENCE   10 (bases 1 to 3122)
  AUTHORS   Deltour,S., Guerardel,C., Stehelin,D. and Leprince,D.
  TITLE     The carboxy-terminal end of the candidate tumor suppressor gene
            HIC-1 is phylogenetically conserved
  JOURNAL   Biochim Biophys Acta 1443 (1-2), 230-232 (1998)
   PUBMED   9838134
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603905.19.
            
            On Jul 22, 2021 this sequence version replaced NM_010430.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF036334.1, SRR7345562.3298555.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AL603905.19        88698-88839         c
            143-3122            AL603905.19        84260-87239         c
FEATURES             Location/Qualifiers
     source          1..3122
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.76 cM"
     gene            1..3122
                     /gene="Hic1"
                     /gene_synonym="HIC-1"
                     /note="hypermethylated in cancer 1"
                     /db_xref="GeneID:15248"
                     /db_xref="MGI:MGI:1338010"
     exon            1..142
                     /gene="Hic1"
                     /gene_synonym="HIC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            143..3122
                     /gene="Hic1"
                     /gene_synonym="HIC-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3095..3100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hic1"
                     /gene_synonym="HIC-1"
                     /note="hexamer: AATAAA"
     polyA_site      3122
                     /gene="Hic1"
                     /gene_synonym="HIC-1"
                     /note="major polyA site"
ORIGIN      
        1 gagacgcgac caggacgcgg ggaggacgga ccggcaagac agaccgaccg ggggcccggc
       61 gggcggaggg cagcgcactg cagccacgtc cccccctgga tccgccggca gccgggcccg
      121 gggcttccga catgcccccc aggagagtgt gctgggcaga cgatgctgga cacgatggag
      181 gcgcctggcc attcgaggca gctactgctg cagctcaaca atcagcgcac caagggcttc
      241 ttgtgcgacg tgatcatcgt ggtgcagaat gccctcttcc gcgcgcacaa gaacgtgctg
      301 gcggccagca gcgcctacct caagtccctg gtggtgcatg acaacctgct aaacctggac
      361 catgacatgg tgagcccggc cgtgttccgc ctggtgctgg acttcatcta caccggccgc
      421 ctgactgaca gtgttgaggc cgcagcagca gcagcggtgg ccccgggcgc ggagccgagc
      481 ctgggcgctg tgctggctgc tgccagctac ctgcagatcc ctgacctcgt ggctctgtgc
      541 aagaagcgcc tcaaacgcca cggcaagtac tgccacctgc ggggaggagg cagcggcggc
      601 ggcggctacg ctccttacgg gcggcccggc cggggcttga gggctgccac gcccgtcatc
      661 caggcttgct actcgtcccc ggccgggcca ccgccgccgc ctgccgccga gccgccgtcg
      721 ggccccgatg cagccgtcaa cacccactgc gctgagctat atgcttcagg cccgggccca
      781 gcagcctcac tctgcgcccc ggagcgtcgc tgctccccgc tttgcggcct ggatctgtcc
      841 aagaagagcc cgccaggttc ctcggtcccc gagcgaccgc ttagtgagcg cgaactgcct
      901 ccacgcccgg atagccctcc cggtgcgggg cccgcagtct acaaggagcc atcactcgcc
      961 ctgcccccgc tgccgccttt gcccttccaa aagctggagg aggccgtacc gactccagac
     1021 ccgtttcgag gaagcggtgg cagtccggga cccgagcccc ccggccgccc cgacggctcc
     1081 agcctcctct accgctggat gaagcacgag ccaggcctgg gtagttatgg cgatgaactg
     1141 gtccgggatc gaggctcccc gggtgagcgc ctggaggagc gcggtgggga tcctgccgcc
     1201 tcacccgggg gccccccgct gggcctggta cccccgccac gctaccccgg gagcctggac
     1261 gggccaggca caggagcaga cggcgacgac tataagagca gcagcgagga gaccggtagc
     1321 agcgaagacc ccagcccacc cggcggccac ctggagggct acccatgccc gcacttggct
     1381 tatggtgagc ctgagagctt tggtgacaac ctgtacgtgt gcatcccatg tggcaaaggc
     1441 ttccccagct cggaacagct gaatgcacac gtggaggctc acgtagagga agaagaggcg
     1501 ttatatggca gggcagaggc tgctgaggtg gctgctgggg ccgccggcct tgggcccccc
     1561 tttggtggcg gtggggacaa ggtcactggg gcgccgggcg gactaggaga gctgctgcgg
     1621 ccataccgct gcgcgtcctg cgacaagagc tacaaggacc cggccacgct gaggcagcac
     1681 gagaagacac actggctgac aaggccctat ccgtgtacca tctgcggaaa gaagttcacg
     1741 caacgcggaa ccatgacacg ccatatgcgc agccacttgg gcctgaagcc ctttgcgtgc
     1801 gacgcgtgcg gcatgcgctt cacccgccag tatcgcctca cggagcacat gcgcatccac
     1861 tctggagaga agccctacga gtgccaggtg tgcggtggca agtttgctca acagcgcaac
     1921 ctcatcagcc atatgaagat gcacgctgta ggtggcgcgg ccggcgcggc cggggcgctg
     1981 gctggcctgg ggggactacc tggcgtccct ggccctgacg gcaagggcaa gctcgacttc
     2041 cctgagggtg tctttgctgt ggcccgcctc acagctgaac agctgagtct gaagcagcag
     2101 gacaaggcag ctgctgccga gctgctggcg cagaccacgc acttcctgca cgaccccaag
     2161 gtggcgctgg agagcctcta cccgctggct aaattcactg ctgagctagg actcagccca
     2221 gacaaggcgg cagaggtgct gagccagggt gcgcacttgg ccgcaggacc ggacagccga
     2281 accatcgacc gtttctctcc cacctagagc gccgtccctc ctaggtgcgc ccggcgctgc
     2341 ctgacagccc ggggataact ggtagcagcg gcagcgccgc agtggtggcc ccacctttct
     2401 acacctcacc tggcctcact gtttagtgcc ttagcctggg gaagtcagtg ggggaaaacc
     2461 ccgggtcggg ggtgggatag gggaagggag atttatattt ttgatatcag ctttgaccaa
     2521 aggagaaccc tgcctctccc tgtggctcat tggccctctc ccccggctcc gtgctgctct
     2581 tgggggaagg atgccattat tcggacggac gctcccagcc ctacctccgg cccttgcgac
     2641 cacacccatt ctcactgtga atctccctgc tggggtcgga gcattgggca cagttggaga
     2701 gaggggaggg gactgagccg gccggagggc ctccccgtcc cctgctcctg cccagcccgg
     2761 gactgataat gtgaagttcc tcattttgca caagtggcac tagccccagg gccaaccctt
     2821 cctttcctca ccaccagggt gggcagctct ggcgccaggg atgacaaccc tgacccatct
     2881 gtctctgctt ccgaggtgtc ccctcctctt cctggggtcc ccggaccata tatttattgc
     2941 atgcgcccta ggtgacccct atcctgagcc caactttagc tgggctggag agaggtctcc
     3001 ttccttggtt cccgttctgt ccctttgtat attctctact ctgtacacag gctcttccag
     3061 agccgcttcc attttctata ctcaaccaaa cagcaataaa gcagtaacca aggtccctat
     3121 aa
//
