LOCUS       NM_146108               1838 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus 3-hydroxyisobutyryl-Coenzyme A hydrolase (Hibch),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_146108
VERSION     NM_146108.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1838)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1838)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110177.19, AK076038.1 and AK082965.1.
            
            On Aug 27, 2015 this sequence version replaced NM_146108.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082965.1, BC026437.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC110177.19        70680-70689         c
            11-1712             AK076038.1         2-1703
            1713-1838           AK082965.1         1705-1830
FEATURES             Location/Qualifiers
     source          1..1838
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.99 cM"
     gene            1..1838
                     /gene="Hibch"
                     /gene_synonym="2610509I15Rik; HIBYL-COA-H"
                     /note="3-hydroxyisobutyryl-Coenzyme A hydrolase"
                     /db_xref="GeneID:227095"
                     /db_xref="MGI:MGI:1923792"
     exon            1..107
                     /gene="Hibch"
                     /gene_synonym="2610509I15Rik; HIBYL-COA-H"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1230
                     /gene="Hibch"
                     /gene_synonym="2610509I15Rik; HIBYL-COA-H"
                     /EC_number="3.1.2.4"
                     /note="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial;
                     HIB-CoA hydrolase"
                     /codon_start=1
                     /product="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
                     precursor"
                     /protein_id="NP_666220.1"
                     /db_xref="CCDS:CCDS14948.1"
                     /db_xref="GeneID:227095"
                     /db_xref="MGI:MGI:1923792"
                     /translation="MGQPYAWRLLSRVSSFRRASVILQHLRMSMHTEAAEVLLERRGC
                     GGVITLNRPKFLNALSLNMIRQIYPQLKTWEQDPDTFLIIIKGAGGKAFCAGGDIKAL
                     SEAKKARQNLTQDLFREEYILNNAIASCQKPYVALIDGITMGGGVGLSVHGQFRVATE
                     RSLFAMPETGIGLFPDVGGGYFLPRLQGKLGYFLALTGYRLKGRDVHRAGIATHFVDS
                     EKLRVLEEELLALKSPSAEDVAGVLESYHAKSKMDQDKSIIFEEHMDKINSCFSANTV
                     EQIIENLRQDGSPFAIEQMKVINKMSPTSLKITLRQLMEGSSKTLQEVLIMEYRITQA
                     CMEGHDFHEGVRAVLIDKDQTPKWKPANLKDVTDEDLNSYFKSLGSSDLKF"
     exon            108..150
                     /gene="Hibch"
                     /gene_synonym="2610509I15Rik; HIBYL-COA-H"
                     /inference="alignment:Splign:2.1.0"
     exon            151..288
                     /gene="Hibch"
                     /gene_synonym="2610509I15Rik; HIBYL-COA-H"
                     /inference="alignment:Splign:2.1.0"
     exon            289..373
                     /gene="Hibch"
                     /gene_synonym="2610509I15Rik; HIBYL-COA-H"
                     /inference="alignment:Splign:2.1.0"
     exon            374..454
                     /gene="Hibch"
                     /gene_synonym="2610509I15Rik; HIBYL-COA-H"
                     /inference="alignment:Splign:2.1.0"
     exon            455..507
                     /gene="Hibch"
                     /gene_synonym="2610509I15Rik; HIBYL-COA-H"
                     /inference="alignment:Splign:2.1.0"
     exon            508..586
                     /gene="Hibch"
                     /gene_synonym="2610509I15Rik; HIBYL-COA-H"
                     /inference="alignment:Splign:2.1.0"
     exon            587..732
                     /gene="Hibch"
                     /gene_synonym="2610509I15Rik; HIBYL-COA-H"
                     /inference="alignment:Splign:2.1.0"
     exon            733..819
                     /gene="Hibch"
                     /gene_synonym="2610509I15Rik; HIBYL-COA-H"
                     /inference="alignment:Splign:2.1.0"
     exon            820..878
                     /gene="Hibch"
                     /gene_synonym="2610509I15Rik; HIBYL-COA-H"
                     /inference="alignment:Splign:2.1.0"
     exon            879..960
                     /gene="Hibch"
                     /gene_synonym="2610509I15Rik; HIBYL-COA-H"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1080
                     /gene="Hibch"
                     /gene_synonym="2610509I15Rik; HIBYL-COA-H"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1114
                     /gene="Hibch"
                     /gene_synonym="2610509I15Rik; HIBYL-COA-H"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1838
                     /gene="Hibch"
                     /gene_synonym="2610509I15Rik; HIBYL-COA-H"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1693..1698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hibch"
                     /gene_synonym="2610509I15Rik; HIBYL-COA-H"
                     /note="hexamer: AATAAA"
     polyA_site      1714
                     /gene="Hibch"
                     /gene_synonym="2610509I15Rik; HIBYL-COA-H"
                     /note="major polyA site"
ORIGIN      
        1 gtgggcgggt ctaactacca gagccggtgg aaccactaca ctctgcttct tctgctcttg
       61 ggtttttagg ccatggggca gccatatgcg tggcggctcc tgtcgagggt cagctccttc
      121 agaagagcca gcgttattct gcaacatctg agaatgtcca tgcacacaga agctgcagaa
      181 gtgctgctgg agaggagagg ctgtggaggc gtcataacgc tcaacagacc caagttcctc
      241 aacgcactga gtctgaatat gatccggcag atctatccac agctaaagac atgggaacaa
      301 gaccctgaca cattcctgat catcataaag ggagccggag gaaaggcctt ctgtgctgga
      361 ggggacatca aagcactctc agaagctaaa aaagcaagac agaatttaac tcaagattta
      421 ttcagagaag aatacatctt gaacaatgca attgcatctt gtcagaaacc atatgttgcc
      481 cttattgatg gaatcacaat gggtggggga gttggtcttt cagtccatgg tcaattccga
      541 gtggctacag aaaggtctct ctttgctatg ccagaaacgg gaataggact atttcctgat
      601 gtgggtggag gttatttctt gccaagactt caaggaaaac tcggttactt ccttgcactg
      661 acaggataca gactaaaggg aagagatgtg cacagagcgg gaattgccac acactttgta
      721 gattcggaaa agttgcgtgt gttggaggag gagctgttag ccttaaagtc accttcagct
      781 gaggatgttg caggtgtctt agaaagctat catgccaagt ccaagatgga tcaagacaaa
      841 tctatcatat ttgaggaaca catggacaaa ataaacagtt gtttttcagc caataccgtg
      901 gaacagataa ttgaaaactt acggcaagat gggtcacctt ttgccataga acagatgaag
      961 gtaattaata aaatgtctcc gacatcacta aagatcacac taaggcaact catggagggc
     1021 tcttcaaaga ctttgcaaga ggtactgatc atggaatatc ggataactca agcatgtatg
     1081 gaagggcatg actttcatga aggtgttaga gctgttctca ttgacaaaga ccagactcca
     1141 aaatggaaac cagccaatct aaaagatgtt acggatgaag acttgaatag ttactttaaa
     1201 tctctgggaa gcagtgattt gaaattctaa agtttatttt ggagcaaagg tcaacacatc
     1261 atagcacaga ggctaggccc attttcatgc agcctacaag ctggaaatgg ttttctcatt
     1321 tttaaatgat tgggaaggaa atgaaaagac taatatttca tgatacagtg gttgcccaaa
     1381 gtttaagcac caatgtttgt aacttttcat gatatgacag ctgagatcca tacaccaatg
     1441 ttttatggaa ccttcctgca gcgtagcaga gcttctctat ggctgcttgg agtggccatg
     1501 gcacagactt tgacccacag cacctcaagg gtctaagttt ctactccagt cttcatcaga
     1561 aatggtttgt tggttcctgg tttataagaa attctcaaga gctccagaga atctcaagtt
     1621 tatttctcat taaaatggta actttgactt tgtttatata ctaattaacc aaattatgta
     1681 caagttagca aaaataaaga ccctgaaatt tggagggggt gtgttgatgc cttataaatg
     1741 ttcctttttt aaacatatga atgtatttta aaacaatact gtagcagaag aactactttg
     1801 taaacatgaa aaatctcatg taaaaaggaa aaaggttg
//
