LOCUS       NP_666220                385 aa            linear   ROD 30-APR-2024
DEFINITION  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial precursor [Mus
            musculus].
ACCESSION   NP_666220
VERSION     NP_666220.1
DBSOURCE    REFSEQ: accession NM_146108.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 385)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 385)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110177.19, AK076038.1 and AK082965.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082965.1, BC026437.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..385
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.99 cM"
     Protein         1..385
                     /product="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
                     precursor"
                     /EC_number="3.1.2.4"
                     /note="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial;
                     HIB-CoA hydrolase"
                     /calculated_mol_wt=39239
     transit_peptide 1..32
                     /note="Mitochondrion. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q8QZS1.1)"
                     /calculated_mol_wt=3817
     mat_peptide     33..385
                     /product="3-hydroxyisobutyryl-CoA hydrolase,
                     mitochondrial. /id=PRO_0000284930"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8QZS1.1)"
                     /calculated_mol_wt=39239
     Region          46..375
                     /region_name="ECH_2"
                     /note="Enoyl-CoA hydratase/isomerase; pfam16113"
                     /db_xref="CDD:465024"
     Site            54
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q8QZS1.1)"
     Site            91
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q8QZS1.1)"
     Site            100
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q8QZS1.1)"
     Site            220
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q8QZS1.1)"
     Site            233
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6NVY1; propagated from
                     UniProtKB/Swiss-Prot (Q8QZS1.1)"
     Site            296
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q8QZS1.1)"
     Site            352
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753,
                     ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q8QZS1.1)"
     Site            359
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q8QZS1.1)"
     Site            364
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q8QZS1.1)"
     CDS             1..385
                     /gene="Hibch"
                     /gene_synonym="2610509I15Rik; HIBYL-COA-H"
                     /coded_by="NM_146108.2:73..1230"
                     /db_xref="CCDS:CCDS14948.1"
                     /db_xref="GeneID:227095"
                     /db_xref="MGI:MGI:1923792"
ORIGIN      
        1 mgqpyawrll srvssfrras vilqhlrmsm hteaaevlle rrgcggvitl nrpkflnals
       61 lnmirqiypq lktweqdpdt fliiikgagg kafcaggdik alseakkarq nltqdlfree
      121 yilnnaiasc qkpyvalidg itmgggvgls vhgqfrvate rslfampetg iglfpdvggg
      181 yflprlqgkl gyflaltgyr lkgrdvhrag iathfvdsek lrvleeella lkspsaedva
      241 gvlesyhaks kmdqdksiif eehmdkinsc fsantveqii enlrqdgspf aieqmkvink
      301 msptslkitl rqlmegsskt lqevlimeyr itqacmeghd fhegvravli dkdqtpkwkp
      361 anlkdvtded lnsyfkslgs sdlkf
//
