LOCUS       NM_145567               1748 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus 3-hydroxyisobutyrate dehydrogenase (Hibadh), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_145567
VERSION     NM_145567.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1748)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1748)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1748)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1748)
  AUTHORS   Tuck,E., Estabel,J., Oellrich,A., Maguire,A.K., Adissu,H.A.,
            Souter,L., Siragher,E., Lillistone,C., Green,A.L., Wardle-Jones,H.,
            Carragher,D.M., Karp,N.A., Smedley,D., Adams,N.C., Bussell,J.N.,
            Adams,D.J., Ramirez-Solis,R., Steel,K.P., Galli,A. and White,J.K.
  CONSRTM   Sanger Institute Mouse Genetics Project
  TITLE     A gene expression resource generated by genome-wide lacZ profiling
            in the mouse
  JOURNAL   Dis Model Mech 8 (11), 1467-1478 (2015)
   PUBMED   26398943
REFERENCE   5  (bases 1 to 1748)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1748)
  AUTHORS   Lehoczky,J.A., Williams,M.E. and Innis,J.W.
  TITLE     Conserved expression domains for genes upstream and within the HoxA
            and HoxD clusters suggests a long-range enhancer existed before
            cluster duplication
  JOURNAL   Evol Dev 6 (6), 423-430 (2004)
   PUBMED   15509224
REFERENCE   7  (bases 1 to 1748)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC003914.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003914.1, SRR1660811.226103.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1748
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 25.6 cM"
     gene            1..1748
                     /gene="Hibadh"
                     /gene_synonym="6430402H10Rik"
                     /note="3-hydroxyisobutyrate dehydrogenase"
                     /db_xref="GeneID:58875"
                     /db_xref="MGI:MGI:1889802"
     exon            1..140
                     /gene="Hibadh"
                     /gene_synonym="6430402H10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1060
                     /gene="Hibadh"
                     /gene_synonym="6430402H10Rik"
                     /EC_number="1.1.1.31"
                     /note="3-hydroxyisobutyrate dehydrogenase, mitochondrial"
                     /codon_start=1
                     /product="3-hydroxyisobutyrate dehydrogenase,
                     mitochondrial precursor"
                     /protein_id="NP_663542.1"
                     /db_xref="CCDS:CCDS20151.1"
                     /db_xref="GeneID:58875"
                     /db_xref="MGI:MGI:1889802"
                     /translation="MAASLGFRGAASGLWYWSGRRRPVGSLAAVCSRSMASKTPVGFI
                     GLGNMGNPMAKNLMKHGYPLILYDVFPDVCKEFKEAGEQVASSPAEVAEKADRIITML
                     PSSMNAVEVYSGANGILKKVKKGSLLIDSSTIDPSVSKELAKEVEKMGAVFMDAPVSG
                     GVGAARSGNLTFMVGGVEDEFAAAQELLECMGSNVVYCGAVGTGQSAKICNNMLLAIS
                     MIGTAEAMNLGIRSGLDPKLLAKILNMSSGRCWSSDTYNPVPGVMHGVPSSNNYQGGF
                     GTTLMAKDLGLAQDSATSTKTPILLGSLAHQIYRMMCSKGYSKKDFSSVFQYLREEEP
                     F"
     exon            141..301
                     /gene="Hibadh"
                     /gene_synonym="6430402H10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            302..411
                     /gene="Hibadh"
                     /gene_synonym="6430402H10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            412..533
                     /gene="Hibadh"
                     /gene_synonym="6430402H10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            534..667
                     /gene="Hibadh"
                     /gene_synonym="6430402H10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            668..744
                     /gene="Hibadh"
                     /gene_synonym="6430402H10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            745..901
                     /gene="Hibadh"
                     /gene_synonym="6430402H10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1734
                     /gene="Hibadh"
                     /gene_synonym="6430402H10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1712..1717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hibadh"
                     /gene_synonym="6430402H10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1734
                     /gene="Hibadh"
                     /gene_synonym="6430402H10Rik"
                     /note="major polyA site"
ORIGIN      
        1 gccgtgtgtg aggcggcgga ggtcacggcg cggaggcggg gcgggggaca gcatggcagc
       61 ctccttgggg ttccggggag cagcctccgg cctctggtac tggagcggcc ggcggcggcc
      121 cgtgggcagc cttgcagcgg tgtgttctag gtcaatggct tctaagactc cagttggatt
      181 cattggactg ggaaacatgg gaaatccaat ggcaaaaaat ctcatgaaac atggctatcc
      241 actcatcctc tatgacgtgt tccctgatgt atgcaaggag tttaaagagg ctggggaaca
      301 ggtagcatcc tccccagcag aagtagccga aaaggctgac aggattatca caatgctgcc
      361 ctccagtatg aatgcggtag aagtttattc tggagcaaac gggattctaa aaaaagtgaa
      421 gaaaggctca ttattaatag attccagtac tattgatcct tcagtttcaa aagaattggc
      481 aaaagaagtt gagaaaatgg gagctgtttt catggacgcc cctgtctccg gtggtgtagg
      541 agctgctcgg tctggaaacc ttacatttat ggtgggagga gttgaagatg agtttgctgc
      601 tgcccaagag ttgctggaat gcatgggctc caacgtggta tactgtggag ctgttggaac
      661 ggggcagtct gcaaagatct gcaacaacat gctgttggct ataagtatga ttggaaccgc
      721 tgaagctatg aaccttggaa tcaggtcagg ccttgaccca aaactattgg ctaaaatcct
      781 gaatatgagc tccggacgat gctggtccag cgacacttac aaccccgtac ccggggttat
      841 gcatggggtc ccctcatcca ataactacca aggtggattt ggaacaacac taatggctaa
      901 ggatctggga ttggctcaag actctgccac cagcaccaag accccaattc tcctaggaag
      961 cctggcccat cagatataca ggatgatgtg ttcaaagggc tactcaaaga aagacttctc
     1021 atctgtgttc cagtatctac gggaggagga gcccttctga ctgcgccctg aggacgtgga
     1081 cgctgttagg aaccaaactc tgtcctgagc ttcctctagc tcactctaga agtaatggtc
     1141 taatcaaagg tcgtctgtct gcttttgatt gtctacatca cagcaatccc tgggaatttc
     1201 tatccatttt aaatgctgcc gctttcatct gtttagccag cacacccaat ggtttcacta
     1261 actagcccag ttgacctttt tgaagtttga gccttgagca ccttcaacaa aattgagcac
     1321 tctgattagg atatccactt tgcaaataaa accaaatgtt ttgtcaacat gatggtaaaa
     1381 aggaaagaaa tctgttacaa agacaaatta gagggaaatt tgtcctgtta accacatgct
     1441 attattcctt cattcagggt tactgaccta ctgtccaggg cttgataggt aaggcagctt
     1501 gttggccctt gttacagtat cttagtgtac cctcctgtta cagcttccac actcagccgg
     1561 cttgcttcag tatttttgct tcctgtatat tcttatacat gtttttgact ccagaaaaat
     1621 gacaccttta gactgtttca gagccaatga tgatatttcc tttaaataat tattacatta
     1681 ttctaactat agtcatatta ttttggattt aaataaattt ctatcctgat aacaaaaaaa
     1741 aaaaaaaa
//
