LOCUS       NM_001044380            2605 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus hedgehog interacting protein-like 1 (Hhipl1), mRNA.
ACCESSION   NM_001044380 XM_147710 XM_912692 XM_978809 XM_978850 XM_978895
            XM_990098
VERSION     NM_001044380.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2605)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2605)
  AUTHORS   Aravani,D., Morris,G.E., Jones,P.D., Tattersall,H.K.,
            Karamanavi,E., Kaiser,M.A., Kostogrys,R.B., Ghaderi Najafabadi,M.,
            Andrews,S.L., Nath,M., Ye,S., Stringer,E.J., Samani,N.J. and
            Webb,T.R.
  TITLE     HHIPL1, a Gene at the 14q32 Coronary Artery Disease Locus,
            Positively Regulates Hedgehog Signaling and Promotes
            Atherosclerosis
  JOURNAL   Circulation 140 (6), 500-513 (2019)
   PUBMED   31163988
  REMARK    GeneRIF: HHIPL1 expression was detected in in smooth muscle within
            atherosclerotic plaques of Apoe(-/-) mice. Its expression increased
            with disease progression in aortic roots of these mice.
            Proliferation and migration were reduced in Hhipl1 knockout mouse
            and HHIPL1 knockdown aortic smooth muscle cells.
REFERENCE   3  (bases 1 to 2605)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 2605)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2605)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC113163.1.
            
            On or before Jan 29, 2007 this sequence version replaced
            XM_147710.8, XM_912692.2, XM_990098.1, XM_978895.1, XM_978850.1,
            XM_978809.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC113163.1, AK166269.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2605
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 59.37 cM"
     gene            1..2605
                     /gene="Hhipl1"
                     /gene_synonym="1600002O04Rik; mKIAA1822"
                     /note="hedgehog interacting protein-like 1"
                     /db_xref="GeneID:214305"
                     /db_xref="MGI:MGI:1919265"
     exon            1..414
                     /gene="Hhipl1"
                     /gene_synonym="1600002O04Rik; mKIAA1822"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..2517
                     /gene="Hhipl1"
                     /gene_synonym="1600002O04Rik; mKIAA1822"
                     /note="HHIP-like protein 1"
                     /codon_start=1
                     /product="HHIP-like protein 1 precursor"
                     /protein_id="NP_001037845.1"
                     /db_xref="CCDS:CCDS36554.1"
                     /db_xref="GeneID:214305"
                     /db_xref="MGI:MGI:1919265"
                     /translation="MAGRRAVARIGPGALLVLRALLAAAHPQCLDFRPPFRPPQPLSF
                     CAQYSAFGCCTAEQDAALARRFRVLETRMDAGVWATCAGYALDLLCQECSPYAAHLYD
                     AEDPATPLRTVPGLCEDYCLDMWQTCRGLFRLLSPDRELWALESNRAKLCRYLSLDDT
                     DYCFPSLLVNENLNSNLGRVVADAKGCLQLCLEEVANGLRNPVAMVHAGDGSHRFFVA
                     EQVGLVWTYLPDRSRLEKPFLNVSQAVLTSPWEGDERGFLGLAFHPRFPHPSKLYVYY
                     SVGVGFREWIRISEFRVSEGDENTVDHGSERIILEIEEPASNHNGGQLLFGDDGFLYI
                     FTGDGGMAGDPFGKFGNAQNKSALLGKVLRIDVDRKERGLHYGIPPDNPFVDDPGARP
                     EVYALGVRNMWRCSFDRGDPMSGTGRGRLFCGDVGQNKYEEVDLVERGRNYGWRAREG
                     FECYDRKLCANTSLDDVLPIFAYPHKLGKSVTGGYVYRGCEYPNLNGLYIFGDFMSGR
                     LMSLRENPETGQWKYSEVCMGRGQTCAFPGLINNYYPYIISFAEDEAGELYFMSTGVP
                     SATAAHGVIYKVIDPSRRAPPGKCKIRPAQVKVRSHLIPFVPKEKFIRTPESTPRPTA
                     RAPTKAPRRRRPTAAPPAPTPRPTKPARPTRRPGARKGGGRRRGRPSTAVPEPENGSV
                     RLVRPAGLSPGRGRVEVFIGGRWGTVCDDAWDTKAAAVVCRQLGFAHAVRAAKRAEFG
                     EGRALRILLDDVRCAGSERNLLECAHAGVGTHNCKHDEDAGVECSHQDPNL"
     exon            415..1061
                     /gene="Hhipl1"
                     /gene_synonym="1600002O04Rik; mKIAA1822"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1205
                     /gene="Hhipl1"
                     /gene_synonym="1600002O04Rik; mKIAA1822"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1534
                     /gene="Hhipl1"
                     /gene_synonym="1600002O04Rik; mKIAA1822"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1661
                     /gene="Hhipl1"
                     /gene_synonym="1600002O04Rik; mKIAA1822"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1807
                     /gene="Hhipl1"
                     /gene_synonym="1600002O04Rik; mKIAA1822"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1889
                     /gene="Hhipl1"
                     /gene_synonym="1600002O04Rik; mKIAA1822"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..1972
                     /gene="Hhipl1"
                     /gene_synonym="1600002O04Rik; mKIAA1822"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2605
                     /gene="Hhipl1"
                     /gene_synonym="1600002O04Rik; mKIAA1822"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggtttccc ggtgatctcc cgggagggtg caagcaaggc tggaggcggg cgctcagggc
       61 gcggccagtg gctcctgggg ggcgcatcgg cggggctggc tggccggcct ttggctgcta
      121 tttctgcaga ctgccaggag aatggcggga cggagggctg tggcccggat cgggcccggg
      181 gcgctgctgg ttctgcgcgc tctgctggcc gccgcgcacc cgcagtgctt ggacttcagg
      241 ccgcccttcc ggccgccgca gccgctgagc ttctgcgcgc agtactccgc cttcggctgc
      301 tgcaccgcgg agcaggacgc ggcgctggcc cggcgcttcc gggtcctgga gacccgcatg
      361 gatgccgggg tgtgggcgac gtgtgccggc tacgctctgg acctgctgtg ccaggaatgt
      421 tcaccctatg cggcccatct ctatgacgct gaggatccag ccaccccact tcggacagtg
      481 cctggcctgt gtgaagatta ttgcctggac atgtggcaga cctgccgagg cctctttcgt
      541 ctcctctccc ctgaccgtga actctgggcc ctggagagca accgggccaa attatgccgc
      601 tacctgtcgc tagatgacac cgactactgt ttcccaagcc tgctggtcaa cgagaacctc
      661 aactcgaacc tgggccgtgt agtggctgat gccaagggct gcctgcagct gtgtttggag
      721 gaggtggcca atggacttcg aaacccggtt gcaatggtac atgctgggga tggcagccac
      781 cgcttcttcg tggccgagca ggtggggctg gtgtggacct acctgcctga ccgctcccgc
      841 ctggagaagc ccttcctgaa tgtgagccaa gcagtgctta cttcgccctg ggaaggggac
      901 gaacgtggct tcctgggtct tgccttccac ccccgcttcc cacatcccag caaactctat
      961 gtctactatt cggtgggggt cggcttccga gagtggatcc gcatcagcga gttcagagtc
     1021 tcagagggtg acgagaacac agtggatcat ggctcagaga ggataattct ggagatcgaa
     1081 gaaccagctt ccaatcacaa tgggggccag ctgctctttg gggatgacgg cttcctctac
     1141 atctttactg gagacggcgg gatggctgga gacccctttg ggaagtttgg aaatgcacaa
     1201 aacaagtctg ctctgctggg caaggtgctg cgcatcgacg tggaccgtaa ggagcgcggc
     1261 ctccactacg gcatccctcc agacaacccg ttcgtggatg atcccggagc tcggcctgag
     1321 gtctatgccc tgggcgtgcg caacatgtgg cgctgctcct tcgaccgcgg agacccaatg
     1381 tctggaactg gccgtgggcg cctgttctgc ggggacgtgg gccagaacaa gtatgaggag
     1441 gtggacctgg tggagcgggg ccgcaactac ggctggcgcg ctcgcgaggg cttcgagtgc
     1501 tacgaccgca agctgtgcgc caacacctcc ctcgatgacg tgctgccgat tttcgcctac
     1561 ccacacaagc tgggtaaatc agtcaccgga ggctacgtgt accggggttg tgagtacccc
     1621 aatctcaatg gcctctacat ttttggcgat ttcatgagcg ggcgactgat gtctctccga
     1681 gagaacccag agacaggcca atggaagtat agcgaggtct gcatgggccg tggacagacc
     1741 tgtgctttcc caggtctcat caacaactac tacccctaca tcatctcctt tgcggaggac
     1801 gaggctgggg agctgtactt catgtccacg ggtgttccca gtgccacggc tgcacatggg
     1861 gtcatctaca aagtcatcga tccctccaga cgggcgcctc cagggaagtg taagatccgc
     1921 cctgctcagg tgaaggtgag gagtcatctc atcccctttg tgcccaagga aaagttcatc
     1981 cggacgccag agagcactcc gcgccccaca gcccgcgctc ccactaaggc gccccgccgt
     2041 aggcgcccca cggctgctcc tcctgccccc accccgcgac ccacaaagcc cgcaaggccc
     2101 acccggcgac caggggcccg gaagggaggc gggcgacggc ggggacgtcc gagtaccgcg
     2161 gtccccgaac ccgagaacgg atcggtgcgt ctggtacggc ccgcaggcct gagccccggc
     2221 cgcggtcgcg tggaagtgtt cataggcgga cgctggggca cggtgtgcga cgacgcctgg
     2281 gacaccaagg cagccgccgt ggtgtgtcgt cagctgggtt ttgcgcacgc ggtgcgagcc
     2341 gccaagcgcg cggagtttgg cgagggccgc gcgctccgga tcttgctgga cgacgtgcgc
     2401 tgcgcgggca gcgaacgcaa cctgctggag tgcgcgcacg ctggcgtggg cacgcacaat
     2461 tgcaagcacg acgaggacgc tggcgtcgag tgcagccacc aagacccgaa cctgtagcct
     2521 gacctctcct acctggcggt gctactctgg gagtggcccc ttgggtttgc gggcacgccg
     2581 tgcagtatgc acgagccagg atgga
//
