LOCUS       NM_008245               1771 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus hematopoietically expressed homeobox (Hhex), mRNA.
ACCESSION   NM_008245
VERSION     NM_008245.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1771)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   2  (bases 1 to 1771)
  AUTHORS   Kane,E., Mak,T.C.S. and Latreille,M.
  TITLE     MicroRNA-7 regulates endocrine progenitor delamination and
            endocrine cell mass in developing pancreatic islets
  JOURNAL   iScience 27 (7), 110332 (2024)
   PUBMED   39055950
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1771)
  AUTHORS   Zhang,Z., Wu,Y., Fu,J., Yu,X., Su,Y., Jia,S., Cheng,H., Shen,Y.,
            He,X., Ren,K., Zheng,X., Guan,H., Rao,F. and Zhao,L.
  TITLE     Proteostatic reactivation of the developmental transcription factor
            TBX3 drives BRAF/MAPK-mediated tumorigenesis
  JOURNAL   Nat Commun 15 (1), 4108 (2024)
   PUBMED   38750011
  REMARK    Erratum:[Nat Commun. 2024 Jun 10;15(1):4936. doi:
            10.1038/s41467-024-49330-w.. PMID: 38858379]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1771)
  AUTHORS   Lu,P., Wang,P., Wu,B., Wang,Y., Liu,Y., Cheng,W., Feng,X., Yuan,X.,
            Atteya,M.M., Ferro,H., Sugi,Y., Rydquist,G., Esmaily,M.,
            Butcher,J.T., Chang,C.P., Lenz,J., Zheng,D. and Zhou,B.
  TITLE     A SOX17-PDGFB signaling axis regulates aortic root development
  JOURNAL   Nat Commun 13 (1), 4065 (2022)
   PUBMED   35831318
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1771)
  AUTHORS   Allegre,N., Chauveau,S., Dennis,C., Renaud,Y., Meistermann,D.,
            Estrella,L.V., Pouchin,P., Cohen-Tannoudji,M., David,L. and
            Chazaud,C.
  TITLE     NANOG initiates epiblast fate through the coordination of
            pluripotency genes expression
  JOURNAL   Nat Commun 13 (1), 3550 (2022)
   PUBMED   35729116
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1771)
  AUTHORS   Keng,V.W., Fujimori,K.E., Myint,Z., Tamamaki,N., Nojyo,Y. and
            Noguchi,T.
  TITLE     Expression of Hex mRNA in early murine postimplantation embryo
            development
  JOURNAL   FEBS Lett 426 (2), 183-186 (1998)
   PUBMED   9599004
REFERENCE   7  (bases 1 to 1771)
  AUTHORS   Thomas,P.Q., Brown,A. and Beddington,R.S.
  TITLE     Hex: a homeobox gene revealing peri-implantation asymmetry in the
            mouse embryo and an early transient marker of endothelial cell
            precursors
  JOURNAL   Development 125 (1), 85-94 (1998)
   PUBMED   9389666
REFERENCE   8  (bases 1 to 1771)
  AUTHORS   Thomas,P., Brickman,J.M., Popperl,H., Krumlauf,R. and
            Beddington,R.S.
  TITLE     Axis duplication and anterior identity in the mouse embryo
  JOURNAL   Cold Spring Harb Symp Quant Biol 62, 115-125 (1997)
   PUBMED   9598343
REFERENCE   9  (bases 1 to 1771)
  AUTHORS   Dear,T.N., Sanchez-Garcia,I. and Rabbitts,T.H.
  TITLE     The HOX11 gene encodes a DNA-binding nuclear transcription factor
            belonging to a distinct family of homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 90 (10), 4431-4435 (1993)
   PUBMED   8099440
REFERENCE   10 (bases 1 to 1771)
  AUTHORS   Bedford,F.K., Ashworth,A., Enver,T. and Wiedemann,L.M.
  TITLE     HEX: a novel homeobox gene expressed during haematopoiesis and
            conserved between mouse and human
  JOURNAL   Nucleic Acids Res 21 (5), 1245-1249 (1993)
   PUBMED   8096636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK033664.1.
            
            On Apr 5, 2007 this sequence version replaced NM_008245.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033664.1, AK149553.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1771              AK033664.1         2-1772
FEATURES             Location/Qualifiers
     source          1..1771
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 32.28 cM"
     gene            1..1771
                     /gene="Hhex"
                     /gene_synonym="Hex; Hex1; Hhex-rs2; Prh; Prhx"
                     /note="hematopoietically expressed homeobox"
                     /db_xref="GeneID:15242"
                     /db_xref="MGI:MGI:96086"
     exon            1..393
                     /gene="Hhex"
                     /gene_synonym="Hex; Hex1; Hhex-rs2; Prh; Prhx"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..845
                     /gene="Hhex"
                     /gene_synonym="Hex; Hex1; Hhex-rs2; Prh; Prhx"
                     /note="mHex; homeobox protein HEX; homeobox protein PRH;
                     proline-rich homeodomain protein; hematopoietically
                     expressed homeobox, related sequence 2"
                     /codon_start=1
                     /product="hematopoietically-expressed homeobox protein
                     Hhex"
                     /protein_id="NP_032271.1"
                     /db_xref="CCDS:CCDS29778.1"
                     /db_xref="GeneID:15242"
                     /db_xref="MGI:MGI:96086"
                     /translation="MQFPHPGPAAAPAVGVPLYAPTPLLQPAHPTPFYIDDILGRGPA
                     APTPTPTLPSPNSSFTSLVSSYRTPVYEPTPVHPAFSHHPAAALAAAYGPSGFGGPLY
                     PFPRTVNDYTHALLRHDPLGKPLLWSPFLQRPLHKRKGGQVRFSNDQTVELEKKFETQ
                     KYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQENPQSNKKDALDSLDTSCEQ
                     GQDLPSEQNKGASLDRSQCSPSPASQEDPDSEISEDSDQEVDIEGDKGYFNAG"
     exon            394..572
                     /gene="Hhex"
                     /gene_synonym="Hex; Hex1; Hhex-rs2; Prh; Prhx"
                     /inference="alignment:Splign:2.1.0"
     exon            573..623
                     /gene="Hhex"
                     /gene_synonym="Hex; Hex1; Hhex-rs2; Prh; Prhx"
                     /inference="alignment:Splign:2.1.0"
     exon            624..1771
                     /gene="Hhex"
                     /gene_synonym="Hex; Hex1; Hhex-rs2; Prh; Prhx"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1675..1680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hhex"
                     /gene_synonym="Hex; Hex1; Hhex-rs2; Prh; Prhx"
                     /note="hexamer: AATGAA"
     polyA_site      1712
                     /gene="Hhex"
                     /gene_synonym="Hex; Hex1; Hhex-rs2; Prh; Prhx"
                     /note="major polyA site"
ORIGIN      
        1 agctctctgc gaggggctgc ggagcggcca tgcagttccc gcacccgggg cccgcggctg
       61 cgcccgccgt gggagtcccg ctgtatgcgc ccacgccgct gctgcagccc gctcacccga
      121 cgcccttcta catcgacgac atcttgggtc gcgggcccgc cgcccccacg cccactccca
      181 cgctgccgtc ccccaactcc tccttcacca gcctcgtgtc ctcctaccgg accccggtgt
      241 acgagcccac gccggtccac cccgccttct cgcaccaccc ggccgccgcg ctggccgccg
      301 cctacggccc cagtggcttc ggaggccctc tgtacccgtt cccgcggacg gtgaacgact
      361 acacgcacgc cctactccgc cacgaccccc tgggcaagcc cttgctctgg agccccttcc
      421 tccagcgacc tctgcacaaa aggaaaggcg gtcaagtgag gttctccaac gaccagaccg
      481 tcgagctgga gaagaagttc gagactcaga aatacctctc cccacccgag agaaagcgtc
      541 tggccaagat gttacagctc agtgagagac aggtcaaaac ctggtttcag aatcgccgag
      601 ctaaatggag aagactgaaa caggagaatc ctcaaagcaa caaaaaggat gcgttggaca
      661 gtttggacac ttcctgtgag cagggtcaag acttgcccag tgaacagaat aaaggtgcct
      721 ctttggatcg ttcgcagtgt tcaccctccc cagcctctca ggaagacccc gactcggaga
      781 tctcagagga ttccgaccag gaggtggaca tcgaggggga taaaggctac tttaatgctg
      841 gatgacagtc atcggccatg tttagagacc ggactttaga ataatgtttt gctacagacc
      901 aactggaaaa ttcgggggga gagagagaga gagaaagaga gagagagaga gagagagaga
      961 gagagataac aattcttgta gagttttgaa aatgtttggt gcactggcta attaacaaac
     1021 atgcattgcg ttgagacctt aactttggtt taacatacgg tatctatacc agtttttaag
     1081 ttgttttgat aaagtgacta aatgtgacct cattttttaa aaagtgaatt tatttctatt
     1141 tatgagaggt aatttgaact tttgtctaaa gcttaaatta tgactttaaa ggttttaagt
     1201 tttaggaggc tgatcttgac tgactttcct aagtctgtag ctattccctc gactttagag
     1261 gtgcacttag gtgggggcaa catttgggga atccatggaa cactttgaaa gggtataccc
     1321 aacttttaca tggcatctta cattgctgcc ttaactccaa agccatttca gagcacttgg
     1381 ctcccggtgt ctgttcttac aagcaagata gttgataaga ttctaaaaat cttgttttgc
     1441 tcagccagtg cctctgaccc tggtgttaag ggatgacgca gtccctacag gcagggaaac
     1501 tgactcattt gagactgatc tcacacgaac tagaaatagc aggacaattc aatgtaagta
     1561 gattgtagat agtgtgtttt atagaaactg tgtctataac atgtatatag cattacttct
     1621 tgtaaaaact ctgccaaaat gatgtttgtt tgtttggttg gttttttgta atttaatgaa
     1681 ttaactttca tatacattca tcatcagatg aacgaccctg tttgaattct cattctttgg
     1741 ttaaaatacc taaacatgac acctaaagag c
//
