LOCUS       NM_029095               1870 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus hedgehog acyltransferase-like (Hhatl), transcript
            variant 1, mRNA.
ACCESSION   NM_029095
VERSION     NM_029095.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1870)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1870)
  AUTHORS   Van,B., Nishi,M., Komazaki,S., Ichimura,A., Kakizawa,S.,
            Nakanaga,K., Aoki,J., Park,K.H., Ma,J., Ueyama,T., Ogata,T.,
            Maruyama,N. and Takeshima,H.
  TITLE     Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic
            reticulum-resident protein essential for postnatal muscle
            maturation
  JOURNAL   FEBS Lett 589 (10), 1095-1104 (2015)
   PUBMED   25841338
  REMARK    GeneRIF: MG56 seems essential for postnatal skeletal muscle
            maturation
REFERENCE   3  (bases 1 to 1870)
  AUTHORS   Richard,A.F., Demignon,J., Sakakibara,I., Pujol,J., Favier,M.,
            Strochlic,L., Le Grand,F., Sgarioto,N., Guernec,A., Schmitt,A.,
            Cagnard,N., Huang,R., Legay,C., Guillet-Deniau,I. and Maire,P.
  TITLE     Genesis of muscle fiber-type diversity during mouse embryogenesis
            relies on Six1 and Six4 gene expression
  JOURNAL   Dev Biol 359 (2), 303-320 (2011)
   PUBMED   21884692
REFERENCE   4  (bases 1 to 1870)
  AUTHORS   Abe,Y., Kita,Y. and Niikura,T.
  TITLE     Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol
            uptake/transporter 1, acts as a negative regulator for N-terminal
            palmitoylation of Sonic hedgehog
  JOURNAL   FEBS J 275 (2), 318-331 (2008)
   PUBMED   18081866
  REMARK    GeneRIF: results suggest that Gup1 is a negative regulator of
            N-terminal palmitoylation of Shh and may contribute to the variety
            of biological actions of Shh
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY290483.1, BY232310.1, AK003605.1, BY703867.1 and AC165080.4.
            
            On Jul 8, 2009 this sequence version replaced NM_029095.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024464.1, AK003605.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                BY290483.1         3-73
            72-123              BY232310.1         47-98
            124-709             AK003605.1         1-586
            710-711             BY703867.1         587-588
            712-1864            AK003605.1         589-1741
            1865-1870           AC165080.4         125689-125694
FEATURES             Location/Qualifiers
     source          1..1870
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 72.62 cM"
     gene            1..1870
                     /gene="Hhatl"
                     /gene_synonym="1110011D13Rik; Gup1; Mg56"
                     /note="hedgehog acyltransferase-like"
                     /db_xref="GeneID:74770"
                     /db_xref="MGI:MGI:1922020"
     exon            1..245
                     /gene="Hhatl"
                     /gene_synonym="1110011D13Rik; Gup1; Mg56"
                     /inference="alignment:Splign:2.1.0"
     exon            246..364
                     /gene="Hhatl"
                     /gene_synonym="1110011D13Rik; Gup1; Mg56"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1770
                     /gene="Hhatl"
                     /gene_synonym="1110011D13Rik; Gup1; Mg56"
                     /note="glycerol uptake/transporter homolog; hedgehog
                     acyltransferase-like protein; Mitsugumin 56"
                     /codon_start=1
                     /product="protein-cysteine N-palmitoyltransferase
                     HHAT-like protein"
                     /protein_id="NP_083371.2"
                     /db_xref="CCDS:CCDS23638.1"
                     /db_xref="GeneID:74770"
                     /db_xref="MGI:MGI:1922020"
                     /translation="MGIKTALPAAELGLYSLVLSGALAYAGRGLLEASQDGAHRKAFR
                     ESVRPGWEYLGRKMDVADFEWVMWFTNFRNVIVFALSGHVLFAKLCTMVAPQLRSWMY
                     AVYGVLAVVGTMGPWYLLLLLGHCMVLYVASLLGQRWLCLALGLASLASFKVDPGISW
                     QSGFVTGTFDLQDVLFHGGSSFTVLRCTSFALESCAHPDRRYSLADLLKYNFYLPFFF
                     FGPIMTFDRFHAQVSQEPVRPEGELWHIQAQAGLSAAAIVAVDVFFHFFYILTIPSDL
                     KFASRLPDSALAGLAYSNLVYDWVKAAVLFGVVNTVARLDHLDPPQPPKCITALYVFG
                     ETHFDRGINDWLCKYVYDHIGGDHSTVIPELAASVATFVVTTLWLGPCDIVYLWSVLN
                     CFGLNFELWVQKLAERGPLAQIEARLSEQMSRRVRALCGAVNFWAIIMYNLVSLNSLE
                     FTELVARRLILTGFPQTTLAVLFVTYCGVQLVKERERSLALEEEQRQDREKLE"
     exon            365..432
                     /gene="Hhatl"
                     /gene_synonym="1110011D13Rik; Gup1; Mg56"
                     /inference="alignment:Splign:2.1.0"
     exon            433..546
                     /gene="Hhatl"
                     /gene_synonym="1110011D13Rik; Gup1; Mg56"
                     /inference="alignment:Splign:2.1.0"
     exon            547..741
                     /gene="Hhatl"
                     /gene_synonym="1110011D13Rik; Gup1; Mg56"
                     /inference="alignment:Splign:2.1.0"
     exon            742..951
                     /gene="Hhatl"
                     /gene_synonym="1110011D13Rik; Gup1; Mg56"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1120
                     /gene="Hhatl"
                     /gene_synonym="1110011D13Rik; Gup1; Mg56"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1265
                     /gene="Hhatl"
                     /gene_synonym="1110011D13Rik; Gup1; Mg56"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1301
                     /gene="Hhatl"
                     /gene_synonym="1110011D13Rik; Gup1; Mg56"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1503
                     /gene="Hhatl"
                     /gene_synonym="1110011D13Rik; Gup1; Mg56"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1645
                     /gene="Hhatl"
                     /gene_synonym="1110011D13Rik; Gup1; Mg56"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1870
                     /gene="Hhatl"
                     /gene_synonym="1110011D13Rik; Gup1; Mg56"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1846..1851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hhatl"
                     /gene_synonym="1110011D13Rik; Gup1; Mg56"
                     /note="hexamer: AATAAA"
     polyA_site      1867
                     /gene="Hhatl"
                     /gene_synonym="1110011D13Rik; Gup1; Mg56"
                     /note="major polyA site"
ORIGIN      
        1 actgcagcac tcggctctgc tccacaaacg gtctgctcca ctccaggaag gccacctcct
       61 cccccccccc ccacctccgg ctgtcaccac tcaccgctct agcctccagg gggtggggac
      121 cccagagctg gacacacccc atcgaagccc cacagctcag ccagccggac agactcacgg
      181 tcggactcaa gaccccggag ccctgaggtg ggcagcgcgc cagggttcct cgcagcctct
      241 tcaagccctc tccaggccat gggcatcaag acagcactgc ctgcagctga gctcggcctc
      301 tattcactgg tgctgagcgg tgccctggct tatgccggcc gaggtctcct ggaggcatca
      361 caagatgggg cccacaggaa ggccttccgg gagtctgtga gacctggctg ggagtacctg
      421 ggccggaaga tggatgtggc tgacttcgag tgggtgatgt ggtttaccaa cttccgaaat
      481 gtcattgtct ttgccctctc tggacacgtg ctgtttgcca aactctgcac gatggtggcc
      541 ccccagctcc gctcctggat gtatgctgta tatggagtcc tggctgtggt gggcacaatg
      601 ggcccatggt acctgctgct gctgcttggc cactgtatgg tcctctatgt ggcctcactc
      661 ttgggccagc gttggctgtg ccttgccctt ggtctggcca gcttggcgtc cttcaaggtt
      721 gaccctggaa tctcttggca gagtgggttt gtaacaggca cctttgatct tcaagacgta
      781 ctgttccacg gtggcagcag cttcacagtt ctgcggtgca ccagcttcgc cctggagagc
      841 tgcgcccacc ccgaccgccg ctactccctt gctgacctgc tcaagtacaa tttctacttg
      901 cccttcttct tcttcggacc catcatgacc ttcgaccgct tccatgctca ggtgagccag
      961 gagccagtga ggccagaggg cgagctatgg cacattcagg cccaggcggg actcagcgcg
     1021 gcagccatcg tggctgttga cgtcttcttt cacttcttct acatcctcac catccccagc
     1081 gatctcaagt tcgccagccg cctcccagac agtgctcttg ctggcctggc gtactcaaac
     1141 ctggtgtatg actgggtgaa ggcagcggtc ctgtttggtg ttgtcaacac tgtggcacgc
     1201 ctggaccacc tggaccctcc tcagcctccc aagtgcatta ctgcgctcta tgtcttcggg
     1261 gaaacgcact tcgaccgtgg tatcaatgat tggctttgca aatatgtgta tgaccacatt
     1321 ggcggggatc actccaccgt gatcccagag ctggccgcat ctgtggccac gttcgtcgtc
     1381 accactctgt ggctcgggcc ttgtgacatc gtctacctgt ggtctgttct taactgcttc
     1441 ggcctcaact ttgagctctg ggtacagaag ctggcagagc gtgggccact ggcacagata
     1501 gaggcccggc tatcagagca gatgtctcgg agggtccggg ccctctgcgg ggctgtaaat
     1561 ttctgggcta tcatcatgta caacctcgtg agcctgaaca gccttgaatt cacagagctg
     1621 gttgcccgac gcctgatact tacaggcttc ccccagacca cactggcggt cttgtttgtc
     1681 acctactgtg gtgtccagct ggtaaaggag cgtgagagat ccctggcact ggaggaggag
     1741 cagcggcagg acagagagaa gctggagtag gcatggggac agaggaccgg gctctgctca
     1801 gctgcttctg ggccccaggc ccaggccacg gagcctgacc aatagaataa aagacttttc
     1861 taccatagta
//
