LOCUS       NM_019447               2172 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus hepatocyte growth factor activator (Hgfac), mRNA.
ACCESSION   NM_019447
VERSION     NM_019447.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2172)
  AUTHORS   Sargsyan,A., Doridot,L., Hannou,S.A., Tong,W., Srinivasan,H.,
            Ivison,R., Monn,R., Kou,H.H., Haldeman,J.M., Arlotto,M.,
            White,P.J., Grimsrud,P.A., Astapova,I., Tsai,L.T. and Herman,M.A.
  TITLE     HGFAC is a ChREBP-regulated hepatokine that enhances glucose and
            lipid homeostasis
  JOURNAL   JCI Insight 8 (1), e153740 (2023)
   PUBMED   36413406
  REMARK    GeneRIF: HGFAC is a ChREBP-regulated hepatokine that enhances
            glucose and lipid homeostasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2172)
  AUTHORS   Banna,F.K.E., Otto,J.M., Mulloy,S.M., Tsai,W., McElroy,S.M.,
            Wong,A.L., Cutts,G., Vrieze,S.I. and Lee,A.M.
  TITLE     Back-translating GWAS findings to animal models reveals a role for
            Hgfac and Slc39a8 in alcohol and nicotine consumption
  JOURNAL   Sci Rep 12 (1), 9336 (2022)
   PUBMED   35661789
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2172)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 2172)
  AUTHORS   Yamagata,Y., Aikou,S., Fukushima,T., Kataoka,H., Seto,Y., Esumi,H.,
            Kaminishi,M., Goldenring,J.R. and Nomura,S.
  TITLE     Loss of HGF activator inhibits foveolar hyperplasia induced by
            oxyntic atrophy without altering gastrin levels
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 303 (11), G1254-G1261
            (2012)
   PUBMED   23064758
REFERENCE   5  (bases 1 to 2172)
  AUTHORS   Ohki,T., Sato,Y., Yoshizawa,T., Yamamura,K., Yamada,K. and
            Yamagata,K.
  TITLE     Identification of hepatocyte growth factor activator (Hgfac) gene
            as a target of HNF1alpha in mouse beta-cells
  JOURNAL   Biochem Biophys Res Commun 425 (3), 619-624 (2012)
   PUBMED   22877752
  REMARK    GeneRIF: HNF1alpha might regulate beta-cell mass or function at
            least partly by modulating Hgfac expression.
REFERENCE   6  (bases 1 to 2172)
  AUTHORS   Ghesquiere,B., Van Damme,J., Martens,L., Vandekerckhove,J. and
            Gevaert,K.
  TITLE     Proteome-wide characterization of N-glycosylation events by
            diagonal chromatography
  JOURNAL   J Proteome Res 5 (9), 2438-2447 (2006)
   PUBMED   16944957
REFERENCE   7  (bases 1 to 2172)
  AUTHORS   Itoh,H., Naganuma,S., Takeda,N., Miyata,S., Uchinokura,S.,
            Fukushima,T., Uchiyama,S., Tanaka,H., Nagaike,K., Shimomura,T.,
            Miyazawa,K., Yamada,G., Kitamura,N., Koono,M. and Kataoka,H.
  TITLE     Regeneration of injured intestinal mucosa is impaired in hepatocyte
            growth factor activator-deficient mice
  JOURNAL   Gastroenterology 127 (5), 1423-1435 (2004)
   PUBMED   15521012
  REMARK    GeneRIF: HGFA is required for repair of injured intestinal mucosa
            but is not essential for normal development during embryogenesis or
            after birth.
REFERENCE   8  (bases 1 to 2172)
  AUTHORS   Iida,I., Johkura,K., Teng,R., Kubota,S., Cui,L., Zhao,X.,
            Ogiwara,N., Okouchi,Y., Asanuma,K., Nakayama,J. and Sasaki,K.
  TITLE     Immunohistochemical localization of hepatocyte growth factor
            activator (HGFA) in developing mouse liver tissues. Heterogeneous
            distribution of HGFA protein
  JOURNAL   J Histochem Cytochem 51 (9), 1139-1149 (2003)
   PUBMED   12923239
REFERENCE   9  (bases 1 to 2172)
  AUTHORS   van Adelsberg,J., Sehgal,S., Kukes,A., Brady,C., Barasch,J.,
            Yang,J. and Huan,Y.
  TITLE     Activation of hepatocyte growth factor (HGF) by endogenous HGF
            activator is required for metanephric kidney morphogenesis in vitro
  JOURNAL   J Biol Chem 276 (18), 15099-15106 (2001)
   PUBMED   11032833
REFERENCE   10 (bases 1 to 2172)
  AUTHORS   Itoh,H., Hamasuna,R., Kataoka,H., Yamauchi,M., Miyazawa,K.,
            Kitamura,N. and Koono,M.
  TITLE     Mouse hepatocyte growth factor activator gene: its expression not
            only in the liver but also in the gastrointestinal tract
  JOURNAL   Biochim Biophys Acta 1491 (1-3), 295-302 (2000)
   PUBMED   10760594
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY195777.1, AK149522.1 and
            AK165433.1.
            
            On Jul 25, 2015 this sequence version replaced NM_019447.2.
            
            Summary: This gene encodes a serine protease enzyme that
            proteolytically activates hepatocyte growth factor (HGF) and plays
            a vital role in the regulation of HGF activity in the regeneration
            and repair of various tissues. The encoded protein is an inactive
            zymogen that is proteolytically activated to generate a
            heterodimeric enzyme consisting of a short chain and a long chain
            linked by a disulfide bridge. Mice lacking the encoded protein
            display an impairment in mucosal regeneration after injury.
            [provided by RefSeq, Jul 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007987.1, AK169989.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                BY195777.1         1-80
            81-2118             AK149522.1         1-2038
            2119-2172           AK165433.1         2424-2477
FEATURES             Location/Qualifiers
     source          1..2172
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.99 cM"
     gene            1..2172
                     /gene="Hgfac"
                     /gene_synonym="HGFA"
                     /note="hepatocyte growth factor activator"
                     /db_xref="GeneID:54426"
                     /db_xref="MGI:MGI:1859281"
     exon            1..202
                     /gene="Hgfac"
                     /gene_synonym="HGFA"
                     /inference="alignment:Splign:2.1.0"
     exon            203..377
                     /gene="Hgfac"
                     /gene_synonym="HGFA"
                     /inference="alignment:Splign:2.1.0"
     exon            378..474
                     /gene="Hgfac"
                     /gene_synonym="HGFA"
                     /inference="alignment:Splign:2.1.0"
     exon            475..554
                     /gene="Hgfac"
                     /gene_synonym="HGFA"
                     /inference="alignment:Splign:2.1.0"
     exon            555..677
                     /gene="Hgfac"
                     /gene_synonym="HGFA"
                     /inference="alignment:Splign:2.1.0"
     exon            678..809
                     /gene="Hgfac"
                     /gene_synonym="HGFA"
                     /inference="alignment:Splign:2.1.0"
     exon            810..920
                     /gene="Hgfac"
                     /gene_synonym="HGFA"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1095
                     /gene="Hgfac"
                     /gene_synonym="HGFA"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1181
                     /gene="Hgfac"
                     /gene_synonym="HGFA"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1437
                     /gene="Hgfac"
                     /gene_synonym="HGFA"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1577
                     /gene="Hgfac"
                     /gene_synonym="HGFA"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1718
                     /gene="Hgfac"
                     /gene_synonym="HGFA"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1867
                     /gene="Hgfac"
                     /gene_synonym="HGFA"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2172
                     /gene="Hgfac"
                     /gene_synonym="HGFA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2101..2106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hgfac"
                     /gene_synonym="HGFA"
                     /note="hexamer: AATAAA"
     polyA_site      2120
                     /gene="Hgfac"
                     /gene_synonym="HGFA"
                     /note="major polyA site"
     polyA_site      2170
                     /gene="Hgfac"
                     /gene_synonym="HGFA"
ORIGIN      
        1 ttatcatgta gccttgaccc cacctgccct ggccacgttc cctggctact ctgttcctgc
       61 tacacctcac gccagctcag gaggagccat ggggcgacag gcctggatct ctagcctctg
      121 tcccttaccc aggccatgtc ccttcctgct gctcctgctg ctgctggtgg tgcctcgggg
      181 ggcccagccc caggctggca ggaaccacac agagccccca ggacctaacg ttacagccac
      241 ccccgtgacc cccacgatcc ctgtgatctc tgggaatgtc agcacctcaa cagaaagtgc
      301 tccagcagca gagactgagg gaccccaaag tgagaggtac cctcctccct ccagcagcag
      361 cccccctggg ggccaagtgc tcaccgagtc tgggcagccg tgcaggttcc ctttccgcta
      421 cggtggccgc atgctgcact cctgtacctc tgagggaagt gcctacagga agtggtgcgc
      481 tacaacacac aactatgacc gagaccgggc ctggggctac tgtgcagagg tgaccctgcc
      541 tgtggaaggt ccagctatcc ttgacccttg tgcctctggg ccctgcctca atgggggcac
      601 atgttccagt acacatgacc atgggtccta ccactgctct tgcccgctgg ccttcacagg
      661 caaggactgt ggcacagaga aatgctttga tgaaacacgc tatgagtatt ttgaggtggg
      721 cgaccactgg gcccgtgtga gcgagggaca tgtggagcaa tgtggctgta tggagggcca
      781 ggcccggtgt gaagacaccc accacacagc ttgtctgagc agcccatgtc tgaacggagg
      841 cacctgccac ctgattgtgg gcacagggac cagcgtctgc acctgcccgt tgggctatgc
      901 tgggcggttc tgtaacattg ttcccacaga gcactgcttc ctgggaaatg gtacagagta
      961 ccgaggcgtg gccagcaccg ctgcctcggg cctgagctgc ctggcctgga attctgacct
     1021 gctctaccag gagctgcacg tggactcagt ggctgctgct gtcctgcttg gcctgggccc
     1081 tcacgcttac tgccggaacc cagacaagga tgagaggcct tggtgctatg tggtgaagga
     1141 caacgcactg tcgtgggagt attgccgcct gacagcctgt gaatccctgg ccagagtcca
     1201 ctcccaaacc ccggagatcc tagcagccct gcccgagtca gccccggctg tgcgtcctac
     1261 ctgtggcaag aggcacaaga agaggacgtt cttgagacca cgcatcatcg ggggctcatc
     1321 atctttgcct ggctcacacc cctggctggc tgccatctac attgggaata gcttctgtgc
     1381 cgggagcctt gtccatacct gctgggtagt gtctgcagcc cactgcttcg ccaacagccc
     1441 ccccagggac agcatcacag tggtactggg tcagcacttc ttcaaccgca ccacggatgt
     1501 gacacagaca tttggcattg agaagtatgt gccctacacc ctgtactcgg tgttcaaccc
     1561 caacaaccat gaccttgtct tgatccggct aaagaagaag ggagagcgct gtgctgtccg
     1621 ctcccagttt gttcaaccca tctgcctgcc tgaggcaggc agctccttcc ctactggaca
     1681 caagtgtcag attgcaggct ggggccacat ggatgaaaat gtgagcagct actccaactc
     1741 cctgctggag gcactggtcc ctcttgttgc tgaccacaag tgtagcagcc cagaggtata
     1801 tggtgctgac atcagcccta acatgctctg tgccggctac ttcgactgca agtccgatgc
     1861 ctgccagggg gactcaggtg ggcccttggt ctgtgagaag aatggtgtgg cttacctgta
     1921 tggcatcatc agctggggtg atggctgtgg gcgcctcaac aagccaggag tctacacccg
     1981 tgtggccaat tatgtggact ggatcaacga ccgtattcga ccgcccaagc gacccgtggc
     2041 tacgtcctga accccggtcc ccaaggaagg gatgctcata gtaccccttc tactaccaac
     2101 aataaaactg tctccaagga cctggcttca cagaggcact gccctgagcc aggcagctct
     2161 ttgtgtccaa gc
//
