LOCUS       NM_010427               2810 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus hepatocyte growth factor (Hgf), transcript variant 3,
            mRNA.
ACCESSION   NM_010427 XM_131908
VERSION     NM_010427.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2810)
  AUTHORS   Ogata,K., Moriyama,M., Kawado,T., Yoshioka,H., Yano,A.,
            Matsumura-Kawashima,M., Nakamura,S. and Kawano,S.
  TITLE     Extracellular vesicles of iPS cells highly capable of producing HGF
            and TGF-beta1 can attenuate Sjogren's syndrome via innate immunity
            regulation
  JOURNAL   Cell Signal 113, 110980 (2024)
   PUBMED   37981065
  REMARK    GeneRIF: Extracellular vesicles of iPS cells highly capable of
            producing HGF and TGF-beta1 can attenuate Sjogren's syndrome via
            innate immunity regulation.
REFERENCE   2  (bases 1 to 2810)
  AUTHORS   Li,Y., Li,X., Yang,Y., Li,F., Chen,Q., Zhao,Z., Zhang,N. and Li,H.
  TITLE     Hepatocyte growth factor attenuates high glucose-disturbed
            mitochondrial dynamics in podocytes by decreasing ARF6-dependent
            DRP1 translocation
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (1), 119623 (2024)
   PUBMED   37913847
  REMARK    GeneRIF: Hepatocyte growth factor attenuates high glucose-disturbed
            mitochondrial dynamics in podocytes by decreasing ARF6-dependent
            DRP1 translocation.
REFERENCE   3  (bases 1 to 2810)
  AUTHORS   Peng,Z., Lv,X., Zhang,P., Chen,Q., Zhang,H., Chen,J., Ma,X.,
            Ouyang,B., Hao,M., Tong,H., Guo,D., Luo,Y. and Huang,S.
  TITLE     Intercellular Interactions Mediated by HGF And TGF-Beta Promote the
            3D Spherical and Xenograft Growth of Liver Cancer Cells
  JOURNAL   Curr Protein Pept Sci 25 (1), 71-82 (2024)
   PUBMED   37642183
  REMARK    GeneRIF: Intercellular Interactions Mediated by HGF And TGF-Beta
            Promote the 3D Spherical and Xenograft Growth of Liver Cancer
            Cells.
REFERENCE   4  (bases 1 to 2810)
  AUTHORS   Fernandes,M., Hoggard,B., Jamme,P., Paget,S., Truong,M.J.,
            Gregoire,V., Vinchent,A., Descarpentries,C., Morabito,A.,
            Stanislovas,J., Farage,E., Meneboo,J.P., Sebda,S.,
            Bouchekioua-Bouzaghou,K., Nollet,M., Humez,S., Perera,T.,
            Fromme,P., Grumolato,L., Figeac,M., Copin,M.C., Tulasne,D.,
            Cortot,A.B., Kermorgant,S. and Kherrouche,Z.
  TITLE     MET exon 14 skipping mutation is a hepatocyte growth factor
            (HGF)-dependent oncogenic driver in vitro and in humanised HGF
            knock-in mice
  JOURNAL   Mol Oncol 17 (11), 2257-2274 (2023)
   PUBMED   36799689
  REMARK    GeneRIF: MET exon 14 skipping mutation is a hepatocyte growth
            factor (HGF)-dependent oncogenic driver in vitro and in humanised
            HGF knock-in mice.
REFERENCE   5  (bases 1 to 2810)
  AUTHORS   Du,J., Jiang,Y., Liu,X., Ji,X., Xu,B., Zhang,Y., Liu,Y., Zhang,T.
            and Lin,J.
  TITLE     HGF Secreted by Menstrual Blood-Derived Endometrial Stem Cells
            Ameliorates Non-Alcoholic Fatty Liver Disease Through
            Downregulation of Hepatic Rnf186
  JOURNAL   Stem Cells 41 (2), 153-168 (2023)
   PUBMED   36573461
  REMARK    GeneRIF: HGF Secreted by Menstrual Blood-Derived Endometrial Stem
            Cells Ameliorates Non-Alcoholic Fatty Liver Disease Through
            Downregulation of Hepatic Rnf186.
REFERENCE   6  (bases 1 to 2810)
  AUTHORS   Nakamura,T., Sakai,K., Nakamura,T. and Matsumoto,K.
  TITLE     Hepatocyte growth factor twenty years on: Much more than a growth
            factor
  JOURNAL   J Gastroenterol Hepatol 26 Suppl 1, 188-202 (2011)
   PUBMED   21199531
  REMARK    Review article
REFERENCE   7  (bases 1 to 2810)
  AUTHORS   Rong,S., Bodescot,M., Blair,D., Dunn,J., Nakamura,T., Mizuno,K.,
            Park,M., Chan,A., Aaronson,S. and Vande Woude,G.F.
  TITLE     Tumorigenicity of the met proto-oncogene and the gene for
            hepatocyte growth factor
  JOURNAL   Mol Cell Biol 12 (11), 5152-5158 (1992)
   PUBMED   1406687
REFERENCE   8  (bases 1 to 2810)
  AUTHORS   Chatani,Y., Itoh,A., Tanaka,E., Hattori,A., Nakamura,T. and
            Kohno,M.
  TITLE     Hepatocyte growth factor rapidly induces the tyrosine
            phosphorylation of 41-kDa and 43-kDa proteins in mouse
            keratinocytes
  JOURNAL   Biochem Biophys Res Commun 185 (3), 860-866 (1992)
   PUBMED   1385703
REFERENCE   9  (bases 1 to 2810)
  AUTHORS   Szpirer,C., Riviere,M., Cortese,R., Nakamura,T., Islam,M.Q.,
            Levan,G. and Szpirer,J.
  TITLE     Chromosomal localization in man and rat of the genes encoding the
            liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1
            (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of
            the hepatocyte growth factor/scatter factor gene (HGF)
  JOURNAL   Genomics 13 (2), 293-300 (1992)
   PUBMED   1535333
REFERENCE   10 (bases 1 to 2810)
  AUTHORS   Coffer,A., Fellows,J., Young,S., Pappin,D. and Rahman,D.
  TITLE     Purification and characterization of biologically active scatter
            factor from ras-transformed NIH 3T3 conditioned medium
  JOURNAL   Biochem J 278 (Pt 1) (Pt 1), 35-41 (1991)
   PUBMED   1831975
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK052289.1, AK042121.1 and
            BC119228.1.
            
            On Jan 22, 2014 this sequence version replaced NM_010427.4.
            
            Summary: This gene encodes a protein that binds to the hepatocyte
            growth factor receptor to regulate cell growth, cell motility and
            morphogenesis in numerous cell and tissue types. The encoded
            preproprotein is proteolytically processed to generate multiple
            protein products, including the hepatocyte growth factor alpha and
            beta chains, which heterodimerize to form the mature active
            protein. Although this protein is a member of the peptidase S1
            family of serine proteases, it lacks peptidase activity. Homozygous
            knockout mice for this gene exhibit embryonic lethality due to
            impaired development of the placenta and liver. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (3) uses an alternate splice site
            in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode
            the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK042121.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AK052289.1         2-56
            56-1014             AK042121.1         2-960
            1015-2396           BC119228.1         902-2283
            2397-2635           AK042121.1         2343-2581
            2636-2810           AK042121.1         2583-2757
FEATURES             Location/Qualifiers
     source          1..2810
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 7.07 cM"
     gene            1..2810
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /note="hepatocyte growth factor"
                     /db_xref="GeneID:15234"
                     /db_xref="MGI:MGI:96079"
     exon            1..150
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            151..268
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..2364
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 3; scatter factor; hepatopoietin-A"
                     /codon_start=1
                     /product="hepatocyte growth factor isoform 1
                     preproprotein"
                     /protein_id="NP_034557.3"
                     /db_xref="CCDS:CCDS19097.1"
                     /db_xref="GeneID:15234"
                     /db_xref="MGI:MGI:96079"
                     /translation="MMWGTKLLPVLLLQHVLLHLLLLHVAIPYAEGQKKRRNTLHEFK
                     KSAKTTLTKEDPLLKIKTKKVNSADECANRCIRNRGFTFTCKAFVFDKSRKRCYWYPF
                     NSMSSGVKKGFGHEFDLYENKDYIRNCIIGKGGSYKGTVSITKSGIKCQPWNSMIPHE
                     HSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGE
                     SYRGPMDHTESGKTCQRWDQQTPHRHKFLPERYPDKGFDDNYCRNPDGKPRPWCYTLD
                     PDTPWEYCAIKTCAHSAVNETDVPMETTECIQGQGEGYRGTSNTIWNGIPCQRWDSQY
                     PHKHDITPENFKCKDLRENYCRNPDGAESPWCFTTDPNIRVGYCSQIPKCDVSSGQDC
                     YRGNGKNYMGNLSKTRSGLTCSMWDKNMEDLHRHIFWEPDASKLNKNYCRNPDDDAHG
                     PWCYTGNPLIPWDYCPISRCEGDTTPTIVNLDHPVISCAKTKQLRVVNGIPTQTTVGW
                     MVSLKYRNKHICGGSLIKESWVLTARQCFPARNKDLKDYEAWLGIHDVHERGEEKRKQ
                     ILNISQLVYGPEGSDLVLLKLARPAILDNFVSTIDLPSYGCTIPEKTTCSIYGWGYTG
                     LINADGLLRVAHLYIMGNEKCSQHHQGKVTLNESELCAGAEKIGSGPCEGDYGGPLIC
                     EQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKVILTYKL"
     exon            269..434
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            435..547
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            548..662
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            663..805
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            806..926
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1045
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1220
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1348
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1451
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1585
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1624
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1721
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1796
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1943
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2050
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2196
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2810
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2498..2503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /note="hexamer: AATATA"
     polyA_site      2521
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /note="major polyA site"
ORIGIN      
        1 aaacggggcg aattggtgtt ctgcctgtgc cttgacttag cgattgggct gagccttgct
       61 cctcccttcc ctactcggat aggagccaca aggatctgga gctccagctt ccaaattgca
      121 gctggcctcg ggccaggtga cctttgcttt agggatcagt ctgctcgaac tgcaagcatg
      181 atgtggggga ccaaacttct gccggtcctg ttgctgcagc atgtcctcct gcacctcctc
      241 ctgcttcatg tcgccatccc ctatgcagaa ggacagaaga aaagaagaaa tacacttcat
      301 gaatttaaaa agtcagcaaa aactactctt accaaggaag acccattact gaagattaaa
      361 accaaaaaag tgaactctgc agatgagtgt gccaacaggt gtatcaggaa caggggcttt
      421 acgttcactt gcaaggcctt cgtttttgat aagtcaagaa aacgatgcta ctggtatcct
      481 ttcaatagta tgtcaagtgg agtgaaaaaa gggtttggcc atgaatttga cctctatgaa
      541 aacaaagact atattagaaa ctgcatcatt ggtaaaggag gcagctataa agggacggta
      601 tccatcacta agagtggcat caaatgccag ccttggaatt ccatgatccc ccatgaacac
      661 agctttttgc cttcgagcta tcgcggtaaa gacctacagg aaaactactg tcgaaatcct
      721 cgaggggaag aagggggacc ctggtgtttc acaagcaatc cagaggtacg ctacgaagtc
      781 tgtgacattc ctcagtgttc agaagttgaa tgcatgacct gcaatggtga aagctacaga
      841 ggtcccatgg atcacacaga atcaggcaag acttgtcagc gctgggacca gcagacacca
      901 caccggcaca agttcttgcc agaaagatat cccgacaagg gctttgatga taattattgc
      961 cgcaatcctg atggcaagcc gaggccatgg tgctacactc ttgaccctga caccccttgg
     1021 gagtattgtg caattaaaac gtgcgctcac agtgctgtga atgagactga tgtccctatg
     1081 gaaacaactg aatgcattca aggccaagga gaaggttaca ggggaaccag caataccatt
     1141 tggaatggaa ttccctgtca gcgttgggat tcgcagtacc ctcacaagca tgatatcact
     1201 cccgagaact tcaaatgcaa ggaccttaga gaaaattatt gccgcaatcc agatggggct
     1261 gaatcaccat ggtgttttac cactgaccca aacatccgag ttggctactg ctctcaaatt
     1321 cccaagtgtg acgtgtcaag tggacaagat tgttatcgtg gcaatgggaa aaattacatg
     1381 ggcaacttat ccaaaacaag gtctggactt acatgttcca tgtgggacaa gaatatggag
     1441 gatttacacc gtcatatctt ctgggagcca gatgctagca aattgaataa gaattactgc
     1501 cggaatcctg atgatgatgc ccatggacct tggtgctaca cggggaatcc tcttattcct
     1561 tgggattatt gccctatttc ccgttgtgaa ggagatacta cacctacaat tgtcaatttg
     1621 gaccatcctg taatatcctg tgccaaaaca aaacaactgc gggttgtaaa tggcattcca
     1681 acacaaacaa cagtagggtg gatggttagt ttgaaataca gaaataaaca tatctgtgga
     1741 ggatcattga taaaggaaag ttgggttctt actgcaagac aatgttttcc agccagaaac
     1801 aaagacttga aagactatga agcttggctt ggcatccacg atgttcatga gagaggcgag
     1861 gagaagcgca agcagatctt aaacatttcc cagctggtct atggtcctga aggctcagac
     1921 ttggttttac tgaagcttgc tcgacctgca atcctggata actttgtcag tacaattgat
     1981 ttacctagtt atggttgtac aatccctgaa aagaccactt gcagtattta cggctggggc
     2041 tacactggat tgatcaacgc ggatggttta ttacgagtag ctcatctgta tattatgggg
     2101 aatgagaaat gcagtcagca ccatcaaggc aaggtgactt tgaatgagtc tgagttatgt
     2161 gctggggctg aaaagattgg atcaggacca tgtgagggag attatggtgg cccactcatt
     2221 tgtgaacaac acaaaatgag aatggttctt ggtgtcattg ttcctggtcg tggatgtgcc
     2281 atcccaaatc gtcctggtat ttttgttcga gtagcatatt atgcaaaatg gatacacaaa
     2341 gtaattttga catacaagtt gtaatagcca tagaagaggc cagtgtgttt gaagcatcca
     2401 tggatacatg aggatttcca agacttcagg atcaaaatgt cacctaaaac aatcctagaa
     2461 caactacttg agtgttgtga gtgttcagat actcattaat atatatgggt gttttctgtt
     2521 gtattgtttg tcagtgtcct ttgtaaatgt tcaagtgaat taaggtacct gcaagtgcag
     2581 taacatatct cctgaagata cttgaatgaa ttaaaaaaat ataaatttag agttgctaga
     2641 tgctaaagtt ttaaagaaaa aggttaatta atcactctat gctgctttcc aggttaatat
     2701 cttagtgatg aataaattgt atgttaaaca ttattttaac cccaccaaaa caatttatac
     2761 attgttttta aattgtaagt ctatattaaa ttatattaca tttcatatgc
//
