LOCUS       NM_001289458            2838 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus hepatocyte growth factor (Hgf), transcript variant 1,
            mRNA.
ACCESSION   NM_001289458 XM_006535629
VERSION     NM_001289458.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2838)
  AUTHORS   Ogata,K., Moriyama,M., Kawado,T., Yoshioka,H., Yano,A.,
            Matsumura-Kawashima,M., Nakamura,S. and Kawano,S.
  TITLE     Extracellular vesicles of iPS cells highly capable of producing HGF
            and TGF-beta1 can attenuate Sjogren's syndrome via innate immunity
            regulation
  JOURNAL   Cell Signal 113, 110980 (2024)
   PUBMED   37981065
  REMARK    GeneRIF: Extracellular vesicles of iPS cells highly capable of
            producing HGF and TGF-beta1 can attenuate Sjogren's syndrome via
            innate immunity regulation.
REFERENCE   2  (bases 1 to 2838)
  AUTHORS   Li,Y., Li,X., Yang,Y., Li,F., Chen,Q., Zhao,Z., Zhang,N. and Li,H.
  TITLE     Hepatocyte growth factor attenuates high glucose-disturbed
            mitochondrial dynamics in podocytes by decreasing ARF6-dependent
            DRP1 translocation
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (1), 119623 (2024)
   PUBMED   37913847
  REMARK    GeneRIF: Hepatocyte growth factor attenuates high glucose-disturbed
            mitochondrial dynamics in podocytes by decreasing ARF6-dependent
            DRP1 translocation.
REFERENCE   3  (bases 1 to 2838)
  AUTHORS   Peng,Z., Lv,X., Zhang,P., Chen,Q., Zhang,H., Chen,J., Ma,X.,
            Ouyang,B., Hao,M., Tong,H., Guo,D., Luo,Y. and Huang,S.
  TITLE     Intercellular Interactions Mediated by HGF And TGF-Beta Promote the
            3D Spherical and Xenograft Growth of Liver Cancer Cells
  JOURNAL   Curr Protein Pept Sci 25 (1), 71-82 (2024)
   PUBMED   37642183
  REMARK    GeneRIF: Intercellular Interactions Mediated by HGF And TGF-Beta
            Promote the 3D Spherical and Xenograft Growth of Liver Cancer
            Cells.
REFERENCE   4  (bases 1 to 2838)
  AUTHORS   Fernandes,M., Hoggard,B., Jamme,P., Paget,S., Truong,M.J.,
            Gregoire,V., Vinchent,A., Descarpentries,C., Morabito,A.,
            Stanislovas,J., Farage,E., Meneboo,J.P., Sebda,S.,
            Bouchekioua-Bouzaghou,K., Nollet,M., Humez,S., Perera,T.,
            Fromme,P., Grumolato,L., Figeac,M., Copin,M.C., Tulasne,D.,
            Cortot,A.B., Kermorgant,S. and Kherrouche,Z.
  TITLE     MET exon 14 skipping mutation is a hepatocyte growth factor
            (HGF)-dependent oncogenic driver in vitro and in humanised HGF
            knock-in mice
  JOURNAL   Mol Oncol 17 (11), 2257-2274 (2023)
   PUBMED   36799689
  REMARK    GeneRIF: MET exon 14 skipping mutation is a hepatocyte growth
            factor (HGF)-dependent oncogenic driver in vitro and in humanised
            HGF knock-in mice.
REFERENCE   5  (bases 1 to 2838)
  AUTHORS   Du,J., Jiang,Y., Liu,X., Ji,X., Xu,B., Zhang,Y., Liu,Y., Zhang,T.
            and Lin,J.
  TITLE     HGF Secreted by Menstrual Blood-Derived Endometrial Stem Cells
            Ameliorates Non-Alcoholic Fatty Liver Disease Through
            Downregulation of Hepatic Rnf186
  JOURNAL   Stem Cells 41 (2), 153-168 (2023)
   PUBMED   36573461
  REMARK    GeneRIF: HGF Secreted by Menstrual Blood-Derived Endometrial Stem
            Cells Ameliorates Non-Alcoholic Fatty Liver Disease Through
            Downregulation of Hepatic Rnf186.
REFERENCE   6  (bases 1 to 2838)
  AUTHORS   Nakamura,T., Sakai,K., Nakamura,T. and Matsumoto,K.
  TITLE     Hepatocyte growth factor twenty years on: Much more than a growth
            factor
  JOURNAL   J Gastroenterol Hepatol 26 Suppl 1, 188-202 (2011)
   PUBMED   21199531
  REMARK    Review article
REFERENCE   7  (bases 1 to 2838)
  AUTHORS   Rong,S., Bodescot,M., Blair,D., Dunn,J., Nakamura,T., Mizuno,K.,
            Park,M., Chan,A., Aaronson,S. and Vande Woude,G.F.
  TITLE     Tumorigenicity of the met proto-oncogene and the gene for
            hepatocyte growth factor
  JOURNAL   Mol Cell Biol 12 (11), 5152-5158 (1992)
   PUBMED   1406687
REFERENCE   8  (bases 1 to 2838)
  AUTHORS   Chatani,Y., Itoh,A., Tanaka,E., Hattori,A., Nakamura,T. and
            Kohno,M.
  TITLE     Hepatocyte growth factor rapidly induces the tyrosine
            phosphorylation of 41-kDa and 43-kDa proteins in mouse
            keratinocytes
  JOURNAL   Biochem Biophys Res Commun 185 (3), 860-866 (1992)
   PUBMED   1385703
REFERENCE   9  (bases 1 to 2838)
  AUTHORS   Szpirer,C., Riviere,M., Cortese,R., Nakamura,T., Islam,M.Q.,
            Levan,G. and Szpirer,J.
  TITLE     Chromosomal localization in man and rat of the genes encoding the
            liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1
            (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of
            the hepatocyte growth factor/scatter factor gene (HGF)
  JOURNAL   Genomics 13 (2), 293-300 (1992)
   PUBMED   1535333
REFERENCE   10 (bases 1 to 2838)
  AUTHORS   Coffer,A., Fellows,J., Young,S., Pappin,D. and Rahman,D.
  TITLE     Purification and characterization of biologically active scatter
            factor from ras-transformed NIH 3T3 conditioned medium
  JOURNAL   Biochem J 278 (Pt 1) (Pt 1), 35-41 (1991)
   PUBMED   1831975
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK052289.1, AC161176.5,
            BC119228.1 and AK042121.1.
            
            On Jan 23, 2014 this sequence version replaced XM_006535629.1.
            
            Summary: This gene encodes a protein that binds to the hepatocyte
            growth factor receptor to regulate cell growth, cell motility and
            morphogenesis in numerous cell and tissue types. The encoded
            preproprotein is proteolytically processed to generate multiple
            protein products, including the hepatocyte growth factor alpha and
            beta chains, which heterodimerize to form the mature active
            protein. Although this protein is a member of the peptidase S1
            family of serine proteases, it lacks peptidase activity. Homozygous
            knockout mice for this gene exhibit embryonic lethality due to
            impaired development of the placenta and liver. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Variants 1, 2, and
            3 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144764.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AK052289.1         2-151
            151-161             AC161176.5         54232-54242
            162-2424            BC119228.1         21-2283
            2425-2663           AK042121.1         2343-2581
            2664-2838           AK042121.1         2583-2757
FEATURES             Location/Qualifiers
     source          1..2838
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 7.07 cM"
     gene            1..2838
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /note="hepatocyte growth factor"
                     /db_xref="GeneID:15234"
                     /db_xref="MGI:MGI:96079"
     exon            1..150
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            151..296
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..2392
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; scatter factor; hepatopoietin-A"
                     /codon_start=1
                     /product="hepatocyte growth factor isoform 1
                     preproprotein"
                     /protein_id="NP_001276387.1"
                     /db_xref="CCDS:CCDS19097.1"
                     /db_xref="GeneID:15234"
                     /db_xref="MGI:MGI:96079"
                     /translation="MMWGTKLLPVLLLQHVLLHLLLLHVAIPYAEGQKKRRNTLHEFK
                     KSAKTTLTKEDPLLKIKTKKVNSADECANRCIRNRGFTFTCKAFVFDKSRKRCYWYPF
                     NSMSSGVKKGFGHEFDLYENKDYIRNCIIGKGGSYKGTVSITKSGIKCQPWNSMIPHE
                     HSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGE
                     SYRGPMDHTESGKTCQRWDQQTPHRHKFLPERYPDKGFDDNYCRNPDGKPRPWCYTLD
                     PDTPWEYCAIKTCAHSAVNETDVPMETTECIQGQGEGYRGTSNTIWNGIPCQRWDSQY
                     PHKHDITPENFKCKDLRENYCRNPDGAESPWCFTTDPNIRVGYCSQIPKCDVSSGQDC
                     YRGNGKNYMGNLSKTRSGLTCSMWDKNMEDLHRHIFWEPDASKLNKNYCRNPDDDAHG
                     PWCYTGNPLIPWDYCPISRCEGDTTPTIVNLDHPVISCAKTKQLRVVNGIPTQTTVGW
                     MVSLKYRNKHICGGSLIKESWVLTARQCFPARNKDLKDYEAWLGIHDVHERGEEKRKQ
                     ILNISQLVYGPEGSDLVLLKLARPAILDNFVSTIDLPSYGCTIPEKTTCSIYGWGYTG
                     LINADGLLRVAHLYIMGNEKCSQHHQGKVTLNESELCAGAEKIGSGPCEGDYGGPLIC
                     EQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKVILTYKL"
     exon            297..462
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            463..575
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            576..690
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            691..833
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            834..954
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1073
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1248
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1376
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1479
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1613
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1652
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1749
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1824
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1971
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2078
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2224
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2838
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2526..2531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /note="hexamer: AATATA"
     polyA_site      2549
                     /gene="Hgf"
                     /gene_synonym="C230052L06Rik; HGF/SF; NK1; NK2; SF;
                     SF/HGF"
                     /note="major polyA site"
ORIGIN      
        1 aaacggggcg aattggtgtt ctgcctgtgc cttgacttag cgattgggct gagccttgct
       61 cctcccttcc ctactcggat aggagccaca aggatctgga gctccagctt ccaaattgca
      121 gctggcctcg ggccaggtga cctttgcttt gattctttca gcccggcatc tcctgcagag
      181 ggatcagtct gctcgaactg caagcatgat gtgggggacc aaacttctgc cggtcctgtt
      241 gctgcagcat gtcctcctgc acctcctcct gcttcatgtc gccatcccct atgcagaagg
      301 acagaagaaa agaagaaata cacttcatga atttaaaaag tcagcaaaaa ctactcttac
      361 caaggaagac ccattactga agattaaaac caaaaaagtg aactctgcag atgagtgtgc
      421 caacaggtgt atcaggaaca ggggctttac gttcacttgc aaggccttcg tttttgataa
      481 gtcaagaaaa cgatgctact ggtatccttt caatagtatg tcaagtggag tgaaaaaagg
      541 gtttggccat gaatttgacc tctatgaaaa caaagactat attagaaact gcatcattgg
      601 taaaggaggc agctataaag ggacggtatc catcactaag agtggcatca aatgccagcc
      661 ttggaattcc atgatccccc atgaacacag ctttttgcct tcgagctatc gcggtaaaga
      721 cctacaggaa aactactgtc gaaatcctcg aggggaagaa gggggaccct ggtgtttcac
      781 aagcaatcca gaggtacgct acgaagtctg tgacattcct cagtgttcag aagttgaatg
      841 catgacctgc aatggtgaaa gctacagagg tcccatggat cacacagaat caggcaagac
      901 ttgtcagcgc tgggaccagc agacaccaca ccggcacaag ttcttgccag aaagatatcc
      961 cgacaagggc tttgatgata attattgccg caatcctgat ggcaagccga ggccatggtg
     1021 ctacactctt gaccctgaca ccccttggga gtattgtgca attaaaacgt gcgctcacag
     1081 tgctgtgaat gagactgatg tccctatgga aacaactgaa tgcattcaag gccaaggaga
     1141 aggttacagg ggaaccagca ataccatttg gaatggaatt ccctgtcagc gttgggattc
     1201 gcagtaccct cacaagcatg atatcactcc cgagaacttc aaatgcaagg accttagaga
     1261 aaattattgc cgcaatccag atggggctga atcaccatgg tgttttacca ctgacccaaa
     1321 catccgagtt ggctactgct ctcaaattcc caagtgtgac gtgtcaagtg gacaagattg
     1381 ttatcgtggc aatgggaaaa attacatggg caacttatcc aaaacaaggt ctggacttac
     1441 atgttccatg tgggacaaga atatggagga tttacaccgt catatcttct gggagccaga
     1501 tgctagcaaa ttgaataaga attactgccg gaatcctgat gatgatgccc atggaccttg
     1561 gtgctacacg gggaatcctc ttattccttg ggattattgc cctatttccc gttgtgaagg
     1621 agatactaca cctacaattg tcaatttgga ccatcctgta atatcctgtg ccaaaacaaa
     1681 acaactgcgg gttgtaaatg gcattccaac acaaacaaca gtagggtgga tggttagttt
     1741 gaaatacaga aataaacata tctgtggagg atcattgata aaggaaagtt gggttcttac
     1801 tgcaagacaa tgttttccag ccagaaacaa agacttgaaa gactatgaag cttggcttgg
     1861 catccacgat gttcatgaga gaggcgagga gaagcgcaag cagatcttaa acatttccca
     1921 gctggtctat ggtcctgaag gctcagactt ggttttactg aagcttgctc gacctgcaat
     1981 cctggataac tttgtcagta caattgattt acctagttat ggttgtacaa tccctgaaaa
     2041 gaccacttgc agtatttacg gctggggcta cactggattg atcaacgcgg atggtttatt
     2101 acgagtagct catctgtata ttatggggaa tgagaaatgc agtcagcacc atcaaggcaa
     2161 ggtgactttg aatgagtctg agttatgtgc tggggctgaa aagattggat caggaccatg
     2221 tgagggagat tatggtggcc cactcatttg tgaacaacac aaaatgagaa tggttcttgg
     2281 tgtcattgtt cctggtcgtg gatgtgccat cccaaatcgt cctggtattt ttgttcgagt
     2341 agcatattat gcaaaatgga tacacaaagt aattttgaca tacaagttgt aatagccata
     2401 gaagaggcca gtgtgtttga agcatccatg gatacatgag gatttccaag acttcaggat
     2461 caaaatgtca cctaaaacaa tcctagaaca actacttgag tgttgtgagt gttcagatac
     2521 tcattaatat atatgggtgt tttctgttgt attgtttgtc agtgtccttt gtaaatgttc
     2581 aagtgaatta aggtacctgc aagtgcagta acatatctcc tgaagatact tgaatgaatt
     2641 aaaaaaatat aaatttagag ttgctagatg ctaaagtttt aaagaaaaag gttaattaat
     2701 cactctatgc tgctttccag gttaatatct tagtgatgaa taaattgtat gttaaacatt
     2761 attttaaccc caccaaaaca atttatacat tgtttttaaa ttgtaagtct atattaaatt
     2821 atattacatt tcatatgc
//
