LOCUS       NM_013905               4532 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus hairy/enhancer-of-split related with YRPW motif-like
            (Heyl), mRNA.
ACCESSION   NM_013905
VERSION     NM_013905.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4532)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   2  (bases 1 to 4532)
  AUTHORS   Wang,Q., Zeng,S., Liang,Y., Zhou,R. and Wang,D.
  TITLE     ASH2L Mediates Epidermal Differentiation and Hair Follicle
            Morphogenesis through H3K4me3 Modification
  JOURNAL   J Invest Dermatol 144 (11), 2406-2416 (2024)
   PUBMED   38582368
REFERENCE   3  (bases 1 to 4532)
  AUTHORS   Iwamori,K., Kubota,M., Zhang,L., Kodama,K., Kubo,A., Kokubo,H.,
            Akimoto,T. and Fukada,S.I.
  TITLE     Decreased number of satellite cells-derived myonuclei in both fast-
            and slow-twitch muscles in HeyL-KO mice during voluntary running
            exercise
  JOURNAL   Skelet Muscle 14 (1), 25 (2024)
   PUBMED   39449015
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4532)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4532)
  AUTHORS   Wu,B., Wu,B., Benkaci,S., Shi,L., Lu,P., Park,T., Morrow,B.E.,
            Wang,Y. and Zhou,B.
  TITLE     Crk and Crkl Are Required in the Endocardial Lineage for Heart
            Valve Development
  JOURNAL   J Am Heart Assoc 12 (18), e029683 (2023)
   PUBMED   37702066
REFERENCE   6  (bases 1 to 4532)
  AUTHORS   Leimeister,C., Schumacher,N., Steidl,C. and Gessler,M.
  TITLE     Analysis of HeyL expression in wild-type and Notch pathway mutant
            mouse embryos
  JOURNAL   Mech Dev 98 (1-2), 175-178 (2000)
   PUBMED   11044625
REFERENCE   7  (bases 1 to 4532)
  AUTHORS   Firulli,B.A., Hadzic,D.B., McDaid,J.R. and Firulli,A.B.
  TITLE     The basic helix-loop-helix transcription factors dHAND and eHAND
            exhibit dimerization characteristics that suggest complex
            regulation of function
  JOURNAL   J Biol Chem 275 (43), 33567-33573 (2000)
   PUBMED   10924525
REFERENCE   8  (bases 1 to 4532)
  AUTHORS   Steidl,C., Leimeister,C., Klamt,B., Maier,M., Nanda,I., Dixon,M.,
            Clarke,R., Schmid,M. and Gessler,M.
  TITLE     Characterization of the human and mouse HEY1, HEY2, and HEYL genes:
            cloning, mapping, and mutation screening of a new bHLH gene family
  JOURNAL   Genomics 66 (2), 195-203 (2000)
   PUBMED   10860664
REFERENCE   9  (bases 1 to 4532)
  AUTHORS   Nakagawa,O., Nakagawa,M., Richardson,J.A., Olson,E.N. and
            Srivastava,D.
  TITLE     HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors
            marking specific cardiac, somitic, and pharyngeal arch segments
  JOURNAL   Dev Biol 216 (1), 72-84 (1999)
   PUBMED   10588864
REFERENCE   10 (bases 1 to 4532)
  AUTHORS   Leimeister,C., Externbrink,A., Klamt,B. and Gessler,M.
  TITLE     Hey genes: a novel subfamily of hairy- and Enhancer of split
            related genes specifically expressed during mouse embryogenesis
  JOURNAL   Mech Dev 85 (1-2), 173-177 (1999)
   PUBMED   10415358
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF172288.1, AK004697.2 and AL606934.12.
            
            On Nov 8, 2006 this sequence version replaced NM_013905.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK080822.1, AK004697.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-911               AF172288.1         1-911
            912-3381            AK004697.2         615-3084
            3382-4532           AL606934.12        170035-171185
FEATURES             Location/Qualifiers
     source          1..4532
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 57.41 cM"
     gene            1..4532
                     /gene="Heyl"
                     /gene_synonym="bHLHb33; hesr3; Hey3; Hrt3"
                     /note="hairy/enhancer-of-split related with YRPW
                     motif-like"
                     /db_xref="GeneID:56198"
                     /db_xref="MGI:MGI:1860511"
     exon            1..391
                     /gene="Heyl"
                     /gene_synonym="bHLHb33; hesr3; Hey3; Hrt3"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..1292
                     /gene="Heyl"
                     /gene_synonym="bHLHb33; hesr3; Hey3; Hrt3"
                     /note="hairy and enhance of split related 3; HRT-3; mHRT3;
                     hairy and enhancer of split-related protein 3;
                     hairy-related transcription factor 3"
                     /codon_start=1
                     /product="hairy/enhancer-of-split related with YRPW
                     motif-like protein"
                     /protein_id="NP_038933.2"
                     /db_xref="CCDS:CCDS18613.1"
                     /db_xref="GeneID:56198"
                     /db_xref="MGI:MGI:1860511"
                     /translation="MKRPRAPSGSDGESDGPIDVGQENDLSQMARPLTTPSPSQMQAR
                     KKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHASG
                     GTGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSHADPVRIRLLSHLKSYAAEM
                     EPSPTTTSALAFPVWPWSFLHSCPGLPSLNSQLAILGRVPGPVLPSISSPPYPISALR
                     SAPVHRPAGTIPPTRRNLLPSRGVTSTQRAHLPERPAAPPPTALDARAARSIVPIPPC
                     SPTTAPGAGKSDDNVSGSISSPCPSGPTGRPAGAVFYHSWVSEITEIGAF"
     exon            392..458
                     /gene="Heyl"
                     /gene_synonym="bHLHb33; hesr3; Hey3; Hrt3"
                     /inference="alignment:Splign:2.1.0"
     exon            459..542
                     /gene="Heyl"
                     /gene_synonym="bHLHb33; hesr3; Hey3; Hrt3"
                     /inference="alignment:Splign:2.1.0"
     exon            543..624
                     /gene="Heyl"
                     /gene_synonym="bHLHb33; hesr3; Hey3; Hrt3"
                     /inference="alignment:Splign:2.1.0"
     exon            625..4532
                     /gene="Heyl"
                     /gene_synonym="bHLHb33; hesr3; Hey3; Hrt3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3353..3358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Heyl"
                     /gene_synonym="bHLHb33; hesr3; Hey3; Hrt3"
                     /note="hexamer: GATAAA"
     polyA_site      3382
                     /gene="Heyl"
                     /gene_synonym="bHLHb33; hesr3; Hey3; Hrt3"
                     /note="major polyA site"
ORIGIN      
        1 ctctgggctt ccccgtgggg cctcccaggg cacctgccca aggccaccca gagcgccagc
       61 ccaggcagcg ccggtggagc ggagccggac ctcccagcgg ccgatggggg cggtgaccgc
      121 ccggggcctt cccacggttc ggtggcgcgt caccgcgggg gcgagggggc gccggggcgc
      181 cccgggctgc ggtgcaggaa agggccctgg gaaagggcgg cgtcggctcc cgggccgggg
      241 cggggctgag gcggggccca acaaccaact ccagggatcg cagggctggg accccgcagc
      301 cagctttcgg catgaagcgg cccagggcgc ccagtggctc cgacggcgag tctgatggac
      361 ccatcgatgt gggtcaagag aacgatctta gccagatggc caggccgctg actaccccca
      421 gcccttcgca gatgcaagcc cggaagaagc gcagagggat catagagaaa cggcgcagag
      481 accgcatcaa cagtagcctt tctgaattgc gacgattggt ccccactgcc tttgagaaac
      541 agggctcctc caagctggag aaagctgagg tcttgcagat gaccgtggat cacttgaaga
      601 tgctccatgc ctctggtggc acagggttct ttgatgcccg agccctggct gttgacttcc
      661 ggagtattgg gtttcgggaa tgcctcactg aggtcataag atacctgggg gtcctggaag
      721 gacccagcag ccatgccgac cctgtccgga ttcgcctcct ctcccacctc aagagctatg
      781 cagcagagat ggagccctca cccacgacca ccagtgccct ggcctttccc gtgtggccct
      841 ggtccttcct gcatagctgt ccaggcttgc cttccctgaa cagtcagctc gccatcctgg
      901 gaagagtgcc cggccctgtc ctccccagca tctcttctcc cccttaccct atctcagccc
      961 tgaggtcggc accagtgcac agacctgctg gtaccatccc cccaacccgg cggaatttgt
     1021 tgcccagccg aggggtgact tccacccaga gagcccatct tcctgagagg ccagctgccc
     1081 ctccacccac agcccttgat gccagggctg ccaggagcat agtcccaatc ccaccatgtt
     1141 cccccacaac agcccctgga gctgggaaat ctgatgacaa tgtgtctggt tctatctcca
     1201 gtccatgtcc ttcagggcca actgggaggc ctgcgggagc agtgttctac cactcttggg
     1261 tctcagaaat cactgaaatt ggggctttct gagctgactt cccacaacca tcccctggga
     1321 atgaggaagg ttcttttttt tttctctccc tgaagctcta aaatggtgcc ctcttttctg
     1381 tttttttttt tctcaaatgg catctacgca aaggcacctc tcctcacccg tcagagcctc
     1441 gcccccctca ccctactcac cactgatgct gacagccacc tggcttctct gcagccttat
     1501 gagagctcag agccttagtg tcctttccca ctggcgcaga tgagttacat ggtgccttgt
     1561 gagcccccag gtactgtgga cccagtatac acatggacct tgggtctggg ttgaagcttt
     1621 aacttcaagg attccatggc cagcaccatg aagaggtgag acacaccgcc cccctcttag
     1681 tggggatgac tggtgggatt cagccatccc aagccaacag gatggaatgt accgtctgca
     1741 tcactccctg aagacgaaag cgaagcaggg gctactggga agtctctgtg gctcacccca
     1801 caacagtgaa acacagaaca gatctgttct ccagtccatc taaggctaca acccttccca
     1861 cagggttccc aggttggagg accagcggcc ccatggtggc acctcccaaa gagtcattcc
     1921 cttgggattc agcaccagac atacgagctg cctggtttgc atccggctcc cagagcccag
     1981 actgctgcca cagccaaggg ctgtcaggct ggataaaaat aacttggagg agggggagaa
     2041 ccatcagagg cggctcttca aggtcatgga gtgggttgag ggcctgagag cctgctcacc
     2101 cagatttcac acagctggtt ctgctcagag gcctgcctca ggcctctggc ttctagtggg
     2161 aataaatggc cagtggaaca acagagaatg aaccaacctt tagggctgtc ctgtcagcgg
     2221 acaaagtgtg gaaacatttt tgtcctcttt ggtgaacacc tgctccccac aattcccccc
     2281 caggaccacc cagcatgccc tctggaagca ccctggctaa tccctggcaa agtcaagact
     2341 gtgggaaact agaactggtt actcactact gctggtacca tgctgatcat gggatacctt
     2401 tgaggtcacc ctggaaaggt ctccccctgc cctcccgcaa accccatccc cagactttgt
     2461 tggaaccatg gtccccaggg ctgttgtaag gagcctgtgg gcacaagatt agagtttaca
     2521 aaaagccgtg gagcaaaaga gtcatttcag aaaagtggaa cagagggcag aggtcacctg
     2581 agtgacccag aaagtgcttg tgaataggtc aagaagtgat aaagactccc tttactctct
     2641 aatgaaagga agctctttta atatcactgc cgtgttggac ctgagtgcat cactgtagtg
     2701 tgcatcacca gacttctgag ggagacagac acagggacag aaggacgctc ctgcaggctc
     2761 ctgcaagtgg ggagaggagg cgattgaagt ccccagatat tcgggtctct gtgcaggcct
     2821 gtagtttggc agcctcctag ccagagattc agtgtcacag ctcacagctt cactgtggga
     2881 aacatttcca tgttgcaggt actcaaactg cagaacagtc tcttgacact atggggacat
     2941 ggcagaagtg gctgaaccct ttgagcatcc atcctgattg gccttgggtt cgttctccca
     3001 ggagactgag agggccaccc tacccccacc cagctgagaa ctcaagtccc ctgtttttag
     3061 tctcagtctg gtgaccccag tagtctcatt ccactctagg gtgttgcaga caaacaatag
     3121 agatgtctag ttctggacac ttccaccaga ctttacgtcc taagtatttc tggagtctct
     3181 gaacctatag ccctggcctc tcccctacat tatccccagc ttccttgctt ctctctggct
     3241 gtgccatcag ttctgaacag ccactggaga gaatgtggca tgtgcagggc acatcacatc
     3301 aacccagcct cagacaccac caccccccat acacacaccc tgttattcta gtgataaaaa
     3361 tcggaacact ttttacaatc cacacctgac ttctagtctt atttcttgct cgctccaatt
     3421 ttgctcagtg tttatgctac gctggcctgt tctctgtccc cagcatttcc tcttagagct
     3481 tctcatatga gggtcccaga atgctccccc actcccttta tgtggcctac ttcagctcca
     3541 tgtcacctcc tcctggaggc cttctgagac tcatgtgctt gaataactca tccatctgaa
     3601 aggtcccatt gtttacctgc ctggagagtt ggctgatgta taactacttg tatgtccact
     3661 tgattaggta tattccccac cggaacgtaa gctcaatgag gccaggggcc agagctggcc
     3721 tgtgctccca tctgcaccca gcattgagca cagtgcctac caacttctgt tgcataaatt
     3781 gatcaaggag gtgagaaggc ttcttgtttc ctgctgtggc tggcagactc cgctaggggt
     3841 gagttccact gccattcctg ctggctgact ttgagaggag acaggagagc cagggccaaa
     3901 ggactggggg ttctggcaga atggtcagaa ggccctggcc agaggagacg caagcgtgct
     3961 ggccttggag tgaatgctga cagctgagct ggccggcggg tttgttctct gctcttggcc
     4021 tggcttctta atacatctag ctcccaacaa atccagcatt catggagatc cactctgtgc
     4081 cagccaagcc tggcagagcc aatggtaaca aacacatggt cactcagagg gcagtgtatc
     4141 ctctacctag ataagatggg catgtgacaa tccctgggga gggcagaagg ctgcagagtt
     4201 gggtaggtgt ctctggctag gcaggctgta ggagggggcc tggaagcaag ccctccctga
     4261 ggaggaccag gggactccct tacagagatc tggaggttta cccaggagct acagaagcag
     4321 gctctgaaca tacgtggagg atgggctagc ctgagctctg ggactaatct ttattacata
     4381 cttgttaatg agaaatcatt ttcttcaagg tctttgccct tcttgaactt acgttttcat
     4441 ctgtaaaatg gctgtgatgc agccatggtt ccccacatat gtgcatgtgt atacatacat
     4501 acaaagaaat aaaattcata atttttttta ag
//
