LOCUS       NM_013904               2549 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus hairy/enhancer-of-split related with YRPW motif 2
            (Hey2), mRNA.
ACCESSION   NM_013904
VERSION     NM_013904.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2549)
  AUTHORS   Defamie,V., Aliar,K., Sarkar,S., Vyas,F., Shetty,R., Reddy
            Narala,S., Fang,H., Saw,S., Tharmapalan,P., Sanchez,O., Knox,J.J.,
            Waterhouse,P.D. and Khokha,R.
  TITLE     Metalloproteinase inhibitors regulate biliary progenitor cells
            through sDLK1 in organoid models of liver injury
  JOURNAL   J Clin Invest 135 (3), e164997 (2024)
   PUBMED   39699962
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2549)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   3  (bases 1 to 2549)
  AUTHORS   Miao,L., Lu,Y., Nusrat,A., Zhao,L., Castillo,M., Xiao,Y., Guo,H.,
            Liu,Y., Gunaratne,P., Schwartz,R.J., Burns,A.R., Kumar,A.,
            DiPersio,C.M. and Wu,M.
  TITLE     beta1 integrins regulate cellular behaviour and cardiomyocyte
            organization during ventricular wall formation
  JOURNAL   Cardiovasc Res 120 (11), 1279-1294 (2024)
   PUBMED   38794925
REFERENCE   4  (bases 1 to 2549)
  AUTHORS   Van Wauwe,J., Mahy,A., Craps,S., Ekhteraei-Tousi,S., Vrancaert,P.,
            Kemps,H., Dheedene,W., Donate Puertas,R., Trenson,S.,
            Roderick,H.L., Beerens,M. and Luttun,A.
  TITLE     PRDM16 determines specification of ventricular cardiomyocytes by
            suppressing alternative cell fates
  JOURNAL   Life Sci Alliance 7 (12), e202402719 (2024)
   PUBMED   39304345
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2549)
  AUTHORS   Zhou,B., Feng,C., Sun,S., Chen,X., Zhuansun,D., Wang,D., Yu,X.,
            Meng,X., Xiao,J., Wu,L., Wang,J., Wang,J., Chen,K., Li,Z., You,J.,
            Mao,H., Yang,S., Zhang,J., Jiao,C., Li,Z., Yu,D., Wu,X., Zhu,T.,
            Yang,J., Xiang,L., Liu,J., Chai,T., Shen,J., Mao,C.X., Hu,J.,
            Hao,X., Xiong,B., Zheng,S., Liu,Z. and Feng,J.
  TITLE     Identification of signaling pathways that specify a subset of
            migrating enteric neural crest cells at the wavefront in mouse
            embryos
  JOURNAL   Dev Cell 59 (13), 1689-1706 (2024)
   PUBMED   38636517
REFERENCE   6  (bases 1 to 2549)
  AUTHORS   Firulli,B.A., Hadzic,D.B., McDaid,J.R. and Firulli,A.B.
  TITLE     The basic helix-loop-helix transcription factors dHAND and eHAND
            exhibit dimerization characteristics that suggest complex
            regulation of function
  JOURNAL   J Biol Chem 275 (43), 33567-33573 (2000)
   PUBMED   10924525
REFERENCE   7  (bases 1 to 2549)
  AUTHORS   Steidl,C., Leimeister,C., Klamt,B., Maier,M., Nanda,I., Dixon,M.,
            Clarke,R., Schmid,M. and Gessler,M.
  TITLE     Characterization of the human and mouse HEY1, HEY2, and HEYL genes:
            cloning, mapping, and mutation screening of a new bHLH gene family
  JOURNAL   Genomics 66 (2), 195-203 (2000)
   PUBMED   10860664
REFERENCE   8  (bases 1 to 2549)
  AUTHORS   Chin,M.T., Maemura,K., Fukumoto,S., Jain,M.K., Layne,M.D.,
            Watanabe,M., Hsieh,C.M. and Lee,M.E.
  TITLE     Cardiovascular basic helix loop helix factor 1, a novel
            transcriptional repressor expressed preferentially in the
            developing and adult cardiovascular system
  JOURNAL   J Biol Chem 275 (9), 6381-6387 (2000)
   PUBMED   10692439
REFERENCE   9  (bases 1 to 2549)
  AUTHORS   Nakagawa,O., Nakagawa,M., Richardson,J.A., Olson,E.N. and
            Srivastava,D.
  TITLE     HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors
            marking specific cardiac, somitic, and pharyngeal arch segments
  JOURNAL   Dev Biol 216 (1), 72-84 (1999)
   PUBMED   10588864
REFERENCE   10 (bases 1 to 2549)
  AUTHORS   Leimeister,C., Externbrink,A., Klamt,B. and Gessler,M.
  TITLE     Hey genes: a novel subfamily of hairy- and Enhancer of split
            related genes specifically expressed during mouse embryogenesis
  JOURNAL   Mech Dev 85 (1-2), 173-177 (1999)
   PUBMED   10415358
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF172287.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF172287.1, AK158000.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2549
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 17.19 cM"
     gene            1..2549
                     /gene="Hey2"
                     /gene_synonym="bHLHb32; CHF1; Herp1; hesr2; Hrt2"
                     /note="hairy/enhancer-of-split related with YRPW motif 2"
                     /db_xref="GeneID:15214"
                     /db_xref="MGI:MGI:1341884"
     exon            1..218
                     /gene="Hey2"
                     /gene_synonym="bHLHb32; CHF1; Herp1; hesr2; Hrt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1155
                     /gene="Hey2"
                     /gene_synonym="bHLHb32; CHF1; Herp1; hesr2; Hrt2"
                     /note="hairy and enhancer of split related 2; HRT-2;
                     mHRT2; HESR-2; protein gridlock homolog; HES-related
                     repressor protein 2; hairy and enhancer of split-related
                     protein 2; Hairy-E(spl)-related with YRPW motif 2;
                     hairy-related transcription factor 2"
                     /codon_start=1
                     /product="hairy/enhancer-of-split related with YRPW motif
                     protein 2"
                     /protein_id="NP_038932.1"
                     /db_xref="CCDS:CCDS23766.1"
                     /db_xref="GeneID:15214"
                     /db_xref="MGI:MGI:1341884"
                     /translation="MKRPCEETTSESDLDETIDVGSENNYPGHATSSVMRSNSPTTTS
                     QIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKM
                     LQATGGKGYFDAHALATDFMSIGFRECLTEVARYLSSVEGLDPSDPLRVRLVSHLSTC
                     ASQREAAVMTSSMAHHHHPLHPHHWAAAFHHLPTALLQPNGLHTSESTPCRLSTSSEV
                     PSAHGSALLTATFAHADSALRMPSGGTVAPCVPPLSTSLLSLSATVHAAAAAATAAAH
                     SFPLSFAGAFPMLPSNAAAAAAVAAATAISPPLSVSAASSPQQTSTGTNNKPYQPWGT
                     EVGAF"
     exon            219..297
                     /gene="Hey2"
                     /gene_synonym="bHLHb32; CHF1; Herp1; hesr2; Hrt2"
                     /inference="alignment:Splign:2.1.0"
     exon            298..381
                     /gene="Hey2"
                     /gene_synonym="bHLHb32; CHF1; Herp1; hesr2; Hrt2"
                     /inference="alignment:Splign:2.1.0"
     exon            382..463
                     /gene="Hey2"
                     /gene_synonym="bHLHb32; CHF1; Herp1; hesr2; Hrt2"
                     /inference="alignment:Splign:2.1.0"
     exon            464..2532
                     /gene="Hey2"
                     /gene_synonym="bHLHb32; CHF1; Herp1; hesr2; Hrt2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2509..2514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hey2"
                     /gene_synonym="bHLHb32; CHF1; Herp1; hesr2; Hrt2"
                     /note="hexamer: ATTAAA"
     polyA_site      2532
                     /gene="Hey2"
                     /gene_synonym="bHLHb32; CHF1; Herp1; hesr2; Hrt2"
                     /note="major polyA site"
ORIGIN      
        1 gaaagaacct ccaggagccg accgcgccgc cgagggagcg gcgcctgcag aagccgggca
       61 gggagggagg gaggaagccc gcggggagcg cgctgcgttc cgctaggcga cagtagctgc
      121 tcctccttcg tcgcgatgaa gcgcccttgt gaggaaacga cctccgaaag cgacctggac
      181 gagaccatcg acgtggggag cgagaacaat taccctgggc acgctacaag ctcagtgatg
      241 aggtccaatt caccgacaac tacctctcag attatggcaa gaaagaaaag gagagggatc
      301 atagaaaaaa ggcgtcggga tcgaataaat aacagtttat ctgaattgag aagactagtg
      361 ccaacagctt ttgaaaaaca aggatctgcc aagttagaaa aggctgaaat attgcaaatg
      421 acagtggatc atttgaagat gctccaggct acagggggta aaggctactt tgatgcccat
      481 gctcttgcca cagacttcat gagcattgga ttccgagagt gcttgacaga agtggctagg
      541 tacctaagct cagtggaagg ccttgacccg tcggacccac tacgcgtgcg ccttgtctct
      601 catctcagca cctgtgcctc ccagcgggag gcagcagtga tgacatcctc catggcccac
      661 caccatcacc ccttgcaccc tcaccactgg gcagctgctt tccaccatct ccccacagcc
      721 ctgctccagc ccaatggact ccacacatca gagtcaaccc catgtcgcct atccacatct
      781 tcagaagtgc cttctgctca tggctctgct ctcctcacag caacgtttgc ccatgcagat
      841 tctgctcttc ggatgccatc agggggcacc gttgcaccct gcgtgccacc tctctccacc
      901 tctcttctgt ctctttcggc cactgtgcat gccgcagctg cagcagccac tgcagctgca
      961 cacagcttcc ctctgtcctt cgcaggggct tttcccatgc tcccgtccaa tgcagcggca
     1021 gcagccgctg ttgctgctgc aacagcaatc agcccaccct tgtcggtatc cgcagcctcc
     1081 agtcctcagc agacaagcac tgggacaaac aataaacctt accaaccctg ggggacagaa
     1141 gttggagcct tttaacttat tcttgaatct ctttgcaata gtaactgatg tcgtccattt
     1201 cggaatcagc ttcaaacctc tgcatcctga aggtagtcat acagatatgt acagttccac
     1261 acagcagcaa taaagcgatt tgagaagcag acttcacaca aatggaaatg tagtattact
     1321 attttttccc tttgtttaag gcagcttggc aagtgacatc agcaacttga aagcagcaca
     1381 ccaacgtcca tttaaacttt cttggaaaac acaccagtgt caccatccgg tggtgcatta
     1441 atactcctga cttggaaaag gaaaacgcca taactgagtt ctcctgatgc tagaagggag
     1501 aagaaaaaca atgccatgtt ttctaagtgc ctgaactaag gaatgtaacg tagcacaaga
     1561 tcagaaggat atagctgtta ggttgagaaa gagaagaagc aggcaatgtg tcaggctgca
     1621 gatacagtgc cctttggaaa ccatcgggtt ttattggcca gaaagatgaa gggaaattaa
     1681 gtcgaaagac ctagttttat ttttattttc tttatacaga cttgccaagc aatgacattt
     1741 agctatgcag tgaaataagc aattccacca gagcctccat taacaaacat ttctgctctg
     1801 ccttcaagct tccatacctc tagtgaaccc tggtttaaaa cacagtgctt ctttatgtaa
     1861 acttacaggt atacagtgca ctagaagcag ttacctactg tgtgcccacc agaggctcat
     1921 tgacaccaac tcaaaaactc ttcagtttgc aagagtttgg gttaatttat tgtttcaaca
     1981 ggactatttt tatatattta acttctccag ttttctcctg acaacatgta atgtctgttt
     2041 ttgtctgttt tggggagagg gtgttgcatt tctggaagta atgagatgag gagagatgat
     2101 atggaaggga aaagctacat aatgtaaatg ccctggtcaa gttagagatt acatttgatc
     2161 ccaaatcaca atgaatgtat ggaatgaggt gtacatgaat tatttttgtc catgactaga
     2221 ctaatgctac atatggtgtt ttggttttga ttttttttta tcttgtttaa tgacaaaata
     2281 atctcctaat acattgaaat tgagcacgtg agattttata tttgaaagat aaagacacag
     2341 catgtactct tatgcacttc atttctctgc tgtgtggaga aagcgataaa caagagacta
     2401 ttaaacatta tggaaagtta tacttataaa tgtttttaaa attactgtac ctagtctttt
     2461 ctatattact ttgtaacttt tttctatgca aaagtctatg tatcactaat taaatgacgt
     2521 cctttttgac taaaaaaaaa aaaaaaaaa
//
