LOCUS       NM_010423               2215 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus hairy/enhancer-of-split related with YRPW motif 1
            (Hey1), mRNA.
ACCESSION   NM_010423
VERSION     NM_010423.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2215)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   2  (bases 1 to 2215)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   3  (bases 1 to 2215)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2215)
  AUTHORS   Ren,R., Ding,S., Ma,K., Jiang,Y., Wang,Y., Chen,J., Wang,Y.,
            Kou,Y., Fan,X., Zhu,X., Qin,L., Qiu,C., Simons,M., Wei,X. and Yu,L.
  TITLE     SUMOylation Fine-Tunes Endothelial HEY1 in the Regulation of
            Angiogenesis
  JOURNAL   Circ Res 134 (2), 203-222 (2024)
   PUBMED   38166414
  REMARK    GeneRIF: SUMOylation Fine-Tunes Endothelial HEY1 in the Regulation
            of Angiogenesis.
REFERENCE   5  (bases 1 to 2215)
  AUTHORS   Honeycutt,S.E., N'Guetta,P.Y., Hardesty,D.M., Xiong,Y.,
            Cooper,S.L., Stevenson,M.J. and O'Brien,L.L.
  TITLE     Netrin 1 directs vascular patterning and maturity in the developing
            kidney
  JOURNAL   Development 150 (22) (2023)
   PUBMED   37818607
REFERENCE   6  (bases 1 to 2215)
  AUTHORS   Steidl,C., Leimeister,C., Klamt,B., Maier,M., Nanda,I., Dixon,M.,
            Clarke,R., Schmid,M. and Gessler,M.
  TITLE     Characterization of the human and mouse HEY1, HEY2, and HEYL genes:
            cloning, mapping, and mutation screening of a new bHLH gene family
  JOURNAL   Genomics 66 (2), 195-203 (2000)
   PUBMED   10860664
REFERENCE   7  (bases 1 to 2215)
  AUTHORS   Chin,M.T., Maemura,K., Fukumoto,S., Jain,M.K., Layne,M.D.,
            Watanabe,M., Hsieh,C.M. and Lee,M.E.
  TITLE     Cardiovascular basic helix loop helix factor 1, a novel
            transcriptional repressor expressed preferentially in the
            developing and adult cardiovascular system
  JOURNAL   J Biol Chem 275 (9), 6381-6387 (2000)
   PUBMED   10692439
REFERENCE   8  (bases 1 to 2215)
  AUTHORS   Nakagawa,O., Nakagawa,M., Richardson,J.A., Olson,E.N. and
            Srivastava,D.
  TITLE     HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors
            marking specific cardiac, somitic, and pharyngeal arch segments
  JOURNAL   Dev Biol 216 (1), 72-84 (1999)
   PUBMED   10588864
REFERENCE   9  (bases 1 to 2215)
  AUTHORS   Kokubo,H., Lun,Y. and Johnson,R.L.
  TITLE     Identification and expression of a novel family of bHLH cDNAs
            related to Drosophila hairy and enhancer of split
  JOURNAL   Biochem Biophys Res Commun 260 (2), 459-465 (1999)
   PUBMED   10403790
REFERENCE   10 (bases 1 to 2215)
  AUTHORS   Leimeister,C., Externbrink,A., Klamt,B. and Gessler,M.
  TITLE     Hey genes: a novel subfamily of hairy- and Enhancer of split
            related genes specifically expressed during mouse embryogenesis
  JOURNAL   Mech Dev 85 (1-2), 173-177 (1999)
   PUBMED   10415358
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK140212.1 and AF172286.1.
            
            On Nov 8, 2006 this sequence version replaced NM_010423.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF172286.1, BC086635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2199              AK140212.1         2-2200
            2200-2215           AF172286.1         2181-2196
FEATURES             Location/Qualifiers
     source          1..2215
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 2.15 cM"
     gene            1..2215
                     /gene="Hey1"
                     /gene_synonym="bHLHb31; CHF2; Herp2; hesr-1; Hesr1; HRT1"
                     /note="hairy/enhancer-of-split related with YRPW motif 1"
                     /db_xref="GeneID:15213"
                     /db_xref="MGI:MGI:1341800"
     exon            1..257
                     /gene="Hey1"
                     /gene_synonym="bHLHb31; CHF2; Herp2; hesr-1; Hesr1; HRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            258..333
                     /gene="Hey1"
                     /gene_synonym="bHLHb31; CHF2; Herp2; hesr-1; Hesr1; HRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            334..417
                     /gene="Hey1"
                     /gene_synonym="bHLHb31; CHF2; Herp2; hesr-1; Hesr1; HRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            418..499
                     /gene="Hey1"
                     /gene_synonym="bHLHb31; CHF2; Herp2; hesr-1; Hesr1; HRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            500..2205
                     /gene="Hey1"
                     /gene_synonym="bHLHb31; CHF2; Herp2; hesr-1; Hesr1; HRT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2183..2188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hey1"
                     /gene_synonym="bHLHb31; CHF2; Herp2; hesr-1; Hesr1; HRT1"
                     /note="hexamer: AATAAA"
     polyA_site      2203
                     /gene="Hey1"
                     /gene_synonym="bHLHb31; CHF2; Herp2; hesr-1; Hesr1; HRT1"
                     /note="major polyA site"
ORIGIN      
        1 atgggaaggg gcgcagcgtg ggaaagggat ggttgagttt taaccggaga ctgagcgtga
       61 gtgggatcag tgtgcacgca cctcccgcag ccgagcgctg agcggccact gcagttaact
      121 cctccttgcc cgccgcgcga ccctcctcgg agcccacgct ccgccaccat gaagagagct
      181 cacccagact acagctcctc agatagtgag ctggacgaga ccatcgaggt ggaaaaggag
      241 agcgcggacg agaatggaaa cttgagttcg gcgctgtgtt ccatgtcccc aacgacatcg
      301 tcccaggttt tggccaggaa aagacggaga ggcatcatcg agaagcgccg acgagaccga
      361 atcaataaca gtttgtctga gctgagaagg ctggtaccca gtgcctttga gaagcaggga
      421 tctgctaagc tagaaaaagc tgagatcttg cagatgactg tggatcacct gaaaatgctg
      481 cacactgcag gagggaaagg ttattttgac gcgcacgccc tggctatgga ctatcggagt
      541 ttggggtttc gggaatgcct ggccgaagtt gcccgttatc tgagcatcat tgaaggactc
      601 gatgcctccg acccgcttcg cgttcgcctg gtctcccatc tcaacaacta cgcatcccag
      661 cgggaagccg cgagcggcgc tcacggtggc ctcggacaca ttccctgggg aagtgccttc
      721 ggacatcacc cacacatcgc acaccctctg ctgctgcccc agaatggcca cgggaacgct
      781 ggcaccgcgg cgtcacccac ggagccgcat caccagggca ggctggcttc tgcccatccg
      841 gaggcgccgg ccttgcgagc gccccctagt ggcggcttgg gaccggtgct tcccgtggtg
      901 acctcggcct ccaaactgtc tccaccgctg ctctcctctg tggcctcgct ctcagccttc
      961 cccttttcct tcagctcctt ccacctactg agcccttcga cacccacgca ggcagcaaac
     1021 cttggcaagc cctatagacc ttgggggaca gagatcggag ctttctaaag aactgatgct
     1081 gtagaacaag ggaggggaaa gcttaaaatc ccaggtgtgt tgggacggtt gtcaacacca
     1141 ccctaaagtc gccagtaagt caggaaaaag gtacattttc agataatttt tttctaaaga
     1201 ctaaaagttt gttggtttac ttttctcttt aattttttat catgtcatgc attagcagtt
     1261 ttaaaaaatt agttgttaat ttttgtttaa aagattcaat tgaggtagtg attacgaacc
     1321 aacactttga tccgttgttt gttctgtgcc tcatttattt tgtaaacctg tctgtctgag
     1381 aatgattccg tttgcctcag cgtggggaat cttaacatta gtgtttgggg tctgtttcct
     1441 ggtgtgtata agttgtaatc ttttgaggat taatttcgca cgccactatg ctcaatgtta
     1501 acacgatttt gttactactt tgatggaccg aggtgttgta taagtggtat tctttgggga
     1561 gggagggtca gcaaagcatt atatttgcaa acaaagcgtt gacaaatcag atgcgcagct
     1621 ttactggaga gcactggctc tctctctgcc tctcagagca gtgaggtgaa gggagaaagg
     1681 tgtctgtgcc ctgaatccag atgaccagct actgtggcct gcttggcttt tctcttctga
     1741 tatttcaggt ttagaaacag ctgctggtag tctaggtccc catttggagc gttggcagca
     1801 agcaagacag ttatgtagac cttgcctgca cttggcagcc ctaagcactc tcagtctcac
     1861 ggatttcacc gttcaccagt gtcgacctgc gtaagcgatc ggagtctgaa agtagcttgg
     1921 tgcctgtgaa acacaacccg attttcctag aactcccata ttttctttta agtggaaatt
     1981 tttatgttgt gttttccttt tggtgcatga aaatgtggtt cttgcagtac ttaaaagggc
     2041 ttctctgcct tctcattcat ttttaaaatt ttgatttggg ctctaaaagt attgttttac
     2101 aggcttaccc ctttagaagg tataatttga acagctcctc tgaactaggt ttgacctctg
     2161 ttgtattgat gtgttgtgac taaataaaaa gcaaagaaca atataaaaaa aaaaa
//
