LOCUS       NM_138753               3401 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus hexamethylene bis-acetamide inducible 1 (Hexim1),
            mRNA.
ACCESSION   NM_138753
VERSION     NM_138753.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3401)
  AUTHORS   Bazi,Z., Bertacchi,M., Abasi,M., Mohammadi-Yeganeh,S.,
            Soleimani,M., Wagner,N. and Ghanbarian,H.
  TITLE     Rn7SK small nuclear RNA is involved in neuronal differentiation
  JOURNAL   J Cell Biochem 119 (4), 3174-3182 (2018)
   PUBMED   29091296
REFERENCE   2  (bases 1 to 3401)
  AUTHORS   Mascareno,E., Gupta,R., Martello,L.A., Dhar-Mascareno,M.,
            Salciccioli,L., Beckles,D., Walsh,M.G., Machado,F.S., Tanowitz,H.B.
            and Haseeb,M.A.
  TITLE     Rapidly progressive course of Trypanosoma cruzi infection in mice
            heterozygous for hexamethylene bis-acetamide inducible 1 (Hexim1)
            gene
  JOURNAL   Microbes Infect 20 (1), 25-36 (2018)
   PUBMED   28951318
  REMARK    GeneRIF: Trypanosoma cruzi (T. cruzi) infected mice heterozygous
            for hexamethylene bis-acetamide inducible 1 (Hexim1) gene have
            compromised cardiac function, altered expression of both pro- and
            anti-inflammatory cytokines, and increased inflammation and
            fibrosis. The profound exacerbation of pathologic findings in the
            tissues of heart, lung, spleen, and intestines suggests a
            protective role for Hexim1 in T. cruzi infection.
REFERENCE   3  (bases 1 to 3401)
  AUTHORS   Dhar-Mascareno,M., Rozenberg,I., Iqbal,J., Hussain,M.M., Beckles,D.
            and Mascareno,E.
  TITLE     Hexim1 heterozygosity stabilizes atherosclerotic plaque and
            decreased steatosis in ApoE null mice fed atherogenic diet
  JOURNAL   Int J Biochem Cell Biol 83, 56-64 (2017)
   PUBMED   28013147
  REMARK    GeneRIF: Decreased Hexim-1 expression does not alter cholesterol
            metabolism in ApoE null background after high fat diet. However, it
            promotes stable atherosclerotic plaque and decreased steatosis by
            promoting the anti-inflammatory TGFbeta pathway and blocking the
            expression of the inducible and pro-inflammatory expression of
            SOCS3 respectively.
REFERENCE   4  (bases 1 to 3401)
  AUTHORS   Dhar-Mascareno,M., Ramirez,S.N., Rozenberg,I., Rouille,Y.,
            Kral,J.G. and Mascareno,E.J.
  TITLE     Hexim1, a Novel Regulator of Leptin Function, Modulates Obesity and
            Glucose Disposal
  JOURNAL   Mol Endocrinol 30 (3), 314-324 (2016)
   PUBMED   26859361
  REMARK    GeneRIF: Hexim1 selectively modulates leptin-mediated signal
            transduction pathways in the hypothalamus.
REFERENCE   5  (bases 1 to 3401)
  AUTHORS   Yoshikawa,N., Shimizu,N., Ojima,H., Kobayashi,H., Hosono,O. and
            Tanaka,H.
  TITLE     Down-regulation of hypoxia-inducible factor-1 alpha and vascular
            endothelial growth factor by HEXIM1 attenuates myocardial
            angiogenesis in hypoxic mice
  JOURNAL   Biochem Biophys Res Commun 453 (3), 600-605 (2014)
   PUBMED   25301555
  REMARK    GeneRIF: conclude that HEXIM1 could prevent RV hypertrophy, at
            least in part, via suppression of myocardial angiogenesis through
            down-regulation of HIF-1alpha and VEGF in the myocardium under
            hypoxic condition
REFERENCE   6  (bases 1 to 3401)
  AUTHORS   Montano,M.M., Doughman,Y.Q., Deng,H., Chaplin,L., Yang,J., Wang,N.,
            Zhou,Q., Ward,N.L. and Watanabe,M.
  TITLE     Mutation of the HEXIM1 gene results in defects during heart and
            vascular development partly through downregulation of vascular
            endothelial growth factor
  JOURNAL   Circ Res 102 (4), 415-422 (2008)
   PUBMED   18079413
  REMARK    GeneRIF: HEXIM1 plays critical roles in coronary vessel development
            and myocardial growth
REFERENCE   7  (bases 1 to 3401)
  AUTHORS   Espinoza-Derout,J., Wagner,M., Shahmiri,K., Mascareno,E.,
            Chaqour,B. and Siddiqui,M.A.
  TITLE     Pivotal role of cardiac lineage protein-1 (CLP-1) in
            transcriptional elongation factor P-TEFb complex formation in
            cardiac hypertrophy
  JOURNAL   Cardiovasc Res 75 (1), 129-138 (2007)
   PUBMED   17459355
REFERENCE   8  (bases 1 to 3401)
  AUTHORS   Huang,F., Wagner,M. and Siddiqui,M.A.
  TITLE     Ablation of the CLP-1 gene leads to down-regulation of the HAND1
            gene and abnormality of the left ventricle of the heart and fetal
            death
  JOURNAL   Mech Dev 121 (6), 559-572 (2004)
   PUBMED   15172687
  REMARK    GeneRIF: CLP-1 and the HAND transcription factors may be part of a
            genetic program critical to proper heart development, and their
            perturbation can lead to cardiomyopathy
REFERENCE   9  (bases 1 to 3401)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3401)
  AUTHORS   Huang,F., Wagner,M. and Siddiqui,M.A.
  TITLE     Structure, expression, and functional characterization of the mouse
            CLP-1 gene
  JOURNAL   Gene 292 (1-2), 245-259 (2002)
   PUBMED   12119119
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731805.8.
            
            On Jan 31, 2007 this sequence version replaced NM_138753.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY090614.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3401              AL731805.8         90843-94243
FEATURES             Location/Qualifiers
     source          1..3401
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.71 cM"
     gene            1..3401
                     /gene="Hexim1"
                     /gene_synonym="7330426E13Rik; CLP-1; Clp1; HIS1"
                     /note="hexamethylene bis-acetamide inducible 1"
                     /db_xref="GeneID:192231"
                     /db_xref="MGI:MGI:2385923"
     exon            1..3401
                     /gene="Hexim1"
                     /gene_synonym="7330426E13Rik; CLP-1; Clp1; HIS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2028..2033
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hexim1"
                     /gene_synonym="7330426E13Rik; CLP-1; Clp1; HIS1"
                     /note="hexamer: AATAAA"
     polyA_site      2053
                     /gene="Hexim1"
                     /gene_synonym="7330426E13Rik; CLP-1; Clp1; HIS1"
                     /note="major polyA site"
     regulatory      2220..2225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hexim1"
                     /gene_synonym="7330426E13Rik; CLP-1; Clp1; HIS1"
                     /note="hexamer: AATACA"
     polyA_site      2241
                     /gene="Hexim1"
                     /gene_synonym="7330426E13Rik; CLP-1; Clp1; HIS1"
ORIGIN      
        1 gaggaaaaga ggaggaggcg gaggagaact gagcggagca tcgagccaga ggggagatga
       61 gtttgtctgt cctcggctaa ggctccggcc cggcctgagg aactgggagc tcgggttgga
      121 gcgacacccg tggaagtggg aggtggcggc tctgggactt taaccccttg tgggctctgc
      181 ggcaggggat ttaacccttt gtggattcgg cccctccgag gcagcgtcat cgggtagttt
      241 taaccctttc gggttgggtt taacccattg gacttaaacc tcctctcctt gcgcaccaac
      301 tcctcgtctg tgggagcact cggcggggag gcgtgaagcc cacccctctg catatttgca
      361 tacggtgcct gctgctgaac ccccggacct gctagttggc cacgcttgtg tgcgcttaac
      421 cctttattga ctggactcca agttgcgatt ggagtttgct gacaggacgg acggaaggcg
      481 tcactgcaga aattactgac cgaagaggac tttgttggac atattttgaa aagaaagaaa
      541 aacctctttc cttaagccag aatttctcaa acttccagaa gagaactcta ctaagccatg
      601 gccgagccac tcttgacaga acatcaacac cagcctcaaa ctagcaactg tacaggtgct
      661 gctgttgtcc atgaagagca tacctctgag cgccccccaa gcgcggagga acgggtgccc
      721 aaggaggaca gtaggtggca atcgagagcg tccttgcagt ccggtagccg tccagggcag
      781 gagggagaag ggggcctgaa gcaccagctg cccccattgc agacgaatgc ctgtccagaa
      841 ttgagctccc tggagaaggg cgagaagggc cagaatgggg aggacttatc cactggcggt
      901 gcctccccgt cggcggaggg agagccgatg tcagagtccc tcgtgcagcc aggtcatgac
      961 tcggaggcca ccaagcagga ggctcctgcc gccggaggcg aggagccatg gggacagcaa
     1021 cagagacagc tgggcaagaa aaaacatcgg agacgcccct caaagaagaa gcggcattgg
     1081 aagccctact acaagctgac ttgggaggag aagaaaaagt tcgacgagaa gcagagcctg
     1141 cgagcttcgc gggttcgagc cgagatgttc gccaagggcc agccagttgc gccctataac
     1201 accacgcagt tcctcatgga tgaccacgat caggaggagc ctgatctcaa aaccggcctt
     1261 taccccaagc gggcagccgc caaatccgac gacaccagcg atgaggattt tgtggaagaa
     1321 gctggtgagg aagacggagg cagcgatggc atgggagggg acggcagcga gtttctgcag
     1381 cgggacttct cggagacgta cgagcggtac cacgccgaga gcctgcagaa catgagcaag
     1441 caggagctca tcaaagagta cctggagctg gagaagtgcc tctcccgcaa ggaggacgaa
     1501 aataaccggc tgcggctgga aagcaagcgg ctgggaggcg tcgacgcgcg agtgcgggag
     1561 ctcgagctag agctggaccg gctgcgcgct gagaacctcc agctgctgac cgagaacgaa
     1621 ctgcaccggc agcaggagcg agcgcctctt tccaagttcg gcgactagac tgaaaacttt
     1681 tggggggagg gggcaaaggg gactttttac agtgctggaa tgtaacatta tatacatgtg
     1741 tatataagac agcggacctt tttatgacac ataatcagaa gagaaaatcg ccccggcttt
     1801 ggtttggtaa atttagctat gatgttgctt gtgtgctttc tcctgttctt taattatgtg
     1861 aaactgaagg gttgcttttc atgttttcct ccttagatgt tgtttcttaa tgtgcaagta
     1921 atctgaccaa gttataatgc atttttctgt tttaaaaaaa aaatcccctc cttaagcgga
     1981 gctataaggt ggccaaatct gagacccatt acattcattc tagttataat aaatttaatg
     2041 tttgtaaatg taacagtttc agtgtgattt ctagagatta aaaatcgtgc tggtttgtgt
     2101 gactgcactt ttgaggtggg gtaccaagat tgttaaattt atctatttgc aaaaatactt
     2161 gaatagaaga aattcagttt gttccctcca cccccaccaa tgggttttta aattttcaaa
     2221 atacagttca ggtaaaatgt actcaatgtt gtgcctgctt cctaatgctg gggagtagaa
     2281 agtggctaca ggcagcagct tagcttgcgc accttgatgg ctgttcaaaa gagtgctaac
     2341 aaaagtataa gcctgatttg gcaattgtta gataacgaaa agcctcattt catctccaca
     2401 agtcaatttt tcagtaatcc tggcttccgt cctaaccacc ccacaaaatt ccaatggagt
     2461 tcctgtttgc ctaccttggt aagtaaggct cctggtaaac ttgctttctt agtacatcca
     2521 agagatagcc aagataaact tgtgagaaaa catgttagcg atatgttgga cttcaaatgg
     2581 ctaagtgatc taaggactta gcatcaatgt ctgacactta agtacttttt ctattgaaaa
     2641 taagaaagaa aagctgccct ttccattaga atccaactga aatttgaaat gcccctttct
     2701 acaagtaaag ctggctcagg agcgggctga ggtctttaga tgatgaatac aaaccctgca
     2761 tgtttccagt actgcagcta ttctcaatct cctgggctgc ctggacagct gcctaggtta
     2821 ggctgctctt gaaaatgcag ggaggctctg agaactaggc cttatcacag aatcaaaatg
     2881 gtaaactcaa cagttctctc atgtcagtat agttaatgca accctgtcac ctgacctgtg
     2941 tcagtgtttc cttagggcaa ttatattgct aaaattatta gcacaactgg ctccgtaact
     3001 tggagtctta aaaaccatag ggggccttgg gggtccacaa gccccacata attgtgtgaa
     3061 tatatatata tataatatat atatatatat attgaatata ttatatatat tcaagtgggt
     3121 tcaagaactc aggaggttgt caaattcctt ggtggttaaa aaccccttag ggcaggggct
     3181 tctcagcctt cctgccagct aaatggtaac agtggagttg actggaacat caagaacgaa
     3241 tgcagctaca aatcaataat caagaaaagc tgtgccagga ggacggcttg ggaccttcaa
     3301 aaccaagctt gctggttcta ttctggcagg tggtctcctg cagaaactgt aaaatcaact
     3361 tttctttgat ctaaagattg cattaaatgt ctattttgaa a
//
