LOCUS       NP_001139545             559 aa            linear   ROD 27-APR-2025
DEFINITION  hexosaminidase D isoform 1 [Mus musculus].
ACCESSION   NP_001139545
VERSION     NP_001139545.1
DBSOURCE    REFSEQ: accession NM_001146073.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 559)
  AUTHORS   Keembiyehetty,C.N., Krzeslak,A., Love,D.C. and Hanover,J.A.
  TITLE     A lipid-droplet-targeted O-GlcNAcase isoform is a key regulator of
            the proteasome
  JOURNAL   J Cell Sci 124 (Pt 16), 2851-2860 (2011)
   PUBMED   21807949
  REMARK    GeneRIF: lipid-droplet-targeted isoform is a key regulator of the
            proteasome
REFERENCE   2  (residues 1 to 559)
  AUTHORS   Tkatchenko,T.V., Moreno-Rodriguez,R.A., Conway,S.J.,
            Molkentin,J.D., Markwald,R.R. and Tkatchenko,A.V.
  TITLE     Lack of periostin leads to suppression of Notch1 signaling and
            calcific aortic valve disease
  JOURNAL   Physiol Genomics 39 (3), 160-168 (2009)
   PUBMED   19723774
REFERENCE   3  (residues 1 to 559)
  AUTHORS   Gutternigg,M., Rendic,D., Voglauer,R., Iskratsch,T. and Wilson,I.B.
  TITLE     Mammalian cells contain a second nucleocytoplasmic hexosaminidase
  JOURNAL   Biochem J 419 (1), 83-90 (2009)
   PUBMED   19040401
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY296469.1, FM204886.1, BC056487.1 and AI481765.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069960.1, FM204886.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..559
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 85.08 cM"
     Protein         1..559
                     /product="hexosaminidase D isoform 1"
                     /EC_number="3.2.1.52"
                     /note="beta-hexosaminidase D; beta-N-acetylhexosaminidase;
                     N-acetyl-beta-galactosaminidase; hexosaminidase
                     domain-containing protein; hexosaminidase (glycosyl
                     hydrolase family 20, catalytic domain) containing"
                     /calculated_mol_wt=62090
     Region          9..323
                     /region_name="GH20_GcnA-like"
                     /note="Glycosyl hydrolase family 20 (GH20) catalytic
                     domain of N-acetyl-beta-D-glucosaminidase (GcnA, also
                     known as BhsA) and related proteins. GcnA is an
                     exoglucosidase which cleaves N-acetyl-beta-D-galactosamine
                     (NAG) and N-acetyl-beta-D-galactosamine...; cd06565"
                     /db_xref="CDD:119335"
     Site            order(18,92,148..149,197,223,298,300)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:119335"
     CDS             1..559
                     /gene="Hexd"
                     /gene_synonym="Hexdc"
                     /coded_by="NM_001146073.1:50..1729"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:238023"
                     /db_xref="MGI:MGI:3605542"
ORIGIN      
        1 mssptpfkmr lvhldlkgap pkvsylsevf plfhalgang llieyedmfp yeghlrllra
       61 khayspsevt eilrlarlse leviplvqtf ghmefvlkha afahlreval fpntlnphea
      121 eslalvqami dqilelhrdv rwlhigcdev yylgegetsk qwlqqeqnsh aklclshmqa
      181 vashvltqhp gvtplvwddm lrdipqeqlk asgvpqlvep vlwdygadld vhgkvfligk
      241 yqecgfqrlw aasafkgatg asqalppveh hirnhelwlq vagsgpkdal qgiiltgwqr
      301 ydhfsvlcel lpvgipslaa clqslvhgal dysasepghl ymdcvvrpga padcaattfh
      361 mftgkqppgl agapqdavpf ahstqrsgvl sehfclwtvs ggfaedvrlr aerflgvssl
      421 eiadtvsega gsfpgsdiha lvtqislhlr ssvdtllern ryvtgwfspy hrrrklvhpv
      481 miqhiqpeal sllsrwnnlv qqlevalqpv fypdtieewl eenvlpslqr lqdllqdlge
      541 aaarqpppts pgwdtgqnp
//
