LOCUS       NM_010422               1922 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus hexosaminidase B (Hexb), mRNA.
ACCESSION   NM_010422
VERSION     NM_010422.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1922)
  AUTHORS   Rosmus,D.D., Koch,J., Hausmann,A., Chiot,A., Arnhold,F., Masuda,T.,
            Kierdorf,K., Hansen,S.M., Kuhrt,H., Froba,J., Wolf,J., Boneva,S.,
            Gericke,M., Ajami,B., Prinz,M., Lange,C. and Wieghofer,P.
  TITLE     Redefining the ontogeny of hyalocytes as yolk sac-derived
            tissue-resident macrophages of the vitreous body
  JOURNAL   J Neuroinflammation 21 (1), 168 (2024)
   PUBMED   38961498
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1922)
  AUTHORS   Li,X., Xiang,C., Zhu,S., Guo,J., Liu,C., Wang,A., Cao,J., Lu,Y.,
            Neculai,D., Xu,P. and Feng,X.H.
  TITLE     SNX8 enables lysosome reformation and reverses lysosomal storage
            disorder
  JOURNAL   Nat Commun 15 (1), 2553 (2024)
   PUBMED   38519472
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1922)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1922)
  AUTHORS   Faust,T.E., Feinberg,P.A., O'Connor,C., Kawaguchi,R., Chan,A.,
            Strasburger,H., Frosch,M., Boyle,M.A., Masuda,T., Amann,L.,
            Knobeloch,K.P., Prinz,M., Schaefer,A. and Schafer,D.P.
  TITLE     A comparative analysis of microglial inducible Cre lines
  JOURNAL   Cell Rep 42 (9), 113031 (2023)
   PUBMED   37635351
REFERENCE   5  (bases 1 to 1922)
  AUTHORS   Eichler,A., Kleidonas,D., Turi,Z., Fliegauf,M., Kirsch,M.,
            Pfeifer,D., Masuda,T., Prinz,M., Lenz,M. and Vlachos,A.
  TITLE     Microglial Cytokines Mediate Plasticity Induced by 10 Hz Repetitive
            Magnetic Stimulation
  JOURNAL   J Neurosci 43 (17), 3042-3060 (2023)
   PUBMED   36977586
REFERENCE   6  (bases 1 to 1922)
  AUTHORS   Lock,L.F., Pines,J., Hunter,T., Gilbert,D.J., Gopalan,G.,
            Jenkins,N.A., Copeland,N.G. and Donovan,P.J.
  TITLE     A single cyclin A gene and multiple cyclin B1-related sequences are
            dispersed in the mouse genome
  JOURNAL   Genomics 13 (2), 415-424 (1992)
   PUBMED   1535334
REFERENCE   7  (bases 1 to 1922)
  AUTHORS   Justice,M.J., Silan,C.M., Ceci,J.D., Buchberg,A.M., Copeland,N.G.
            and Jenkins,N.A.
  TITLE     A molecular genetic linkage map of mouse chromosome 13 anchored by
            the beige (bg) and satin (sa) loci
  JOURNAL   Genomics 6 (2), 341-351 (1990)
   PUBMED   2307475
REFERENCE   8  (bases 1 to 1922)
  AUTHORS   Bapat,B., Ethier,M., Neote,K., Mahuran,D. and Gravel,R.A.
  TITLE     Cloning and sequence analysis of a cDNA encoding the beta-subunit
            of mouse beta-hexosaminidase
  JOURNAL   FEBS Lett 237 (1-2), 191-195 (1988)
   PUBMED   2971567
REFERENCE   9  (bases 1 to 1922)
  AUTHORS   Killary,A.M., Leach,R.J., Moran,R.G. and Fournier,R.E.
  TITLE     Assignment of genes encoding dihydrofolate reductase and
            hexosaminidase B to Mus musculus chromosome 13
  JOURNAL   Somat Cell Mol Genet 12 (6), 641-648 (1986)
   PUBMED   2947337
REFERENCE   10 (bases 1 to 1922)
  AUTHORS   Gilbert,F., Kucherlapati,R., Creagan,R.P., Murnane,M.J.,
            Darlington,G.J. and Ruddle,F.H.
  TITLE     Tay-Sachs' and Sandhoff's diseases: the assignment of genes for
            hexosaminidase A and B to individual human chromosomes
  JOURNAL   Proc Natl Acad Sci U S A 72 (1), 263-267 (1975)
   PUBMED   1054503
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY145642.1, AK168825.1 and CD775639.1.
            
            On Mar 26, 2009 this sequence version replaced NM_010422.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151149.1, AK159178.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02415128 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BY145642.1         2-28
            28-1450             AK168825.1         2-1424
            1451-1922           CD775639.1         1-472               c
FEATURES             Location/Qualifiers
     source          1..1922
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 50.66 cM"
     gene            1..1922
                     /gene="Hexb"
                     /note="hexosaminidase B"
                     /db_xref="GeneID:15212"
                     /db_xref="MGI:MGI:96074"
     exon            1..332
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1707
                     /gene="Hexb"
                     /EC_number="3.2.1.52"
                     /note="beta-hexosaminidase subunit beta; hexosaminidase
                     subunit B; beta-N-acetylhexosaminidase subunit beta;
                     N-acetyl-beta-glucosaminidase subunit beta"
                     /codon_start=1
                     /product="beta-hexosaminidase subunit beta precursor"
                     /protein_id="NP_034552.1"
                     /db_xref="CCDS:CCDS26709.1"
                     /db_xref="GeneID:15212"
                     /db_xref="MGI:MGI:96074"
                     /translation="MPQSPRSAPGLLLLQALVSLVSLALVAPARLQPALWPFPRSVQM
                     FPRLLYISAEDFSIDHSPNSTAGPSCSLLQEAFRRYYNYVFGFYKRHHGPARFRAEPQ
                     LQKLLVSITLESECESFPSLSSDETYSLLVQEPVAVLKANSVWGALRGLETFSQLVYQ
                     DSFGTFTINESSIADSPRFPHRGILIDTSRHFLPVKTILKTLDAMAFNKFNVLHWHIV
                     DDQSFPYQSTTFPELSNKGSYSLSHVYTPNDVRMVLEYARLRGIRVIPEFDTPGHTQS
                     WGKGQKNLLTPCYNQKTKTQVFGPVDPTVNTTYAFFNTFFKEISSVFPDQFIHLGGDE
                     VEFQCWASNPNIQGFMKRKGFGSDFRRLESFYIKKILEIISSLKKNSIVWQEVFDDKV
                     ELQPGTVVEVWKSEHYSYELKQVTGSGFPAILSAPWYLDLISYGQDWKNYYKVEPLNF
                     EGSEKQKQLVIGGEACLWGEFVDATNLTPRLWPRASAVGERLWSPKTVTDLENAYKRL
                     AVHRCRMVSRGIAAQPLYTGYCNYENKI"
     exon            333..478
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            479..544
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            545..591
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            592..702
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            703..804
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            805..934
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1115
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1202
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1275
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1450
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1541
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1646
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1905
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1796..1801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hexb"
                     /note="hexamer: AATAAA"
     polyA_site      1821
                     /gene="Hexb"
                     /note="major polyA site"
     regulatory      1874..1879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hexb"
                     /note="hexamer: AATAAA"
     polyA_site      1905
                     /gene="Hexb"
ORIGIN      
        1 atctgacttg gtgacccggg cacggatgct ttcttcccag cgacccagac tggaaggttg
       61 gtccaaagac tgcctagcca gactcgcgga gcagtcatgc cgcagtcccc gcgtagcgcc
      121 cccgggctgc tgctgctgca ggcgctggtg tcgctagtgt cgctggccct agtggccccg
      181 gcccgactgc aacctgcgct atggcccttc ccgcgctcgg tgcagatgtt cccgcggctg
      241 ttgtacatct ccgcggagga cttcagcatc gaccacagtc ccaattccac agcgggccct
      301 tcctgctcgc tgctacagga ggcgtttcgg cgatattaca actatgtttt tggtttctac
      361 aagagacatc atggccctgc tagatttcga gctgagccac agttgcagaa gctcctggtc
      421 tccattaccc tcgagtcaga gtgcgagtcc ttccctagtc tgtcttcaga tgaaacctat
      481 tctctgcttg tacaagaacc agtagccgtc ctcaaggcca acagcgtttg gggagcgtta
      541 cgaggtttag agacgtttag ccagttagtt taccaagact ctttcgggac tttcaccatc
      601 aatgaatcca gtatagctga ttctccaaga ttccctcata gaggaatttt aattgataca
      661 tctagacact tcctgcctgt gaagacaatt ttaaaaactc tggatgccat ggcttttaat
      721 aagtttaatg ttcttcactg gcacatagtg gacgaccagt ctttccctta tcagagtacc
      781 acttttcctg agctaagcaa taagggaagc tactctttgt ctcatgtcta tacaccaaac
      841 gatgtccgga tggtgctgga gtacgcccgg ctccgaggga ttcgagtcat accagaattt
      901 gatacccctg gccatacaca gtcttggggc aaaggacaga aaaaccttct aactccatgt
      961 tacaatcaaa aaactaaaac tcaagtgttt gggcctgtag acccaactgt aaacacaacg
     1021 tatgcattct ttaacacatt tttcaaagaa atcagcagtg tgtttccaga tcagttcatc
     1081 cacttgggag gagatgaagt agaatttcaa tgttgggcat caaatccaaa catccaaggt
     1141 ttcatgaaga gaaagggctt tggcagcgat tttagaagac tagaatcctt ttatattaaa
     1201 aagattttgg aaattatttc atccttaaag aagaactcca ttgtttggca agaagttttt
     1261 gatgataagg tggagcttca gccgggcaca gtagtcgaag tgtggaagag tgagcattat
     1321 tcatatgagc taaagcaagt cacaggctct ggcttccctg ccatcctttc tgctccttgg
     1381 tacttagacc tgatcagcta tgggcaagac tggaaaaact actacaaagt tgagcccctt
     1441 aattttgaag gctctgagaa gcagaaacaa cttgttattg gtggagaagc ttgcctgtgg
     1501 ggagaatttg tggatgcaac taaccttact ccaagattat ggcctcgagc aagcgctgtt
     1561 ggtgagagac tctggagccc taaaactgtc actgacctag aaaatgccta caaacgactg
     1621 gccgtgcacc gctgcagaat ggtcagccgt ggaatagctg cacaacctct ctatactgga
     1681 tactgtaact atgagaataa aatatagaag tgacagacgt ctacagcatt ccagctatga
     1741 tcatgttgat tctgaaatca tgtaaattaa gatttgttag gctgtttttt ttttaaataa
     1801 accatctttt tattgattga atctttctat ccctgaatca aacactgaat cttttatgtg
     1861 agcagcttaa gaaaataaaa ggaaaagcct tgcactagca ctccaaaaaa aaaaaaaaaa
     1921 aa
//
