LOCUS       NM_010420               1144 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus homeobox gene expressed in ES cells (Hesx1), mRNA.
ACCESSION   NM_010420
VERSION     NM_010420.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1144)
  AUTHORS   Gonzalez-Meljem JM, Ivins S, Andoniadou CL, Le Tissier P, Scambler
            P and Martinez-Barbera JP.
  TITLE     An expression and function analysis of the CXCR4/SDF-1 signalling
            axis during pituitary gland development
  JOURNAL   PLoS One 18 (2), e0280001 (2023)
   PUBMED   36800350
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1144)
  AUTHORS   Bando H, Brinkmeier ML, Castinetti F, Fang Q, Lee MS, Saveanu A,
            Albarel F, Dupuis C, Brue T and Camper SA.
  TITLE     Heterozygous variants in SIX3 and POU1F1 cause pituitary hormone
            deficiency in mouse and man
  JOURNAL   Hum Mol Genet 32 (3), 367-385 (2023)
   PUBMED   35951005
REFERENCE   3  (bases 1 to 1144)
  AUTHORS   Brinkmeier ML, Bando H, Camarano AC, Fujio S, Yoshimoto K, de Souza
            FS and Camper SA.
  TITLE     Rathke's cleft-like cysts arise from Isl1 deletion in murine
            pituitary progenitors
  JOURNAL   J Clin Invest 130 (8), 4501-4515 (2020)
   PUBMED   32453714
REFERENCE   4  (bases 1 to 1144)
  AUTHORS   Cheung LYM and Camper SA.
  TITLE     PROP1-Dependent Retinoic Acid Signaling Regulates Developmental
            Pituitary Morphogenesis and Hormone Expression
  JOURNAL   Endocrinology 161 (2) (2020)
   PUBMED   31913463
REFERENCE   5  (bases 1 to 1144)
  AUTHORS   Pozzi S, Bowling S, Apps J, Brickman JM, Rodriguez TA and
            Martinez-Barbera JP.
  TITLE     Genetic Deletion of Hesx1 Promotes Exit from the Pluripotent State
            and Impairs Developmental Diapause
  JOURNAL   Stem Cell Reports 13 (6), 970-979 (2019)
   PUBMED   31761678
  REMARK    GeneRIF: our data provide evidence for a novel role of Hesx1 in the
            control of self-renewal and maintenance of the undifferentiated
            state in ESCs and mouse embryos.
REFERENCE   6  (bases 1 to 1144)
  AUTHORS   Sheng HZ, Zhadanov AB, Mosinger B Jr, Fujii T, Bertuzzi S, Grinberg
            A, Lee EJ, Huang SP, Mahon KA and Westphal H.
  TITLE     Specification of pituitary cell lineages by the LIM homeobox gene
            Lhx3
  JOURNAL   Science 272 (5264), 1004-1007 (1996)
   PUBMED   8638120
REFERENCE   7  (bases 1 to 1144)
  AUTHORS   Hermesz E, Mackem S and Mahon KA.
  TITLE     Rpx: a novel anterior-restricted homeobox gene progressively
            activated in the prechordal plate, anterior neural plate and
            Rathke's pouch of the mouse embryo
  JOURNAL   Development 122 (1), 41-52 (1996)
   PUBMED   8565852
REFERENCE   8  (bases 1 to 1144)
  AUTHORS   Thomas PQ, Johnson BV, Rathjen J and Rathjen PD.
  TITLE     Sequence, genomic organization, and expression of the novel
            homeobox gene Hesx1
  JOURNAL   J Biol Chem 270 (8), 3869-3875 (1995)
   PUBMED   7876132
REFERENCE   9  (bases 1 to 1144)
  AUTHORS   Webb GC, Thomas PQ, Ford JH and Rathjen PD.
  TITLE     Hesx1, a homeobox gene expressed by murine embryonic stem cells,
            maps to mouse chromosome 14, bands A3-B
  JOURNAL   Genomics 18 (2), 464-466 (1993)
   PUBMED   7904583
REFERENCE   10 (bases 1 to 1144)
  AUTHORS   Thomas PQ and Rathjen PD.
  TITLE     HES-1, a novel homeobox gene expressed by murine embryonic stem
            cells, identifies a new class of homeobox genes
  JOURNAL   Nucleic Acids Res 20 (21), 5840 (1992)
   PUBMED   1360650
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124603.5, BC132051.1 and U40720.1.
            
            [WARNING] On Sep 25, 2023 this sequence was replaced by
            NM_010420.3.
            
            On Mar 21, 2009 this sequence version replaced NM_010420.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U40720.1, AK082831.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-515               AC124603.5         115103-115617
            516-817             BC132051.1         342-643
            818-1144            U40720.1           816-1142
FEATURES             Location/Qualifiers
     source          1..1144
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 16.09 cM"
     gene            1..1144
                     /gene="Hesx1"
                     /gene_synonym="HES-1; Rpx"
                     /note="homeobox gene expressed in ES cells"
                     /db_xref="GeneID:15209"
                     /db_xref="MGI:MGI:96071"
     exon            1..515
                     /gene="Hesx1"
                     /gene_synonym="HES-1; Rpx"
                     /inference="alignment:Splign:2.1.0"
     CDS             359..916
                     /gene="Hesx1"
                     /gene_synonym="HES-1; Rpx"
                     /note="homeobox protein ANF; rathke pouch homeo box;
                     anterior-restricted homeobox protein; homeo box gene
                     expressed in ES cells"
                     /codon_start=1
                     /product="homeobox expressed in ES cells 1"
                     /protein_id="NP_034550.2"
                     /db_xref="CCDS:CCDS26884.1"
                     /db_xref="GeneID:15209"
                     /db_xref="MGI:MGI:96071"
                     /translation="MSPSLREGAQLRESKPAPCSFSIESILGLDQKKDCTTSVRPHRP
                     WTDTCGDSEKGGNPPLHAPDLPSETSFPCPVDHPRPEERAPKYENYFSASETRSLKRE
                     LSWYRGRRPRTAFTQNQVEVLENVFRVNCYPGIDIREDLAQKLNLEEDRIQIWFQNRR
                     AKMKRSRRESQFLMAKKPFNPDLLK"
     exon            516..715
                     /gene="Hesx1"
                     /gene_synonym="HES-1; Rpx"
                     /inference="alignment:Splign:2.1.0"
     exon            716..817
                     /gene="Hesx1"
                     /gene_synonym="HES-1; Rpx"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1138
                     /gene="Hesx1"
                     /gene_synonym="HES-1; Rpx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gattttatac attaatgatc tcaaataaaa gaggagtgct atgttcgtgc accacttctt
       61 ctgagaaagt taagtctgcg ttctgcttag gagagataac actttttgtc cctgtaggtg
      121 gccccctggt gtagccatta gttgctaatt acttgcaaac aaataaacaa ttaactcctt
      181 aagccgctgg ctgggcaagt gttcattgac ttgctaaaac tttctaaaac aggattttaa
      241 ttagtgactt tggaaaccca gccccctagt cagcaaagct acaaggtgaa ctgctggaag
      301 atcccagctc tgcacacgtg gggcaggagc cctccggcgc tgtacgaccc agaagagaat
      361 gtctcccagc cttcgggaag gtgctcagct ccgggaaagc aagcccgcgc cctgctcctt
      421 ctcaattgag agcattttag gactggacca gaaaaaagat tgtacaacgt cagtaagacc
      481 ccacagaccc tggacagaca cctgcggtga ctcagagaaa ggtggcaacc cacccctaca
      541 tgccccagat cttcccagtg agacttcatt tccttgtcca gtggatcatc caaggccaga
      601 agaaagggct ccgaaatatg aaaattattt ttcagcctcc gaaacacgct ctttgaaaag
      661 agaattgagt tggtaccgag gacgaaggcc aagaaccgct ttcacccaga accaggtcga
      721 agtattggaa aatgtcttta gagtgaactg ctaccctggc attgacatca gagaggacct
      781 agctcaaaag ctgaacttag aggaagacag aatccagatt tggttccaaa atcgccgagc
      841 aaagatgaaa aggtcccgta gagaatcaca gtttctaatg gcgaaaaaac ccttcaaccc
      901 agatcttctg aaataggtag aaaattacac atgttggctt ctcttccagt tgtatagtac
      961 agaagaaatc aatggaaatt ccaagtactt aaaatgttac agttctctcc tgtatctaat
     1021 ctagattttg tcattctttc tgaaaatact gcaaataatt atggttctag aacagtacat
     1081 ttttagttat aattaaaaca tctttcctat atatttttaa taaaaaaatt ttcagaaaaa
     1141 aaaa
//
