LOCUS       NM_033041               1779 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus hes family bHLH transcription factor 7 (Hes7),
            transcript variant 1, mRNA.
ACCESSION   NM_033041
VERSION     NM_033041.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1779)
  AUTHORS   El Azhar,Y., Schulthess,P., van Oostrom,M.J., Weterings,S.D.C.,
            Meijer,W.H.M., Tsuchida-Straeten,N., Thomas,W.M., Bauer,M. and
            Sonnen,K.F.
  TITLE     Unravelling differential Hes1 dynamics during axis elongation of
            mouse embryos through single-cell tracking
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39315665
REFERENCE   2  (bases 1 to 1779)
  AUTHORS   Clark,J.F. and Soriano,P.
  TITLE     Diverse Fgfr1 signaling pathways and endocytic trafficking regulate
            mesoderm development
  JOURNAL   Genes Dev 38 (9-10), 393-414 (2024)
   PUBMED   38834239
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1779)
  AUTHORS   Feng,X., Ye,Y., Zhang,J., Zhang,Y., Zhao,S., Mak,J.C.W., Otomo,N.,
            Zhao,Z., Niu,Y., Yonezawa,Y., Li,G., Lin,M., Li,X., Cheung,P.W.H.,
            Xu,K., Takeda,K., Wang,S., Xie,J., Kotani,T., Choi,V.N.T.,
            Song,Y.Q., Yang,Y., Luk,K.D.K., Lee,K.S., Li,Z., Li,P.S.,
            Leung,C.Y.H., Lin,X., Wang,X., Qiu,G., Watanabe,K., Wu,Z.,
            Posey,J.E., Ikegawa,S., Lupski,J.R., Cheung,J.P.Y., Zhang,T.J.,
            Gao,B. and Wu,N.
  CONSRTM   DISCO (Deciphering disorders Involving Scoliosis and COmorbidities)
            study group; Japanese Early Onset Scoliosis Research Group
  TITLE     Core planar cell polarity genes VANGL1 and VANGL2 in predisposition
            to congenital vertebral malformations
  JOURNAL   Proc Natl Acad Sci U S A 121 (18), e2310283121 (2024)
   PUBMED   38669183
REFERENCE   4  (bases 1 to 1779)
  AUTHORS   Kim,J., Muraoka,M., Okada,H., Toyoda,A., Ajima,R. and Saga,Y.
  TITLE     The RNA helicase DDX6 controls early mouse embryogenesis by
            repressing aberrant inhibition of BMP signaling through
            miRNA-mediated gene silencing
  JOURNAL   PLoS Genet 18 (10), e1009967 (2022)
   PUBMED   36197846
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1779)
  AUTHORS   Falk,H.J., Tomita,T., Monke,G., McDole,K. and Aulehla,A.
  TITLE     Imaging the onset of oscillatory signaling dynamics during mouse
            embryo gastrulation
  JOURNAL   Development 149 (13) (2022)
   PUBMED   35686648
REFERENCE   6  (bases 1 to 1779)
  AUTHORS   Bessho,Y., Hirata,H., Masamizu,Y. and Kageyama,R.
  TITLE     Periodic repression by the bHLH factor Hes7 is an essential
            mechanism for the somite segmentation clock
  JOURNAL   Genes Dev 17 (12), 1451-1456 (2003)
   PUBMED   12783854
  REMARK    GeneRIF: periodic repression by Hes7 protein is critical for the
            cyclic transcription of Hes7 and Lfng, and this negative feedback
            represents a molecular basis for the segmentation clock
REFERENCE   7  (bases 1 to 1779)
  AUTHORS   Serth,K., Schuster-Gossler,K., Cordes,R. and Gossler,A.
  TITLE     Transcriptional oscillation of lunatic fringe is essential for
            somitogenesis
  JOURNAL   Genes Dev 17 (7), 912-925 (2003)
   PUBMED   12670869
REFERENCE   8  (bases 1 to 1779)
  AUTHORS   Schroder,N. and Gossler,A.
  TITLE     Expression of Notch pathway components in fetal and adult mouse
            small intestine
  JOURNAL   Gene Expr Patterns 2 (3-4), 247-250 (2002)
   PUBMED   12617809
REFERENCE   9  (bases 1 to 1779)
  AUTHORS   Bessho,Y., Sakata,R., Komatsu,S., Shiota,K., Yamada,S. and
            Kageyama,R.
  TITLE     Dynamic expression and essential functions of Hes7 in somite
            segmentation
  JOURNAL   Genes Dev 15 (20), 2642-2647 (2001)
   PUBMED   11641270
REFERENCE   10 (bases 1 to 1779)
  AUTHORS   Bessho,Y., Miyoshi,G., Sakata,R. and Kageyama,R.
  TITLE     Hes7: a bHLH-type repressor gene regulated by Notch and expressed
            in the presomitic mesoderm
  JOURNAL   Genes Cells 6 (2), 175-185 (2001)
   PUBMED   11260262
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645527.20.
            
            On Nov 17, 2022 this sequence version replaced NM_033041.4.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050791.1, BC134378.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AL645527.20        36996-37078
            84-179              AL645527.20        38073-38168
            180-267             AL645527.20        38706-38793
            268-1779            AL645527.20        39106-40617
FEATURES             Location/Qualifiers
     source          1..1779
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.38 cM"
     gene            1..1779
                     /gene="Hes7"
                     /gene_synonym="bHLHb37"
                     /note="hes family bHLH transcription factor 7"
                     /db_xref="GeneID:84653"
                     /db_xref="MGI:MGI:2135679"
     exon            1..83
                     /gene="Hes7"
                     /gene_synonym="bHLHb37"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..719
                     /gene="Hes7"
                     /gene_synonym="bHLHb37"
                     /note="isoform 1 is encoded by transcript variant 1; bHLH
                     factor Hes7; transcription factor HES-7; hairy and
                     enhancer of split 7"
                     /codon_start=1
                     /product="transcription factor HES-7 isoform 1"
                     /protein_id="NP_149030.2"
                     /db_xref="CCDS:CCDS24883.1"
                     /db_xref="GeneID:84653"
                     /db_xref="MGI:MGI:2135679"
                     /translation="MVTRERAENRDGPKMLKPLVEKRRRDRINRSLEELRLLLLERTR
                     DQNLRNPKLEKAEILEFAVGYLRERSRVEPPGVPRSPGQDAEALASCYLSGFRECLLR
                     LAAFAHDASPAARSQLFSALHGYRRPKPPRPEAVDPGLPAPRPPLDPASPILGPALHQ
                     RPPVHQGPPSPRLAWSPSHCSSRAGDSGAPAPLTGLLPPPPPPYRQDGAPKAPSLPPP
                     AFWRPWP"
     exon            84..179
                     /gene="Hes7"
                     /gene_synonym="bHLHb37"
                     /inference="alignment:Splign:2.1.0"
     exon            180..267
                     /gene="Hes7"
                     /gene_synonym="bHLHb37"
                     /inference="alignment:Splign:2.1.0"
     exon            268..1779
                     /gene="Hes7"
                     /gene_synonym="bHLHb37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      970..975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hes7"
                     /gene_synonym="bHLHb37"
                     /note="hexamer: AATAAA"
     polyA_site      991
                     /gene="Hes7"
                     /gene_synonym="bHLHb37"
                     /note="major polyA site"
     regulatory      1199..1204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hes7"
                     /gene_synonym="bHLHb37"
                     /note="hexamer: AATAAA"
     polyA_site      1241
                     /gene="Hes7"
                     /gene_synonym="bHLHb37"
                     /note="major polyA site"
     regulatory      1758..1763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hes7"
                     /gene_synonym="bHLHb37"
                     /note="hexamer: AATAAA"
     polyA_site      1779
                     /gene="Hes7"
                     /gene_synonym="bHLHb37"
                     /note="major polyA site"
ORIGIN      
        1 aggcagcacg cgctgagtcc accgaagggt ccggaggagc aatggtcacc cgggagcgag
       61 ctgagaatag ggacggcccc aagatgctga agccgttggt ggagaagcgg cgccgggacc
      121 gcatcaaccg cagcctagaa gagctgaggc tgctgctcct ggagaggacc agggaccaga
      181 acctccggaa cccgaagctg gagaaagcgg agatactgga gttcgccgtg ggctacttga
      241 gggagcgaag ccgggtggag cccccggggg ttccccggtc cccaggccag gacgccgagg
      301 cgctcgccag ctgctacttg tccggcttcc gcgagtgcct gcttcgcttg gcggcctttg
      361 cgcacgacgc cagcccggcc gcacgctccc agcttttctc cgcgctgcac ggctaccggc
      421 gccccaaacc gccccggccc gaggccgtag atccagggct cccagcgccg cgcccaccgc
      481 tggaccccgc ttcaccaatc cttggccccg cgctgcacca gcgcccccca gtgcaccagg
      541 gccctcctag tccccgcctc gcttggtccc catcccactg ctcctctcgc gccggggatt
      601 cgggcgcgcc ggcgcccctc accggactgc tgccgccacc gccaccgcct tacagacaag
      661 acggggcgcc caaggccccg tcactcccac cgcccgcgtt ttggagacct tggccctgag
      721 cttttggggg ctggggcggg gattgggggt ggtgtagaga ctccagtcag agggcaggag
      781 agggatccgg gcgaggaggg cagcggggcg cgcgggctca gcgcgcgggt gagatgtggt
      841 ctatattaga gtatctatat aaatatatat tttcccatcc cttttccctg tcccacttcc
      901 ctgtgtgtag cattgtactc tctctaccct agtccagtcc cagtcccttc ccgagtccct
      961 agtgcatgga ataaaatcgt tattaaatcc cggtgtgtcc cctagccagg ggcctgcctt
     1021 tatattggcg ccacgcctac ttgcccatac ccttctccca cctttaggcc tgctctccac
     1081 ggcccaagcc ctgggggaga caggtaagta aagagcggag cgacagactg aggttggagc
     1141 tgaactttat ttgtgggtct ttaaattttt taaaagccaa gaaaagatta aaatgagtaa
     1201 taaaaccgac tctggtggga ttcgaaccca caacctttga atcgctttct cgtcactaga
     1261 agtccaatgc gctatccatt gcgccacaga gccacatggc gggcggcgcc tccttccggc
     1321 ttacggacac cagtatagga aaaaaagggg tagcgtggga gggagagaga gagagacaga
     1381 gagagagaca gagagacaga gagacagaga gacagagaga gagagagaga gagagagaga
     1441 gagagagaga gagagagagt gtgagtgaga gagagagaga gagtgtgtgt gtgagagaga
     1501 gagagtgtgt gtgtgtccgt gtgcaaggag atggggcgga gcgtcatagg agctagaggt
     1561 gacagcctca ggtcagcgga atgaaatgta gtgtatggaa agcgcatgag ctaggtgaca
     1621 ggaagggtgg atgcaggtgc gagaaacaga gagggagact aacgaaattt gagctcccca
     1681 gcagtgcaaa gctcgggctg cttcttgcgt aagctaccaa gctcagactt gctcggttcc
     1741 cagatttgat ctcactaaat aaacttgttt tgttgtaaa
//
