LOCUS       NM_019479               1335 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus hairy and enhancer of split 6 (Hes6), transcript
            variant 1, mRNA.
ACCESSION   NM_019479
VERSION     NM_019479.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1335)
  AUTHORS   Hermosilla Aguayo,V., Martin,P., Tian,N., Zheng,J., Aho,R., Losa,M.
            and Selleri,L.
  TITLE     ESCRT-dependent control of craniofacial morphogenesis with
            concomitant perturbation of NOTCH signaling
  JOURNAL   Dev Biol 503, 25-42 (2023)
   PUBMED   37573008
REFERENCE   2  (bases 1 to 1335)
  AUTHORS   Su-Feher,L., Rubin,A.N., Silberberg,S.N., Catta-Preta,R., Lim,K.J.,
            Ypsilanti,A.R., Zdilar,I., McGinnis,C.S., McKinsey,G.L.,
            Rubino,T.E. Jr., Hawrylycz,M.J., Thompson,C., Gartner,Z.J.,
            Puelles,L., Zeng,H., Rubenstein,J.L.R. and Nord,A.S.
  TITLE     Single cell enhancer activity distinguishes GABAergic and
            cholinergic lineages in embryonic mouse basal ganglia
  JOURNAL   Proc Natl Acad Sci U S A 119 (15), e2108760119 (2022)
   PUBMED   35377797
REFERENCE   3  (bases 1 to 1335)
  AUTHORS   Sun,Y., Wang,L., Zhu,T., Wu,B., Wang,G., Luo,Z., Li,C., Wei,W. and
            Liu,Z.
  TITLE     Single-cell transcriptomic landscapes of the otic neuronal lineage
            at multiple early embryonic ages
  JOURNAL   Cell Rep 38 (12), 110542 (2022)
   PUBMED   35320729
REFERENCE   4  (bases 1 to 1335)
  AUTHORS   Kurz,J., Weiss,A.C., Thiesler,H., Qasrawi,F., Deuper,L., Kaur,J.,
            Rudat,C., Ludtke,T.H., Wojahn,I., Hildebrandt,H., Trowe,M.O. and
            Kispert,A.
  TITLE     Notch signaling is a novel regulator of visceral smooth muscle cell
            differentiation in the murine ureter
  JOURNAL   Development 149 (4) (2022)
   PUBMED   35103284
REFERENCE   5  (bases 1 to 1335)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1335)
  AUTHORS   Leimeister,C., Dale,K., Fischer,A., Klamt,B., Hrabe de Angelis,M.,
            Radtke,F., McGrew,M.J., Pourquie,O. and Gessler,M.
  TITLE     Oscillating expression of c-Hey2 in the presomitic mesoderm
            suggests that the segmentation clock may use combinatorial
            signaling through multiple interacting bHLH factors
  JOURNAL   Dev Biol 227 (1), 91-103 (2000)
   PUBMED   11076679
REFERENCE   7  (bases 1 to 1335)
  AUTHORS   Vasiliauskas,D. and Stern,C.D.
  TITLE     Expression of mouse HES-6, a new member of the Hairy/Enhancer of
            split family of bHLH transcription factors
  JOURNAL   Mech Dev 98 (1-2), 133-137 (2000)
   PUBMED   11044617
REFERENCE   8  (bases 1 to 1335)
  AUTHORS   Koyano-Nakagawa,N., Kim,J., Anderson,D. and Kintner,C.
  TITLE     Hes6 acts in a positive feedback loop with the neurogenins to
            promote neuronal differentiation
  JOURNAL   Development 127 (19), 4203-4216 (2000)
   PUBMED   10976052
REFERENCE   9  (bases 1 to 1335)
  AUTHORS   Pissarra,L., Henrique,D. and Duarte,A.
  TITLE     Expression of hes6, a new member of the Hairy/Enhancer-of-split
            family, in mouse development
  JOURNAL   Mech Dev 95 (1-2), 275-278 (2000)
   PUBMED   10906477
REFERENCE   10 (bases 1 to 1335)
  AUTHORS   Bae,S., Bessho,Y., Hojo,M. and Kageyama,R.
  TITLE     The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal
            differentiation
  JOURNAL   Development 127 (13), 2933-2943 (2000)
   PUBMED   10851137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK076135.1.
            
            On Apr 6, 2007 this sequence version replaced NM_019479.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076135.1, AK155340.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1335              AK076135.1         1-1335
FEATURES             Location/Qualifiers
     source          1..1335
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 46.12 cM"
     gene            1..1335
                     /gene="Hes6"
                     /gene_synonym="bHLHb41"
                     /note="hairy and enhancer of split 6"
                     /db_xref="GeneID:55927"
                     /db_xref="MGI:MGI:1859852"
     exon            1..166
                     /gene="Hes6"
                     /gene_synonym="bHLHb41"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..760
                     /gene="Hes6"
                     /gene_synonym="bHLHb41"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription cofactor HES-6"
                     /codon_start=1
                     /product="transcription cofactor HES-6 isoform 1"
                     /protein_id="NP_062352.1"
                     /db_xref="CCDS:CCDS15163.1"
                     /db_xref="GeneID:55927"
                     /db_xref="MGI:MGI:1859852"
                     /translation="MAPSQAPSRDRAGQEDEDRWEARGDRKARKPLVEKKRRARINES
                     LQELRLLLAGTEVQAKLENAEVLELTVRRVQGALRGRAREREQLQAEASERFAAGYIQ
                     CMHEVHTFVSTCQAIDATVSAELLNHLLESMPLREGSSFQDLLGDSLAGLPGGSGRSS
                     WPPGGSPESPLSSPPGPGDDLCSDLEEIPEAELNRVPAEGPDLVSTSLGSLTAARRAQ
                     SVWRPW"
     exon            167..253
                     /gene="Hes6"
                     /gene_synonym="bHLHb41"
                     /inference="alignment:Splign:2.1.0"
     exon            254..335
                     /gene="Hes6"
                     /gene_synonym="bHLHb41"
                     /inference="alignment:Splign:2.1.0"
     exon            336..1335
                     /gene="Hes6"
                     /gene_synonym="bHLHb41"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1296..1301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hes6"
                     /gene_synonym="bHLHb41"
                     /note="hexamer: AATAAA"
     polyA_site      1315
                     /gene="Hes6"
                     /gene_synonym="bHLHb41"
                     /note="major polyA site"
ORIGIN      
        1 gaagactccg gagagctagt ggggcctccg ggctgcgacc cacctcgctg agtagtttgc
       61 actagggcgc cgggctccgt agaccatggc tccgtcccag gcgcccagcc gggaccgtgc
      121 aggccaggag gatgaggacc gctgggaagc acggggggac cgcaaggccc ggaagcccct
      181 ggtggagaag aagcgacgcg cacggatcaa cgagagtctt caggagctgc ggctgctgct
      241 ggccggtacc gaggtgcagg ccaagctaga gaacgccgag gttctggagc tgaccgtgag
      301 gcgcgtgcag ggcgcgctgc gaggccgggc gcgcgagcgg gagcagctgc aggctgaagc
      361 aagcgagcgc ttcgctgctg gctacatcca gtgcatgcat gaggtgcaca cgttcgtgtc
      421 cacgtgccaa gccatcgatg ccactgtctc agctgaactc ctgaaccacc tgctagaatc
      481 catgccgctg cgtgagggta gcagctttca ggatctgctg ggggactccc tagctgggct
      541 gcctggaggc tctgggagga gcagctggcc tccaggaggg tccccagaat ccccattgtc
      601 cagtccccca ggtcccgggg acgacctgtg ttctgaccta gaggagatcc cagaggctga
      661 actaaaccgg gtgcctgctg aggggccgga tttggtgtct acatccttag gcagcctgac
      721 tgcagctcgc cgggctcaga gtgtgtggag gccttggtga ccaacactta ccagggacct
      781 gtgaatggtg gctgccatcc ttaagtttgc ttcctccctg ggtatcagat aaggtggaga
      841 cagctcagga tgccccccag gtatgccctc cccactctcc aacagatgac ttgaatgaca
      901 accctaatgg ccaggccctg caggtcccta gcactatttt ttcgtggacc ctagagctct
      961 ggatggtggc tggggggcca gggggtgcac taaagaaaga caggagactt ttggagagct
     1021 gccagggctc cctcgtgttc acctctccct gccttttggg cattctgagg atctagggca
     1081 gaagtggcca atcttgagac tgagcattag ggtcctgggc agggacacac aggccacagc
     1141 aatcctgacc tgaaaggaag ttcagatttg ctactttggc tatgagacca ggggaggcgg
     1201 gcatattctg cggtcactga agctgctcct cgtttgtaac acagttgcgc gcgtgtgagt
     1261 ttggttgcca tcccatcgat gctccaaccg aattaaataa agaactttgg agttagttgc
     1321 tcctggtgta ctgtc
//
