LOCUS       NM_010419               1273 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus hes family bHLH transcription factor 5 (Hes5),
            transcript variant 1, mRNA.
ACCESSION   NM_010419
VERSION     NM_010419.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1273)
  AUTHORS   Xu,X., Fang,M., Chen,L., Huang,H., Dai,Z.M., Yang,J. and Qiu,M.
  TITLE     Nzf2 promotes oligodendrocyte differentiation and regeneration via
            repressing HDAC1-mediated histone deacetylation
  JOURNAL   Sci Adv 10 (50), eadf8405 (2024)
   PUBMED   39671488
REFERENCE   2  (bases 1 to 1273)
  AUTHORS   Pang,Y., Ruan,X., Liu,W., Hou,L., Yin,B., Shu,P. and Peng,X.
  TITLE     MicroRNA-495 Modulates Neuronal Layer Fate Determination by
            Targeting Tcf4
  JOURNAL   Int J Biol Sci 20 (15), 6207-6221 (2024)
   PUBMED   39664574
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1273)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   4  (bases 1 to 1273)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   5  (bases 1 to 1273)
  AUTHORS   El Azhar,Y., Schulthess,P., van Oostrom,M.J., Weterings,S.D.C.,
            Meijer,W.H.M., Tsuchida-Straeten,N., Thomas,W.M., Bauer,M. and
            Sonnen,K.F.
  TITLE     Unravelling differential Hes1 dynamics during axis elongation of
            mouse embryos through single-cell tracking
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39315665
REFERENCE   6  (bases 1 to 1273)
  AUTHORS   de la Pompa,J.L., Wakeham,A., Correia,K.M., Samper,E., Brown,S.,
            Aguilera,R.J., Nakano,T., Honjo,T., Mak,T.W., Rossant,J. and
            Conlon,R.A.
  TITLE     Conservation of the Notch signalling pathway in mammalian
            neurogenesis
  JOURNAL   Development 124 (6), 1139-1148 (1997)
   PUBMED   9102301
REFERENCE   7  (bases 1 to 1273)
  AUTHORS   Ishibashi,M., Ang,S.L., Shiota,K., Nakanishi,S., Kageyama,R. and
            Guillemot,F.
  TITLE     Targeted disruption of mammalian hairy and Enhancer of split
            homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix
            factors, premature neurogenesis, and severe neural tube defects
  JOURNAL   Genes Dev 9 (24), 3136-3148 (1995)
   PUBMED   8543157
REFERENCE   8  (bases 1 to 1273)
  AUTHORS   Takebayashi,K., Akazawa,C., Nakanishi,S. and Kageyama,R.
  TITLE     Structure and promoter analysis of the gene encoding the mouse
            helix-loop-helix factor HES-5. Identification of the neural
            precursor cell-specific promoter element
  JOURNAL   J Biol Chem 270 (3), 1342-1349 (1995)
   PUBMED   7836401
REFERENCE   9  (bases 1 to 1273)
  AUTHORS   Sakagami,T., Sakurada,K., Sakai,Y., Watanabe,T., Nakanishi,S. and
            Kageyama,R.
  TITLE     Structure and chromosomal locus of the mouse gene encoding a
            cerebellar Purkinje cell-specific helix-loop-helix factor Hes-3
  JOURNAL   Biochem Biophys Res Commun 203 (1), 594-601 (1994)
   PUBMED   8074710
REFERENCE   10 (bases 1 to 1273)
  AUTHORS   Akazawa,C., Sasai,Y., Nakanishi,S. and Kageyama,R.
  TITLE     Molecular characterization of a rat negative regulator with a basic
            helix-loop-helix structure predominantly expressed in the
            developing nervous system
  JOURNAL   J Biol Chem 267 (30), 21879-21885 (1992)
   PUBMED   1400497
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX004788.7.
            
            On Apr 27, 2007 this sequence version replaced NM_010419.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156545.1, AK087508.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               BX004788.7         42713-42839
            128-293             BX004788.7         42926-43091
            294-1273            BX004788.7         43182-44161
FEATURES             Location/Qualifiers
     source          1..1273
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 86.01 cM"
     gene            1..1273
                     /gene="Hes5"
                     /gene_synonym="bHLHb38"
                     /note="hes family bHLH transcription factor 5"
                     /db_xref="GeneID:15208"
                     /db_xref="MGI:MGI:104876"
     exon            1..127
                     /gene="Hes5"
                     /gene_synonym="bHLHb38"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..577
                     /gene="Hes5"
                     /gene_synonym="bHLHb38"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor HES-5; hairy and enhancer of split 5"
                     /codon_start=1
                     /product="transcription factor HES-5 isoform 1"
                     /protein_id="NP_034549.1"
                     /db_xref="CCDS:CCDS19018.1"
                     /db_xref="GeneID:15208"
                     /db_xref="MGI:MGI:104876"
                     /translation="MAPSTVAVEMLSPKEKNRLRKPVVEKMRRDRINSSIEQLKLLLE
                     QEFARHQPNSKLEKADILEMAVSYLKHSKAFAAAAGPKSLHQDYSEGYSWCLQEAVQF
                     LTLHAASDTQMKLLYHFQRPPAPAAPAKEPPAPGAAPQPARSSAKAAAAAVSTSRQPA
                     CGLWRPW"
     exon            128..293
                     /gene="Hes5"
                     /gene_synonym="bHLHb38"
                     /inference="alignment:Splign:2.1.0"
     exon            294..1273
                     /gene="Hes5"
                     /gene_synonym="bHLHb38"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgccagtcc gggacgcctg gctctgtccg ctccgctccg ctccgctcgc taatcgcctc
       61 cagagctcca ggcatggccc caagtaccgt ggcggtggag atgctcagtc ccaaggagaa
      121 aaaccgactg cggaagccgg tggtggagaa gatgcgtcgg gaccgcatca acagcagcat
      181 agagcagctg aagctgctgc tggagcagga gttcgcgcgg caccagccca actccaagct
      241 ggagaaggcc gacatcctgg agatggccgt cagctacctg aaacacagca aagccttcgc
      301 cgcggccgcc ggccccaaga gcctgcacca ggactacagc gagggctact cctggtgcct
      361 gcaggaggcg gtacagttcc tgaccctgca cgccgccagc gacacgcaga tgaagctgct
      421 ttaccacttc cagcggcccc cagctcccgc cgctcctgcc aaggagcccc cggcgcccgg
      481 agctgcgccc caaccggccc gctcctccgc taaggctgct gctgctgcgg tctccacctc
      541 gcgccaaccc gcctgcggcc tctggcggcc ctggtgaccc agcggccgac cggtgcctgg
      601 agcggaccag aggatgagct cgttcctctg gatgtgggaa gacattcccc agccgcagtt
      661 cagccccagg ttggccgcta ccttcttccg aaggctccct cctccggctg gctggccagc
      721 aggagggtca ttcttagaga atgtgtgtgc agagttgtca tttggggata atcagggccc
      781 accctctgcc gcccgtccga ccccgtgggg ttgttttgtg tttgcatttc agcaagtgac
      841 ttctgcgaag ttcctggtca ccaccggggg ttctatgata tttgtagagt cgggggttgg
      901 ctcaccccag cccgtagagg actttcttca gggcccgttg ctgctgggca agcaccctgc
      961 aggcgggctg tgccctgggc acatttgcct tttgtgaagg cggaactgca ggtgtttcct
     1021 cataggaaag cactcagcct gcgtgggcgt agggcccatg gggcctcacc tcaaggtcca
     1081 catggccttg gctgtctgat gcgcgctcac agtgggctgt ctgggagggt ggggtctcca
     1141 cgatgatcct taaaggattc ctttgtatgg gtgggtgcat gtgggcacga ttttgtactt
     1201 agaatttgaa ctcttggtca tgtgggagaa cacaggctgt tctgaaggct tctaataaaa
     1261 tatcaagccc tcc
//
