LOCUS       NM_001403793            2057 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus hes family bHLH transcription factor 3 (Hes3), mRNA.
ACCESSION   NM_001403793 XM_036163691
VERSION     NM_001403793.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2057)
  AUTHORS   Bosze,B., Suarez-Navarro,J., Cajias,I., Brzezinski Iv,J.A. and
            Brown,N.L.
  TITLE     Notch pathway mutants do not equivalently perturb mouse embryonic
            retinal development
  JOURNAL   PLoS Genet 19 (9), e1010928 (2023)
   PUBMED   37751417
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2057)
  AUTHORS   Maeda,Y., Isomura,A., Masaki,T. and Kageyama,R.
  TITLE     Differential cell-cycle control by oscillatory versus sustained
            Hes1 expression via p21
  JOURNAL   Cell Rep 42 (5), 112520 (2023)
   PUBMED   37200191
REFERENCE   3  (bases 1 to 2057)
  AUTHORS   Kurz,J., Weiss,A.C., Thiesler,H., Qasrawi,F., Deuper,L., Kaur,J.,
            Rudat,C., Ludtke,T.H., Wojahn,I., Hildebrandt,H., Trowe,M.O. and
            Kispert,A.
  TITLE     Notch signaling is a novel regulator of visceral smooth muscle cell
            differentiation in the murine ureter
  JOURNAL   Development 149 (4) (2022)
   PUBMED   35103284
REFERENCE   4  (bases 1 to 2057)
  AUTHORS   La Manno,G., Siletti,K., Furlan,A., Gyllborg,D., Vinsland,E., Mossi
            Albiach,A., Mattsson Langseth,C., Khven,I., Lederer,A.R.,
            Dratva,L.M., Johnsson,A., Nilsson,M., Lonnerberg,P. and
            Linnarsson,S.
  TITLE     Molecular architecture of the developing mouse brain
  JOURNAL   Nature 596 (7870), 92-96 (2021)
   PUBMED   34321664
REFERENCE   5  (bases 1 to 2057)
  AUTHORS   Ochi,S., Imaizumi,Y., Shimojo,H., Miyachi,H. and Kageyama,R.
  TITLE     Oscillatory expression of Hes1 regulates cell proliferation and
            neuronal differentiation in the embryonic brain
  JOURNAL   Development 147 (4) (2020)
   PUBMED   32094111
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2057)
  AUTHORS   Lobe,C.G.
  TITLE     Expression of the helix-loop-helix factor, Hes3, during embryo
            development suggests a role in early midbrain-hindbrain patterning
  JOURNAL   Mech Dev 62 (2), 227-237 (1997)
   PUBMED   9152013
REFERENCE   7  (bases 1 to 2057)
  AUTHORS   de la Pompa,J.L., Wakeham,A., Correia,K.M., Samper,E., Brown,S.,
            Aguilera,R.J., Nakano,T., Honjo,T., Mak,T.W., Rossant,J. and
            Conlon,R.A.
  TITLE     Conservation of the Notch signalling pathway in mammalian
            neurogenesis
  JOURNAL   Development 124 (6), 1139-1148 (1997)
   PUBMED   9102301
REFERENCE   8  (bases 1 to 2057)
  AUTHORS   Nakayama,H., Liu,Y., Stifani,S. and Cross,J.C.
  TITLE     Developmental restriction of Mash-2 expression in trophoblast
            correlates with potential activation of the notch-2 pathway
  JOURNAL   Dev Genet 21 (1), 21-30 (1997)
   PUBMED   9291577
REFERENCE   9  (bases 1 to 2057)
  AUTHORS   Sakagami,T., Sakurada,K., Sakai,Y., Watanabe,T., Nakanishi,S. and
            Kageyama,R.
  TITLE     Structure and chromosomal locus of the mouse gene encoding a
            cerebellar Purkinje cell-specific helix-loop-helix factor Hes-3
  JOURNAL   Biochem Biophys Res Commun 203 (1), 594-601 (1994)
   PUBMED   8074710
REFERENCE   10 (bases 1 to 2057)
  AUTHORS   Sasai,Y., Kageyama,R., Tagawa,Y., Shigemoto,R. and Nakanishi,S.
  TITLE     Two mammalian helix-loop-helix factors structurally related to
            Drosophila hairy and Enhancer of split
  JOURNAL   Genes Dev 6 (12B), 2620-2634 (1992)
   PUBMED   1340473
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL611985.22.
            
            On Apr 4, 2022 this sequence version replaced XM_036163691.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363660.2486566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               AL611985.22        31517-31754         c
            239-462             AL611985.22        29111-29334         c
            463-593             AL611985.22        28794-28924         c
            594-689             AL611985.22        28578-28673         c
            690-771             AL611985.22        28416-28497         c
            772-2057            AL611985.22        26760-28045         c
FEATURES             Location/Qualifiers
     source          1..2057
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 83.01 cM"
     gene            1..2057
                     /gene="Hes3"
                     /gene_synonym="bHLHb43; Hes-3"
                     /note="hes family bHLH transcription factor 3"
                     /db_xref="GeneID:15207"
                     /db_xref="MGI:MGI:104877"
     exon            1..238
                     /gene="Hes3"
                     /gene_synonym="bHLHb43; Hes-3"
                     /inference="alignment:Splign:2.1.0"
     exon            239..462
                     /gene="Hes3"
                     /gene_synonym="bHLHb43; Hes-3"
                     /inference="alignment:Splign:2.1.0"
     exon            463..593
                     /gene="Hes3"
                     /gene_synonym="bHLHb43; Hes-3"
                     /inference="alignment:Splign:2.1.0"
     exon            594..689
                     /gene="Hes3"
                     /gene_synonym="bHLHb43; Hes-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             609..1136
                     /gene="Hes3"
                     /gene_synonym="bHLHb43; Hes-3"
                     /note="hairy and enhancer of split 3"
                     /codon_start=1
                     /product="transcription factor HES-3"
                     /protein_id="NP_001390722.1"
                     /db_xref="GeneID:15207"
                     /db_xref="MGI:MGI:104877"
                     /translation="MEKKRRARINVSLEQLRSLLERHYSHQIRKRKLEKADILELSVK
                     YMRSLQNSLQGLWPVPSGVDYPSGFQGGLRGVSQRLRPGEGDSGLRCPLLLQRREGST
                     TDSANPQATSVLNPCLPAIWAPSRAAGGSHSPQSPLPLPGGLLESSTDVVAPHPASNC
                     QAESTRPGFRVWRPW"
     exon            690..771
                     /gene="Hes3"
                     /gene_synonym="bHLHb43; Hes-3"
                     /inference="alignment:Splign:2.1.0"
     exon            772..2057
                     /gene="Hes3"
                     /gene_synonym="bHLHb43; Hes-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2033..2038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hes3"
                     /gene_synonym="bHLHb43; Hes-3"
                     /note="hexamer: AATAAA"
     polyA_site      2057
                     /gene="Hes3"
                     /gene_synonym="bHLHb43; Hes-3"
                     /note="major polyA site"
ORIGIN      
        1 gctggagggg ggccagagaa ggggacttta tagtgaccct aattctggag agggggcggg
       61 cccagtgccc ggtaccccgc ggtgcgtcgg gagagctgtg cacagcacca ttagtttgct
      121 aatgcactgg actgaaagga gaaggtaaca gtttctgggg aagtattgta attacaagac
      181 aaattgccct gctgctggct tggcttgaga gcaagaaggg tggagaggac ccgcccaggg
      241 cgactaattc agcatcccag cgtggccaga gcgtgaaggg agcagaaaag catcactggc
      301 cagcatcctt gcctcagcat ctttatcagg cctcaggaca cccagagctc caccatcatc
      361 atttaggacg gcccccagct ctcaaagctc cctgccatag cggaggacca ccagaagaat
      421 gctggctaag aagcagccag gacttggcaa gcagacatag tgaggtccat tgacatgtaa
      481 acgaggtacc ctataaaggc aatgcagccc actgcctgtg tgaacatcac agcatgggca
      541 ccgagcccac atcgagggac agcctcggtg gcccagccag cagcttccga aagatctcca
      601 agcctctgat ggagaagaag cgccgtgcac gcatcaacgt gtcactggag cagctgaggt
      661 ctcttctgga gagacactac tcacatcaga tacggaaacg aaagctggag aaggccgata
      721 tcctggagct gagtgttaag tacatgagaa gcctccagaa ctcactgcaa ggactctggc
      781 cagtacccag tggggtggac tacccgtccg gcttccaagg cggcttgcgt ggcgtgagcc
      841 agaggcttcg gcccggagag ggagacagcg gcctgcgctg ccccttgctg ctccagcgca
      901 gggaaggcag caccacggac agcgccaacc cacaggcgac ctctgttctc aacccttgcc
      961 tcccggccat ctgggccccc agtcgcgctg caggtggctc ccactccccg cagtccccgc
     1021 tccctctccc tggaggtctc cttgagtctt ccaccgatgt tgtggcacca catcctgcat
     1081 caaactgcca ggccgagagt acgagacccg ggtttcgcgt gtggcgaccg tggtgagacg
     1141 taggcaagga tttagactca agctctctcc ccacgtcccc atcaccccgc catctagtct
     1201 ggggaaacta ttttggggca cccatggtga ctgcaggaac tctatcaatc ggtggcctgg
     1261 ggggggggag tgcaggaaat ccacggaacc attggcgatt cgggtctgca ctgctaggtg
     1321 aactcatcca ctccagcccc acccactcca tccagaccag ctctctacct cccgcttcta
     1381 gagaagatgg gaggggacgg gtgagctgta cccctttccc agggacccgg ggctggcagc
     1441 ccgcccctgc cccctctcca cggctgcgtc acggtgagaa ggtcgcggtt gcttgcagca
     1501 cagagcggac ccctcgcagc gaggagaatc gctgccccgc cctggcccat tcaaccggcc
     1561 tcgcgcgctc cgttcccacc ggcacaaagc gggccgggct ccgccccttc agcaaggggc
     1621 tcccatccta tcaccaccca agaccttctc actaccatcg aaacccatca ccccctctac
     1681 accgattcca cactgctggg gcgctctcag gccctcaact gcgcaaatac ttatggctgc
     1741 ggcgtgctgg cgtagaacat tggatccgcc cctaaggtac ttgcgtgccc gacgccccgc
     1801 ctagccacaa tctatagtcc tgggtcccac ccatccctgc ttagcactgc tgagacctga
     1861 gcattttgtg ttctgcaaag accactttag tgccttctga gccctggact cgaactaaga
     1921 gcctgttagt taccatgagc gtcgactgtg ttggggagag ggctcctgtc gtggaccagt
     1981 ctggggtcca gtgcaaaatc ccagaatctc ttattaccaa tatacaatta tgaataaaga
     2041 ctgggcgtga atacaga
//
