LOCUS       NM_001301805            2915 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus hes family bHLH transcription factor 2 (Hes2),
            transcript variant 1, mRNA.
ACCESSION   NM_001301805 XM_006538549
VERSION     NM_001301805.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2915)
  AUTHORS   Littlejohn,R., Zambrano-Carrasco,J., Zou,J., Yao,Y., Kim,I.M.,
            Zhou,J., Li,J. and Su,H.
  TITLE     Inhibition of cardiomyocyte neddylation impairs embryonic cardiac
            morphogenesis
  JOURNAL   J Mol Cell Cardiol 197, 40-44 (2024)
   PUBMED   39437885
REFERENCE   2  (bases 1 to 2915)
  AUTHORS   Kurz,J., Weiss,A.C., Thiesler,H., Qasrawi,F., Deuper,L., Kaur,J.,
            Rudat,C., Ludtke,T.H., Wojahn,I., Hildebrandt,H., Trowe,M.O. and
            Kispert,A.
  TITLE     Notch signaling is a novel regulator of visceral smooth muscle cell
            differentiation in the murine ureter
  JOURNAL   Development 149 (4) (2022)
   PUBMED   35103284
REFERENCE   3  (bases 1 to 2915)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 2915)
  AUTHORS   Murta,D., Batista,M., Silva,E., Trindade,A., Henrique,D., Duarte,A.
            and Lopes-da-Costa,L.
  TITLE     Dynamics of Notch pathway expression during mouse testis post-natal
            development and along the spermatogenic cycle
  JOURNAL   PLoS One 8 (8), e72767 (2013)
   PUBMED   24015274
  REMARK    GeneRIF: The transcription and expression patterns of Notch pathway
            components (Notch 1-3, Delta1 and 4, Jagged1) and effectors (Hes1,
            Hes2, Hes5 and Nrarp) were evaluated in the mouse testis
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2915)
  AUTHORS   Jackson,T., Thomas,J., Green,E.D. and Noben-Trauth,K.
  TITLE     Genetic and physical maps of jerker (Espn(je)) on mouse chromosome
            4
  JOURNAL   Biochem Biophys Res Commun 296 (5), 1143-1147 (2002)
   PUBMED   12207892
REFERENCE   6  (bases 1 to 2915)
  AUTHORS   Gong,T.W., Winnicki,R.S., Kohrman,D.C. and Lomax,M.I.
  TITLE     A novel mouse kinesin of the UNC-104/KIF1 subfamily encoded by the
            Kif1b gene
  JOURNAL   Gene 239 (1), 117-127 (1999)
   PUBMED   10571041
REFERENCE   7  (bases 1 to 2915)
  AUTHORS   Herranz,M., Santos,J., Salido,E., Fernandez-Piqueras,J. and
            Serrano,M.
  TITLE     Mouse p73 gene maps to the distal part of chromosome 4 and might be
            involved in the progression of gamma-radiation-induced T-cell
            lymphomas
  JOURNAL   Cancer Res 59 (9), 2068-2071 (1999)
   PUBMED   10232589
REFERENCE   8  (bases 1 to 2915)
  AUTHORS   Nishimura,M., Isaka,F., Ishibashi,M., Tomita,K., Tsuda,H.,
            Nakanishi,S. and Kageyama,R.
  TITLE     Structure, chromosomal locus, and promoter of mouse Hes2 gene, a
            homologue of Drosophila hairy and Enhancer of split
  JOURNAL   Genomics 49 (1), 69-75 (1998)
   PUBMED   9570950
REFERENCE   9  (bases 1 to 2915)
  AUTHORS   Nakayama,H., Liu,Y., Stifani,S. and Cross,J.C.
  TITLE     Developmental restriction of Mash-2 expression in trophoblast
            correlates with potential activation of the notch-2 pathway
  JOURNAL   Dev Genet 21 (1), 21-30 (1997)
   PUBMED   9291577
REFERENCE   10 (bases 1 to 2915)
  AUTHORS   Ishibashi,M., Sasai,Y., Nakanishi,S. and Kageyama,R.
  TITLE     Molecular characterization of HES-2, a mammalian helix-loop-helix
            factor structurally related to Drosophila hairy and Enhancer of
            split
  JOURNAL   Eur J Biochem 215 (3), 645-652 (1993)
   PUBMED   8354270
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK053792.1, BC138112.1 and
            AL772240.7.
            
            On Sep 16, 2014 this sequence version replaced XM_006538549.1.
            
            Summary: The protein encoded by this gene belongs to the mammalian
            Hes gene family, the mammalian homologues of Drosophila hairy and
            Enhancer of split. Hes 2 is a basic helix-loop-helix
            transcriptional repressor and is an effector of the Notch signaling
            pathway. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138112.1, SRR13948564.1238641.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AK053792.1         2-67
            67-1625             BC138112.1         1-1559
            1626-1626           AL772240.7         52829-52829
            1627-1737           BC138112.1         1561-1671
            1738-1754           AK053792.1         1345-1361
            1755-1755           AL772240.7         52958-52958
            1756-2915           AK053792.1         1363-2522
FEATURES             Location/Qualifiers
     source          1..2915
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 82.92 cM"
     gene            1..2915
                     /gene="Hes2"
                     /gene_synonym="HES-2"
                     /note="hes family bHLH transcription factor 2"
                     /db_xref="GeneID:15206"
                     /db_xref="MGI:MGI:1098624"
     exon            1..457
                     /gene="Hes2"
                     /gene_synonym="HES-2"
                     /inference="alignment:Splign:2.1.0"
     exon            458..566
                     /gene="Hes2"
                     /gene_synonym="HES-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             522..995
                     /gene="Hes2"
                     /gene_synonym="HES-2"
                     /note="hairy and enhancer of split 2"
                     /codon_start=1
                     /product="transcription factor HES-2"
                     /protein_id="NP_001288734.1"
                     /db_xref="CCDS:CCDS18995.1"
                     /db_xref="GeneID:15206"
                     /db_xref="MGI:MGI:1098624"
                     /translation="MRLPRRVEDAAELRKNLKPLLEKRRRARINESLSQLKGLVLPLL
                     GAETSRSSKLEKADILEMTVRFLQEQPATLYSSAAPGPLNSYLEGYRACLARLARVLP
                     ACSVLEPAVSARLLEHLRQRTVSDDSPSLTLPPAPAPAPSPPVPPPGSSGLWRPW"
     exon            567..662
                     /gene="Hes2"
                     /gene_synonym="HES-2"
                     /inference="alignment:Splign:2.1.0"
     exon            663..762
                     /gene="Hes2"
                     /gene_synonym="HES-2"
                     /inference="alignment:Splign:2.1.0"
     exon            763..2915
                     /gene="Hes2"
                     /gene_synonym="HES-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaggtggaa tctggagtcc agagcaagtt gaaaatgaga tgaactccga ggaccccggg
       61 ggttgcctct tcttgggaag cggagctacg gtttcttttt cacaccctaa ggccggggaa
      121 ccaggtcatt tttaagtcaa tggggtgctc tagattttat ggagcactta atgtgagggg
      181 tccagcgacc ccagtattgg ttatggccgc taggtcggag aaagattgga ccttgcagag
      241 acaggatttc cgtgcccagc ttaaaagcag ttggtagaac gaatctcctt tcaaaccctt
      301 gttgtatctc tctgaggtcc ccggctggaa gctctgcagc cgctggggac ctttcggtgg
      361 cctagggaag agctcgcaga tccgtgggcg tgaatgaagc catagggtgc aggagaggag
      421 gcgaggcctg gccccaacca ctcttcctgt ccaggagcag gggcaaggat cctccacccc
      481 gaggtaacag accctgtgca cccttcgctt tcctgcagag catgaggctg cccagaagag
      541 ttgaggacgc ggcggagctg cgcaagaacc taaagccgct gctggagaag cgccggcgcg
      601 cgcggatcaa cgagagccta agccagctga agggtctcgt attgccgctg ctgggcgcgg
      661 agacttcccg ctcttcgaag ttggagaagg cagacatcct ggaaatgact gtgcgcttcc
      721 tacaggagca gcctgcgacc ctgtactcct ctgcagcacc tgggcctttg aatagctacc
      781 tcgagggtta ccgagcctgt ctggcgcgac tggcccgcgt actgcccgcc tgcagcgtcc
      841 tggagcccgc agtgagcgcg cgcctactag agcacctgcg acagaggact gtcagtgatg
      901 actcgccctc actgacgcta ccacccgctc cagctccagc tccttctccg ccggtgcctc
      961 ctccaggcag ttctggcctt tggaggccat ggtaggttcc tggatatttc acaggcacct
     1021 gctgccggct gtcagggacc tggatgggct accggaccaa ggaagttctc catggcaact
     1081 gcatcttctc actcactttg agaacagtct agctccaact gccctgtcaa gaatcagata
     1141 ctgtgacctg gctgggtgat gaaaccttca aggaagggct cggccagagg gtgaaatggg
     1201 gccaaaggaa aaagagcaaa tatgtgcagg gtgaggagaa gcccagactg gaagaagtgg
     1261 tgcctcggca gggacacacc tgccctacag tgggcagcag accaaagtct ggtcttgaag
     1321 ctcacctggg cctggtgcca cacctgctag gatgggtcac tgtgtttcca gccacgcctg
     1381 gatatactgc cagctcagct gggcttgtga cgtctttatg aacagagcag tggcttgggg
     1441 actttgaccg tgcctcctca gagcactgag cagggcaaag gaacagcagg gcagtcaatc
     1501 ctgttcaact cctccaatcc taggcttccc ttcccactga tctgtagaag ggggtgtgga
     1561 ctctcccttt taattctcta agtgttattt ctcccccacc gcaggtctgg tggtcttggg
     1621 atgtgagggg agggtgagac aagagggagg cttccctgtg gctttggagg agcagagcac
     1681 aggctctgga atggcaggga ctctggagaa gcagaggcag gaccaccatc agccttgcct
     1741 gctttctctg gtaaacccct ctctgaatcc aggcagctgg cctatcagaa acttgctcag
     1801 aggttatttc taccccacgg aagcctggaa gcccatcaag actcagggaa gggccttcag
     1861 atcccaggag tgggtgcttc acagaaagtg ggaggatttg tgagccaggg tcactccaag
     1921 tccatgggga tttgcagcgc ctagccacaa agctgcttcc aagtctgcac tgggaaccag
     1981 gtcactaaag ccaggaagac agactgacca gggaagggac agtcactatc tgctttgcta
     2041 tgcatgtcta tgatggatct gggcactgat ttaggtagta ggaggtgagg aaattggagg
     2101 cattcataag aagaaagaca ataaagatga agagggaagg gggctcccgg cagtgctggg
     2161 ctgggcccgg ttgcctagac tgtaaactct tgggaggcgg ggctgggtat agtgctcctg
     2221 tgtgtacctc tgcggtactg gatgcacagt ggctgtgcaa caaacaggat ggattaaagg
     2281 agtcatgtga ctggctcaca ctgtatcgga ccttggacag cctggccttt gcttagatca
     2341 ccactccaaa ttcctagagc agaggttctc aaccttccta acggggcaac tctttaatac
     2401 agtaactcat gttgtagtga ccttcccccc acccccagcc ataaaattat tttgttgcta
     2461 cttcacaact aaaaattgct gtgttatgaa taatgatgta aacatctgtg ttttctgatg
     2521 gcctcggatg accctgtgga agaatcatac ccccactcca aggggtcgcg acccacaggt
     2581 tgagaaccac taccctaggc tcacccacat atttgtccaa ccagggtaca tatgcagtct
     2641 gttttgttgt tcttggtgga gcaagaagag gctgagaaat cgttggccct ggcccaaact
     2701 cacccaagag gctctgggct tctccttgaa tataaaggga catcctcctg tctccacaca
     2761 taagaactct caatacttgt ttacacaatg agttttcagc catctttgcc tgaggattga
     2821 gaccctgcct caaagaggga aaaaaaaaat ctggtctgcc tgcttctgcg tcctgagtgc
     2881 tgggattaaa ggcgtgtgcc accacccgca gcttg
//
