LOCUS       NM_008235               1464 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus hes family bHLH transcription factor 1 (Hes1),
            transcript variant 1, mRNA.
ACCESSION   NM_008235 XM_192801
VERSION     NM_008235.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1464)
  AUTHORS   Defamie,V., Aliar,K., Sarkar,S., Vyas,F., Shetty,R., Reddy
            Narala,S., Fang,H., Saw,S., Tharmapalan,P., Sanchez,O., Knox,J.J.,
            Waterhouse,P.D. and Khokha,R.
  TITLE     Metalloproteinase inhibitors regulate biliary progenitor cells
            through sDLK1 in organoid models of liver injury
  JOURNAL   J Clin Invest 135 (3), e164997 (2024)
   PUBMED   39699962
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1464)
  AUTHORS   Littlejohn,R., Zambrano-Carrasco,J., Zou,J., Yao,Y., Kim,I.M.,
            Zhou,J., Li,J. and Su,H.
  TITLE     Inhibition of cardiomyocyte neddylation impairs embryonic cardiac
            morphogenesis
  JOURNAL   J Mol Cell Cardiol 197, 40-44 (2024)
   PUBMED   39437885
REFERENCE   3  (bases 1 to 1464)
  AUTHORS   Hofstetter,K.S., Haas,P.M., Kuntz,J.P., Zheng,Y. and Fuhrmann,S.
  TITLE     Loss of Cdc42 causes abnormal optic cup morphogenesis and
            microphthalmia in mouse
  JOURNAL   Front Cell Neurosci 18, 1474010 (2024)
   PUBMED   39650797
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1464)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   5  (bases 1 to 1464)
  AUTHORS   El Azhar,Y., Schulthess,P., van Oostrom,M.J., Weterings,S.D.C.,
            Meijer,W.H.M., Tsuchida-Straeten,N., Thomas,W.M., Bauer,M. and
            Sonnen,K.F.
  TITLE     Unravelling differential Hes1 dynamics during axis elongation of
            mouse embryos through single-cell tracking
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39315665
  REMARK    GeneRIF: Unravelling differential Hes1 dynamics during axis
            elongation of mouse embryos through single-cell tracking.
REFERENCE   6  (bases 1 to 1464)
  AUTHORS   Tomita,K., Ishibashi,M., Nakahara,K., Ang,S.L., Nakanishi,S.,
            Guillemot,F. and Kageyama,R.
  TITLE     Mammalian hairy and Enhancer of split homolog 1 regulates
            differentiation of retinal neurons and is essential for eye
            morphogenesis
  JOURNAL   Neuron 16 (4), 723-734 (1996)
   PUBMED   8607991
REFERENCE   7  (bases 1 to 1464)
  AUTHORS   Ishibashi,M., Ang,S.L., Shiota,K., Nakanishi,S., Kageyama,R. and
            Guillemot,F.
  TITLE     Targeted disruption of mammalian hairy and Enhancer of split
            homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix
            factors, premature neurogenesis, and severe neural tube defects
  JOURNAL   Genes Dev 9 (24), 3136-3148 (1995)
   PUBMED   8543157
REFERENCE   8  (bases 1 to 1464)
  AUTHORS   Ishibashi,M., Moriyoshi,K., Sasai,Y., Shiota,K., Nakanishi,S. and
            Kageyama,R.
  TITLE     Persistent expression of helix-loop-helix factor HES-1 prevents
            mammalian neural differentiation in the central nervous system
  JOURNAL   EMBO J 13 (8), 1799-1805 (1994)
   PUBMED   7909512
REFERENCE   9  (bases 1 to 1464)
  AUTHORS   Takebayashi,K., Sasai,Y., Sakai,Y., Watanabe,T., Nakanishi,S. and
            Kageyama,R.
  TITLE     Structure, chromosomal locus, and promoter analysis of the gene
            encoding the mouse helix-loop-helix factor HES-1. Negative
            autoregulation through the multiple N box elements
  JOURNAL   J Biol Chem 269 (7), 5150-5156 (1994)
   PUBMED   7906273
REFERENCE   10 (bases 1 to 1464)
  AUTHORS   Sasai,Y., Kageyama,R., Tagawa,Y., Shigemoto,R. and Nakanishi,S.
  TITLE     Two mammalian helix-loop-helix factors structurally related to
            Drosophila hairy and Enhancer of split
  JOURNAL   Genes Dev 6 (12B), 2620-2634 (1992)
   PUBMED   1340473
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030736.8.
            
            On Nov 3, 2022 this sequence version replaced NM_008235.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018375.1, AK133538.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-355               CT030736.8         134957-135311
            356-451             CT030736.8         135444-135539
            452-539             CT030736.8         135776-135863
            540-1464            CT030736.8         136485-137409
FEATURES             Location/Qualifiers
     source          1..1464
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 21.09 cM"
     gene            1..1464
                     /gene="Hes1"
                     /gene_synonym="bHLHb39; Hry"
                     /note="hes family bHLH transcription factor 1"
                     /db_xref="GeneID:15205"
                     /db_xref="MGI:MGI:104853"
     exon            1..355
                     /gene="Hes1"
                     /gene_synonym="bHLHb39; Hry"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1096
                     /gene="Hes1"
                     /gene_synonym="bHLHb39; Hry"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor HES-1; hairy and enhancer of split 1"
                     /codon_start=1
                     /product="transcription factor HES-1 isoform 1"
                     /protein_id="NP_032261.1"
                     /db_xref="CCDS:CCDS28098.1"
                     /db_xref="GeneID:15205"
                     /db_xref="MGI:MGI:104853"
                     /translation="MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEK
                     RRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALST
                     DPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQAH
                     PALQAPPPPPPSGPAGPQHAPFAPPPPPLVPIPGGAAPPPGSAPCKLGSQAGEAAKVF
                     GGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGSSLTSDSM
                     WRPWRN"
     exon            356..451
                     /gene="Hes1"
                     /gene_synonym="bHLHb39; Hry"
                     /inference="alignment:Splign:2.1.0"
     exon            452..539
                     /gene="Hes1"
                     /gene_synonym="bHLHb39; Hry"
                     /inference="alignment:Splign:2.1.0"
     exon            540..1464
                     /gene="Hes1"
                     /gene_synonym="bHLHb39; Hry"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1443..1448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hes1"
                     /gene_synonym="bHLHb39; Hry"
                     /note="hexamer: AATAAA"
     polyA_site      1464
                     /gene="Hes1"
                     /gene_synonym="bHLHb39; Hry"
                     /note="major polyA site"
ORIGIN      
        1 acacaggatc tggagctggt gctgataaca gcggaatccc ctgtctacct ctctccttgg
       61 tcctggaata gtgctaccga tcactaagta gccctaagac ataataaacc ttcaactgct
      121 cagtagtttt tcttatgaaa gtcaagtaaa aggacgtaag caaaaaaaaa ttattttttt
      181 tttgcgtgaa ggattccaaa aataaaattc tctggggact gagaagaaaa aaaaaaaaaa
      241 aacgaaaatg ccagctgata taatggagaa aaattcctcc tccccggtgg ctgctacccc
      301 agccagtgtc aacacgacac cggacaaacc aaagacggcc tctgagcaca gaaagtcatc
      361 aaagcctatc atggagaaga ggcgaagggc aagaataaat gaaagtctaa gccaactgaa
      421 aacactgatt ttggatgcac ttaagaaaga tagctcccgg cattccaagc tagagaaggc
      481 agacattctg gaaatgactg tgaagcacct ccggaacctg cagcgggcgc agatgaccgc
      541 cgcgctcagc acagacccga gcgtgttggg gaaataccgc gccggcttca gcgagtgcat
      601 gaacgaggtg acccgcttcc tgtccacgtg tgagggcgtt aacaccgagg tgcgcactcg
      661 gctgctgggc cacctggcca actgcatgac ccagatcaac gccatgacct accccgggca
      721 ggcgcacccc gccttgcagg cgccgccgcc gccgcccccg tcaggacctg ccggtcccca
      781 gcacgcgcca ttcgcgccgc cgccgccgcc gcttgtgccc atccccgggg gcgcggcgcc
      841 ccctcccggc agcgcaccct gcaagttggg cagccaggct ggagaggctg ccaaggtttt
      901 tggcggcttc caagtggtgc cggctcctga cggccaattt gcctttctca tccccaacgg
      961 ggccttcgct cacagcggcc cggtcatccc ggtctacacc agcaacagtg ggacctcggt
     1021 gggtcctaac gcagtgtcac cttccagtgg ctcctcgctc acttcggact ccatgtggag
     1081 accgtggcgg aactgagagc ctcaggccac tgctacccgt aaagtcccta gcccacctct
     1141 ctcttctgac ggacactaaa aacgaacttg gattttagga gagactttta taatttggtg
     1201 gttattttgt tgcttttttt aattctaaaa agttactttt tgtagagagc tgtattaagt
     1261 gactgaccat gcactgcatt tgtatatatt ttatatgttc atattggatt gcgcctttgt
     1321 attataaaag ttgagatgac atttcgtttt ttacacgaga tttctttttt tatgtgatgc
     1381 caaagatgtt tgaaaatgct cttaaaatat cttcctttgg ggaagtttat ttgagaaaat
     1441 ataataaaag agtgaaggct ttta
//
