LOCUS       NM_022331               1955 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus homocysteine-inducible, endoplasmic reticulum
            stress-inducible, ubiquitin-like domain member 1 (Herpud1),
            transcript variant 1, mRNA.
ACCESSION   NM_022331
VERSION     NM_022331.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1955)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1955)
  AUTHORS   Xie,W., Shan,Y., Wu,Z., Liu,N., Yang,J., Zhang,H., Sun,S., Chi,J.,
            Feng,W., Lin,H. and Guo,H.
  TITLE     Herpud1 deficiency alleviates homocysteine-induced aortic valve
            calcification
  JOURNAL   Cell Biol Toxicol 39 (6), 2665-2684 (2023)
   PUBMED   36746840
  REMARK    GeneRIF: Herpud1 deficiency alleviates homocysteine-induced aortic
            valve calcification.
REFERENCE   3  (bases 1 to 1955)
  AUTHORS   Neupane,S., Berardinelli,S.J., Cameron,D.C., Grady,R.C.,
            Komatsu,D.E., Percival,C.J., Takeuchi,M., Ito,A., Liu,T.W.,
            Nairn,A.V., Moremen,K.W., Haltiwanger,R.S. and Holdener,B.C.
  TITLE     O-fucosylation of thrombospondin type 1 repeats is essential for
            ECM remodeling and signaling during bone development
  JOURNAL   Matrix Biol 107, 77-96 (2022)
   PUBMED   35167946
REFERENCE   4  (bases 1 to 1955)
  AUTHORS   Li,W., Wang,Y., Zhu,L., Du,S., Mao,J., Wang,Y., Wang,S., Bo,Q.,
            Tu,Y. and Yi,Q.
  TITLE     The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and
            the development of choroidal neovascularization
  JOURNAL   J Cell Mol Med 25 (14), 6709-6720 (2021)
   PUBMED   34057287
  REMARK    GeneRIF: The P300/XBP1s/Herpud1 axis promotes macrophage M2
            polarization and the development of choroidal neovascularization.
REFERENCE   5  (bases 1 to 1955)
  AUTHORS   Lei,Z.X., Wang,J.J., Li,K. and Liu,P.
  TITLE     Herp knockout protects against nonalcoholic fatty liver disease in
            mice on a high fat diet
  JOURNAL   Kaohsiung J Med Sci 37 (6), 487-496 (2021)
   PUBMED   33464700
  REMARK    GeneRIF: Herp knockout protects against nonalcoholic fatty liver
            disease in mice on a high fat diet.
REFERENCE   6  (bases 1 to 1955)
  AUTHORS   Okuda-Shimizu,Y. and Hendershot,L.M.
  TITLE     Characterization of an ERAD pathway for nonglycosylated BiP
            substrates, which require Herp
  JOURNAL   Mol Cell 28 (4), 544-554 (2007)
   PUBMED   18042451
  REMARK    GeneRIF: Herp is in a complex with ubiquitinated proteins and with
            the 26S proteasome, suggesting that it plays a role in linking
            substrates with the proteasome.
REFERENCE   7  (bases 1 to 1955)
  AUTHORS   Hori,O., Ichinoda,F., Yamaguchi,A., Tamatani,T., Taniguchi,M.,
            Koyama,Y., Katayama,T., Tohyama,M., Stern,D.M., Ozawa,K., Kitao,Y.
            and Ogawa,S.
  TITLE     Role of Herp in the endoplasmic reticulum stress response
  JOURNAL   Genes Cells 9 (5), 457-469 (2004)
   PUBMED   15147274
REFERENCE   8  (bases 1 to 1955)
  AUTHORS   Ma,Y. and Hendershot,L.M.
  TITLE     Herp is dually regulated by both the endoplasmic reticulum
            stress-specific branch of the unfolded protein response and a
            branch that is shared with other cellular stress pathways
  JOURNAL   J Biol Chem 279 (14), 13792-13799 (2004)
   PUBMED   14742429
  REMARK    GeneRIF: Herp represents a second target, in addition to CHOP, that
            is dually regulated by both the shared and the ER stress-specific
            branches during unfolded protein activation
REFERENCE   9  (bases 1 to 1955)
  AUTHORS   Chtarbova,S., Nimmrich,I., Erdmann,S., Herter,P., Renner,M.,
            Kitajewski,J. and Muller,O.
  TITLE     Murine Nr4a1 and Herpud1 are up-regulated by Wnt-1, but the
            homologous human genes are independent from beta-catenin activation
  JOURNAL   Biochem J 367 (Pt 3), 723-728 (2002)
   PUBMED   12153396
  REMARK    GeneRIF: upregulation by Wnt-1
REFERENCE   10 (bases 1 to 1955)
  AUTHORS   Kokame,K., Agarwala,K.L., Kato,H. and Miyata,T.
  TITLE     Herp, a new ubiquitin-like membrane protein induced by endoplasmic
            reticulum stress
  JOURNAL   J Biol Chem 275 (42), 32846-32853 (2000)
   PUBMED   10922362
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY318096.1, AB034991.1 and AV229138.1.
            
            On Oct 24, 2017 this sequence version replaced NM_022331.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159500.1, AK165832.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                BY318096.1         1-71
            72-1942             AB034991.1         1-1871
            1943-1955           AV229138.1         236-248
FEATURES             Location/Qualifiers
     source          1..1955
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 46.46 cM"
     gene            1..1955
                     /gene="Herpud1"
                     /gene_synonym="Herp; Mifl; SUP"
                     /note="homocysteine-inducible, endoplasmic reticulum
                     stress-inducible, ubiquitin-like domain member 1"
                     /db_xref="GeneID:64209"
                     /db_xref="MGI:MGI:1927406"
     exon            1..310
                     /gene="Herpud1"
                     /gene_synonym="Herp; Mifl; SUP"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1339
                     /gene="Herpud1"
                     /gene_synonym="Herp; Mifl; SUP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homocysteine-responsive endoplasmic reticulum-resident
                     ubiquitin-like domain member 1 protein"
                     /codon_start=1
                     /product="homocysteine-responsive endoplasmic
                     reticulum-resident ubiquitin-like domain member 1 protein
                     isoform 1"
                     /protein_id="NP_071726.1"
                     /db_xref="CCDS:CCDS22541.1"
                     /db_xref="GeneID:64209"
                     /db_xref="MGI:MGI:1927406"
                     /translation="MEPEPQPEPVTLLVKSPNQRHRDLELSGDRSWSVSRLKAHLSRV
                     YPERPRPEDQRLIYSGKLLLDHQCLQDLLPKQEKRHVLHLVCNVKNPSKMPETSTKGA
                     ESTEQPDNSNQTQHPGDSSSDGLRQREVLRNLSPSGWENISRPEAVQQTFQGLGPGFS
                     GYTTYGWLQLSWFQQIYARQYYMQYLAATAASGTFVPTPSAQEIPVVSTPAPAPIHNQ
                     FPAENQPANQNAAAQAVVNPGANQNLRMNAQGGPLVEEDDEINRDWLDWTYSAATFSV
                     FLSILYFYSSLSRFLMVMGATVVMYLHHVGWFPFRQRPVQNFPDDGGPRDAANQDPNN
                     NLQGGMDPEMEDPNRLPPDREVLDPEHTSPSFMSTAWLVFKTFFASLLPEGPPALAN"
     exon            311..388
                     /gene="Herpud1"
                     /gene_synonym="Herp; Mifl; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            389..463
                     /gene="Herpud1"
                     /gene_synonym="Herp; Mifl; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            464..594
                     /gene="Herpud1"
                     /gene_synonym="Herp; Mifl; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            595..717
                     /gene="Herpud1"
                     /gene_synonym="Herp; Mifl; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            718..1068
                     /gene="Herpud1"
                     /gene_synonym="Herp; Mifl; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1174
                     /gene="Herpud1"
                     /gene_synonym="Herp; Mifl; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1955
                     /gene="Herpud1"
                     /gene_synonym="Herp; Mifl; SUP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1917..1922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Herpud1"
                     /gene_synonym="Herp; Mifl; SUP"
                     /note="hexamer: AATAAA"
     polyA_site      1943
                     /gene="Herpud1"
                     /gene_synonym="Herp; Mifl; SUP"
                     /note="major polyA site"
ORIGIN      
        1 agagagcgct atctgcggag ccctggcacg gggcgcccat aaaaggtacc cgagacgggg
       61 gcgcgtgtcc caaagacgcc aagtgtcgtt gtgtggtctc agacggctgc gtcgccgccc
      121 gttcggcatc cctgagcgca gtcgagccgc cagcgacgca gacatggagc ccgagccaca
      181 gcccgagccg gtcacgctgc tggtgaagag tcccaatcag cgccaccgcg acttggagct
      241 gagtggcgac cgcagttgga gtgtgagtcg cctcaaggcc cacctgagcc gagtctaccc
      301 cgagcgcccg cgtccagagg accagaggtt aatttattct gggaagctgc tgttggatca
      361 ccagtgtctc caagatttgc ttccaaagca ggaaaagcga catgttttgc accttgtgtg
      421 caatgtgaag aatccctcca aaatgccaga aaccagcaca aagggtgctg aatccacaga
      481 gcagccggac aactctaatc agacacagca tcctggggac tcctcaagtg atggtttacg
      541 gcaaagagaa gttcttcgga acctttctcc ctccggatgg gagaacatct ctaggcctga
      601 ggctgtccag cagactttcc aaggcctggg gcctggcttc tctggctaca caacgtatgg
      661 gtggctgcag ctctcctggt tccagcagat ctatgcaagg cagtactaca tgcaatactt
      721 agctgccact gctgcatcag gaacttttgt cccgacacca agtgcacaag agatacctgt
      781 ggtctctaca cctgctccgg ctcctataca caaccagttt ccggcagaaa accagccggc
      841 caatcagaat gcagctgctc aagcggttgt caatcccgga gccaatcaga acttgcggat
      901 gaatgcacaa ggtggccccc tggtggagga agatgatgag ataaaccgag actggttgga
      961 ttggacctat tccgcagcga cgttttctgt tttcctcagc atcctttact tctactcctc
     1021 gctgagcaga tttctcatgg tcatgggtgc cactgtagtc atgtacctgc accacgtcgg
     1081 gtggtttccg ttcagacaga ggccagttca gaacttcccg gatgatggtg gtcctcgaga
     1141 tgctgccaac caggacccca acaataacct ccagggaggt atggacccag aaatggaaga
     1201 ccccaaccgc ctccccccag accgcgaagt gctggaccct gagcacacca gcccctcgtt
     1261 tatgagcaca gcatggctag tcttcaagac tttctttgcc tctcttcttc cagaaggccc
     1321 accagcccta gccaactgat ggcccttgtg ctctgtcgct ggtggctttg acagctcgga
     1381 ctggatcgtc tggctccggc tccttttcct cccctggcgt ggactcgaca gagtcattga
     1441 aaacccacag gatgacatgt gcttctgtgc caagcaaaag cacaaactaa gacatgaagc
     1501 cgtggtacaa actgaacagg gcccctcatg tcgttattct gaagagcttt aatgtatact
     1561 gtatgtagtt tcataggcac tgtaagcaga aggcccaggg tcgcatgttc tgcctgagca
     1621 cctccccaga tgtgtgtgca tgtgtgctgt acatggaagt catagacgtg tgtgcatgtg
     1681 tgctctacat ggaagtcata gatgcagaaa cggttctgct ggttcgattt gattcctgtt
     1741 ggaatgttca aattacacta agtgtactac tttatataat cagtgaattg ctagacatgt
     1801 tagcaggact tttctaggag agacttatgt ataattgctt tttaaaatgc agtgctttcc
     1861 tttaaaccga gggtggcgac ttggcagagg taaaaccttt gccgagtttt ctgttcaata
     1921 aagttttgct atgaatgact gtagcagaga ctccc
//
