LOCUS       NM_026101               4019 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus hect domain and RLD 4 (Herc4), transcript variant 2,
            mRNA.
ACCESSION   NM_026101
VERSION     NM_026101.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4019)
  AUTHORS   Zhang,Z., Tong,J., Tang,X., Juan,J., Cao,B., Hurren,R., Chen,G.,
            Taylor,P., Xu,X., Shi,C.X., Du,J., Hou,J., Wang,G., Wu,D.,
            Stewart,A.K., Schimmer,A.D., Moran,M.F. and Mao,X.
  TITLE     The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays
            the growth of multiple myeloma xenografts in nude mice
  JOURNAL   Blood 127 (13), 1676-1686 (2016)
   PUBMED   26825710
  REMARK    GeneRIF: HERC4 plays an important role in Multiple myeloma
            progression.
REFERENCE   2  (bases 1 to 4019)
  AUTHORS   Rodriguez,C.I. and Stewart,C.L.
  TITLE     Disruption of the ubiquitin ligase HERC4 causes defects in
            spermatozoon maturation and impaired fertility
  JOURNAL   Dev Biol 312 (2), 501-508 (2007)
   PUBMED   17967448
  REMARK    GeneRIF: The E3 ubiquitin ligase Herc4, though ubiquitously
            expressed in all tissues, is most highly expressed in the testis,
            specifically during spermiogenesis
REFERENCE   3  (bases 1 to 4019)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   4  (bases 1 to 4019)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   5  (bases 1 to 4019)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 4019)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ899503.1, AK147723.1 and BM249989.2.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_026101.5.
            
            On Dec 1, 2010 this sequence version replaced NM_026101.3.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            3' coding region, compared to variant 1. It encodes a shorter
            isoform (2), compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147723.1, BC043082.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               BQ899503.1         1-114
            115-4012            AK147723.1         2-3899
            4013-4019           BM249989.2         1-7                 c
FEATURES             Location/Qualifiers
     source          1..4019
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.56 cM"
     gene            1..4019
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /note="hect domain and RLD 4"
                     /db_xref="GeneID:67345"
                     /db_xref="MGI:MGI:1914595"
     exon            1..367
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     exon            368..398
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     exon            399..702
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     CDS             477..3626
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /EC_number="2.3.2.26"
                     /note="isoform 2 is encoded by transcript variant 2;
                     probable E3 ubiquitin-protein ligase HERC4; HECT domain
                     and RCC1-like domain-containing protein 4; HECT-type E3
                     ubiquitin transferase HERC4"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase HERC4
                     isoform 2"
                     /protein_id="NP_080377.2"
                     /db_xref="CCDS:CCDS23897.1"
                     /db_xref="GeneID:67345"
                     /db_xref="MGI:MGI:1914595"
                     /translation="MLCWGNASYGQLGLGGIDEEIVLEPRRSDFFVNKKVRDVGCGLR
                     HTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVACGEAHTLALNDK
                     GQVYAWGLDSDGQLGLQGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFC
                     WGQNKYGQLGLGIDCQKQTSPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNK
                     FGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGH
                     NSTSHEINPRKVFELMGSIVTQVACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSN
                     RKSPFTVKGNWFSYNGQCPQDIGSEDYFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRC
                     SDPSKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAISNDDHYR
                     TGTRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKLTSSLPDVEALRFYL
                     TLPECPLMSDCNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEV
                     VVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKTGQLIQYDKFYIHEVQEL
                     IDIRNDYINWVQQQAYGVLADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAH
                     RQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAV
                     DAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVICGLAI
                     YNFTIVDLHFPLALYKKLLKRKPSLDDLKELMPAVGRSMQQLLDYPEDDIEETFCLNF
                     TITVENFGATEVKELVLNGADTAVNRQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHK
                     VCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWADHPTIKIFWEVFHELP
                     LEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGESYLPVSHTCFNLLDLPKYTEKE
                     TLRCKLIQAIDHNEGFSLI"
     exon            703..862
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     exon            863..939
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1161
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1253
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1384
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1545
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1622
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1747
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1807
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1919
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2109
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2282
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2402
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2501
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2669
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2813
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..2980
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     exon            2981..3047
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     exon            3048..3130
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..3314
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     exon            3315..3417
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
     exon            3418..4019
                     /gene="Herc4"
                     /gene_synonym="1700056O17Rik; 4921531D01Rik;
                     9530080M15Rik; mKIAA1593"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caccgcccct ctcccttgtc gcctggctct ccctcgtcgc cagcctctcc ctcagctctc
       61 tccacccctc gtggtctccg ccctgctcac cgccagccct tcccctcccg ctccatccgg
      121 gtcgctgacg gcttgtctct cggtccggag agtgctggcg gcagcgtttc tcggaggagc
      181 ctgggaaagt ttcacgggcg agccgggcag cagaggcagc ggagctgcgg tcggggacgt
      241 cggaggagcc gtggtaatcg ccgcggccgg ctgaaggagg aaggtcttgg gagctggaga
      301 gccgcccaga ggtccaggga gcgtccgtcc tccatcgctt agggctctcc ctgccctgag
      361 agacccgata agaacttcca ttttctgttg atgtggagac atagggtacc tcccagtttc
      421 cagtgtttca gaagggactt ttgtattgaa actggaagac caaggtcatt ccaagcatgt
      481 tgtgctgggg caatgcatcc tatggacaac taggtttggg aggaattgat gaagaaattg
      541 tactagagcc caggagaagt gactttttcg tgaacaaaaa ggtccgagat gtaggctgtg
      601 gactcaggca cactgtgttt gtcctggatg atgggactgt gtacacatgt ggatgtaatg
      661 atctaggaca gctaggtcat gaaaagtcca gaaagaaacc agagcaggtt gttgccctgg
      721 atgcccagaa tatcgtagct gttgcgtgtg gagaagctca cacgttagcg ctgaatgaca
      781 agggccaggt gtatgcttgg ggtctcgact ctgacggaca gcttggccta cagggatcag
      841 aggaatgtat cagagtaccc agaaatatta aaagtctttc ggatatccag atagtacagg
      901 ttgcgtgtgg ttactatcat tcgcttgcac tttctaaagc aagtgaagtt ttctgttggg
      961 gacagaataa atatggccag ctgggtctag gcattgattg tcaaaagcaa acttcaccac
     1021 agctgattaa gtctttgctt ggaataccat tcatgcaagt cgcagcagga ggagcccata
     1081 gttttgtact caccctttcc ggagctatct ttggatgggg acgtaacaaa tttggtcagc
     1141 taggtcttaa tgatgaaaat gataggtatg ttcctaattt actaaagtca ctaagatctc
     1201 agaaaatagt ttatatttgt tgcggagaag atcatactgc tgcattaacc aaggaaggtg
     1261 gagtgtttac ctttggagct gggggctatg gccagctggg tcataattct accagtcatg
     1321 agataaatcc caggaaagtt tttgaactca tgggaagcat tgttactcag gtcgcttgtg
     1381 gaaggcagca tacctctgca tttgttcctt cttcaggacg aatttactcc tttggtcttg
     1441 gtggtaatgg gcagttggga actggttcaa ccagcaacag aaaaagccct ttcactgtaa
     1501 aaggaaactg gttttcttat aatggacagt gtccacaaga tattggttct gaagactatt
     1561 tctgtgtcaa aagaattttc tcaggtggag atcaaagctt ttcacattac tctagtcctc
     1621 agaactgtgg acctccagat gactttagat gctccgaccc ttccaagcag atctggacag
     1681 tgaacgaagc tctgattcag aaatggctca gctacccctc tggaaggttc cctgtggaga
     1741 tagccaatga gatagatgga acattttctt catctggctg cctaaatgga agttttctgg
     1801 ctattagcaa tgacgatcac tatagaacag gtaccagatt ttcaggggtt gatatgaacg
     1861 ctgctagact cttattccac aaacttatac aacctgatca tcctcagata tctcagcagg
     1921 tggcagctag tttggaaaag aatctaatcc ctaaactgac tagttcccta cctgatgttg
     1981 aagctctgag gttttatctt accctgccag agtgtcccct gatgagtgac tgcaacaatt
     2041 tcacaacaat agcaatcccc tttggtacag ctcttgtgaa cctagaaaag gcaccactga
     2101 aagtacttga aaactggtgg tcagtacttg aacctccact attcctcaag atagtagaac
     2161 tttttaagga agttgtggta catcttttga aactctacaa gatcggcatt cccccttctg
     2221 aaagaagaat tttcaacagt tttcttcata ccgcattaaa ggttttagaa atattgcata
     2281 gggtaaatga gaaaacagga caacttattc aatatgacaa gttttacatc catgaagtcc
     2341 aagagctgat agacataagg aatgactata tcaactgggt ccagcagcaa gcctatggag
     2401 tgttggcaga tatcccggtg acaatttgta catatccatt tgtatttgat gcccaggcaa
     2461 aaactactct gctccagaca gatgcagtct tgcagatgca gatggccatt gaccaggccc
     2521 acaggcagaa tgtctcctct ctttttctcc cagtgatcga gtctgtgaat ccttgcttaa
     2581 ttctagttgt tcgcagagag aatattgtag gagatgcgat ggaagtcctc aggaaaacca
     2641 agaatataga ttataaaaag ccactcaagg ttatatttgt tggagaagat gctgttgatg
     2701 caggaggtgt tcgcaaagaa tttttcttgc ttatcatgag ggaattgttg gatcctaaat
     2761 acggcatgtt tcgatattat gaagattcca ggctcatttg gttttcagat aagacatttg
     2821 aagacagtga tttgttccac ttgatcggtg ttatctgtgg attagcaatt tataatttta
     2881 ccattgtgga cctccatttc cctttggctt tatataagaa actgctgaaa aggaagccgt
     2941 ccctggatga tctgaaagag ctgatgccag ccgtcgggag aagcatgcag caattgctgg
     3001 actatccaga agatgacata gaggaaacat tttgtctaaa ctttacgatc acagttgaga
     3061 acttcggtgc aacagaagta aaagagctgg ttctgaacgg ggcagacact gctgttaata
     3121 gacagaatcg gcaggagttt gttgatgcct atgtggatta catattcaat aaatcagtgg
     3181 catctttatt tgatgctttc catgcgggct ttcataaggt ctgtggagga aaagttcttc
     3241 tgctcttcca gcctaatgaa ttacaagcta tggttattgg gaatacaaat tatgattgga
     3301 aagaactgga gaagaataca gaatacaaag gagagtattg ggcagaccat cccacgataa
     3361 aaattttttg ggaagtgttt catgaattac cactagagaa gaagaaacaa tttctattat
     3421 ttttgacagg tagtgatcgg attcccattc ttggtatgaa gagtctgaaa ctagtcatcc
     3481 agtcaacagg aggtggtgag agctatctcc cggtttccca tacctgtttt aatcttctag
     3541 atctcccaaa atatacagag aaagaaaccc tccgatgtaa actgatccaa gctattgatc
     3601 acaatgaagg cttcagttta atatgacctt ggacttttct gtttagtaca aaaaccactc
     3661 gtgtttctct tgtgaattca gcacagtgag agttacttct gtaattctta cttataaatt
     3721 gttcactact gtactgatga aagcccaaaa ttaaaaactg tgcattaata ctaaactgta
     3781 cagaaccatg aattgtccat cctcatacaa gtattgtgaa tacattaaag ttttactcac
     3841 aggaatttta agagtttgca tatttcggaa attacctgat gtgtgggtgc atggaaatgt
     3901 tgcttactgt ttcttcaatc actgggggga aagactacga tggcctgccc acagtcattt
     3961 gattattttt ccattttgta aataaaaatt ttgtaataaa atagtgacat tcagatacc
//
