LOCUS       NM_001361966            5262 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus hect domain and RLD 3 (Herc3), transcript variant 1,
            mRNA.
ACCESSION   NM_001361966 XM_006506695
VERSION     NM_001361966.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5262)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5262)
  AUTHORS   Zegeye,Y., Aredo,B., Yuksel,S., Kirman,D.C., Kumar,A., Chen,B.,
            Turpin,E., Shresta,S., He,Y.G., Gautron,L., Tang,M., Li,X.,
            DiCesare,S.M., Hulleman,J.D., Xing,C., Ludwig,S., Moresco,E.M.Y.,
            Beutler,B.A. and Ufret-Vincenty,R.L.
  TITLE     E3 ubiquitin ligase Herc3 deficiency leads to accumulation of
            subretinal microglia and retinal neurodegeneration
  JOURNAL   Sci Rep 14 (1), 3010 (2024)
   PUBMED   38321224
  REMARK    GeneRIF: E3 ubiquitin ligase Herc3 deficiency leads to accumulation
            of subretinal microglia and retinal neurodegeneration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5262)
  AUTHORS   Li,X., Wang,X., Chen,C., Zhang,E., Zhang,Y., Li,H., Lei,Y., Lou,Z.
            and Zhang,F.
  TITLE     Accumulation of NCOA1 dependent on HERC3 deficiency transactivates
            matrix metallopeptidases and promotes extracellular matrix
            degradation in intervertebral disc degeneration
  JOURNAL   Life Sci 320, 121555 (2023)
   PUBMED   36878279
  REMARK    GeneRIF: Accumulation of NCOA1 dependent on HERC3 deficiency
            transactivates matrix metallopeptidases and promotes extracellular
            matrix degradation in intervertebral disc degeneration.
REFERENCE   4  (bases 1 to 5262)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5262)
  AUTHORS   Liakath-Ali,K., Vancollie,V.E., Heath,E., Smedley,D.P., Estabel,J.,
            Sunter,D., Ditommaso,T., White,J.K., Ramirez-Solis,R., Smyth,I.,
            Steel,K.P. and Watt,F.M.
  TITLE     Novel skin phenotypes revealed by a genome-wide mouse reverse
            genetic screen
  JOURNAL   Nat Commun 5, 3540 (2014)
   PUBMED   24721909
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5262)
  AUTHORS   Cowley,M., Wood,A.J., Bohm,S., Schulz,R. and Oakey,R.J.
  TITLE     Epigenetic control of alternative mRNA processing at the imprinted
            Herc3/Nap1l5 locus
  JOURNAL   Nucleic Acids Res 40 (18), 8917-8926 (2012)
   PUBMED   22790983
  REMARK    GeneRIF: Allele-specific polyadenylation occurs at the imprinted
            Herc3/Nap1l5 locus.
REFERENCE   7  (bases 1 to 5262)
  AUTHORS   Karp,N.A., Baker,L.A., Gerdin,A.K., Adams,N.C., Ramirez-Solis,R.
            and White,J.K.
  TITLE     Optimising experimental design for high-throughput phenotyping in
            mice: a case study
  JOURNAL   Mamm Genome 21 (9-10), 467-476 (2010)
   PUBMED   20799038
REFERENCE   8  (bases 1 to 5262)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115881.8 and AC166819.2.
            
            On Mar 31, 2018 this sequence version replaced XM_006506695.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219379.52611.1,
                                           SRR1660813.239638.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-468               AC115881.8         78394-78861         c
            469-603             AC115881.8         77790-77924         c
            604-858             AC115881.8         66468-66722         c
            859-1018            AC115881.8         55294-55453         c
            1019-1095           AC115881.8         54512-54588         c
            1096-1317           AC115881.8         53512-53733         c
            1318-1409           AC115881.8         52540-52631         c
            1410-1540           AC115881.8         51243-51373         c
            1541-1701           AC115881.8         49914-50074         c
            1702-1778           AC115881.8         47277-47353         c
            1779-1903           AC115881.8         41560-41684         c
            1904-1963           AC115881.8         40113-40172         c
            1964-2075           AC166819.2         195708-195819       c
            2076-2265           AC166819.2         195153-195342       c
            2266-2429           AC166819.2         192901-193064       c
            2430-2543           AC166819.2         192672-192785       c
            2544-2567           AC166819.2         184580-184603       c
            2568-2657           AC166819.2         184396-184485       c
            2658-2828           AC166819.2         181975-182145       c
            2829-2972           AC166819.2         180790-180933       c
            2973-3139           AC166819.2         179319-179485       c
            3140-3206           AC166819.2         175439-175505       c
            3207-3289           AC166819.2         174929-175011       c
            3290-3473           AC166819.2         152958-153141       c
            3474-3576           AC166819.2         152669-152771       c
            3577-5262           AC166819.2         149155-150840       c
FEATURES             Location/Qualifiers
     source          1..5262
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.82 cM"
     gene            1..5262
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /note="hect domain and RLD 3"
                     /db_xref="GeneID:73998"
                     /db_xref="MGI:MGI:1921248"
     exon            1..468
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            469..603
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            604..858
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     CDS             633..3785
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /EC_number="2.3.2.26"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase HERC3
                     isoform a"
                     /protein_id="NP_001348895.1"
                     /db_xref="CCDS:CCDS20196.1"
                     /db_xref="GeneID:73998"
                     /db_xref="MGI:MGI:1921248"
                     /translation="MLCWGYWSLGQPGISSNLQGIVAEPQVCRFVSDRSIKEVACGGN
                     HSVFLLEDGEVYTCGVNTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDR
                     GQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFT
                     WGKNSHGQLGLGKEFPSQTSPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNN
                     AGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGH
                     DSVNDEVNPRRVLELMGSEVTQIACGRQHTLALVPSSGLIYAFGCGAKGQLGTGHTCN
                     VKCPSPVKGHWAAHSSQLSARADRFKYRVVKQIFSGGDQTFVLCSTYENSSPAVDFRT
                     VNQTHYTNLINDETIAVWRQKLTEHNNANTVNGVVQILSSAACWNGSFLEKKIDEHFK
                     TSPKIPGIDLNSTRILFEKLMHSQHSMILEQILNSFESCLIPQLSSSPPDVEAMRIYL
                     ILPEFPLLQDSKYYITLTIPLAMAILRLETNPSKVLDNWWSQACPKYFMKLVTLYKGA
                     VLYLLRGRKTFLIPVLFNNYMTATLKLLEKLYKVNLKVKHVEYDKFYIPEISSLVDIQ
                     EDYLMWFLHQSGMKARPSIMQDAVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGAN
                     LQNVFMLLTLEPLLARSPFLVLHVRRNHLVGDALRELSIHSDIDLKKPLKVIFDGEEG
                     VDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEHNWFHLIGITCGLA
                     IYNSTVVDLHFPLALYKKLLNVKPSLEDLKELSPTEGRSLQELLDYPGEDIEETFCLN
                     FTVCRESYGVIEQKKLIPGGDRVAVCKDNRQEFVDAYVNYIFQISVHEWYTAFSSGFL
                     KVCGGKVLELFQPAELRAMMVGNSNYDWEELEETAVYRGDYSSTHPTVKLFWETFHEF
                     PLEKKKKFLLFLTGSDRIPIYGMASLQIIIQSTATGEEYLPVAHTCYNLLDLPKYSSK
                     EIMKARLTQALDNYEGFSLA"
     exon            859..1018
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1095
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1317
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1409
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1540
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1701
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1778
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1903
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..1963
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2075
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2265
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2429
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..2543
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2567
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2657
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2828
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            2829..2972
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3139
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..3206
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            3207..3289
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            3290..3473
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            3474..3576
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     exon            3577..5262
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5237..5242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /note="hexamer: AATAAA"
     polyA_site      5262
                     /gene="Herc3"
                     /gene_synonym="5730409F18Rik; mKIAA0032"
                     /note="major polyA site"
ORIGIN      
        1 gcgccccgcc ccgctgccgc cgccaccatt ggccaggcgg gaagtcggtc tcccagctca
       61 ttctgcgccc gcgggagtgc gggggaaact tcattattac tgtgacgctg aaggccgggg
      121 aggcccgagc tgcctgaggg ctgcgaccgc ggggtcggcg ctgcggaccc gggtgcaggt
      181 gcgggcgggg cggggatctc agggcaccga gcccgccgca cccgcggagg agggggctgg
      241 gctgtccgca gctccctgtc gccgaggcgc ctcccggctc tgcttagccg cttagccgcg
      301 ggcggcgggt gacctccctg cgtgaagagc atcgcggcgc cgcggcaggg gaattcgcgt
      361 tgcggctggc cgcgggctcc tcccacccag ctggcgggcg gggctcgggg acctggtgtc
      421 tggtgcagac gccgctgcgg ccgagccgac ggctggaccc tggagcagaa aaacaaaatc
      481 ggtggcttac tccagttttg accccatctg agaagttaaa ctgcaggaat caaattagat
      541 gcaaaactcc tttgtcgtga aaaatagaag catggttcac tgttagccag ttggacttgt
      601 tcagctatat gagaccctga aggataagaa caatgttatg ttgggggtat tggtctctgg
      661 gccaaccagg catcagctcc aacctgcaag gaatcgtggc tgagccccag gtgtgccgct
      721 ttgtatcgga cagaagcatc aaggaagtgg cgtgcggagg aaaccactcc gtgttcctgc
      781 tggaggacgg ggaggtttac acgtgtggag taaacaccaa ggggcagctt ggccatgaga
      841 gggaaggtaa caagccagaa caaattggag cattagctga tcagcatatc atacacgtgg
      901 catgtggcga gtcacacagt ctggctctca gtgaccgggg tcagctgttt tcttggggtg
      961 caggaagtga tggccaactg ggcctcatga ctactgagga ttccgtggct gtgcccaggc
     1021 taatccagaa actgaaccag cagaccatat tacaagtttc ctgtggcaac tggcactgct
     1081 tggctctggc agctgatggc cagttcttca catgggggaa gaacagccat ggacagctgg
     1141 gactggggaa ggagttcccc tcccaaacca gcccacagag ggtgagatct ttggaaggga
     1201 tcccgctggc tcaggtggct gcaggagggg ctcatagctt tgccctgtct ctctcgggag
     1261 ctgtttttgg ctggggaatg aataatgcag ggcagctagg gctcagtgat gaaaaagacc
     1321 gggagtctcc atgccacgtg aagcttttac gcacacagaa agtcgtctat attagttgtg
     1381 gagaggagca cacagcagtt ctcacaaaga gtgggggcgt gtttaccttt ggtgctggct
     1441 cctgtgggca gcttggacat gactcggtga atgatgaagt taatccgaga agagtcctgg
     1501 agctgatggg cagtgaagta actcagattg cttgtggcag acagcacact ctagcccttg
     1561 tgccttcttc tggactcatc tatgcatttg gttgtggagc taaaggtcag ctgggaaccg
     1621 gacatacatg taatgtcaag tgcccatctc ctgtgaaggg ccactgggct gcccacagca
     1681 gtcagctttc agctcgcgcc gatcgcttta agtatcgtgt cgttaagcag atcttctctg
     1741 gaggggacca gacttttgta ctttgctcca cgtatgagaa ttcttctcct gctgttgact
     1801 tcagaactgt gaaccaaaca cattatacca acttaataaa tgatgaaacc atagcagttt
     1861 ggagacaaaa actcacagaa cacaacaacg caaatactgt caatggtgtt gttcagatac
     1921 tgtcttctgc agcttgttgg aatggaagct ttctggaaaa aaaaattgat gaacatttta
     1981 aaactagtcc caaaatcccc gggattgacc tgaactcaac taggatttta tttgagaagt
     2041 taatgcactc tcagcactcc atgattctag aacagatatt aaacagcttt gaaagttgcc
     2101 tcattcccca gttatcaagt tcacccccag atgtggaagc aatgagaatc tatttaatcc
     2161 taccggagtt tccgctgctt caggactcta agtattacat aacgctgacc attcccctgg
     2221 caatggccat tctgcggctg gaaacaaacc ctagcaaagt attagataac tggtggtctc
     2281 aggcatgccc caaatatttc atgaagctgg taaccctgta taaaggtgcc gtcctttacc
     2341 tcctaagggg aaggaagaca ttcctaatcc cggtactgtt taacaactac atgactgcaa
     2401 ccctcaagct tctggagaag ttgtacaagg taaatcttaa ggtgaagcat gtggaatacg
     2461 ataagtttta tatccctgag atttctagtc ttgtggacat tcaggaagac tacctcatgt
     2521 ggtttttgca tcaatctggg atgaaggcta gaccctctat catgcaggat gctgtaaccc
     2581 tttgttccta tcctttcatc tttgatgccc aagctaagac caagatgctg cagactgatg
     2641 ccgagttaca gatgcaggtg gcagtcaatg gagccaacct gcagaatgtc ttcatgcttc
     2701 ttaccctgga gcctctgctg gccagaagcc ccttcctggt cctccatgtc cgtaggaacc
     2761 accttgttgg agatgccctg agagagctga gcattcactc tgacattgac ttgaagaagc
     2821 ctctcaaagt aatctttgat ggggaagaag gagtagatgc tggtggtgtt acgaaggagt
     2881 tctttctttt gctattaaaa gaacttttga atcccattta tgggatgttt acctactatc
     2941 aagattcaaa tctcttgtgg ttttcagata catgttttgt agagcacaac tggtttcact
     3001 tgattggcat aacctgtgga ttagctatct acaactccac tgtggttgac ctccacttcc
     3061 cgttggctct ctacaagaag ttactgaatg taaagcccag cttggaagat ttgaaggaac
     3121 tgtcaccaac tgaaggaagg agtcttcaag agcttctaga ttaccccggt gaagacatcg
     3181 aggagacctt ttgcctcaac ttcacggtgt gccgagaaag ctatggggtg atagaacaga
     3241 agaagttgat acccggggga gacagagtgg ccgtgtgcaa agacaacagg caagaattcg
     3301 tggacgctta tgtgaattac atcttccaaa tttcggttca cgagtggtac acagccttct
     3361 ccagtggctt cctaaaggtg tgtggtggca aagtcctcga gctcttccag cctgcagaac
     3421 tgagggccat gatggtgggg aacagcaact atgactggga agagctggaa gagactgctg
     3481 tctacagggg tgattattca agcacacatc ccactgtgaa actcttctgg gagacattcc
     3541 acgagttccc attggagaag aagaagaagt ttcttttgtt cctaacaggc agtgaccgga
     3601 ttcccatcta tggcatggcc agtcttcaga tcatcatcca gtccacagcc actggggagg
     3661 aatacttacc cgtggcccat acctgctaca accttcttga cctccctaag tatagcagca
     3721 aagagatcat gaaggctcgg ctgacccagg ccctcgacaa ctatgagggt tttagtttgg
     3781 cctgaggtac cccagcttac ctaagacatc catcccttcc ttcttctgtg gccacattga
     3841 ggctgaataa aataccatgg gaagtgattt ctattttttt attgtttaag tggtttgaaa
     3901 cttttgaatc ctaaacccta gtcaaggtgt ttctggggtt caatagtgaa tagtctttct
     3961 gaaaaaatca gtggttgggg atgagccaaa aaaaaaattg gctttggtat gggaagtgga
     4021 cttgattttg ttttgttttg ttttgtttta aaccgaggta cctgttgttc cttcatctgt
     4081 gaatgtgttg caatctgctg gatttaatgg cagtaggttt tcagcttttg tttcccagat
     4141 gtccctcagt cctgatgttt cttcaccatg ctttgctgct ctcttcctgg cctctcagtc
     4201 cctacagggg tgacttgatg gatatgtccc ttcttgcccg ccatgcagaa catttcctac
     4261 tcctcagcac tggaaatgca tggcttgttg cagcccagcc cagcccacag atggaactcc
     4321 caagacaaag aagctgagcc ttgtcatagc tcttgagtct ttgtgggaac ctttatgaac
     4381 atgtcctgct ttaaggaaat aggtcatgag tgcctactgc ctgggcctcc tgaaacacac
     4441 atacacaaga gccgcaggtt gcaggcgggc tgcatgtgtc ttgttagcca tgacccgtgg
     4501 atttacagtg aattggtaga ccttctttat catacttttg aaatgcaagt tgcattttct
     4561 tgtttccata ttgcctaaga acagtacaat taataaaggt ttccccttct ttattccttt
     4621 ctagctcctg ctctcttcct tccctttctt cttgtgctcc cctctcctcc cttcctcttg
     4681 ctctcctact cttccttgtc tttgctgctt gactccgttc ccctcttcct tctggtagtg
     4741 gatgcatgct gtctttttta ttttaaattt tgtaagtttt tttttaaacc tctgtctcta
     4801 actgtgaaaa tatgaagata ctctttataa tagagttttt gttttatcac atgtgaagtg
     4861 tgcatttaca gtgaaatttc agcaggggga ttatgttaag tcaaatgcgt gtgtctcaaa
     4921 agtgacatgt ttaactgctc atcactgtat aagaaaattc tacatggtca aagagttcat
     4981 gtaattctaa ttttaaatct gtagtagata gagaaagtat ttatttatct aaaatgaagt
     5041 acttatagat tgtgatgcag caccgagtct tgatgaagga atgtagattt ttgcttttcc
     5101 tgtttttgtt ttgaaaagtt actccaattg ctaaattggt agtttttttg tccttataaa
     5161 tataacattt aaaaaagata cacaattata taaaatgttt attttctatg tgtctgcata
     5221 tagttcaata ttatccaata aatttggtgt tttaacttaa aa
//
