LOCUS       NM_145617              15229 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus HECT and RLD domain containing E3 ubiquitin protein
            ligase family member 1 (Herc1), mRNA.
ACCESSION   NM_145617 XM_001477062 XM_918072
VERSION     NM_145617.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 15229)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 15229)
  AUTHORS   Pedrazza,L., Martinez-Martinez,A., Sanchez-de-Diego,C., Valer,J.A.,
            Pimenta-Lopes,C., Sala-Gaston,J., Szpak,M., Tyler-Smith,C.,
            Ventura,F. and Rosa,J.L.
  TITLE     HERC1 deficiency causes osteopenia through transcriptional program
            dysregulation during bone remodeling
  JOURNAL   Cell Death Dis 14 (1), 17 (2023)
   PUBMED   36635269
  REMARK    GeneRIF: HERC1 deficiency causes osteopenia through transcriptional
            program dysregulation during bone remodeling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 15229)
  AUTHORS   Lalonde,R. and Strazielle,C.
  TITLE     The Herc1 gene in neurobiology
  JOURNAL   Gene 814, 146144 (2022)
   PUBMED   34990797
  REMARK    GeneRIF: The Herc1 gene in neurobiology.
            Review article
REFERENCE   4  (bases 1 to 15229)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 15229)
  AUTHORS   Butterfield,N.C., Curry,K.F., Steinberg,J., Dewhurst,H.,
            Komla-Ebri,D., Mannan,N.S., Adoum,A.T., Leitch,V.D., Logan,J.G.,
            Waung,J.A., Ghirardello,E., Southam,L., Youlten,S.E.,
            Wilkinson,J.M., McAninch,E.A., Vancollie,V.E., Kussy,F.,
            White,J.K., Lelliott,C.J., Adams,D.J., Jacques,R., Bianco,A.C.,
            Boyde,A., Zeggini,E., Croucher,P.I., Williams,G.R. and
            Bassett,J.H.D.
  TITLE     Accelerating functional gene discovery in osteoarthritis
  JOURNAL   Nat Commun 12 (1), 467 (2021)
   PUBMED   33473114
  REMARK    Erratum:[Nat Commun. 2021 May 28;12(1):3302. PMID: 34050183]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 15229)
  AUTHORS   Hochrainer,K., Mayer,H., Baranyi,U., Binder,B., Lipp,J. and
            Kroismayr,R.
  TITLE     The human HERC family of ubiquitin ligases: novel members, genomic
            organization, expression profiling, and evolutionary aspects
  JOURNAL   Genomics 85 (2), 153-164 (2005)
   PUBMED   15676274
REFERENCE   7  (bases 1 to 15229)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 15229)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 15229)
  AUTHORS   Rossi,F., Jankovski,A. and Sotelo,C.
  TITLE     Target neuron controls the integrity of afferent axon phenotype: a
            study on the Purkinje cell-climbing fiber system in cerebellar
            mutant mice
  JOURNAL   J Neurosci 15 (3 Pt 1), 2040-2056 (1995)
   PUBMED   7891151
REFERENCE   10 (bases 1 to 15229)
  AUTHORS   Wassef,M., Sotelo,C., Cholley,B., Brehier,A. and Thomasset,M.
  TITLE     Cerebellar mutations affecting the postnatal survival of Purkinje
            cells in the mouse disclose a longitudinal pattern of
            differentially sensitive cells
  JOURNAL   Dev Biol 124 (2), 379-389 (1987)
   PUBMED   3678603
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161382.4 and AC166755.2.
            
            On or before Sep 9, 2009 this sequence version replaced
            XM_918072.2, XM_001477062.1, NM_145617.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849383,
                              SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               AC161382.4         66592-66763
            173-1128            AC161382.4         87928-88883
            1129-1224           AC161382.4         92459-92554
            1225-1419           AC161382.4         101135-101329
            1420-1731           AC161382.4         102741-103052
            1732-1828           AC161382.4         104303-104399
            1829-1972           AC161382.4         104897-105040
            1973-2100           AC161382.4         107502-107629
            2101-2245           AC161382.4         110802-110946
            2246-2417           AC161382.4         111070-111241
            2418-2552           AC161382.4         112778-112912
            2553-2718           AC161382.4         113395-113560
            2719-2844           AC161382.4         113980-114105
            2845-3066           AC161382.4         115400-115621
            3067-3219           AC161382.4         115910-116062
            3220-3352           AC161382.4         116189-116321
            3353-3544           AC161382.4         118666-118857
            3545-3766           AC161382.4         124126-124347
            3767-3940           AC161382.4         127158-127331
            3941-4055           AC161382.4         130217-130331
            4056-4176           AC161382.4         130421-130541
            4177-4348           AC161382.4         132326-132497
            4349-4661           AC161382.4         134538-134850
            4662-4782           AC161382.4         135271-135391
            4783-4834           AC161382.4         137139-137190
            4835-5103           AC161382.4         144953-145221
            5104-5319           AC161382.4         149418-149633
            5320-5440           AC161382.4         149866-149986
            5441-5678           AC161382.4         150208-150445
            5679-5866           AC161382.4         150553-150740
            5867-6022           AC161382.4         153737-153892
            6023-6129           AC161382.4         155320-155426
            6130-6240           AC161382.4         155938-156048
            6241-6417           AC161382.4         158045-158221
            6418-6657           AC161382.4         161595-161834
            6658-6741           AC161382.4         162227-162310
            6742-7262           AC161382.4         164154-164674
            7263-8038           AC161382.4         166845-167620
            8039-8237           AC166755.2         118685-118883       c
            8238-8398           AC166755.2         116124-116284       c
            8399-8515           AC166755.2         114667-114783       c
            8516-8747           AC166755.2         113795-114026       c
            8748-8872           AC166755.2         111688-111812       c
            8873-9093           AC166755.2         110300-110520       c
            9094-9362           AC166755.2         109123-109391       c
            9363-9415           AC166755.2         107462-107514       c
            9416-9616           AC166755.2         106639-106839       c
            9617-9791           AC166755.2         105547-105721       c
            9792-10062          AC166755.2         104567-104837       c
            10063-10276         AC166755.2         104247-104460       c
            10277-10482         AC166755.2         103037-103242       c
            10483-10610         AC166755.2         101855-101982       c
            10611-10738         AC166755.2         100247-100374       c
            10739-10939         AC166755.2         98637-98837         c
            10940-11070         AC166755.2         97356-97486         c
            11071-11270         AC166755.2         96100-96299         c
            11271-11376         AC166755.2         95787-95892         c
            11377-11523         AC166755.2         93129-93275         c
            11524-11625         AC166755.2         92688-92789         c
            11626-11799         AC166755.2         91185-91358         c
            11800-12093         AC166755.2         90123-90416         c
            12094-12159         AC166755.2         88498-88563         c
            12160-12285         AC166755.2         88217-88342         c
            12286-12424         AC166755.2         87183-87321         c
            12425-12606         AC166755.2         85972-86153         c
            12607-12762         AC166755.2         85141-85296         c
            12763-12885         AC166755.2         84149-84271         c
            12886-12988         AC166755.2         82788-82890         c
            12989-13158         AC166755.2         80093-80262         c
            13159-13297         AC166755.2         78926-79064         c
            13298-13467         AC166755.2         76151-76320         c
            13468-13637         AC166755.2         74882-75051         c
            13638-13803         AC166755.2         74466-74631         c
            13804-13880         AC166755.2         73464-73540         c
            13881-14133         AC166755.2         70792-71044         c
            14134-14286         AC166755.2         70138-70290         c
            14287-14592         AC166755.2         67327-67632         c
            14593-15229         AC166755.2         63445-64081         c
FEATURES             Location/Qualifiers
     source          1..15229
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 35.86 cM"
     gene            1..15229
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /note="HECT and RLD domain containing E3 ubiquitin protein
                     ligase family member 1"
                     /db_xref="GeneID:235439"
                     /db_xref="MGI:MGI:2384589"
     exon            1..172
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            173..1128
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..14778
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /EC_number="2.3.2.26"
                     /note="hect (homologous to the E6-AP (UBE3A) carboxyl
                     terminus) domain and RCC1 (CHC1)-like domain (RLD) 1"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase HERC1"
                     /protein_id="NP_663592.3"
                     /db_xref="CCDS:CCDS52840.1"
                     /db_xref="GeneID:235439"
                     /db_xref="MGI:MGI:2384589"
                     /translation="MATMVPPVKLKWLEHLNSSWITEDSESIATREGVTVLYSKLISN
                     KEVVPLPQQVLCLKGPQLPDFERESLSSDEQDHYLDALLSSQLALAKMVCSDSPFAGA
                     LRKRLLVLQRVFYALSNKYHDKGKVKQQQHSPESSSGSADVHSVSERPRSSTDALIEM
                     GVRTGLSLLFALLRQSWMMPVSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKIPPMG
                     LDCLSQVTTFLKGVTIPNSGADTLGRRLASELLLGLAAQRGSLRYLLEWIEMALGASA
                     VVYTMEKNKLLSSQEGMISFDCFMAILMQMRRSLGSSADRSQWREPTRTSEGLCSLYE
                     AALCLFEEVCRMASDYSRTCASPDSIQTGDAPIVSETCEVYVWGSNSSHQLVEGTQEK
                     ILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLT
                     FEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPL
                     QGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEV
                     SCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQ
                     SSLALTSTGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVDISIGDSHCLSLSH
                     DNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWTALPRDR
                     QVVAWHRPYCVDLEESTFSHLRSFLERYCDKINSEIPPLPFPSSREHHNFLKLCLKLL
                     SNHLALALAGGVATSILGRQAGPLRNLLFRLMDSTVPDEIQEVVIETLSVGATMLLPP
                     LRERMELLHSLLPQGPDRWESLSKGQRMQLDIILTSLQDHTHVASLLGYSSPSDAADL
                     STVCMGYGNLSDQPYGSQICHPDTHLAEILMKTLLRNLGFYTDQAFGELEKNSDKYLL
                     GTSSSENSQPAHLHELLCSLQKQLLAFCHINNVTENSSSVALLHKHLQLLLPHATDIY
                     SRSANLLKESPWNGSVGEKLRDVIYVSAAGSMLCQIVNSLLLLPVSVARPLLSYLLDL
                     LPPLDCLNRLLPAAALLEDQELQWPLHGGPEVIDPAGVPLPQPAQSWVWLVDLERTIA
                     LLIGRCLGGMLQGSPVSPEEQDTAYWMKTPLFSDGVEMDTPQLDKCMSCLLEVALSGN
                     EEQKPFDYKLRPEVAVYVDLALGCSKEPARSLWISMQDYAVSKDWDSATLSNESLLDT
                     VSRFVLAALLKHTNLLSQACGESRYQPGKSLSEVYRCVYKVRSRLLACKNLELIQTRS
                     SSRDRWITDNQDSADVDPQEHSFTRTIDEEAEMEELAERDREDGHPEPEDEEEEREHE
                     VMTAGKIFQCFLSAREVARSRDRDRMNSGAGSGVRADDPPPQSQQERRVSTDLPEGQD
                     VYTAACNSVIHRCALLILGVSPVIDELQKRREEGQLQQPSVSASEGTGLMTRSESLTA
                     ESRLVHASPSYRLIKSRSESDLSQPESDEEGYALSGRRNVDFDLASSHRKRGPMHSQL
                     ESLSDSWTRLKHTRDWFYNSSYSFESDFDLTKSLGVHTLIENVVSFVSGDVGNAPGFK
                     EPEESMSTSPQASIIAMEQQQLRAELRLEALHQILTLLSGMEEKGNVLLTGSRSSSGF
                     QSSTLLTSVRLQFLAGCFGLGTVGHTGTKGESGRLHHYQDGIRAAKRNIQVEIQVAVH
                     KIYQQLSATLERALQANKHHIEAQQRLLLVTVFALSVHYQPVDVSLAISTGLLNVLSQ
                     LCGTDTMLGQPLQLLPKTGVSQLSTALKVASTRLLQILAITTGTYADKLSPKVVQSLL
                     DLLCSQLKNLLSQTGVLFMASFGEGEEGEEEEKKVDSSGEAEKRDFRAALRKQHAAEL
                     HLGDFLVFLRRVVSSKAIQSKMASPKWTEVLLNIASQKCSSGIPLVGNLRTRLLALHV
                     LEAVLPACESGVEDDQMAQVVERLFSLLSDCMWETPIAQAKHAIQIKEKEQEIKLQKQ
                     GELEEEDENLPIQEVSFDPEKAQCCIVENGQILTHGSGGKGYGLASTGVTSGCYQWKF
                     YIVKENRGNEGTCVGVSRWPVHDFNHRTTSDMWLYRAYSGNLYHNGEQTLTLSSFTQG
                     DFITCVLDMEARTISFGKNGEEPKLAFEDVDAAELYPCVMFYSSNPGEKVKICDMQMR
                     GTPRDLLPGDPICSPVAAVLAEATIQLIRILHRTDRWTYCINKKMMERLHKIKICIKE
                     SGQKLKKSRSVQSREENEMREEKENKEEEKGKHNRHGLADLSEPQLRTLCIEVWPVLA
                     VIGGVDAGLRVGGRCVHKQTGRHATLLGVVKEGSTSAKVQWDEAEITISFPTFWSPSD
                     TPLYNLEPCEPLLFDVARFRGLTASVLLDLTYLTGIHEDVGKQSIKRHEKKHRHESEE
                     KGDIEQKPESESILDVRTGLMSDDVKSQGTTSSKSENEIASFSLEPTLPGVESQHQIT
                     EGKRKNHEHISKTHDIAQSEIRAVQLSYLYLGAMKSLSALLGCSKYAELLLIPKVLAE
                     NGHNSDCASSPVVHEDVEMRAALQFLMRHMVKRAVMRSPIKRALGLADLERAQAMIYK
                     LVVHGLLEDQFGGKIKQEIDQQAEESDQAQQAQTPVTTSPSASSTTSFMSSSLEDTTT
                     ATTPVTDTETVPASESPGVMPLSLLRQMFSSYPTTTVLPTRRAQTPPISSLPASPSDE
                     VGRRQSLTSPDSQSTRPANRTALSDPSSRLSTSPPPPAIAVPLLEMGFSLRQIAKAME
                     ATGARGEADAQSITVLAMWMIEHPGHEDEEEPQPSSTADSRHGATVLGSGGKSNDPCY
                     LQSPGDIPSADAAEMEEGFSESPDNLDHTENAASGSGPPTRGRSTVTRRHKFDLAART
                     LLARAAGLYRSVQAHRNQSRREGISLQQDPGALYDFNLDEELEIDLDDEAMEAMFGQD
                     LTSDNDILGMWIPEVLDWPTWHVCESEDREEVVVCELCECNVVSFNQHMKRNHPGCGR
                     SANRQGYRSNGSYVDGWFGGECGSGNPYYLLCGSCREKYLALKTKTKTTNSERYKGQA
                     PDLIGKQDSVYEEDWDMLDVDEDEKLTGEEEFELLAGPLGLNDRRIVPEPVQFPDSDP
                     LGASVAMVTATNSMEETLMQIGCHGSVEKSSSGRVTLGEQAAALANPHDRVVALRRVT
                     AAAQVLLARTMVMRALSLLSVSGSSCSLAAGLESLGLTDIRTLVRLMCLAAAGRAGLS
                     TSPSAIASTSERSRGGHSKASKPISCLAYLSTAVGCLASNTPSAAKLLVQLCTQNLIS
                     AATGVNLTTVDDPIQRKFLPSFLRGIAEENKLVTSPNFVVTQALVALLADKGAKLRPN
                     YDKTEIEKKGPLELANALAACCLSSRLSSQHRQWAAQQLVRTLAAHDRDNQTAPQTLA
                     DMGGDLRKCSFIKLEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWNVTKKQYSLQQTC
                     VFNRLEGDAEESLGSPSDPSFSPVSWSISGKYLAGALEKMVNIWQVNGGKGLVDIQPH
                     WVSALAWPEEGPATTWSGESPELLLVGRMDGSLGLIEVVDVSTMHRRELEHCYRKDVS
                     VTCIAWFSEDRPFAVGYFDGKLLMGTKEPLEKGGIVLIDAHKETLVSMKWDPTGHILM
                     TCAKEENVKLWGPVSGCWRCLHSLCHPSTVNGIAWCSLPGKGSKMQLLMATGCQNGLV
                     CVWRIPQDTTQTSMTSSEGWWDQESNCQDGYRKSAGAKCVYQLRGHITPVRTVAFSSD
                     GLALVSGGLGGLMNIWSLRDGSVLQTVVIGSGAIQTTVWIPEVGVAACSNRSKDVLVV
                     NCTAEWASANHILATCRTALKQQGVLGLNMAPCMRAFLERLPMMLQEQYAYEKPHVVC
                     GDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPTSWNPNEWAWLECFST
                     TIKAAEALTNGAQFPESFTVPDLEPVPEDELVLLMDNSKWINGMDEQIMSWATSRPED
                     WHLGGKCDVYLWGAGRHGQLAEAGRNVMVPATAPSFSQAQQVICGQNCTFVIQANGTV
                     LACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSW
                     GDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYG
                     RLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLG
                     NSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHN
                     RPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVT
                     VLQGKNIRQISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDAVPPQYGALREVSIHT
                     VRARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYTL
                     PMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAW
                     KVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSA
                     CLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQT
                     LNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVER
                     AIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEICVDVLKKVVRY
                     REVDEQHQLVQWLWRTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPY
                     DSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMDNYMLSRNVDNAEGSDTD
                     Y"
     exon            1129..1224
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1419
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1731
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1828
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1972
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2100
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2245
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2417
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2552
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2718
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2844
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..3066
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            3067..3219
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            3220..3352
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            3353..3544
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            3545..3766
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            3767..3940
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            3941..4055
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            4056..4176
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            4177..4348
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            4349..4661
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            4662..4782
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            4783..4834
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            4835..5103
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            5104..5319
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            5320..5440
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            5441..5678
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            5679..5866
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            5867..6022
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            6023..6129
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            6130..6240
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            6241..6417
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            6418..6657
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            6658..6741
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            6742..7262
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            7263..8038
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            8039..8237
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            8238..8398
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            8399..8515
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            8516..8747
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            8748..8872
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            8873..9093
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            9094..9362
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            9363..9415
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            9416..9616
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            9617..9791
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            9792..10062
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            10063..10276
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            10277..10482
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            10483..10610
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            10611..10738
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            10739..10939
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            10940..11070
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            11071..11270
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            11271..11376
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            11377..11523
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            11524..11625
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            11626..11799
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            11800..12093
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            12094..12159
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            12160..12285
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            12286..12424
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            12425..12606
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            12607..12762
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            12763..12885
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            12886..12988
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            12989..13158
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            13159..13297
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            13298..13467
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            13468..13637
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            13638..13803
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            13804..13880
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            13881..14133
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            14134..14286
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            14287..14592
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     exon            14593..15229
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      15206..15211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /note="hexamer: AATAAA"
     polyA_site      15229
                     /gene="Herc1"
                     /gene_synonym="2810449H11Rik; B230218H07; D130015N03Rik;
                     tbl"
                     /note="major polyA site"
ORIGIN      
        1 gctgccgccg tcgctgccgc cgctgccgcc gccgcctctt acgtctttcc ctttgacaag
       61 tcgccgccgc tgcagcaaaa atataaagga cgcggctagc gcggccgctg gccagccggg
      121 tgccgggtgc tggagccgca ccccatcgcc gccagctccc gacccacgta cgaactaatg
      181 gctgaagagt aaatcaacat ggcgactatg gttccaccag tgaaactgaa atggcttgaa
      241 catctgaata gctcctggat cacagaggac agtgaatcta ttgctacaag agagggagtt
      301 accgttttgt attctaaact gatcagcaat aaggaagtag tacctttgcc tcaacaggtt
      361 ttatgcctca aaggaccaca gttgcctgat tttgaacgtg agtctctttc aagtgatgag
      421 caggaccatt atttggatgc ccttcttagc agccagctag cactagcaaa gatggtatgt
      481 tcagattctc catttgctgg ggcgctaaga aaacgactgc ttgtactcca acgtgtcttt
      541 tatgcacttt ctaataagta ccatgacaaa ggcaaagtga aacagcagca gcattctccg
      601 gagagcagct ctggttcagc agatgtccat tctgtcagtg aacgcccccg gtcaagcact
      661 gatgcactta tagaaatggg tgtccgaact ggtctaagtt tgttatttgc acttctgaga
      721 cagagttgga tgatgcctgt gtcgggacct ggcctcagtc tctgcaacga cgttattcat
      781 actgcaattg aagttgtgag ctctttgcct ccattgtctt tagcaaatga aagcaagatt
      841 cctcctatgg gcttggactg cttatcacaa gtcacaacat ttcttaaagg agtaactatt
      901 cccaattctg gggcagacac tttaggtcgt cgattagctt ctgagttgct gcttggctta
      961 gcagctcaga gaggctcttt gagatacctt cttgaatgga tagaaatggc tttgggggct
     1021 tcagcagttg tatatactat ggagaaaaac aaactactgt caagccagga aggaatgatc
     1081 agctttgact gctttatggc tatattaatg cagatgaggc gatctttggg ttcatctgct
     1141 gatcggagtc agtggagaga accaactaga acatctgaag gcttatgttc actctatgag
     1201 gcagcattat gtctttttga agaggtttgc agaatggctt ctgactattc aagaacatgt
     1261 gctagcccag atagcattca gactggtgat gctcccattg tttctgaaac ctgtgaggta
     1321 tatgtttggg gcagcaacag cagccatcag ttggtagaag gcacacagga gaaaatacta
     1381 caacccaaac tggctcctag tttctctgat gctcagacca ttgaagctgg acagtattgc
     1441 acttttgtca tttctacaga tggctctgtc agagcttgtg gtaaaggcag ctatgggaga
     1501 ctgggcctcg gagattccaa taatcagtct accttaaaaa agttaacttt tgagcctcac
     1561 cggtctatta agaaagtttc atcatctaaa ggctctgatg gtcacacttt agcttttact
     1621 acagaaggtg aagtcttcag ctggggagat ggtgactatg ggaaactagg acatgggaat
     1681 agttcaaccc agaaataccc caagcttatc cagggcccac tacagggaaa ggtagtagtt
     1741 tgtgtatcag ctggatacag acatagtgct gctgtcacag aggatggtga attatatact
     1801 tggggtgaag gagacttcgg aagattaggt catggtgaca gtaacagccg taacattcca
     1861 acattagtaa aagacattag caatgtagga gaggtttctt gtggaagttc acatacgatt
     1921 gctttgtcca aagatggaag aactgtgtgg tcttttggag gaggtgacaa tggcaaactt
     1981 ggccatggtg ataccaacag agtatataaa cctaaagtta ttgaagcttt acaaggaatg
     2041 tttattcgca aagtctgtgc tgggagccaa tcttcacttg ctttgacatc aacagggcag
     2101 gtttatgctt ggggctgtgg ggcttgtcta ggttgtggtt cttcagaagc tactgctttg
     2161 agacccaagc tcattgaaga attggctgcc acaagaatag ttgatatttc aattggagat
     2221 agtcattgtt tgtctctttc tcatgataat gaagtttatg cctggggcaa taactccatg
     2281 ggacaatgtg gccagggaaa ttcaacaggt cctattacta aaccaaagaa agtgagtggc
     2341 ttagatggca tagctattca gcagatctca gctggaacat cacatagttt ggcatggact
     2401 gctctcccta gggacagaca agttgttgca tggcacaggc cttattgtgt agatcttgaa
     2461 gagagtacct tctcacatct gcgatctttt cttgagagat actgtgataa aataaacagt
     2521 gagattcccc cactgccttt cccttcatca agggaacacc ataattttct taagctgtgc
     2581 ctgaagttgc tttcaaatca ccttgctctg gccctggcgg gaggggtagc taccagtatt
     2641 cttgggagac aggcaggtcc acttcgaaat ttgctcttca ggctgatgga ttcaactgtc
     2701 ccagatgaaa tccaagaggt ggtaattgaa acactctcag ttggagcaac catgctgtta
     2761 cctccattaa gagaacggat ggaattactt cattctcttt taccccaagg acctgataga
     2821 tgggaaagct tatccaaagg acagagaatg caactggata taattctgac aagtttacaa
     2881 gatcataccc atgtagcctc ccttcttggc tatagctcac cttccgatgc tgctgacctt
     2941 tcgactgtgt gcatgggata tggaaacctg tcagaccaac catatggttc tcagatctgc
     3001 catccagaca ctcatctggc cgaaatttta atgaagactc tcttaagaaa tttagggttt
     3061 tatacggatc aagcatttgg agagctggaa aagaatagtg ataaatatct tcttggaaca
     3121 tcatcttcag agaacagtca gcctgctcat cttcatgaac tactgtgttc attacagaaa
     3181 caactgcttg ctttttgcca cattaataat gttactgaga actcaagcag tgtggcattg
     3241 cttcataaac atcttcagct tttgctgcct catgccacag atatttattc acgttccgca
     3301 aatttgctta aagaaagtcc ttggaatggc agtgttggag aaaaattgag agatgtgatc
     3361 tatgtgtcag ctgcaggcag tatgctctgc cagattgtta actccctact gttactcccg
     3421 gtgtcagtgg ctcgtccttt attgagttac ctcctcgacc tcttgccacc tcttgattgc
     3481 cttaatagac tcctgccagc tgctgctctt ttagaagacc aagaattaca gtggcctctt
     3541 catggggggc cagaagtaat tgacccagct ggtgtgccat tacctcaacc agctcaatct
     3601 tgggtatggc ttgtggatct ggaaagaaca attgctctcc tcattggccg atgtcttggt
     3661 ggcatgcttc aaggctcccc cgtgtctcca gaggaacagg atactgcata ttggatgaaa
     3721 acaccacttt tcagtgatgg tgtggaaatg gacacccctc agttggataa atgcatgagc
     3781 tgcctactag aagtagctct ttcaggaaat gaagaacaga agccttttga ttacaaattg
     3841 cggcctgaag ttgctgtcta tgtagacttg gcattgggtt gttctaaaga gcctgccaga
     3901 agcctttgga tcagcatgca ggattatgct gtcagtaaag attgggacag tgcaacttta
     3961 agcaatgagt cactcttgga cactgtgtct agatttgttc ttgcagcact cctcaaacac
     4021 acaaacttac ttagtcaagc atgtggagaa agccgatacc aacctggtaa aagcttatca
     4081 gaagtgtatc gttgtgtata caaagttcga agtcgtttac ttgcttgcaa gaaccttgaa
     4141 cttattcaaa ccaggtcatc atcacgagac agatggatca cagataacca agactctgca
     4201 gatgttgatc ctcaagaaca ttcctttacc cggaccattg atgaagaagc tgaaatggaa
     4261 gagctggctg agagagacag ggaggatggc cacccagagc cagaagatga ggaagaagag
     4321 cgggaacatg aagtaatgac agctggcaaa atctttcagt gtttcctctc agcccgagaa
     4381 gtagctcgta gccgagaccg agatagaatg aacagtgggg cagggtctgg ggtccgagct
     4441 gatgacccac ctccacagtc tcagcaggaa cgacgggtca gcacagacct tcctgagggg
     4501 caggatgtgt acactgctgc ctgcaactct gtgatccacc gctgtgcgct cctaatatta
     4561 ggagtaagtc ctgtgattga tgagcttcag aagcgaaggg aagaagggca gttacagcag
     4621 ccttctgtga gtgcctctga aggcaccgga cttatgacca ggagtgaaag tctcactgct
     4681 gagagccgcc tagttcatgc aagtccaagt tacagactga tcaaatcaag gagtgaatct
     4741 gatctgtctc agcctgaatc agatgaagag ggttatgcac tgagtggccg acgaaatgtt
     4801 gactttgatt tggcatcatc tcataggaag agaggtccta tgcatagtca attagaatct
     4861 ctgagtgact cttggactcg cctgaaacat accagagatt ggttctacaa ctcctcttac
     4921 tcctttgagt ctgattttga ccttaccaag tctttgggag ttcacacatt gattgaaaat
     4981 gttgtaagtt ttgtgagtgg agatgtgggg aatgctccag gtttcaagga gccggaagaa
     5041 agtatgtcta caagtcccca ggcctccatc attgcaatgg agcagcaaca gctaagggca
     5101 gagcttcgtt tggaggcact tcaccagatc ctcactctat tgtctggcat ggaagaaaag
     5161 ggtaacgtct tgctgacagg aagcagatca agttcaggct ttcagtcatc caccctgctc
     5221 acatctgtga gattgcagtt tctagcaggg tgtttcggtt taggtactgt tggacacacg
     5281 ggaaccaaag gagagagtgg ccgactgcat cactatcaag atggaatcag agcagctaaa
     5341 agaaatattc aggttgaaat ccaggtggct gttcataaga tttaccaaca attgtctgct
     5401 actctagaga gagcccttca agcaaataag catcacattg aagcccagca acgtcttctt
     5461 ttggttacag tttttgccct cagtgttcat tatcagccag ttgatgtttc tttggcaatt
     5521 tccactggtc tgctgaatgt attgtcacag ttatgtggaa cagacaccat gttaggacag
     5581 cccctgcaat tgttgccaaa gactggtgtt tctcagctta gcacagcttt gaaagtggcc
     5641 agtacaaggt tgctccagat tctagccatc actactggaa cttatgctga taaactgagc
     5701 cccaaagtag ttcagtcctt gttggatcta ctctgtagtc aactgaagaa tttattgtct
     5761 caaactggtg tgctgtttat ggcctctttt ggagaaggag aagagggtga agaagaagaa
     5821 aaaaaagttg actccagtgg agaagctgag aagagagatt tcagagctgc tcttaggaaa
     5881 caacatgcag ctgaactcca tctaggggat tttttagttt ttcttcgcag agttgtgtct
     5941 tcaaaagcaa ttcaatcaaa aatggcttcc cccaaatgga cagaagtgct tctaaacata
     6001 gcatctcaga agtgttcttc aggtattcct ctagttggta acttaagaac gaggcttctt
     6061 gctcttcacg tccttgaggc tgtgctacca gcttgtgaat ctggtgtaga agatgaccaa
     6121 atggcccagg ttgttgaacg cttattttcc cttctgtcgg attgtatgtg ggagactccc
     6181 attgctcagg ccaaacatgc tattcaaata aaggaaaaag aacaagaaat aaaattgcag
     6241 aagcaaggag agttggagga agaggatgaa aatctcccca tacaagaagt ctcttttgat
     6301 ccagagaagg ctcagtgttg cattgtggaa aatggacaga ttttaactca tggcagtgga
     6361 ggaaaaggat atggattagc atctactggg gtgacttctg ggtgctatca gtggaagttt
     6421 tatattgtga aggaaaatag aggtaatgaa ggtacatgtg ttggagtctc tcgctggcca
     6481 gtacatgatt ttaatcaccg cactacctca gacatgtggc tctatagggc gtatagtggt
     6541 aacctctatc acaatggaga acagactctg acgctgtcca gctttactca aggggatttt
     6601 attacctgtg tgttagacat ggaagccagg accatttcct ttgggaaaaa tggagaggaa
     6661 cccaaattag cctttgaaga tgtggatgca gcagagttgt acccatgtgt aatgttctat
     6721 agcagcaacc cgggtgagaa ggtgaaaatt tgtgatatgc agatgcgtgg cacgccacgg
     6781 gatttacttc caggagaccc tatttgtagt ccagtagcag cagtgctagc tgaagccact
     6841 attcagctta tccgtatcct tcaccggaca gaccgttgga cttactgtat taataaaaag
     6901 atgatggaaa gactccataa aattaagata tgtattaaag agtcaggtca gaagctaaag
     6961 aaaagccgct cggttcaaag ccgagaggaa aatgaaatga gagaggagaa agagaacaaa
     7021 gaagaagaga aaggtaaaca taacaggcat ggtcttgctg acctctcaga accgcagctg
     7081 aggactcttt gcatagaggt gtggcccgtg ctagcagtaa taggaggagt tgatgctggt
     7141 cttagagttg gaggtcggtg tgttcacaag caaactgggc gccatgccac gctgctggga
     7201 gtggtcaaag aaggcagcac atctgccaag gtccagtggg atgaagcaga gattaccatc
     7261 agcttcccaa ctttttggtc gcctagtgat actccattat ataacctgga accctgtgaa
     7321 ccactgctgt ttgatgtggc gcgattccga ggcctgacag cttctgtgct gctggaccta
     7381 acatatctga caggcattca tgaagatgtg gggaaacaga gcatcaagcg acatgaaaag
     7441 aaacaccgtc atgagtctga ggaaaagggg gacattgagc agaaacctga gagtgaatcc
     7501 attttagatg tgcgaacagg gttaatgtct gatgatgtca aaagtcaggg taccacaagc
     7561 tccaaatcag aaaatgaaat agcttcattt tctttagaac caacactgcc aggtgtggaa
     7621 tcccaacatc aaataacaga aggaaagaga aaaaatcatg aacacatatc caaaacccat
     7681 gacatagctc agtcagaaat cagagcagtc cagctttcct atctctacct cggtgctatg
     7741 aagtcactta gtgctcttct tggctgtagt aaatatgctg agctcttgct gatcccaaaa
     7801 gttctcgctg aaaatggcca caactcagac tgtgcaagtt ctccagttgt tcacgaggat
     7861 gtggagatgc gtgctgctct acagttcctg atgcggcaca tggtgaagcg agcagtcatg
     7921 cggtcaccca taaagcgagc attggggtta gctgatctgg aacgggctca agctatgatt
     7981 tacaaactgg tggtccatgg gcttttggaa gaccagtttg ggggcaaaat taagcaagag
     8041 attgatcaac aagctgaaga aagtgaccaa gcacagcagg cacagacacc agtgaccacc
     8101 agcccgtcag catccagcac aacttccttt atgagcagct ccctcgagga caccacaact
     8161 gccaccactc ctgtcacgga cacagaaacg gtgcctgcat ctgagtcccc tggagtgatg
     8221 ccacttagtc ttctcaggca aatgttttct agttatccaa ctaccactgt acttcctaca
     8281 cgccgtgcac agactcctcc aatatcatca ttaccagcct ctccttctga tgaagtagga
     8341 agaaggcaga gtttaacttc tccagattcc cagtctacaa ggccagctaa tcgcacagcc
     8401 ttgtcagacc caagcagcag actttcaacg tcccctcctc ccccagcaat tgcagtccct
     8461 ttactggaaa tgggcttctc tcttcgacag attgctaaag ccatggaagc tacaggtgct
     8521 cgaggagagg ctgatgccca gagcatcact gttcttgcta tgtggatgat agagcaccct
     8581 gggcatgagg atgaggagga gccccagccc agcagcacag cagactccag acatggagcg
     8641 acagttctgg gaagtggtgg gaagtcaaat gatccctgtt atttacagtc accaggagac
     8701 ataccatcag ctgatgctgc tgaaatggag gaaggcttta gtgaaagccc tgataatctg
     8761 gatcatacag agaacgcagc ttctggaagt ggaccaccaa ctagaggtcg ctcaacagta
     8821 acaagaaggc acaaatttga cttagcagcg cgcactctgc ttgcaagagc agcggggtta
     8881 taccgctctg tgcaggctca caggaatcaa agtcggagag aaggaatatc tttgcagcaa
     8941 gacccagggg cgttgtatga ctttaattta gatgaggaat tggaaattga tcttgatgat
     9001 gaagcaatgg aagctatgtt tggacaagac ctgaccagtg acaatgatat tctgggaatg
     9061 tggatcccag aggtactgga ttggcctacc tggcatgttt gtgagtctga agacagggaa
     9121 gaagtggtcg tgtgtgaact ttgcgaatgc aatgtcgtca gcttcaacca gcacatgaag
     9181 agaaaccacc ctggctgtgg gcgcagtgca aaccgccagg ggtatcgcag caatggctcc
     9241 tatgtggatg gctggtttgg tggtgaatgt gggagtggaa atccatacta cctgctgtgt
     9301 ggcagctgca gggagaagta cttagccctg aagaccaaga ccaagactac aaattctgaa
     9361 aggtacaagg gacaagcccc agatctaatt ggcaagcagg acagtgtgta tgaagaagac
     9421 tgggacatgt tagatgttga tgaagatgaa aaactaacag gtgaagaaga atttgaattg
     9481 cttgctggac cacttggttt aaatgaccgg cgcattgtgc cagaaccagt tcagttccct
     9541 gacagtgacc ccctgggagc atcagtagca atggtcacag ctaccaacag tatggaagag
     9601 actttgatgc aaattggttg ccatgggtct gtggaaaaga gttcctctgg gagagtaaca
     9661 ttaggagagc aggcagcagc ccttgcaaat cctcatgacc gagtagtggc tttaaggagg
     9721 gtgactgctg ccgctcaagt ccttctggcc agaaccatgg tcatgcgagc actgtctctt
     9781 ctctcagtca gtggttccag ttgtagcctg gctgctggtc tcgagtctct ggggttaaca
     9841 gatatccgta cactggttcg gttaatgtgc ttagctgcag cagggagagc tggcctttcc
     9901 accagccctt ctgccatagc cagtacctca gaacgttcac gaggtggaca cagtaaggcc
     9961 agcaagccca tttcttgcct ggcctacctg agcacagcag tgggatgcct ggcatcaaat
    10021 actccaagtg ctgcaaagct gctggtccag ctgtgtacac agaacttgat ttctgctgca
    10081 acaggtgtca atctcaccac agtggatgat cccattcagc ggaagttcct accaagcttt
    10141 ctccgtggaa ttgctgaaga gaataagctt gtaacatccc caaactttgt tgtaactcaa
    10201 gcccttgtgg cattattggc agacaaaggg gccaaactga gacctaacta tgataagaca
    10261 gaaatagaaa aaaaaggccc tctggagctg gctaatgccc tggcagcctg ctgcctctcc
    10321 tctaggctat cctcacagca taggcaatgg gctgctcaac aacttgtgcg cactcttgct
    10381 gcacatgacc gtgacaacca aactgctcca caaacacttg ctgatatggg aggagatctc
    10441 agaaaatgct cttttatcaa gttggaggct caccaaaaca gagtaatgac atgtgtttgg
    10501 tgtaataaaa aaggcctatt ggctaccagt ggcaatgatg gcactattcg ggtgtggaat
    10561 gttaccaaga agcaatactc actacagcaa acctgtgtgt tcaatagact ggaaggggat
    10621 gctgaggaaa gccttgggtc acccagcgac ccaagcttct cacctgtttc ctggagtatc
    10681 agtggcaaat accttgctgg ggctttggag aagatggtga acatctggca agttaatgga
    10741 ggaaaaggat tagtagatat tcagcctcac tgggtatctg ccctggcctg gccagaagaa
    10801 ggtccagcta caacctggtc aggagagtct ccagagttac tgctggtggg acggatggac
    10861 ggatctctag gactgattga agttgttgat gtgtccacta tgcaccgccg agaactggaa
    10921 cactgctatc gaaaggatgt atctgtcacc tgcattgctt ggttcagtga agacagacca
    10981 tttgcagtag gttattttga tggaaaattg ttaatgggaa caaaagaacc acttgagaaa
    11041 ggaggcattg ttcttattga tgcacataag gaaactcttg ttagtatgaa atgggaccca
    11101 acaggccata ttctcatgac atgtgccaaa gaagaaaatg tgaaactctg ggggcctgtt
    11161 tcaggatgct ggcgctgtct acattcactc tgccatccat ccactgtaaa tggcatcgcc
    11221 tggtgcagcc ttccagggaa aggatccaag atgcagttac tgatggccac tggctgtcaa
    11281 aatggcttag tgtgtgtttg gcgtattcct caagatacca cacagaccag tatgactagc
    11341 tcagaaggat ggtgggacca ggaatcaaat tgtcaggatg gctataggaa atcggcagga
    11401 gccaagtgtg tttatcagct gcggggacac atcacacctg ttcggactgt ggccttcagt
    11461 tctgatggct tggccttggt gtctggtgga cttggagggc ttatgaacat ttggtcttta
    11521 agggatggct ctgtcttgca aactgttgta atcggctctg gagctattca gaccacagta
    11581 tggattccag aagttggggt agctgcctgc tcaaatagat caaaggatgt tttggttgtt
    11641 aattgcacag cagaatgggc ttctgccaat cacattttag caacttgtag aacagccctg
    11701 aaacaacagg gtgttctggg attaaacatg gctccctgca tgagagcatt tctggaacgg
    11761 ctacccatga tgcttcaaga gcaatatgcc tatgaaaagc ctcatgtagt ttgtggtgac
    11821 cagcttgttc atagccccta catgcaatgt ttggcttccc ttgctgtggg acttcatctg
    11881 gatcagctgt tgtgtaaccc tccagtgcca ccacaccatc agaactgtct ccctgaccct
    11941 acatcctgga atcccaatga gtgggcctgg ttagaatgct tttcaaccac tatcaaggct
    12001 gcagaggccc tcaccaacgg agcgcagttt ccagagtcat ttactgtccc agatctagag
    12061 cctgttcctg aggatgagct agtgctcctc atggataaca gcaagtggat caatggcatg
    12121 gatgaacaaa ttatgtcttg ggcaacttcc agacctgagg actggcacct gggaggtaaa
    12181 tgtgatgtct acttatgggg tgctggcagg catggacagc tggccgaagc tggaagaaac
    12241 gtaatggtac cagctacagc gccttcattc tcacaagccc aacaggttat atgtggtcag
    12301 aactgtacct ttgtcatcca ggccaatggg acagtgttgg cttgtgggga aggaagttat
    12361 ggcagattag ggcaaggaaa ttcagacgac cttcatgtgc tgactgtgat ttcagcccta
    12421 caaggttttg tggtgaccca gctggtgact tcctgtggct cagatgggca ctcaatggcc
    12481 ttgacagaaa gtggtgaagt ctttagctgg ggagatgggg actatggcaa acttggccat
    12541 ggaaacagtg acagacagcg gcgaccaagg cagattgagg ccttacaagg agaagaagtg
    12601 gtacagatgt cttgtggctt caagcattca gcagtggtaa catcggatgg caaactcttt
    12661 acctttggga acggtgacta tggccgtctg ggtcttggaa acacctctaa caaaaaactt
    12721 ccagagagag tgaccgcgct ggagggatat cagattggac aggtggcctg tgggctgaac
    12781 cacaccttgg cagtgtcagc agatggctcc atggtgtggg cctttggaga tggagactat
    12841 ggtaaactgg gcctaggaaa ttccacagca aagtcttctc ctcagaaagt tgatgtcctc
    12901 tgtggaattg gaattaaaaa ggttgcttgt ggaactcagt tttctgtggc tttgactaaa
    12961 gatggtcatg tgtacacttt tggtcaagac cgattgatag gcttgcctga gggacgtgct
    13021 cgtaatcata atcgacccca acaaatccct gtcctggctg gagtggtcat tgaagatgtg
    13081 gctgttggag ctgaacacac acttgctttg gcatcaactg gagatgttta tgcctggggt
    13141 agcaattcag aagggcagct tggcctaggc cacaccaacc acgttcgaga accaaccctg
    13201 gtaacagttc tgcaagggaa aaacatccgc cagatttcag cgggccgttg ccacagtgct
    13261 gcatggacag ccccaccagt cccaccaaga gcaccaggtg tgtcagtgcc tctccagttg
    13321 ggcctgcctg acgcagtgcc cccacagtat ggggcactga gagaggtgag cattcacacc
    13381 gtgcgagcaa ggctccggct gctctaccac ttctctgacc tcatgtactc atcatggagg
    13441 ttgctgaatc tcagccccaa caaccagaac agcacatctc attacaatgc tggaacatgg
    13501 ggcattgtac agggacaact tcggcctctg ttagctccaa gagtctacac actccccatg
    13561 gtgcgctcca tagggaagac catggttcaa ggcaaaaatt atgggcctca gattactgta
    13621 aagagaatat caaccagagg acggaagtgt aagcccatct ttgttcaaat agcaagacaa
    13681 gtggtaaagc taaatgcatc agacctccgt ctaccctccc gagcatggaa ggttaagctg
    13741 gttggagaag gagctgatga tgctggagga gtgtttgatg acactatcac agaaatgtgc
    13801 caggaacttg agactggaat agttgacctt ctcataccct ctcctaatgc tactgcagaa
    13861 gtcggttaca acagagacag gttccttttt aatccctctg cctgccttga tgaacattta
    13921 atgcagttta agttcttagg aattttaatg ggggttgcca ttcgtacaaa gaagcctctg
    13981 gaccttcacc tggcccctct ggtgtggaaa cagctgtgct gtgtcccact taccctggag
    14041 gacctggagg aagtggatct gctttatgtg cagaccctta acagcatcct tcacattgaa
    14101 gacagtggca ttactgaaga gagtttccat gagatgattc ctcttgattc ttttgtcggc
    14161 cagagtgctg atggtaaaat ggtccccata atccctggag gaaatagtat cccactcacg
    14221 ttttccaata ggaaggagta cgtagagagg gccattgagt atcgacttca tgagatggac
    14281 cggcaggtgg ctgcagttcg agaagggatg tcctggattg tccctgtacc attgctgtcc
    14341 ctcctcacgg ccaaacagct ggaacagatg gtgtgtggga tgcctgagat ctgtgtggat
    14401 gtcctgaaga aggtggtgcg ataccgtgag gtggacgagc agcaccagct ggtgcagtgg
    14461 ctctggcgca cactggaaga gttctccaat gaggagcggg tgctcttcat gcgcttcgtg
    14521 tctgggcgct cccgactgcc agccaacacc gctgacattt cccagaggtt tcaaatcatg
    14581 aaggtcgata ggccttatga cagtctgcct acctcacaga cctgcttctt ccagctgcgg
    14641 ctgcccccct attccagcca gctggtcatg gctgagcgct tgagatatgc catcaacaac
    14701 tgccgttcaa ttgacatgga caactacatg ctctcaagaa atgtggacaa tgcagagggc
    14761 tctgacactg actactgact gatgagggtg ctgtcaccca cctttctcaa taatgctcac
    14821 ttccaatttg atgttggtat acttttatgg taactacata gatgttttag gaacataagc
    14881 tgatacaaac agtggccaca tttagttact tcaaatgaaa caaagaaatt agatggtttt
    14941 atttttctgt gattgtacaa aacaaagagc agaaactgct cagtcaggtt ttcctctgta
    15001 ttttttggtc actgtggata agtttgcatg gagccatttt ggtgtatttt tagttgagaa
    15061 tgatacattt ttgtaagccc acccagtgaa catgaaattg tacattgtgt ataattgttc
    15121 attagaaagg acagttttac atgaatattc atatatttat tttgttttag tttgattcgc
    15181 ctgtgcaggg ttccttatgc agagaaataa agcagattca ggaatcaga
//
