LOCUS       NM_001164797            5261 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus hephaestin-like 1 (Hephl1), mRNA.
ACCESSION   NM_001164797 XM_146812 XM_986515
VERSION     NM_001164797.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5261)
  AUTHORS   Eragene,S., Stewart,J.J., Samuel-Constanzo,J.I., Tan,T.,
            Esgdaille,N.Z., Bigiarelli,K.J., DaCosta,V.D., Jimenez,H. and
            King,T.R.
  TITLE     The mouse curly whiskers (cw) mutations are recessive alleles of
            hephaestin-like 1 (Hephl1)
  JOURNAL   Mol Genet Metab Rep 20, 100478 (2019)
   PUBMED   31293895
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5261)
  AUTHORS   Sharma,P., Reichert,M., Lu,Y., Markello,T.C., Adams,D.R.,
            Steinbach,P.J., Fuqua,B.K., Parisi,X., Kaler,S.G., Vulpe,C.D.,
            Anderson,G.J., Gahl,W.A. and Malicdan,M.C.V.
  TITLE     Biallelic HEPHL1 variants impair ferroxidase activity and cause an
            abnormal hair phenotype
  JOURNAL   PLoS Genet 15 (5), e1008143 (2019)
   PUBMED   31125343
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5261)
  AUTHORS   Wierzbicka,D. and Gromadzka,G.
  TITLE     [Ceruloplasmin, hephaestin and zyklopen: the three multicopper
            oxidases important for human iron metabolism]
  JOURNAL   Postepy Hig Med Dosw (Online) 68, 912-924 (2014)
   PUBMED   24988611
  REMARK    GeneRIF: Reviewed available data indicate that zyklopen is
            responsible for the placental iron transport.
            Review article
REFERENCE   4  (bases 1 to 5261)
  AUTHORS   Chen,H., Attieh,Z.K., Syed,B.A., Kuo,Y.M., Stevens,V., Fuqua,B.K.,
            Andersen,H.S., Naylor,C.E., Evans,R.W., Gambling,L., Danzeisen,R.,
            Bacouri-Haidar,M., Usta,J., Vulpe,C.D. and McArdle,H.J.
  TITLE     Identification of zyklopen, a new member of the vertebrate
            multicopper ferroxidase family, and characterization in rodents and
            human cells
  JOURNAL   J Nutr 140 (10), 1728-1735 (2010)
   PUBMED   20685892
REFERENCE   5  (bases 1 to 5261)
  AUTHORS   Angel,J.M. and Bedigian,H.G.
  TITLE     Expression of murine leukemia viruses in B-cell lymphomas of
            CWD/Agl mice
  JOURNAL   J Virol 52 (2), 691-694 (1984)
   PUBMED   6092692
REFERENCE   6  (bases 1 to 5261)
  AUTHORS   Douglas,T.C., Meo,T. and Skarvall,H.
  TITLE     Location of the gene for theta antigen in the mouse. II.
            Three-point crosses place Thy-1 in proximal region of chromosome 9
  JOURNAL   J Hered 69 (4), 224-228 (1978)
   PUBMED   310441
REFERENCE   7  (bases 1 to 5261)
  AUTHORS   Lyon,M.F., Butler,J.M. and Kemp,R.
  TITLE     The positions of the centromeres in linkage groups II and IX of the
            mouse
  JOURNAL   Genet Res 11 (2), 193-199 (1968)
   PUBMED   5647630
REFERENCE   8  (bases 1 to 5261)
  AUTHORS   Falconer,D.S. and Isaacson,J.H.
  TITLE     Curly-whiskers and its linkage with tail-kinks in linkage group II
            of the mouse
  JOURNAL   Genet Res 8 (1), 111-113 (1966)
   PUBMED   5911159
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132457.1, AC156500.2, BB618242.1 and AC154295.2.
            
            On or before Sep 20, 2009 this sequence version replaced
            XM_986515.2, XM_146812.7.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-372               AK132457.1         2-373
            373-373             AC156500.2         101689-101689
            374-991             AK132457.1         375-992
            992-992             AC156500.2         110648-110648
            993-2734            AK132457.1         994-2735
            2735-3108           BB618242.1         253-626
            3109-3209           AC154295.2         184958-185058       c
            3210-3281           AC154295.2         184423-184494       c
            3282-5261           AC154295.2         182348-184327       c
FEATURES             Location/Qualifiers
     source          1..5261
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9"
     gene            1..5261
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /note="hephaestin-like 1"
                     /db_xref="GeneID:244698"
                     /db_xref="MGI:MGI:2685355"
     exon            1..171
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..3484
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /EC_number="1.16.3.1"
                     /note="hephaestin-like protein 1; tail hair depletion;
                     ferroxidase HEPHL1"
                     /codon_start=1
                     /product="ferroxidase HEPHL1 precursor"
                     /protein_id="NP_001158269.1"
                     /db_xref="CCDS:CCDS52725.1"
                     /db_xref="GeneID:244698"
                     /db_xref="MGI:MGI:2685355"
                     /translation="MFLKQPGGCILLQFLGLLGLVGAVTRTYYIGIVEEYWNYVPQGK
                     DVITGKSFSEDKLATLFLERGPNRIGGIYKKAVYRHFTDGSYSTEIPKPPWLGFLGPI
                     LRAEVGDVIVIHLMNFASRPFSLHPHGVFYDKDSEGALYPDGTSGRNKEDDMVPPGKN
                     YTYVWPVREEYAPAPADANCLTWVYHSHIDAPKDICSGLIGPLLVCKEGVLNRYSGMR
                     TDVDREFVIMFTLVDENQSWYLDDNIKQFCTNPNSVDKSDAVFQRSNKMHALNGFLFG
                     NMPEPEMCVGESVSWHLFGMGNEIDIHSIYFYGNTFITRGHRADVVNLFPATFLTTEM
                     IVENPGKWMITCQVSDHLQAGMLGQYSVGNCRGNAPHPKVQGQQRRYFIAAEKVLWDY
                     GPQGYDKFTGFPLNTSGSDSAVYFTQADNRIGGKYWKARYTEYVDATFSRRKMPSDSE
                     AHLGILGPVIKAEVGDILLVTFANKADKVYSILPHGVFYDKASDAAPNVDGFLKPGAH
                     VKPGETFTYRWTVPESVSPTDEDPPCLTYLYFSAVQPIKDTSAGLVGPLLVCKKGTLN
                     ADGTQKGIDKEFYLLFTVFDENFSSYLDENIKKFTWHPFSVDKEDKEFVKSNRMHAVN
                     GYMYGSQPGLSMCKKDRVSWHLIGMGTDTDMHGVYFQGNTIHLRGTHRDSLALFPHMA
                     TTAYMQPDHSGIFKVFCSTLPHFTRGMGQIYEISSCGNRDPSEPPYGMLRTFFIAAEE
                     VEWDYAPNKNWEFEKQHLDAGGERHGDIFMNHTENWIGSQYRKVVYREYTNGEFVEIK
                     ARPPQEEHLQLLGPMIHAEVGDSILIIFKNKASRPYSIAAQGVEDSNNGKLLNVPVTK
                     PGEIKTYRWNVPKRSGPGPSDPNCIPWVYFSTANFVKDTYSGLMGPLITCREGVLNEK
                     GRRSDVDYEFALLFLVFNENESWYLDDNIKKYLNKDPRDFKHTDDFEESNKMHAINGK
                     IFGNLPGLIMTEDSMTNWYLLGIGSEVDIHTIHYHAESFLFKIDKSYREDVYDLFPGT
                     FQTIELFADHPGTWLLHCHVSDHIHAGMETTYTVLRNIDNRIPYSTKTPSGAGSHAVT
                     VPSQEQPGKEELYFFGKNLRPRGAKAALVILFILGLLLLVATVVLALRLRSSRRQMAY
                     REVQSCALPTDAL"
     exon            172..416
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /inference="alignment:Splign:2.1.0"
     exon            417..629
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /inference="alignment:Splign:2.1.0"
     exon            630..809
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /inference="alignment:Splign:2.1.0"
     exon            810..1064
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1233
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1373
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1505
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1717
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1868
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..2081
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2295
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2435
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2576
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2683
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2906
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..3046
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /inference="alignment:Splign:2.1.0"
     exon            3047..3209
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3281
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..5261
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5236..5241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /note="hexamer: AATAAA"
     polyA_site      5261
                     /gene="Hephl1"
                     /gene_synonym="cw; Gm509; thd; Zp; zyklopen"
                     /note="major polyA site"
ORIGIN      
        1 acaaatgttt ctgaagcagc cgggtggctg catccttctc cagttcctgg gtctgcttgg
       61 actagttggt gcagtcacca gaacatacta cattgggatt gtggaggaat actggaacta
      121 tgtgcctcaa gggaaggatg ttattaccgg gaagagtttc tcagaagaca aacttgcgac
      181 cttatttctg gagcgagggc ccaacaggat aggtgggatc tacaagaagg cggtttatag
      241 acacttcaca gatgggagct actccacgga gattcccaaa cccccctggc tggggtttct
      301 gggtcccatc ctgagggcag aagtgggaga cgtgatcgtt atccacctga tgaactttgc
      361 ttccagacct ttctctttgc accctcacgg tgttttctac gacaaggatt cggaaggagc
      421 cttataccca gatgggacat ctggaaggaa caaggaagat gacatggtcc cccctggcaa
      481 aaactacacc tatgtctggc cagtgagaga agaatatgca cctgctccag cagatgccaa
      541 ctgcctgacc tgggtgtacc actcacacat tgatgcccct aaggatatct gctctgggct
      601 aattggcccc ctgctggtgt gtaaggaagg tgtactgaat agatactcag ggatgaggac
      661 tgatgtggac cgagagtttg ttatcatgtt cactcttgtg gatgagaacc agagctggta
      721 tctggatgac aacatcaagc aattctgcac taatccaaat tccgttgaca aaagtgatgc
      781 tgttttccag aggagcaaca agatgcatgc cctcaatgga ttcctttttg gaaacatgcc
      841 tgagcctgag atgtgcgttg gcgaatctgt gtcctggcac ctgtttggga tggggaatga
      901 gatagacatc cattccatct atttttatgg taacaccttc atcaccagag ggcaccgggc
      961 agatgttgtc aacctgtttc cagctacctt cctcacaaca gaaatgatag tggagaatcc
     1021 tgggaaatgg atgataacct gccaagtcag tgaccacctg caagctggta tgctgggaca
     1081 gtacagcgtg ggcaactgca ggggtaatgc tcctcaccca aaggtgcagg gtcaacagcg
     1141 gcgctacttc atagcggctg aaaaagtcct ctgggattat ggtccccaag gctatgataa
     1201 attcactgga tttcccctga atacatctgg cagtgactct gcagtgtact tcacacaagc
     1261 tgacaacaga ataggaggaa aatattggaa ggctcggtac acggagtatg ttgatgccac
     1321 tttcagtaga agaaagatgc cctctgattc agaagcccat cttggaatcc ttggtccagt
     1381 catcaaagca gaggtgggtg acatcctgct agtgaccttt gccaacaaag ctgacaaagt
     1441 ctacagcatc ttaccccatg gcgtgttcta tgacaaagca tcagatgcag ctccaaatgt
     1501 agatggattt ctgaaaccag gggctcacgt caagccaggt gaaaccttca cctacaggtg
     1561 gacagtgcca gaaagcgtca gcccgacaga tgaagacccc ccgtgcctga cctatcttta
     1621 cttctcagcg gtccagccta tcaaggacac tagtgctggg cttgtggggc ctttgttggt
     1681 ctgcaaaaag ggcacgctca atgccgatgg gacacagaaa ggaatagaca aggaatttta
     1741 cctactgttc acagtctttg atgagaattt cagcagctat cttgatgaaa acatcaaaaa
     1801 gtttacttgg catcccttca gtgttgacaa agaagacaag gagtttgtga aatccaatcg
     1861 gatgcatgct gttaacggct acatgtacgg cagccagcca ggcctgagca tgtgcaagaa
     1921 ggacagagtt tcctggcact tgattggaat gggcaccgac acagatatgc atggagttta
     1981 tttccaaggc aacaccatcc acctacgagg gactcatcgt gactccctgg ctctgtttcc
     2041 ccatatggcc acaacggcat acatgcagcc agaccattca ggtattttca aggtgttctg
     2101 ttccacctta ccccacttca cgagaggcat gggtcagatc tatgagatca gcagctgtgg
     2161 caacagggac ccttctgagc cgccctacgg gatgctaaga acctttttca tcgccgctga
     2221 agaggtagaa tgggattatg cccctaacaa aaactgggag ttcgaaaagc agcacttgga
     2281 cgcaggaggg gaaagacatg gagatatatt tatgaaccac actgaaaact ggattggctc
     2341 tcagtacagg aaggttgttt atagggaata tacaaatgga gaatttgtgg agattaaagc
     2401 tcggccacct caagaagagc accttcaact cctgggacca atgattcatg ctgaggtggg
     2461 ggactccatt ctcattatct ttaagaacaa agccagccgg ccctactcca ttgcagccca
     2521 aggtgtggag gactcaaaca atggaaaact ccttaatgtg cctgtcacaa agccaggaga
     2581 aatcaaaact tacagatgga atgtcccgaa gagatccggt cctgggccct ctgatcccaa
     2641 ttgtattcca tgggtttact tttcaacagc aaattttgtg aaggatacat acagtggttt
     2701 gatggggcct ctgatcacat gtcgagaggg ggtgctaaac gaaaagggaa gaagaagcga
     2761 tgttgactat gagtttgcac tgttgttcct ggtcttcaat gagaatgagt catggtatct
     2821 ggatgacaat atcaagaagt atctcaataa agatccacgg gatttcaagc acacagacga
     2881 ctttgaagag agcaacaaaa tgcatgccat taatggaaag atttttggaa acctccctgg
     2941 tctcataatg actgaagact caatgactaa ctggtatctg ctgggcatcg gaagtgaagt
     3001 ggacatacac acaatccatt accatgcaga gagctttctg ttcaaaatag ataagtccta
     3061 ccgagaagat gtgtatgatc tctttcctgg gacatttcaa accattgagc tgtttgctga
     3121 tcacccagga acatggcttc ttcactgcca tgtgtccgac cacattcatg ctggcatgga
     3181 gaccacctac actgtcctca ggaacataga caacaggatt ccatattcta ccaagacgcc
     3241 ttctggagca ggatctcacg cagtcacagt gccctcccag gaacaacctg gcaaggaaga
     3301 gctctatttc tttggcaaga atctgcgtcc aagaggagcc aaggcagccc tggtcatcct
     3361 tttcatcctg ggactcctcc ttctagtggc caccgtggtt ctcgccctca gactccgatc
     3421 ttcaaggagg cagatggctt acagggaagt ccagtcctgt gcactcccca cggatgctct
     3481 gtgaatgccc tgactccctg ctcagcagga gcgtgtcagg ttccacaact ggacgcacag
     3541 tagctaacag aaacgggacc gatgcattgt tcaccaagga acttggacac tgtatcctag
     3601 atcaggcttc tgggcctctg gaatgtgtca tccaaagcaa tgtgctttat ttatttattt
     3661 tttaactggc tgtgaatgat tctcaggtat aaaacacacg acaaaggaaa atgcactgga
     3721 ttgagagctg ctgaccctca gtctgctgtg aacaactggg aggttaccct ctggaagatg
     3781 ttttcactga cttaagtcaa acaatgctgc ctcaggtagc ccaatgttct agatgtgtag
     3841 cttctagaaa acattagagt gccgtggaca tctgtctgtc tggagtcaca ctggtgctaa
     3901 acactgtcac atgaaactgt gccctcagtt gttccaaggt ggacaagctc ccgaggagtt
     3961 tgtgggaggt ccaagtccat ctgcactgat ggaagtggga tctcctgaat cctccggagc
     4021 cccccgtagt tctcctgacc ttccccctct aacgcagaga gccacgcatt gtttgttata
     4081 cataccaaag ctatatggtt atttatttca ttgctgctga ttttaattca acctgtagga
     4141 atacttgaat gtttacaatt cacttcatgc tacattttac catgtgtctc cttggcaatg
     4201 cctgtacttt cagaaatcga ctacggcatt ttttatttca ggctgcagga gggctaaaat
     4261 cagtggagaa gcaggcttga cttcttcgtc ataagccaga ggctccctgt ctctgccaga
     4321 atctcgactc tcacttttca ttcatttagg gggcattttt ccacatctgc atcttctatg
     4381 aaagttatga tttcatcata tgaggggtag caggaggcat atatcaatgc aactgattga
     4441 caaggaggag aaaggacctt taaaatcctg cattctctgc ttgttaaaga caagacctct
     4501 ggcgggggtg ggggcagcta gaaaagagta gtcctggtat tttttaaacc attaaatcag
     4561 tgttagaaat tagaaatata gctgccaaga cacacacaaa tataaaatgc ttaacaacag
     4621 aactaaacct gtaagaacac aatgcaccct ctccttaggc tccctagaca ttagaggtaa
     4681 gattgataaa agcaacattg tttattatag actgggaatt ctaccttagc tcagggcaag
     4741 ctgccctggg atgctgttgc cagacacatg acgttagagc actgcctttg tggtgggtca
     4801 cttgaatgtc caggtgaaca agtaggacct aataaatact ctggtgaagg gatctttcat
     4861 gcttttaaac attattatta ttattactgg tgaggggaaa ttgatagaag ccatagtctt
     4921 aggtaaaatg atgcaaccac taatagttgt ttgtagtttg cttgaccgca tcgtcaaaca
     4981 gtggacacaa atgactctga attccagcct gctaactact gacagtgtga ttgcgtggct
     5041 tattgaacta cctgctctgt ggcgttcata cgtgggaggc tgcacaattg cacagaagca
     5101 gggcaagcat ccattactta tccttagtat gtcaaagact gtttagttat aaaaggtttt
     5161 ttgccctttt tcatttagtt ttttttttta atggaaacaa accacaagta gttttgtttc
     5221 actatttctc tttttaataa agtttcacac atggcaattt a
//
