LOCUS       NM_175189               3103 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus hepatocyte cell adhesion molecule (Hepacam), mRNA.
ACCESSION   NM_175189 XM_984838
VERSION     NM_175189.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3103)
  AUTHORS   Jin,S., Chen,X., Tian,Y., Jarvis,R., Promes,V. and Yang,Y.
  TITLE     Astroglial exosome HepaCAM signaling and ApoE antagonization
            coordinates early postnatal cortical pyramidal neuronal axon growth
            and dendritic spine formation
  JOURNAL   Nat Commun 14 (1), 5150 (2023)
   PUBMED   37620511
  REMARK    GeneRIF: Astroglial exosome HepaCAM signaling and ApoE
            antagonization coordinates early postnatal cortical pyramidal
            neuronal axon growth and dendritic spine formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3103)
  AUTHORS   Alonso-Gardon,M., Elorza-Vidal,X., Castellanos,A., La Sala,G.,
            Armand-Ugon,M., Gilbert,A., Di Pietro,C., Pla-Casillanis,A.,
            Ciruela,F., Gasull,X., Nunes,V., Martinez,A., Schulte,U.,
            Cohen-Salmon,M., Marazziti,D. and Estevez,R.
  TITLE     Identification of the GlialCAM interactome: the G protein-coupled
            receptors GPRC5B and GPR37L1 modulate megalencephalic
            leukoencephalopathy proteins
  JOURNAL   Hum Mol Genet 30 (17), 1649-1665 (2021)
   PUBMED   34100078
REFERENCE   3  (bases 1 to 3103)
  AUTHORS   Baldwin,K.T., Tan,C.X., Strader,S.T., Jiang,C., Savage,J.T.,
            Elorza-Vidal,X., Contreras,X., Rulicke,T., Hippenmeyer,S.,
            Estevez,R., Ji,R.R. and Eroglu,C.
  TITLE     HepaCAM controls astrocyte self-organization and coupling
  JOURNAL   Neuron 109 (15), 2427-2442 (2021)
   PUBMED   34171291
  REMARK    GeneRIF: HepaCAM controls astrocyte self-organization and coupling.
REFERENCE   4  (bases 1 to 3103)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3103)
  AUTHORS   Goppner,C., Soria,A.H., Hoegg-Beiler,M.B. and Jentsch,T.J.
  TITLE     Cellular basis of ClC-2 Cl- channel-related brain and testis
            pathologies
  JOURNAL   J Biol Chem 296, 100074 (2021)
   PUBMED   33187987
REFERENCE   6  (bases 1 to 3103)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   7  (bases 1 to 3103)
  AUTHORS   Jeworutzki,E., Lopez-Hernandez,T., Capdevila-Nortes,X., Sirisi,S.,
            Bengtsson,L., Montolio,M., Zifarelli,G., Arnedo,T., Muller,C.S.,
            Schulte,U., Nunes,V., Martinez,A., Jentsch,T.J., Gasull,X.,
            Pusch,M. and Estevez,R.
  TITLE     GlialCAM, a protein defective in a leukodystrophy, serves as a
            ClC-2 Cl(-) channel auxiliary subunit
  JOURNAL   Neuron 73 (5), 951-961 (2012)
   PUBMED   22405205
REFERENCE   8  (bases 1 to 3103)
  AUTHORS   Lopez-Hernandez,T., Ridder,M.C., Montolio,M., Capdevila-Nortes,X.,
            Polder,E., Sirisi,S., Duarri,A., Schulte,U., Fakler,B., Nunes,V.,
            Scheper,G.C., Martinez,A., Estevez,R. and van der Knaap,M.S.
  TITLE     Mutant GlialCAM causes megalencephalic leukoencephalopathy with
            subcortical cysts, benign familial macrocephaly, and macrocephaly
            with retardation and autism
  JOURNAL   Am J Hum Genet 88 (4), 422-432 (2011)
   PUBMED   21419380
REFERENCE   9  (bases 1 to 3103)
  AUTHORS   Favre-Kontula,L., Rolland,A., Bernasconi,L., Karmirantzou,M.,
            Power,C., Antonsson,B. and Boschert,U.
  TITLE     GlialCAM, an immunoglobulin-like cell adhesion molecule is
            expressed in glial cells of the central nervous system
  JOURNAL   Glia 56 (6), 633-645 (2008)
   PUBMED   18293412
  REMARK    GeneRIF: GlialCAM, an immunoglobulin-like cell adhesion molecule is
            expressed in glial cells of the central nervous system.
REFERENCE   10 (bases 1 to 3103)
  AUTHORS   Visel,A., Carson,J., Oldekamp,J., Warnecke,M., Jakubcakova,V.,
            Zhou,X., Shaw,C.A., Alvarez-Bolado,G. and Eichele,G.
  TITLE     Regulatory pathway analysis by high-throughput in situ
            hybridization
  JOURNAL   PLoS Genet 3 (10), 1867-1883 (2007)
   PUBMED   17953485
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY753058.1, BC082537.1 and AW060627.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_984838.1, NM_175189.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082537.1, SRR1660821.62295.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                BY753058.1         236-321
            87-3084             BC082537.1         1-2998
            3085-3103           AW060627.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..3103
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 20.76 cM"
     gene            1..3103
                     /gene="Hepacam"
                     /gene_synonym="2900042E01Rik; Glialcam; Hepn1"
                     /note="hepatocyte cell adhesion molecule"
                     /db_xref="GeneID:72927"
                     /db_xref="MGI:MGI:1920177"
     exon            1..156
                     /gene="Hepacam"
                     /gene_synonym="2900042E01Rik; Glialcam; Hepn1"
                     /inference="alignment:Splign:2.1.0"
     exon            157..498
                     /gene="Hepacam"
                     /gene_synonym="2900042E01Rik; Glialcam; Hepn1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..780
                     /gene="Hepacam"
                     /gene_synonym="2900042E01Rik; Glialcam; Hepn1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..880
                     /gene="Hepacam"
                     /gene_synonym="2900042E01Rik; Glialcam; Hepn1"
                     /inference="alignment:Splign:2.1.0"
     exon            881..954
                     /gene="Hepacam"
                     /gene_synonym="2900042E01Rik; Glialcam; Hepn1"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1025
                     /gene="Hepacam"
                     /gene_synonym="2900042E01Rik; Glialcam; Hepn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..3089
                     /gene="Hepacam"
                     /gene_synonym="2900042E01Rik; Glialcam; Hepn1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1590..1595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hepacam"
                     /gene_synonym="2900042E01Rik; Glialcam; Hepn1"
                     /note="hexamer: ATTAAA"
     polyA_site      1616
                     /gene="Hepacam"
                     /gene_synonym="2900042E01Rik; Glialcam; Hepn1"
                     /note="major polyA site"
     regulatory      3067..3072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hepacam"
                     /gene_synonym="2900042E01Rik; Glialcam; Hepn1"
                     /note="hexamer: AATAAA"
     polyA_site      3089
                     /gene="Hepacam"
                     /gene_synonym="2900042E01Rik; Glialcam; Hepn1"
ORIGIN      
        1 acaaagggac gtgcccggag tggagaaatc atgctaattg tctgcaccag agctggagaa
       61 cgccacccaa aatgaagaga gaaaggggag ccctgtcaag agcctccagg gctctgcgcc
      121 tctctccttt tgtctacctg cttctcatcc agccagtccc cctggagggg gtgaacatca
      181 ccagcccagt acgtctgatc cacggcacag tggggaagtc ggccctgctt tccgtgcagt
      241 acagtagcac cagcagcgac aagcccgtgg tgaagtggca gctgaagcgt gacaagccag
      301 tgaccgtggt gcagtctata ggcacagagg tcattggcac tctgcggcct gactatcgag
      361 accgtatccg gctctttgaa aatggctcct tgcttctcag cgacctgcag ctggcggatg
      421 agggaaccta tgaagtggag atttccatca ctgacgacac cttcaccggg gagaagacca
      481 tcaacctcac cgtggatgtg cccatttcaa ggccgcaggt attagtggct tcaaccactg
      541 tgctggagct cagtgaggcc ttcaccctca actgctccca tgagaatggc accaagccta
      601 gctacacgtg gctgaaggat ggcaaacccc tcctcaatga ctcccgaatg ctcctgtccc
      661 ctgaccaaaa ggtgctcacc atcacccgag tactcatgga agatgacgac ctgtacagct
      721 gtgtggtgga gaaccccatc agccaggtcc gcagcctgcc tgtcaagatc actgtgtata
      781 gaagaagctc cctctatatc atcttgtcta caggaggcat cttcctcctt gtgaccctgg
      841 tgacagtttg tgcctgctgg aaaccctcaa aaaagtctag gaagaagagg aagttggaga
      901 agcaaaactc cttggaatac atggatcaga atgatgaccg cctaaaatca gaagcagata
      961 ccctaccccg aagtggagaa caggagcgga agaacccaat ggcactctat atcctgaagg
     1021 ataaggattc ctcagagcca gatgaaaacc ctgctacaga gccacggagc accacagaac
     1081 ccggtccccc tggctactcc gtgtcgccgc ccgtgcccgg ccgctctccg gggcttccca
     1141 tccgctcagc ccgccgctac ccgcgctccc cagcacgttc ccctgccact ggccggacgc
     1201 acacgtcgcc accgcgggcc ccgagctcgc caggccgctc gcgcagctct tcgcgctcac
     1261 tgcggactgc aggcgtgcag agaatccggg agcaggacga gtcagggcag gtggagatca
     1321 gtgcctgagc ctcctcgaga gccctctgcg gttgcccacg gtctgctgtc cgcggctggg
     1381 gggggaggct gagaagtcct gatgcctctg gccaggagtg aaaggagatc gtggcctgat
     1441 ccccgtttag ggtgcacacg cgtgtgagtt tgcacaaatg gctgatcttg gtgttaaacc
     1501 cggttgcatg tgcgctgggt ttactggctg tgttctctgg ctgtgttctc agtgggtatg
     1561 agctgtgccc tcttaggact acatagatta ttaaatttct ggcccaatcc cctaaaggat
     1621 tttatggaaa ctaacagtaa ttttacccag tgagacgatc ctatgcgccc cctggcagtg
     1681 tttatacttc ccatccacct cccaatccca catgcctcta acccctaaag tctgtggtag
     1741 cccccccccc agcccaattt agaggccact tacccccgaa cacacattgt cctaaaacta
     1801 aagacaagtc tgatgctggt tcctgggtac acagggcctg ttctgattac aaagatgtcg
     1861 tcttaaggac cttttctgga catctgcttc cccatctttc caggtgataa gagtgaaccc
     1921 caggtgcatt cctaagaccc tgggaacttg gggctaggcc aggacaagct atcaggcctc
     1981 cagtggcctc cccaaaagtg tgtcatactg gtcttccttc cagtttgcgt tcatgagaat
     2041 gtgggtaggc ttgttcctat agagactggt gtggccactc accgacgacc cagcaaactg
     2101 cccctgacaa ggacctggtt ttaaccattc atgctcttct tcctgactgt tattttacaa
     2161 aacaagcttt caatcatccc caggaaggct gagaagcttc cttgagctgt aagaaaaaaa
     2221 taagattcca ctctccagag aaacgtggaa agagaaagaa gcttaacatg ccccaacatg
     2281 tcaaagcaag atggccaacc ccctcgcctc ctgctttcca cctgccgtgg tcctagatgc
     2341 tcagaaccca ggacagtgga cagagctgta aaaacagcac atgaatagat gaaagacaag
     2401 aagacccggg gcggggggtg ggggtgggtg ggttctgtcc tctctcccct aatgtcccca
     2461 gggacccttg aatctcttgt ccctcctcga ctcgtacaac ttcatctttt cttctgcatc
     2521 atctcatgaa caacttccaa gaccccatat ccatcacctc cacaccagaa cacacttcac
     2581 cccggccctg caggcaccaa gatttctggt ttgcctgtgt cccctcaccc caccagcatg
     2641 actctcagtc cccccatcct gatggccttc tacctgctca cgtggcaggt gtgtctgcag
     2701 ctctccttac ttagccagaa cccacaatcc actaacctcc ccaggtgcct catccaccat
     2761 aaaatagtac ttgtaggcga tagtgcaggc aggttaggag aagcaagact tggaagacta
     2821 cctgttgctc agccttgaga tacaggggtg aggggtaggg tgagatgaga gcatgccaca
     2881 ccctggtgct gaatcccggc cgggctggct tctcagactc aagccaaatt tgccttaaat
     2941 ttggattaag taaagaagtg gggttttttt gttttttgtt tttttaattt tgttttgctt
     3001 tgttttgatc ttcatctttg tattcactta gcatctagca gagtgcatag cacaacctgg
     3061 atgctcaata aacttttgat gaaacgaaaa aaaaaaaaaa aaa
//
