LOCUS       NP_780398                418 aa            linear   ROD 20-SEP-2024
DEFINITION  hepatic and glial cell adhesion molecule precursor [Mus musculus].
ACCESSION   NP_780398 XP_989932
VERSION     NP_780398.2
DBSOURCE    REFSEQ: accession NM_175189.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 418)
  AUTHORS   Jin,S., Chen,X., Tian,Y., Jarvis,R., Promes,V. and Yang,Y.
  TITLE     Astroglial exosome HepaCAM signaling and ApoE antagonization
            coordinates early postnatal cortical pyramidal neuronal axon growth
            and dendritic spine formation
  JOURNAL   Nat Commun 14 (1), 5150 (2023)
   PUBMED   37620511
  REMARK    GeneRIF: Astroglial exosome HepaCAM signaling and ApoE
            antagonization coordinates early postnatal cortical pyramidal
            neuronal axon growth and dendritic spine formation.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 418)
  AUTHORS   Alonso-Gardon,M., Elorza-Vidal,X., Castellanos,A., La Sala,G.,
            Armand-Ugon,M., Gilbert,A., Di Pietro,C., Pla-Casillanis,A.,
            Ciruela,F., Gasull,X., Nunes,V., Martinez,A., Schulte,U.,
            Cohen-Salmon,M., Marazziti,D. and Estevez,R.
  TITLE     Identification of the GlialCAM interactome: the G protein-coupled
            receptors GPRC5B and GPR37L1 modulate megalencephalic
            leukoencephalopathy proteins
  JOURNAL   Hum Mol Genet 30 (17), 1649-1665 (2021)
   PUBMED   34100078
REFERENCE   3  (residues 1 to 418)
  AUTHORS   Baldwin,K.T., Tan,C.X., Strader,S.T., Jiang,C., Savage,J.T.,
            Elorza-Vidal,X., Contreras,X., Rulicke,T., Hippenmeyer,S.,
            Estevez,R., Ji,R.R. and Eroglu,C.
  TITLE     HepaCAM controls astrocyte self-organization and coupling
  JOURNAL   Neuron 109 (15), 2427-2442 (2021)
   PUBMED   34171291
  REMARK    GeneRIF: HepaCAM controls astrocyte self-organization and coupling.
REFERENCE   4  (residues 1 to 418)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 418)
  AUTHORS   Goppner,C., Soria,A.H., Hoegg-Beiler,M.B. and Jentsch,T.J.
  TITLE     Cellular basis of ClC-2 Cl- channel-related brain and testis
            pathologies
  JOURNAL   J Biol Chem 296, 100074 (2021)
   PUBMED   33187987
REFERENCE   6  (residues 1 to 418)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   7  (residues 1 to 418)
  AUTHORS   Jeworutzki,E., Lopez-Hernandez,T., Capdevila-Nortes,X., Sirisi,S.,
            Bengtsson,L., Montolio,M., Zifarelli,G., Arnedo,T., Muller,C.S.,
            Schulte,U., Nunes,V., Martinez,A., Jentsch,T.J., Gasull,X.,
            Pusch,M. and Estevez,R.
  TITLE     GlialCAM, a protein defective in a leukodystrophy, serves as a
            ClC-2 Cl(-) channel auxiliary subunit
  JOURNAL   Neuron 73 (5), 951-961 (2012)
   PUBMED   22405205
REFERENCE   8  (residues 1 to 418)
  AUTHORS   Lopez-Hernandez,T., Ridder,M.C., Montolio,M., Capdevila-Nortes,X.,
            Polder,E., Sirisi,S., Duarri,A., Schulte,U., Fakler,B., Nunes,V.,
            Scheper,G.C., Martinez,A., Estevez,R. and van der Knaap,M.S.
  TITLE     Mutant GlialCAM causes megalencephalic leukoencephalopathy with
            subcortical cysts, benign familial macrocephaly, and macrocephaly
            with retardation and autism
  JOURNAL   Am J Hum Genet 88 (4), 422-432 (2011)
   PUBMED   21419380
REFERENCE   9  (residues 1 to 418)
  AUTHORS   Favre-Kontula,L., Rolland,A., Bernasconi,L., Karmirantzou,M.,
            Power,C., Antonsson,B. and Boschert,U.
  TITLE     GlialCAM, an immunoglobulin-like cell adhesion molecule is
            expressed in glial cells of the central nervous system
  JOURNAL   Glia 56 (6), 633-645 (2008)
   PUBMED   18293412
  REMARK    GeneRIF: GlialCAM, an immunoglobulin-like cell adhesion molecule is
            expressed in glial cells of the central nervous system.
REFERENCE   10 (residues 1 to 418)
  AUTHORS   Visel,A., Carson,J., Oldekamp,J., Warnecke,M., Jakubcakova,V.,
            Zhou,X., Shaw,C.A., Alvarez-Bolado,G. and Eichele,G.
  TITLE     Regulatory pathway analysis by high-throughput in situ
            hybridization
  JOURNAL   PLoS Genet 3 (10), 1867-1883 (2007)
   PUBMED   17953485
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY753058.1, BC082537.1 and AW060627.1.
            
            On or before May 4, 2006 this sequence version replaced
            XP_989932.1, NP_780398.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082537.1, SRR1660821.62295.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 20.76 cM"
     Protein         1..418
                     /product="hepatic and glial cell adhesion molecule
                     precursor"
                     /note="protein hepaCAM; hepatic and glial cell adhesion
                     molecule"
                     /calculated_mol_wt=42647
     sig_peptide     1..33
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3739
     mat_peptide     34..418
                     /product="Hepatic and glial cell adhesion molecule.
                     /evidence=ECO:0000255. /id=PRO_0000298778"
                     /note="propagated from UniProtKB/Swiss-Prot (Q640R3.2)"
                     /calculated_mol_wt=42647
     Site            35
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q640R3.2)"
     Region          43..141
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          55..59
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409431"
     Region          66..70
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409431"
     Region          105..109
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409431"
     Region          119..124
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409431"
     Region          134..137
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409431"
     Site            138
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q640R3.2)"
     Region          148..236
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          164..168
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409402"
     Site            167
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q640R3.2)"
     Region          178..182
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409402"
     Site            189
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q640R3.2)"
     Region          200..204
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409402"
     Region          214..219
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409402"
     Region          229..232
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409402"
     Site            241..261
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q640R3.2)"
     Region          271..418
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q640R3.2)"
     Site            280
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q640R3.2)"
     Site            321
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q640R3.2)"
     Region          <324..383
                     /region_name="Herpes_UL1"
                     /note="Herpesvirus glycoprotein L; cl29975"
                     /db_xref="CDD:392246"
     Site            352
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q640R3.2)"
     Site            379
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q640R3.2)"
     CDS             1..418
                     /gene="Hepacam"
                     /gene_synonym="2900042E01Rik; Glialcam; Hepn1"
                     /coded_by="NM_175189.4:72..1328"
                     /db_xref="CCDS:CCDS22976.1"
                     /db_xref="GeneID:72927"
                     /db_xref="MGI:MGI:1920177"
ORIGIN      
        1 mkrergalsr asralrlspf vyllliqpvp legvnitspv rlihgtvgks allsvqysst
       61 ssdkpvvkwq lkrdkpvtvv qsigtevigt lrpdyrdrir lfengsllls dlqladegty
      121 eveisitddt ftgektinlt vdvpisrpqv lvasttvlel seaftlncsh engtkpsytw
      181 lkdgkpllnd srmllspdqk vltitrvlme dddlyscvve npisqvrslp vkitvyrrss
      241 lyiilstggi fllvtlvtvc acwkpskksr kkrklekqns leymdqnddr lkseadtlpr
      301 sgeqerknpm alyilkdkds sepdenpate prsttepgpp gysvsppvpg rspglpirsa
      361 rryprspars patgrthtsp prapsspgrs rsssrslrta gvqrireqde sgqveisa
//
