LOCUS       NM_025723               2121 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus HEN1 methyltransferase homolog 1 (Arabidopsis)
            (Henmt1), transcript variant 1, mRNA.
ACCESSION   NM_025723
VERSION     NM_025723.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2121)
  AUTHORS   Gainetdinov,I., Colpan,C., Cecchini,K., Arif,A., Jouravleva,K.,
            Albosta,P., Vega-Badillo,J., Lee,Y., Ozata,D.M. and Zamore,P.D.
  TITLE     Terminal modification, sequence, length, and PIWI-protein identity
            determine piRNA stability
  JOURNAL   Mol Cell 81 (23), 4826-4842 (2021)
   PUBMED   34626567
REFERENCE   2  (bases 1 to 2121)
  AUTHORS   Hutt,K.J., Lim,S.L., Zhang,Q.H., Gonzalez,M., O'Connor,A.E.,
            Merriner,D.J., Liew,S.H., Al-Zubaidi,U., Yuen,W.S., Adhikari,D.,
            Robker,R.L., Mann,J.R., Carroll,J. and O'Bryan,M.K.
  TITLE     HENMT1 is involved in the maintenance of normal female fertility in
            the mouse
  JOURNAL   Mol Hum Reprod 27 (11) (2021)
   PUBMED   34590701
  REMARK    GeneRIF: HENMT1 is involved in the maintenance of normal female
            fertility in the mouse.
REFERENCE   3  (bases 1 to 2121)
  AUTHORS   Peng,L., Zhang,F., Shang,R., Wang,X., Chen,J., Chou,J.J., Ma,J.,
            Wu,L. and Huang,Y.
  TITLE     Identification of substrates of the small RNA methyltransferase
            Hen1 in mouse spermatogonial stem cells and analysis of its
            methyl-transfer domain
  JOURNAL   J Biol Chem 293 (26), 9981-9994 (2018)
   PUBMED   29703750
  REMARK    GeneRIF: methylation substrates in mouse spermatogonial stem cells
            and the substrate-recognition mechanism of mammalian Hen1
REFERENCE   4  (bases 1 to 2121)
  AUTHORS   Lim,S.L., Qu,Z.P., Kortschak,R.D., Lawrence,D.M., Geoghegan,J.,
            Hempfling,A.L., Bergmann,M., Goodnow,C.C., Ormandy,C.J., Wong,L.,
            Mann,J., Scott,H.S., Jamsai,D., Adelson,D.L. and O'Bryan,M.K.
  TITLE     HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell
            Transposon Repression and to Define the Spermatogenic Program in
            the Mouse
  JOURNAL   PLoS Genet 11 (10), e1005620 (2015)
   PUBMED   26496356
  REMARK    GeneRIF: DNA damage and a catastrophic deregulation of the haploid
            germ cell gene expression. Collectively these results define a
            critical role for HENMT1 and piRNAs in the maintenance of TE
            repression in adult germ cells and setting the spermatogenic
            program.
            Erratum:[PLoS Genet. 2015 Dec 29;11(12):e1005782. doi:
            10.1371/journal.pgen.1005782. PMID: 26714033]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2121)
  AUTHORS   Kirino,Y. and Mourelatos,Z.
  TITLE     The mouse homolog of HEN1 is a potential methylase for
            Piwi-interacting RNAs
  JOURNAL   RNA 13 (9), 1397-1401 (2007)
   PUBMED   17652135
REFERENCE   6  (bases 1 to 2121)
  AUTHORS   Kirino,Y. and Mourelatos,Z.
  TITLE     2'-O-methyl modification in mouse piRNAs and its methylase
  JOURNAL   Nucleic Acids Symp Ser (Oxf) (51), 417-418 (2007)
   PUBMED   18029764
REFERENCE   7  (bases 1 to 2121)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV650789.1 and BC099408.1.
            
            On Nov 25, 2006 this sequence version replaced NM_025723.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085587.1, SRR11927938.2874212.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-698               DV650789.1         68-765
            699-2121            BC099408.1         365-1787
FEATURES             Location/Qualifiers
     source          1..2121
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 47.99 cM"
     gene            1..2121
                     /gene="Henmt1"
                     /gene_synonym="4921515J06Rik; Hen1; mHEN1"
                     /note="HEN1 methyltransferase homolog 1 (Arabidopsis)"
                     /db_xref="GeneID:66715"
                     /db_xref="MGI:MGI:1913965"
     exon            1..348
                     /gene="Henmt1"
                     /gene_synonym="4921515J06Rik; Hen1; mHEN1"
                     /inference="alignment:Splign:2.1.0"
     exon            349..496
                     /gene="Henmt1"
                     /gene_synonym="4921515J06Rik; Hen1; mHEN1"
                     /inference="alignment:Splign:2.1.0"
     exon            497..625
                     /gene="Henmt1"
                     /gene_synonym="4921515J06Rik; Hen1; mHEN1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..738
                     /gene="Henmt1"
                     /gene_synonym="4921515J06Rik; Hen1; mHEN1"
                     /inference="alignment:Splign:2.1.0"
     exon            739..873
                     /gene="Henmt1"
                     /gene_synonym="4921515J06Rik; Hen1; mHEN1"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1053
                     /gene="Henmt1"
                     /gene_synonym="4921515J06Rik; Hen1; mHEN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1231
                     /gene="Henmt1"
                     /gene_synonym="4921515J06Rik; Hen1; mHEN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..2098
                     /gene="Henmt1"
                     /gene_synonym="4921515J06Rik; Hen1; mHEN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2079..2084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Henmt1"
                     /gene_synonym="4921515J06Rik; Hen1; mHEN1"
                     /note="hexamer: ATTAAA"
     polyA_site      2098
                     /gene="Henmt1"
                     /gene_synonym="4921515J06Rik; Hen1; mHEN1"
                     /note="major polyA site"
ORIGIN      
        1 acacgggacg ccacggacct aacagccgcc gagcacgcag tctggccgcc agtctgggtc
       61 gcatccaaca gtcgccgcag gggcaggtca acgcagcgcg agggtctggg atgctgtggg
      121 gctgagggtc gtggtcctcc ccagggttcg gaagataggt gggaaaatgt cttcagggca
      181 tgcgccacag cggccgttaa atgacccaaa accgacacct tggaggcggc agccgggagg
      241 catggggccg gagcatggcc gggcttcgca cgcccagcga ggaccctgag ggcgcagagc
      301 gcaggcgcga ggcgcagggc cagccagctg ccaggtgcgg ccagccaggc atctcgtgtg
      361 aaaaggaatt acttggcatt tacagctgag ttgccgctga ttctgatcca gagcccagag
      421 gataaatctg cattattctt atttttttgt cacaatagaa gccggaaaca aaatggaaat
      481 ggcagaaagc ataccgtgca atagtgtggt tggtggcaat tttaaagaag ttagtccaga
      541 gaaggtaatt cggttcaaac caccattata caaacaacgg tatcagtttg ttagagattt
      601 agtggatcgc catgaaccca agaaggttgc cgacctggga tgtggagatg ccaagctcct
      661 aaagctgcta aaaatctacc catgcattca actgcttgtt ggggtggata tcaatgaaga
      721 aaaattgcat tcaaatgggc atcgcttgtc tccctatttg ggggagtttg taaaaccccg
      781 agatctagat ttgactgtca ccttgtatca tggctctgtt gtggagagag actcccgctt
      841 gcttggattc gatttgataa catgcattga attaatagaa cacttggatt cagatgatct
      901 ggccagattt cctgatgtgg tttttggata cctgtcacca gccatggttg tcatcagcac
      961 cccaaatgct gaattcaacc ccctgtttcc tacagtcacc ctgagggacg ccgaccataa
     1021 atttgagtgg agcagaatgg agtttcagac ctgggcttta cacgtggcaa actgctacaa
     1081 ttaccgtgtg gagtttactg gggtagggac accgccagct ggatctgagc atgttggata
     1141 ttgtacccag ataggtgtct ttacaaagaa tggcgggaag ctctctaaac cttcggtttc
     1201 ccagcagtgt gaccagcacg tttataaacc tgtttataca acctcctacc cgagtttaca
     1261 gcaggagaag gtgctcaagt ttgttctggt tggggaactc ctgatacaag tggaccgact
     1321 gaggctgaga taccagagaa tgctgcggga ccgggagaag gaccggggcc ctaagccagg
     1381 ggacatggac tcctgcccag ccccacacct actgttggga gcagtcttca cggaggctga
     1441 aaaggccagg atagaaagtt ctcccaaacc cttctgtgaa ggagagaagt tttacatacc
     1501 cctgcagaga ctgctcactt accccaaact gcaccgcctg tgtgctgatg aggacagggt
     1561 gcggtccctc attgctgact cggtttgctt aagcagtgat ggctccgcag tcgtggttga
     1621 cctgcataat tcttgggatt atcggccgga agagaactga gccacccgga tttcttgaag
     1681 ctcagagacc cactgatagt tgggtttgct tagaattcaa acttctttca ttttagtggt
     1741 gccaggactc gaacccttgc acatgctaag caagcactct accactcagc tacatcctca
     1801 gccctagaat ttaaactctg tacagtcata attcaagaaa tagtttgaga gttttaacac
     1861 aaattgggtc ctgatctcga tgacagatct gcctgacata tagactgctc tttgcctgag
     1921 aaagggctta actaaaagta gttgctttct tttaaaatta gatttttatt ttttaaaaaa
     1981 attggagttt acaacaatga agaaattgga tgtggtaatg tgttaatttt gtcttcaccc
     2041 atattttggt gttagaacaa gcgtatgttg tatgtgacat taaaacattt aaatgtaaaa
     2101 aaaaaaaaaa aaaaaaaaaa a
//
