LOCUS       NM_133984               2194 bp    mRNA    linear   ROD 24-JAN-2025
DEFINITION  Mus musculus HemK methyltransferase family member 1 (Hemk1), mRNA.
ACCESSION   NM_133984
VERSION     NM_133984.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2194)
  AUTHORS   Magdaleno,S., Jensen,P., Brumwell,C.L., Seal,A., Lehman,K.,
            Asbury,A., Cheung,T., Cornelius,T., Batten,D.M., Eden,C.,
            Norland,S.M., Rice,D.S., Dosooye,N., Shakya,S., Mehta,P. and
            Curran,T.
  TITLE     BGEM: an in situ hybridization database of gene expression in the
            embryonic and adult mouse nervous system
  JOURNAL   PLoS Biol 4 (4), e86 (2006)
   PUBMED   16602821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672070.12.
            
            On Aug 8, 2009 this sequence version replaced NM_133984.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011431.1, SRR5189676.65783.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AL672070.12        149194-149263       c
            71-448              AL672070.12        147914-148291       c
            449-540             AL672070.12        147485-147576       c
            541-634             AL672070.12        147092-147185       c
            635-769             AL672070.12        142358-142492       c
            770-834             AL672070.12        142004-142068       c
            835-884             AL672070.12        141686-141735       c
            885-993             AL672070.12        140237-140345       c
            994-1089            AL672070.12        139348-139443       c
            1090-1203           AL672070.12        139089-139202       c
            1204-2194           AL672070.12        137995-138985       c
FEATURES             Location/Qualifiers
     source          1..2194
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 58.0 cM"
     gene            1..2194
                     /gene="Hemk1"
                     /gene_synonym="2310008M14Rik"
                     /note="HemK methyltransferase family member 1"
                     /db_xref="GeneID:69536"
                     /db_xref="MGI:MGI:1916786"
     exon            1..70
                     /gene="Hemk1"
                     /gene_synonym="2310008M14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            71..448
                     /gene="Hemk1"
                     /gene_synonym="2310008M14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1240
                     /gene="Hemk1"
                     /gene_synonym="2310008M14Rik"
                     /EC_number="2.1.1.297"
                     /codon_start=1
                     /product="MTRF1L release factor glutamine
                     methyltransferase"
                     /protein_id="NP_598745.2"
                     /db_xref="CCDS:CCDS23488.1"
                     /db_xref="GeneID:69536"
                     /db_xref="MGI:MGI:1916786"
                     /translation="MKLWGQILWTLLSVPRGRRGVLQGWAFNSWKTYSSLTGPLSATG
                     MVNHWTRVFEERGIPEARESSEYIVAHVLGAKTFQSLKPALWTKPLTPQQLECIQELC
                     GRRLQRMPVQYILGEWDFQGLSLKMVPPVFIPRPETEELVEWVLEEVAQRPHAVRAQD
                     GPLILEVGCGSGAITLSLLSQLPKSRVVAVDKEEAAVSLTHENAQRLQLQDRIRIIHL
                     DITSEGCCTHLLPWSPLDLVVSNPPYIFRKDMEQLAPEICSYEDLVALDGGDEGMDII
                     THILTLAPQLLNASGSIFLEVDPRHPELVSSWLQSHPDLHLSLVGVREDFCGRPRFLH
                     VQKSAP"
     exon            449..540
                     /gene="Hemk1"
                     /gene_synonym="2310008M14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            541..634
                     /gene="Hemk1"
                     /gene_synonym="2310008M14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            635..769
                     /gene="Hemk1"
                     /gene_synonym="2310008M14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            770..834
                     /gene="Hemk1"
                     /gene_synonym="2310008M14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            835..884
                     /gene="Hemk1"
                     /gene_synonym="2310008M14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            885..993
                     /gene="Hemk1"
                     /gene_synonym="2310008M14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1089
                     /gene="Hemk1"
                     /gene_synonym="2310008M14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1203
                     /gene="Hemk1"
                     /gene_synonym="2310008M14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..2194
                     /gene="Hemk1"
                     /gene_synonym="2310008M14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1568..1573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hemk1"
                     /gene_synonym="2310008M14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1569
                     /gene="Hemk1"
                     /gene_synonym="2310008M14Rik"
                     /note="major polyA site"
     regulatory      2175..2180
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hemk1"
                     /gene_synonym="2310008M14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2193
                     /gene="Hemk1"
                     /gene_synonym="2310008M14Rik"
ORIGIN      
        1 gggggggcgc taaccctggg tcaattttct ggtacttgtg tgtgggccgg gcgagcgtgc
       61 atgccctctg ggtagcagaa acatctgaga aacaaaacag agaactggaa cccatgactg
      121 attcttcacc cagcccagcc cagggatcac cctgagcccc tacctcagtg cagatagcac
      181 aagagagact caggcacttg gaagcctttc tccaagaatg aagctctggg gacaaatact
      241 ttggaccctt ctatctgttc cccgaggaag gaggggagtc ctccagggct gggccttcaa
      301 ctcatggaag acttattcat ccctgactgg gccgttgagt gccacaggga tggttaatca
      361 ctggacacgg gtctttgagg aaagaggtat cccagaggcc cgggaatcca gtgagtacat
      421 cgtggctcat gtcctcggag ccaaaacatt tcagagcctg aaaccagcac tttggaccaa
      481 gccactgacc cctcaacaat tggaatgcat ccaggagcta tgtggccgta gattacagag
      541 gatgccggtg cagtatatcc ttggggagtg ggactttcag gggctcagtc tgaagatggt
      601 acccccagtg ttcatccctc ggccagagac agaagaactg gttgaatggg ttttagagga
      661 agtggcccag aggccccatg cagtgagagc ccaggatggt cccctcattc tggaggtggg
      721 ctgtggatca ggagccatta ctctcagcct gctgagccag ctccccaaga gtcgagttgt
      781 tgctgtggat aaggaggaag ctgctgttag tctgacccat gagaatgctc agaggcttca
      841 gctgcaggac aggatccgga tcatccacct tgatataact tcagaggggt gctgcacaca
      901 ccttttgccc tggagcccct tggacttggt ggtcagcaac cctccctaca tcttccgcaa
      961 ggacatggaa cagctggctc cagagatctg cagttacgaa gatctggtgg ccctggatgg
     1021 tggtgacgaa ggcatggaca tcatcaccca catcttgacc ttggcacccc agctcttgaa
     1081 tgcctctgga agcatcttct tagaagtaga cccaagacac ccagagcttg tcagcagttg
     1141 gcttcagagc catcctgacc tgcaccttag tcttgtggga gtccgtgaag acttctgtgg
     1201 gaggccccgg ttcctgcatg tccagaagtc tgcaccatag cgtggctact ctgtgaacac
     1261 ccggccagga ttctagcctg ctgggtggct ggcttaccct gtgtggaatg ccgcccaggg
     1321 gaaggtgaac agcgctgtcc tgggcccctg gcacggccat ggtcctgtga ttccccatga
     1381 tggatgtttc taggagactt ggaaagaagg atggagtgtt cttcctgggg cagcaaagaa
     1441 cagagaccca agagctgggt ttccagcctg gccctgcccc ctctgtgtag caggctactt
     1501 ggtgttcctc ttggtgaaat tgctataaag atgttgggaa ggatggctag taaagtgttg
     1561 agagagcaat aaatggtgag ccagtatttt gttattaaca ttcatgggcc ctcgttcccc
     1621 atgcaggact aggcctgaga gcctctccct tctgcagcaa gtcaagccga ctgtgtggtg
     1681 taaggatacc aggtgatagg gacaggggat ggggaggctc agtcctggcc ttggacactg
     1741 tagggcctgc acagaatagc ccactctggt tagcgtcatc cggatgctcc agcctgggaa
     1801 tgcctacatt ctctaccttg actgggcctg tgtaggactg tgaaaggcag cctggttcct
     1861 ggttgagcta aagttggaaa ccccagtgat cctgaggaac ggcaggcatt ttgcctggtt
     1921 ctcagactct aggcttcaga caggaggcca cagccctcca tagatttgtg gccagcagtc
     1981 acgtaagggc aacgccccca aacccctcca cagaaggctc aagacagatc tccattttaa
     2041 taagatactt aaaggcctga gggcttagcc aataaactcc ccttcccaga cactcctccc
     2101 tacaaaaggt atttaacctc aggccagccc tgagaagtgg ggtatggttt tattcatcca
     2161 ctttctgcca tgacaataaa cgccttaaaa ccat
//
