LOCUS       NM_173789               1548 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus helt bHLH transcription factor (Helt), mRNA.
ACCESSION   NM_173789
VERSION     NM_173789.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1548)
  AUTHORS   Tran,H.N., Nguyen,Q.H. and Jeong,Y.
  TITLE     Dbx1 is a dorsal midbrain-specific determinant of GABAergic neuron
            fate and regulates differentiation of the dorsal midbrain into the
            inferior and superior colliculi
  JOURNAL   Front Cell Dev Biol 12, 1336308 (2024)
   PUBMED   38344749
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1548)
  AUTHORS   Meier,S., Alfonsi,F., Kurniawan,N.D., Milne,M.R., Kasherman,M.A.,
            Delogu,A., Piper,M. and Coulson,E.J.
  TITLE     The p75 neurotrophin receptor is required for the survival of
            neuronal progenitors and normal formation of the basal forebrain,
            striatum, thalamus and neocortex
  JOURNAL   Development 146 (18) (2019)
   PUBMED   31488566
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1548)
  AUTHORS   Thompson,J., Mendoza,F., Tan,E., Bertol,J.W., Gaggar,A.S., Jun,G.,
            Biguetti,C. and Fakhouri,W.D.
  TITLE     A cleft lip and palate gene, Irf6, is involved in osteoblast
            differentiation of craniofacial bone
  JOURNAL   Dev Dyn 248 (3), 221-232 (2019)
   PUBMED   30684382
REFERENCE   4  (bases 1 to 1548)
  AUTHORS   Lee,B., Lee,M., Song,S., Loi,L.D., Lam,D.T., Yoon,J., Baek,K.,
            Curtis,D.J. and Jeong,Y.
  TITLE     Specification of neurotransmitter identity by Tal1 in thalamic
            nuclei
  JOURNAL   Dev Dyn 246 (10), 749-758 (2017)
   PUBMED   28685891
REFERENCE   5  (bases 1 to 1548)
  AUTHORS   Lee,M., Yoon,J., Song,H., Lee,B., Lam,D.T., Yoon,J., Baek,K.,
            Clevers,H. and Jeong,Y.
  TITLE     Tcf7l2 plays crucial roles in forebrain development through
            regulation of thalamic and habenular neuron identity and
            connectivity
  JOURNAL   Dev Biol 424 (1), 62-76 (2017)
   PUBMED   28219675
REFERENCE   6  (bases 1 to 1548)
  AUTHORS   Guimera,J., Weisenhorn,D.V. and Wurst,W.
  TITLE     Megane/Heslike is required for normal GABAergic differentiation in
            the mouse superior colliculus
  JOURNAL   Development 133 (19), 3847-3857 (2006)
   PUBMED   16968817
  REMARK    GeneRIF: Homozygous Mgn-null mice die between the second and the
            fifth postnatal week of age, and show a complete depletion of Gad65
            and Gad67 expression in the superior colliculus and a reduction in
            the inferior colliculus.
REFERENCE   7  (bases 1 to 1548)
  AUTHORS   Guimera,J., Vogt Weisenhorn,D., Echevarria,D., Martinez,S. and
            Wurst,W.
  TITLE     Molecular characterization, structure and developmental expression
            of Megane bHLH factor
  JOURNAL   Gene 377, 65-76 (2006)
   PUBMED   16644143
  REMARK    GeneRIF: Mgn is a single copy gene on mouse chromosome 8 and
            encodes a 27kDa protein that functions in the nucleus.
REFERENCE   8  (bases 1 to 1548)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human HESL, rat Hesl and
            rainbow trout hesl genes in silico
  JOURNAL   Int J Mol Med 14 (4), 747-751 (2004)
   PUBMED   15375612
REFERENCE   9  (bases 1 to 1548)
  AUTHORS   Nakatani,T., Mizuhara,E., Minaki,Y., Sakamoto,Y. and Ono,Y.
  TITLE     Helt, a novel basic-helix-loop-helix transcriptional repressor
            expressed in the developing central nervous system
  JOURNAL   J Biol Chem 279 (16), 16356-16367 (2004)
   PUBMED   14764602
  REMARK    GeneRIF: Helt acts as a transcriptional repressor to regulate
            neuronal differentiation and/or identity
REFERENCE   10 (bases 1 to 1548)
  AUTHORS   Miyoshi,G., Bessho,Y., Yamada,S. and Kageyama,R.
  TITLE     Identification of a novel basic helix-loop-helix gene, Heslike, and
            its role in GABAergic neurogenesis
  JOURNAL   J Neurosci 24 (14), 3672-3682 (2004)
   PUBMED   15071116
  REMARK    GeneRIF: identification of a novel mouse bHLH factor, termed
            Heslike, that has Hes1-like bHLH domain and transcriptional
            repressor activity; Heslike is coexpressed with the bHLH factor
            Mash1 in brain regions that give rise to GABAergic neurons
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB120968.1.
            
            On Apr 2, 2004 this sequence version replaced NM_173789.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB120968.1, BC103599.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1548
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="BALB/c"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 26.32 cM"
     gene            1..1548
                     /gene="Helt"
                     /gene_synonym="A830086M02; Hesl; Heslike; megane; Mgn"
                     /note="helt bHLH transcription factor"
                     /db_xref="GeneID:234219"
                     /db_xref="MGI:MGI:3040955"
     exon            1..648
                     /gene="Helt"
                     /gene_synonym="A830086M02; Hesl; Heslike; megane; Mgn"
                     /inference="alignment:Splign:2.1.0"
     CDS             622..1344
                     /gene="Helt"
                     /gene_synonym="A830086M02; Hesl; Heslike; megane; Mgn"
                     /note="bHLH transcription factor megane; mesencephalic
                     GABAergic neurons enhancer of split related protein;
                     protein megane; HES/HEY-like transcription factor;
                     Hes-like transcription factor"
                     /codon_start=1
                     /product="hairy and enhancer of split-related protein
                     HELT"
                     /protein_id="NP_776150.2"
                     /db_xref="CCDS:CCDS22290.1"
                     /db_xref="GeneID:234219"
                     /db_xref="MGI:MGI:3040955"
                     /translation="MSDRLKERKRTPVSHKVIEKRRRDRINRCLNELGKTVPMALAKQ
                     SSGKLEKAEILEMTVQYLRALHSADFPRGREKELLAEFANYFHYGYHECMKNLVHYLT
                     TVERMETKDTKYARILAFLQSKARLGAEPTFPPLSLPEPDFSYQLHAASPEFPGHSPG
                     EATMFPQGATPGSFPWPPGAARSPALPYLSSATVPLPSPAQQHSPFLAPMQGLDRHYL
                     NLIGHGHPNGLNLHTPQHPPVL"
     exon            649..753
                     /gene="Helt"
                     /gene_synonym="A830086M02; Hesl; Heslike; megane; Mgn"
                     /inference="alignment:Splign:2.1.0"
     exon            754..850
                     /gene="Helt"
                     /gene_synonym="A830086M02; Hesl; Heslike; megane; Mgn"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1533
                     /gene="Helt"
                     /gene_synonym="A830086M02; Hesl; Heslike; megane; Mgn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctattaaag gcttacttaa ttactttaat gactctggac aggctttaaa acgcactcgg
       61 cgctgggacc gcgggcttgc tgggatttgt aaacaggcga tcgtgtgaga ctcagcggtg
      121 ggactaaagg aagcgacgct gttttgtgaa ggtcctcgcc ccccggtgcc cgcagccact
      181 gcgcccctgc gctctgcgcc ggctaagagt gcaggcgctc gctggtccgc cggctccagt
      241 ttctcgcccc ctcttcctga ggtgcctgtt gccatgcaaa tgttattcct ggacgaatca
      301 cgtgtccttt gaagagccac gtggattaac aaagctgatc tgcccccacc tcgcccccct
      361 cggctgctaa aaattttttt gtcaacttct ttaaaactga ccttgaatgc atacatgctc
      421 caaacgcaga actcctaatc ctatggaata attcagcgcg tgagaatgca cttgcagtcc
      481 tagatggctg ctttataaag ggagccccct cggacctggg aggctgcagt ctacctggaa
      541 cacttgaaga ggcacacgag gtggaacgtg gacgagtgcc tcgcgccacc gcctctgccg
      601 agggcgcgca cgcacaccag aatgtctgac aggctcaagg aacgcaaaag aaccccggtt
      661 tctcataaag tgatagaaaa gagaaggagg gaccgaatta accgctgctt gaacgagctg
      721 ggcaagacag tccctatggc cctggcgaaa cagagttccg ggaaactgga gaaggcggag
      781 atcctggaga tgacagtgca gtacctcaga gctctgcatt ccgcggattt tccccgggga
      841 agggaaaaag agcttttagc agaatttgcc aactacttcc actacggtta ccacgagtgc
      901 atgaagaacc tggtgcacta cctcaccacc gtggagcgga tggagaccaa agacaccaag
      961 tatgcgcgca tcctcgcctt cttgcaatcc aaggcccgcc tgggcgccga gcccaccttt
     1021 ccgccgctct cgcttccgga gccagatttc tcctatcagc tgcatgcagc aagcccagag
     1081 ttcccgggcc acagcccagg tgaagccaca atgttcccgc agggggctac cccagggtca
     1141 ttcccatggc ctcctggagc tgcccgcagc ccagcactgc cttacttgtc cagcgcgacg
     1201 gtacctctcc ccagcccggc acagcagcac agccccttct tggctccgat gcagggcctg
     1261 gaccggcatt atctcaatct gatcggccat ggccacccca acggcctcaa cctgcacacg
     1321 ccccagcacc ctccggtgct ctgacaccca ctcactgcct agattacttt gcgattcggt
     1381 ggcggcttga gacgatgtat atgttgtacg agtgtaaata gtgtgctaac aagatctgga
     1441 tgggaaagcg tcagaagcga attcgccttc tgaaggtcct ccccaaccaa taaatatttt
     1501 tgtgctaaag atcaataaat attttgtgct aaaaaaaaaa aaaaaaaa
//
