LOCUS       NP_001074576            1069 aa            linear   ROD 29-JUL-2024
DEFINITION  helicase POLQ-like isoform 1 [Mus musculus].
ACCESSION   NP_001074576 XP_132236
VERSION     NP_001074576.1
DBSOURCE    REFSEQ: accession NM_001081107.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1069)
  AUTHORS   Wan,C., Huang,Y., Xue,X., Chang,G., Wang,M., Zhao,X.Y., Luo,F. and
            Tang,Z.Z.
  TITLE     HELQ deficiency impairs the induction of primordial germ cell-like
            cells
  JOURNAL   FEBS Open Bio 14 (7), 1087-1100 (2024)
   PUBMED   38720471
  REMARK    GeneRIF: HELQ deficiency impairs the induction of primordial germ
            cell-like cells.
REFERENCE   2  (residues 1 to 1069)
  AUTHORS   Bakhshalizadeh,S., Bird,A.D., Sreenivasan,R., Bell,K.M.,
            Robevska,G., van den Bergen,J., Asghari-Jafarabadi,M., Kueh,A.J.,
            Touraine,P., Lokchine,A., Jaillard,S., Ayers,K.L., Wilhelm,D.,
            Sinclair,A.H. and Tucker,E.J.
  TITLE     A Human Homozygous HELQ Missense Variant Does Not Cause Premature
            Ovarian Insufficiency in a Mouse Model
  JOURNAL   Genes (Basel) 15 (3), 333 (2024)
   PUBMED   38540391
  REMARK    GeneRIF: A Human Homozygous HELQ Missense Variant Does Not Cause
            Premature Ovarian Insufficiency in a Mouse Model.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1069)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 1069)
  AUTHORS   Zhao,J., Lu,P., Wan,C., Huang,Y., Cui,M., Yang,X., Hu,Y., Zheng,Y.,
            Dong,J., Wang,M., Zhang,S., Liu,Z., Bian,S., Wang,X., Wang,R.,
            Ren,S., Wang,D., Yao,Z., Chang,G., Tang,F. and Zhao,X.Y.
  TITLE     Cell-fate transition and determination analysis of mouse male germ
            cells throughout development
  JOURNAL   Nat Commun 12 (1), 6839 (2021)
   PUBMED   34824237
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1069)
  AUTHORS   Murtaza,G., Yang,L., Khan,I., Unar,A., Khan,M., Huan,Z., Khan,R.
            and Shi,Q.
  TITLE     Identification and Functional Investigation of Novel Heterozygous
            HELQ Mutations in Patients with Sertoli Cell-only Syndrome
  JOURNAL   Genet Test Mol Biomarkers 25 (10), 654-659 (2021)
   PUBMED   34672775
  REMARK    GeneRIF: Identification and Functional Investigation of Novel
            Heterozygous HELQ Mutations in Patients with Sertoli Cell-only
            Syndrome.
REFERENCE   6  (residues 1 to 1069)
  AUTHORS   Luebben,S.W., Kawabata,T., Akre,M.K., Lee,W.L., Johnson,C.S.,
            O'Sullivan,M.G. and Shima,N.
  TITLE     Helq acts in parallel to Fancc to suppress replication-associated
            genome instability
  JOURNAL   Nucleic Acids Res 41 (22), 10283-10297 (2013)
   PUBMED   24005041
  REMARK    GeneRIF: The findings suggest that HELQ contributes to genome
            stability in unchallenged conditions through a mechanism distinct
            from the function of FANCC.
REFERENCE   7  (residues 1 to 1069)
  AUTHORS   Adelman,C.A., Lolo,R.L., Birkbak,N.J., Murina,O., Matsuzaki,K.,
            Horejsi,Z., Parmar,K., Borel,V., Skehel,J.M., Stamp,G.,
            D'Andrea,A., Sartori,A.A., Swanton,C. and Boulton,S.J.
  TITLE     HELQ promotes RAD51 paralogue-dependent repair to avert germ cell
            loss and tumorigenesis
  JOURNAL   Nature 502 (7471), 381-384 (2013)
   PUBMED   24005329
  REMARK    GeneRIF: results reveal a critical role for HELQ in
            replication-coupled DNA repair, germ cell maintenance and tumour
            suppression in mammals
REFERENCE   8  (residues 1 to 1069)
  AUTHORS   Marini,F., Kim,N., Schuffert,A. and Wood,R.D.
  TITLE     POLN, a nuclear PolA family DNA polymerase homologous to the DNA
            cross-link sensitivity protein Mus308
  JOURNAL   J Biol Chem 278 (34), 32014-32019 (2003)
   PUBMED   12794064
  REMARK    GeneRIF: identification of homolog to POLN
REFERENCE   9  (residues 1 to 1069)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 1069)
  AUTHORS   Marini,F. and Wood,R.D.
  TITLE     A human DNA helicase homologous to the DNA cross-link sensitivity
            protein Mus308
  JOURNAL   J Biol Chem 277 (10), 8716-8723 (2002)
   PUBMED   11751861
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161510.10.
            
            On Feb 6, 2007 this sequence version replaced XP_132236.6.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082601.1, SRR17253014.1204720.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1069
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 48.52 cM"
     Protein         1..1069
                     /product="helicase POLQ-like isoform 1"
                     /EC_number="3.6.4.12"
                     /note="DNA helicase Hel308; POLQ-like helicase;
                     mus308-like helicase; helicase, mus308-like"
                     /calculated_mol_wt=118968
     Region          1..73
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2VPA6.2)"
     Region          129..239
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2VPA6.2)"
     Region          278..845
                     /region_name="BRR2"
                     /note="Replicative superfamily II helicase [Replication,
                     recombination and repair]; COG1204"
                     /db_xref="CDD:440817"
     Region          278..480
                     /region_name="DEXHc_POLQ-like"
                     /note="DEXH-box helicase domain of DNA polymerase theta;
                     cd18026"
                     /db_xref="CDD:350784"
     Site            order(292,294,299,320..326,422)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350784"
     Site            order(349..350,377,396,398..399,402,432)
                     /site_type="other"
                     /note="nucleic acid binding site [nucleotide binding]"
                     /db_xref="CDD:350784"
     Region          422..425
                     /region_name="DEAH box.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00541"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2VPA6.2)"
     Region          971..1024
                     /region_name="HHH_5"
                     /note="Helix-hairpin-helix domain; pfam14520"
                     /db_xref="CDD:434010"
     CDS             1..1069
                     /gene="Helq"
                     /gene_synonym="D430018E21Rik; Hel308"
                     /coded_by="NM_001081107.1:128..3337"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS39184.1"
                     /db_xref="GeneID:191578"
                     /db_xref="MGI:MGI:2176740"
ORIGIN      
        1 medgcprirr rvsvrkrnrg nlenlraspt paelqpaedt edeaaagsrr rktgspehaq
       61 endseedmfg dydsftessf lahvddleqr ymqlpecgdr dadsgtkdlc saglknnlrv
      121 ttvinltdpe tsehgqkqsh ldvpaepepg sdlsfdvpss qilyfenpqn spealgdpct
      181 kktngdpqks sheelvssht eqpepnndfs nvraasessr rkslkdhlks tmagnaraqt
      241 pafprskhlr eallseeisv akkaiespsd dlgpfyslps kvrdlyvqlk gikklydwqh
      301 tcltlrsvqe rknliyslpt sggktlvaei lmlqellcrq kdvlmilpyv aivqekissl
      361 ssfgielgff veeyagskgr fppikrrekk slyiatieka hslvnaliet srlstlglvv
      421 vdelhmigeg srgailemtl akvlytsktt qiigmsatln nvedlqaflk aeyytsqfrp
      481 velkeflkvn dtiyevdsqa adgmtfsrll sykysealkk mdpdrlvalv tevipnyscl
      541 vfcpskknce nvaemlckfl skdylnhrek ekcevikslr nigngkvcpv lkrtvpfgia
      601 yhhsgltsee rklleeayst gvlclltcts tlaagvnlpa rrvilrapyv antflkrnqy
      661 kqmvgragra gidtagesil llqekdkqqv lelisgplet ccshlveeft kgiqalflsl
      721 iglkiaaslg diyqfmsgtf fgvqqkillk ekslweitvd alehltekgl lqkdscgdne
      781 glechfritk lgqasfkgai dlaycdtlyr dlkkgleglv lesllhliyl ttpydlaaqs
      841 epdwmvyfkq fgqlspteqn vaallgvses figkkaagqa vrkkvdknvv nrlylsfvly
      901 sllketnvws vsekfnlprg yiqnllmgaa sfsscvlhfc eeleefwvyk allveltkkl
      961 tycvkaelip lmevtgvleg rakqlynagy rsimhlanan pevlvktidh lsrrqarqiv
     1021 ssakmllhek aealqgeaee llrlpadlpg lggpsserag shagdvtls
//
