LOCUS       NM_008234               3039 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus helicase, lymphoid specific (Hells), mRNA.
ACCESSION   NM_008234
VERSION     NM_008234.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3039)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3039)
  AUTHORS   Vukic,M., Chouaref,J., Della Chiara,V., Dogan,S., Ratner,F.,
            Hogenboom,J.Z.M., Epp,T.A., Chawengsaksophak,K., Vonk,K.K.D.,
            Breukel,C., Ariyurek,Y., San Leon Granado,D., Kloet,S.L. and
            Daxinger,L.
  TITLE     CDCA7-associated global aberrant DNA hypomethylation translates to
            localized, tissue-specific transcriptional responses
  JOURNAL   Sci Adv 10 (6), eadk3384 (2024)
   PUBMED   38335290
REFERENCE   3  (bases 1 to 3039)
  AUTHORS   Cousu,C., Mulot,E., De Smet,A., Formichetti,S., Lecoeuche,D.,
            Ren,J., Muegge,K., Boulard,M., Weill,J.C., Reynaud,C.A. and
            Storck,S.
  TITLE     Germinal center output is sustained by HELLS-dependent
            DNA-methylation-maintenance in B cells
  JOURNAL   Nat Commun 14 (1), 5695 (2023)
   PUBMED   37709749
  REMARK    GeneRIF: Germinal center output is sustained by HELLS-dependent
            DNA-methylation-maintenance in B cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3039)
  AUTHORS   Prakash Yadav,R., Leskinen,S., Ma,L., Makela,J.A. and Kotaja,N.
  TITLE     Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically
            expressed during mouse spermatogenesis
  JOURNAL   Reproduction 165 (1), 49-63 (2022)
   PUBMED   36194437
  REMARK    GeneRIF: Chromatin remodelers HELLS, WDHD1 and BAZ1A are
            dynamically expressed during mouse spermatogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3039)
  AUTHORS   Ni,K., Ren,J., Xu,X., He,Y., Finney,R., Braun,S.M.G.,
            Hathaway,N.A., Crabtree,G.R. and Muegge,K.
  TITLE     LSH mediates gene repression through macroH2A deposition
  JOURNAL   Nat Commun 11 (1), 5647 (2020)
   PUBMED   33159050
  REMARK    GeneRIF: LSH mediates gene repression through macroH2A deposition.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3039)
  AUTHORS   Geiman,T.M., Tessarollo,L., Anver,M.R., Kopp,J.B., Ward,J.M. and
            Muegge,K.
  TITLE     Lsh, a SNF2 family member, is required for normal murine
            development
  JOURNAL   Biochim Biophys Acta 1526 (2), 211-220 (2001)
   PUBMED   11325543
REFERENCE   7  (bases 1 to 3039)
  AUTHORS   Raabe,E.H., Abdurrahman,L., Behbehani,G. and Arceci,R.J.
  TITLE     An SNF2 factor involved in mammalian development and cellular
            proliferation
  JOURNAL   Dev Dyn 221 (1), 92-105 (2001)
   PUBMED   11357197
REFERENCE   8  (bases 1 to 3039)
  AUTHORS   Geiman,T.M. and Muegge,K.
  TITLE     Lsh, an SNF2/helicase family member, is required for proliferation
            of mature T lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 97 (9), 4772-4777 (2000)
   PUBMED   10781083
REFERENCE   9  (bases 1 to 3039)
  AUTHORS   Geiman,T.M., Durum,S.K. and Muegge,K.
  TITLE     Characterization of gene expression, genomic structure, and
            chromosomal localization of Hells (Lsh)
  JOURNAL   Genomics 54 (3), 477-483 (1998)
   PUBMED   9878251
REFERENCE   10 (bases 1 to 3039)
  AUTHORS   Jarvis,C.D., Geiman,T., Vila-Storm,M.P., Osipovich,O., Akella,U.,
            Candeias,S., Nathan,I., Durum,S.K. and Muegge,K.
  TITLE     A novel putative helicase produced in early murine lymphocytes
  JOURNAL   Gene 169 (2), 203-207 (1996)
   PUBMED   8647447
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF155210.1.
            
            On Feb 16, 2006 this sequence version replaced NM_008234.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF155210.1, BC100394.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3039
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 33.57 cM"
     gene            1..3039
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /note="helicase, lymphoid specific"
                     /db_xref="GeneID:15201"
                     /db_xref="MGI:MGI:106209"
     exon            1..86
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /inference="alignment:Splign:2.1.0"
     exon            87..208
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..2569
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /note="proliferation-associated SNF2-like protein"
                     /codon_start=1
                     /product="lymphocyte-specific helicase"
                     /protein_id="NP_032260.2"
                     /db_xref="CCDS:CCDS29789.1"
                     /db_xref="GeneID:15201"
                     /db_xref="MGI:MGI:106209"
                     /translation="MAEQTEPAVITPAMLEEEEQLEAAGLEKERKMLEEAQKSWDRES
                     TEIRYRRLQHLLEKSNIYSKFLLTKMEQQQLEEQKKKEKLEKKKRSLKLTEGKSLVDG
                     NGEKPVMKKKRGREDESYNISEVMSKEEILSVAKKHKDNEDESSSTTSLCVEDIQKNK
                     DSNSMIKDRLSQTVRQNSKFFFDPVRKCNGQPVPFQQPKHFTGGVMRWYQVEGMEWLR
                     MLWENGINGILADEMGLGKTVQCIATIALMIQRGVPGPFLVCGPLSTLPNWMAEFKRF
                     TPEIPTLLYHGTREDRRKLVKNIHKRQGTLQIHPVVVTSFEIAMRDQNALQHCYWKYL
                     IVDEGHRIKNMKCRLIRELKRFNADNKLLLTGTPLQNNLSELWSLLNFLLPDVFDDLK
                     SFESWFDITSLSETAEDIIAKEREQNVLHMLHQILTPFLLRRLKSDVALEVPPKREVV
                     VYAPLCNKQEIFYTAIVNRTIANMFGSCEKETVELSPTGRPKRRSRKSINYSELDQFP
                     SELEKLISQIQPEVNRERTVVEGNIPIESEVNLKLRNIMMLLRKCCNHPYMIEYPIDP
                     VTQEFKIDEELVTNSGKFLILDRMLPELKKRGHKVLVFSQMTSMLDILMDYCHLRNFI
                     FSRLDGSMSYSEREKNIYSFNTDPDVFLFLVSTRAGGLGINLTAADTVIIYDSDWNPQ
                     SDLQAQDRCHRIGQTKPVVVYRLVTANTIDQKIVERAAAKRKLEKLIIHKNHFKGGQS
                     GLSQSKNFLDAKELMELLKSRDYEREVKGSREKVISDEDLELLLDRSDLIDQMKASRP
                     IKGKTGIFKILENSEDSSAECLF"
     exon            209..331
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /inference="alignment:Splign:2.1.0"
     exon            332..388
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /inference="alignment:Splign:2.1.0"
     exon            389..425
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /inference="alignment:Splign:2.1.0"
     exon            426..490
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /inference="alignment:Splign:2.1.0"
     exon            491..529
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /inference="alignment:Splign:2.1.0"
     exon            530..757
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /inference="alignment:Splign:2.1.0"
     exon            758..940
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1084
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1281
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1378
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1540
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1680
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1819
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1903
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2023
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2140
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2300
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2397
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2474
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..3019
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3000..3005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /note="hexamer: AATAAA"
     polyA_site      3019
                     /gene="Hells"
                     /gene_synonym="E130115I21Rik; LSH; Lysh; PASG; YFK8"
                     /note="major polyA site"
ORIGIN      
        1 tgaggattta gctcgcggcg tttgaggcga ctgggtcccc ggccggtgtc cagccgtgcc
       61 tgcggagccg cccgcgagca gcagcgggtc cttggctcca gagatggccg aacaaacgga
      121 gcctgcggtg attactccag ccatgctgga ggaggaggaa cagctcgagg ctgcgggact
      181 tgagaaagag cggaagatgt tagaagaggc tcaaaagtct tgggacagag agtccactga
      241 aattcggtac cgcagacttc agcatttgct tgaaaaaagc aatatctact caaaattttt
      301 gttgactaaa atggaacaac agcaattgga ggaacagaag aagaaagaga agttggagaa
      361 aaaaaaacgg tcattaaaac ttacagaggg taaaagttta gttgatggga atggagagaa
      421 accagtcatg aaaaagaaaa gaggaagaga agatgaatct tataatattt cagaggtcat
      481 gtcaaaagag gaaattttgt ccgtagctaa aaaacataag gataatgagg atgaaagctc
      541 ttccactacg agtctttgtg tagaagatat tcagaaaaat aaggattcaa atagtatgat
      601 taaagataga ttgtctcaaa ctgttaggca gaattctaaa ttcttttttg acccagttcg
      661 gaaatgtaac ggacagcctg taccctttca acaaccaaag catttcacag gaggagtaat
      721 gaggtggtac caagtagaag gcatggaatg gcttaggatg ctttgggaaa atggaattaa
      781 tggcatttta gcagatgaaa tgggtttggg aaagactgtt cagtgcattg ctacaattgc
      841 attgatgatt cagaggggag tacctggacc ttttcttgtt tgtggccctt tgtctacact
      901 tcctaactgg atggctgaat ttaaaagatt tactccagaa attcctactc tgctgtatca
      961 tggaacccgg gaggaccgtc ggaaattagt aaagaatatc cacaaaagac aagggacact
     1021 gcagattcat cctgtggtgg tcacatcatt cgagatcgct atgcgagacc agaatgcttt
     1081 acagcattgc tattggaaat acttaatagt agatgaagga cacaggatta agaatatgaa
     1141 gtgccggcta atcagggagt taaaacggtt caatgctgat aacaaacttc ttttgactgg
     1201 tactcccttg caaaacaatt tatcagaact ttggtcattg ctaaactttt tgttgccaga
     1261 tgtatttgat gacttgaaaa gctttgagtc ttggtttgat atcactagtc tttctgaaac
     1321 tgctgaagat attatagcta aagagagaga acagaatgtt ttacatatgc tgcaccagat
     1381 tttaacgcct ttcctactga gaagactgaa gtctgatgtt gctcttgaag tcccccctaa
     1441 gcgagaagta gttgtttatg caccactttg caataaacaa gagatcttct atacagctat
     1501 tgtgaaccgc acaattgcaa acatgtttgg atcctgtgag aaggaaacag ttgagctaag
     1561 tcctactgga agaccaaaac gacgaagtag aaagtcaata aattacagcg aactagatca
     1621 gttccctagt gaattagaaa aactaataag tcaaatacag ccagaagtaa acagagagag
     1681 gactgttgtg gaaggtaata tccctataga atctgaagtt aatctgaagc tgcggaatat
     1741 aatgatgcta cttcgaaagt gctgtaatca cccatatatg attgaatatc ctattgaccc
     1801 tgtcacacaa gaatttaaga ttgatgaaga gttggtaaca aattctggga agttcttaat
     1861 tttggatcga atgctgcccg aacttaaaaa aagaggtcac aaggttctgg tgttttcaca
     1921 aatgacaagc atgttggaca tcttgatgga ttattgccat cttagaaact tcatctttag
     1981 cagacttgat gggtccatgt cttattcgga aagagaaaaa aatatataca gtttcaacac
     2041 ggatccagat gtttttcttt tcttagtgag tacacgagct ggtggtttag gcataaactt
     2101 gactgcagca gatacagtga tcatttatga cagtgattgg aatcctcagt ctgatctcca
     2161 ggctcaagat agatgtcata gaattggtca gacaaagcca gttgttgtgt atcgtcttgt
     2221 aacagcaaat actattgacc agaaaattgt ggaaagagca gctgctaaaa gaaagttgga
     2281 gaagttgata atccataaaa atcatttcaa aggtggtcag tctgggttaa gtcaatctaa
     2341 gaatttctta gatgcaaagg aattaatgga gttattaaaa tctagagatt atgaaaggga
     2401 agtaaaagga tccagagaga aggtcattag tgacgaagat ctagaattac tgttggatcg
     2461 aagtgatctc attgatcaaa tgaaggcttc aagaccaatt aaagggaaga cagggatatt
     2521 caaaatacta gaaaattctg aagattccag tgctgaatgt ttattttaat gtagaactaa
     2581 atggctttta aaaactttgg tttacatcca ttctggtaat ttgcctgttg gctttgaaat
     2641 ccatattgtt cactttactt ttataatata tcagttttta taatgtaact agtattgcat
     2701 acttgatgaa aattttgtgg attttactta gtataaaatt cctataaatt taaatttttc
     2761 agttagtttt tgggactggg tagtacttct gagtttgtta ttatgtactt aaccattgcc
     2821 aagtttatca gtcttcctgt ggaagtttag tgtctccccc acccccttta gtaatgtaat
     2881 tcatgggatt tggacttcag ttatggagta ggcgtctgat agggggagat tgattgaaac
     2941 tgtactttct gttgctgaag taaagttttt gatttttggg tcaataattt gacttaccaa
     3001 ataaatgttt attataataa aaaaaaaaaa aaaaaaaaa
//
