LOCUS       NM_080446               4540 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus helicase (DNA) B (Helb), mRNA.
ACCESSION   NM_080446 XM_985772
VERSION     NM_080446.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4540)
  AUTHORS   Piprek,R.P., Rams-Pociecha,I., Zdanowski,R., Kloc,M. and
            Kubiak,J.Z.
  TITLE     Desmoplakin (Dsp) conditional knockout in NR5A1+ somatic cells
            affects germ cell survival in developing mouse gonads
  JOURNAL   Reproduction 163 (4), 199-207 (2022)
   PUBMED   35119382
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4540)
  AUTHORS   Tkac,J., Xu,G., Adhikary,H., Young,J.T.F., Gallo,D.,
            Escribano-Diaz,C., Krietsch,J., Orthwein,A., Munro,M., Sol,W.,
            Al-Hakim,A., Lin,Z.Y., Jonkers,J., Borst,P., Brown,G.W.,
            Gingras,A.C., Rottenberg,S., Masson,J.Y. and Durocher,D.
  TITLE     HELB Is a Feedback Inhibitor of DNA End Resection
  JOURNAL   Mol Cell 61 (3), 405-418 (2016)
   PUBMED   26774285
  REMARK    GeneRIF: Conclude that mammalian DNA end resection triggers its own
            inhibition via the recruitment of HELB.
REFERENCE   3  (bases 1 to 4540)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
REFERENCE   4  (bases 1 to 4540)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 4540)
  AUTHORS   Tada,S., Kobayashi,T., Omori,A., Kusa,Y., Okumura,N., Kodaira,H.,
            Ishimi,Y., Seki,M. and Enomoto,T.
  TITLE     Molecular cloning of a cDNA encoding mouse DNA helicase B, which
            has homology to Escherichia coli RecD protein, and identification
            of a mutation in the DNA helicase B from tsFT848
            temperature-sensitive DNA replication mutant cells
  JOURNAL   Nucleic Acids Res 29 (18), 3835-3840 (2001)
   PUBMED   11557815
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131122.1 and AB048542.1.
            
            On Jan 18, 2008 this sequence version replaced NM_080446.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB048542.1, AK131122.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4525              AK131122.1         23-4547
            4526-4540           AB048542.1         4450-4464
FEATURES             Location/Qualifiers
     source          1..4540
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 67.94 cM"
     gene            1..4540
                     /gene="Helb"
                     /gene_synonym="D10Ertd664e"
                     /note="helicase (DNA) B"
                     /db_xref="GeneID:117599"
                     /db_xref="MGI:MGI:2152895"
     exon            1..281
                     /gene="Helb"
                     /gene_synonym="D10Ertd664e"
                     /inference="alignment:Splign:2.1.0"
     exon            282..677
                     /gene="Helb"
                     /gene_synonym="D10Ertd664e"
                     /inference="alignment:Splign:2.1.0"
     exon            678..847
                     /gene="Helb"
                     /gene_synonym="D10Ertd664e"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1726
                     /gene="Helb"
                     /gene_synonym="D10Ertd664e"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1901
                     /gene="Helb"
                     /gene_synonym="D10Ertd664e"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2043
                     /gene="Helb"
                     /gene_synonym="D10Ertd664e"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2198
                     /gene="Helb"
                     /gene_synonym="D10Ertd664e"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2289
                     /gene="Helb"
                     /gene_synonym="D10Ertd664e"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2349
                     /gene="Helb"
                     /gene_synonym="D10Ertd664e"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2554
                     /gene="Helb"
                     /gene_synonym="D10Ertd664e"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2698
                     /gene="Helb"
                     /gene_synonym="D10Ertd664e"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..3166
                     /gene="Helb"
                     /gene_synonym="D10Ertd664e"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..4532
                     /gene="Helb"
                     /gene_synonym="D10Ertd664e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4506..4511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Helb"
                     /gene_synonym="D10Ertd664e"
                     /note="hexamer: AATAAA"
     polyA_site      4526
                     /gene="Helb"
                     /gene_synonym="D10Ertd664e"
                     /note="major polyA site"
ORIGIN      
        1 ggaagctgac cggcttaccc gggtcgagtt gattggttgc agttttggac accgcgcgcc
       61 aggttttgta gagttgtttt gagccaagtt cgccgaagag ataatggcta ggcaggatcg
      121 tctgcgcgag ctcctgggcc ctctgcaccc gtacaagagc gacgacgagg aggaggattg
      181 tgcgcaggag gaggaggggg agcaggagga ggagtttgtg gatgccgagg aactctgcag
      241 cgggggcatc aaggcgggca gcctccctgg gcgcgcgcga gtgtctatcc ctgatgagta
      301 tactaaagag aaatgtaccg tgtacggacg tttcccactc aaaggtccgt ggtggcgcgt
      361 gaaggtccag gtcctgaaac cccagcgatc caggagctat caagttcaag gctttccggc
      421 atactttcta caggttgata tgtcgccacc agatcaaaaa caaatctgtt cgctttttct
      481 taaagaatgc aacttagcct ctgagcgcat acaggaattt ttaaaatggg tagaaaaagt
      541 gtcaagcttt gaaaatctac actttgaaaa tctttgggaa acattaaggc ttttctacag
      601 agaaaccgaa aagaaagata aaaagctgtc tacaccaagg gagcagcagg gtgaggagat
      661 gagagtggaa aaatcattcg catttataag tgcaatggta gctctgcaat tccccaaagt
      721 catggaattc cttccatcgc ttttccctcg acacttcaaa aggctcatca gctcgagttc
      781 tgattgggtg ctgggatgca tagaagatgt tctgggtaca cagccgtgga agctgggctt
      841 caggaggata acctacagag aaatgaaact agtgcgctgt gaggccagct ggacagcgtt
      901 cagtcagtgc ccctcgctgc tccagctgat gacgcccctg cagaagaatg cattggtcat
      961 atattctaag ctgaggcaga catgcagaga agacggacac acgtacattg aagtaaaaga
     1021 cttgacctcg ggcttgtcgg agcatatgtc attcgaggaa gcgtgtcagt ctctggcgtt
     1081 tctgaaggac attgacgtgg tcatttatga gaaggactat gtctttcttt ctgaactgta
     1141 cgaggccgag caagacatcg cctcctccat ctgcgagctg atgagcagac ctccgtggca
     1201 cttaaaagtg gacgtgaaga acgtcctggc gtcaattaga ggcgcaaagc ccaacgatcc
     1261 aggaagtgct gaggcagtgg aagggagcaa gccggaggag gtggggtcag agcagggtga
     1321 cagtgtttta gacgcccaag atggcgatga ccatgttaga agcaatggcg aacacgtcgc
     1381 aaatgcagaa ataaacgacg tcccactgga tcaagatcag gtggtcgccc tggagacgat
     1441 ctgcgccaac gcggtgactg tcctcagtgg gaaaggcggc tgtgggaaga ccaccattgt
     1501 tagccgtctt tttaagcaca tggaacatct ggaagaaacg gaagtgcagc aagcctgcga
     1561 ggattttgaa caagaccagg aagcctcaga agagtggctt gactgtccta agcagagccc
     1621 agccggtgtg gacaaggctg tagaagtctt gctcaccgca cctacaggga aggctgctgg
     1681 cttattgagg cagaggaccg atcttccggc ttacacgctg tgccaggtca attacagctt
     1741 ctatatgtgg aaaacgaaaa atgaggtgga caagccgtgg aaattctcca cggttcgagt
     1801 tctggttgtg gacgaaggga gtttggtgtc tgtagggatc ttcaagtcag tgttacagtt
     1861 gctgtgcaaa cactccaagc tgtccaagct catcatcctt ggtgatgtta gacagttgcc
     1921 cagtattgaa cctggtaaca tgctgcagga tgtctttgag actcttaagt caagacagtg
     1981 tgccatcgaa ctaaagacga accacaggac agagtctcag ctgattgtgg acaatgctac
     2041 aagaatctcc agacgtcagt ttccaaaatt tgatgctgaa ctaaatatct gtggtaatcc
     2101 tacattacct ctctccattc aagataagac atttatcttt gtgagactcc ctgaagaaga
     2161 cagcagatct cagtcgtcta aaggtgaaca ccgatctaat ttatatactg cagttaaaac
     2221 tttgcttcaa ggaaaggact tctgctcttt tgaaagttca aaaacatcgc aatttattgc
     2281 atttagaagg caagactgtg acctcatcaa tgactgctgc tgcaagcact acacaggcca
     2341 cctcatcaaa gaccatgaga agaaactcat ctttgccgtc ggtgataaga tctgctgtac
     2401 ccggaatgca tacctctcag atttactccc cgacaaagac caggaagccg aggggaaagg
     2461 ctatggagac gcccctgacg acgatgctaa aatcaaacag gatttcgaaa gcagcacccg
     2521 cctgtgcaac ggggaaatat ttttcataac acgggatgta actgacgtaa ctttcaaaag
     2581 aaaaagactt ctgaccatta ataacgaggc cggtttggaa gtgactgtgg actttagcaa
     2641 actaatggca aactgtcaga tcaagcatgc ctgggcaagg accattcata cttttcaggg
     2701 gtccgaggag aacacagtcg tctacgtcgt ggggaaggca ggccgccagc actggcaaca
     2761 tgtttacacg gcagtgaccc ggggccgctc cagagtgtac atcatcgcgc aggagtctga
     2821 actcaggagt gccacccgga agcgcggttt ccccaggcag acgcgtttga aacacttctt
     2881 gcagaagaag ctctctggca gctgcgcacc ctcaacaggt ttcgcatccc agccttcgag
     2941 ccctcgagtc ggaggaagac ctgacaccca gcctccagcg tcacacctct gtagaacccc
     3001 agacaacaaa gccactgcag acagcgccag aggcgacgaa agatggctgt cagcttctgt
     3061 taacgatgac gtggatacgg atgaggagtc agcacagctc agagggtcca aaagaatcgg
     3121 tgacggcttc ccgtttgatg aagaaagccc cagtaaattc cgtatggttg aagcgccatc
     3181 tccacaggtg tcctctgtgt ttcagaatat gaggttgaat actctcactc ccagacagct
     3241 ttttaaaccc accgacaatc aagacacagg tacggcaggt gtggcggacg acgccaacga
     3301 tcccagcaat caggagatgg aaatgtgagg atctgcgttc atggccagcc tgggcaacat
     3361 cgtaagaccc tgctcagccc ataccaccac caccaccacc accactgaaa acctcaaagc
     3421 agaaaaaaaa aagtttactt catattaatc aagaaattat tatttttttc ctcccaagac
     3481 aagatgaaca ttttagcttc aaagtttcaa acttcaaact ctgagaagac agcattatgg
     3541 ttttgggcat ttgtaatttt gggcacatga cccaaaataa aatttttata ttatttttaa
     3601 atctaagttt caaaaggagg tattctaaaa tcacccaatc caagaaaacc atgatgattt
     3661 cagcctctgt cctcgtgaga acagttgaca ggggacacag ttaggggaaa aggtgctgta
     3721 tgcttaaaac actcccgttt taggggctgc tggatgtttt gtgataatgc catgtgatca
     3781 ttgcggatct cctttgccag cacactgaac cagcaaaggt ggactgattg tacctgttga
     3841 ttgtaacaca ttcaaggatg ctgtttgtgg cgacatcctt gctgtgatgc tgtggccatc
     3901 actccattcc tgtgcctggg gctctgcgta cgtggggctt ggatatgcct ttctgagttg
     3961 ggagtaagtt tagcatatat cccattgtag ggaagacttt ctcttaaagc atattggttt
     4021 ttaaatattt attacctagt ggtactgtgg cttgatcgtg tcttcccaaa cctgtgtgag
     4081 tttttttttg ggggggtggg ggtggggggt ggtttcgaga cagggtttct ctgtacagcc
     4141 ctggggctga cctggaactc actttgtaga ccaggctggc ctcaaactca gaaatccgcc
     4201 tgcctctgcc tcccgagtgc tgggattaaa ggcgtgcgcc accactgcct ggcatggcag
     4261 agtggtagag agagtttttc catctttctc ccttcttttg gtgctggaac tgaagccaag
     4321 gtctcattcc ttctaagaaa gcactttact gcttaatttt attcctgatc ctaaacataa
     4381 cttttatatg taccaggaag taaacaaaca agaccagtca tgtgatgcag ctgatggtaa
     4441 tgcttttgtt atttcgggtg ccctgggact gatctgcagc atttctgaga tagacctttg
     4501 tgagaaataa atccactatt cttttacttc ataaaaaaaa
//
