LOCUS       NM_175256               4804 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus heart development protein with EGF-like domains 1
            (Heg1), mRNA.
ACCESSION   NM_175256 XM_193824
VERSION     NM_175256.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4804)
  AUTHORS   Tamargo,I.A., Baek,K.I., Xu,C., Kang,D.W., Kim,Y., Andueza,A.,
            Williams,D., Demos,C., Villa-Roel,N., Kumar,S., Park,C., Choi,R.,
            Johnson,J., Chang,S., Kim,P., Tan,S., Jeong,K., Tsuji,S. and Jo,H.
  TITLE     HEG1 Protects Against Atherosclerosis by Regulating Stable
            Flow-Induced KLF2/4 Expression in Endothelial Cells
  JOURNAL   Circulation 149 (15), 1183-1201 (2024)
   PUBMED   38099436
  REMARK    GeneRIF: HEG1 Protects Against Atherosclerosis by Regulating Stable
            Flow-Induced KLF2/4 Expression in Endothelial Cells.
REFERENCE   2  (bases 1 to 4804)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4804)
  AUTHORS   Manuel,M., Tan,K.B., Kozic,Z., Molinek,M., Marcos,T.S.,
            Razak,M.F.A., Dobolyi,D., Dobie,R., Henderson,B.E.P.,
            Henderson,N.C., Chan,W.K., Daw,M.I., Mason,J.O. and Price,D.J.
  TITLE     Pax6 limits the competence of developing cerebral cortical cells to
            respond to inductive intercellular signals
  JOURNAL   PLoS Biol 20 (9), e3001563 (2022)
   PUBMED   36067211
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4804)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4804)
  AUTHORS   Wu,D., Schieren,I., Qian,Y., Zhang,C., Jessell,T.M. and de
            Nooij,J.C.
  TITLE     A Role for Sensory end Organ-Derived Signals in Regulating Muscle
            Spindle Proprioceptor Phenotype
  JOURNAL   J Neurosci 39 (22), 4252-4267 (2019)
   PUBMED   30926747
REFERENCE   6  (bases 1 to 4804)
  AUTHORS   de Kreuk,B.J., Gingras,A.R., Knight,J.D., Liu,J.J., Gingras,A.C.
            and Ginsberg,M.H.
  TITLE     Heart of glass anchors Rasip1 at endothelial cell-cell junctions to
            support vascular integrity
  JOURNAL   Elife 5, e11394 (2016)
   PUBMED   26780829
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4804)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 4804)
  AUTHORS   Zheng,X., Xu,C., Smith,A.O., Stratman,A.N., Zou,Z., Kleaveland,B.,
            Yuan,L., Didiku,C., Sen,A., Liu,X., Skuli,N., Zaslavsky,A.,
            Chen,M., Cheng,L., Davis,G.E. and Kahn,M.L.
  TITLE     Dynamic regulation of the cerebral cavernous malformation pathway
            controls vascular stability and growth
  JOURNAL   Dev Cell 23 (2), 342-355 (2012)
   PUBMED   22898778
REFERENCE   9  (bases 1 to 4804)
  AUTHORS   Oeschger,F.M., Wang,W.Z., Lee,S., Garcia-Moreno,F., Goffinet,A.M.,
            Arbones,M.L., Rakic,S. and Molnar,Z.
  TITLE     Gene expression analysis of the embryonic subplate
  JOURNAL   Cereb Cortex 22 (6), 1343-1359 (2012)
   PUBMED   21862448
REFERENCE   10 (bases 1 to 4804)
  AUTHORS   Kleaveland,B., Zheng,X., Liu,J.J., Blum,Y., Tung,J.J., Zou,Z.,
            Sweeney,S.M., Chen,M., Guo,L., Lu,M.M., Zhou,D., Kitajewski,J.,
            Affolter,M., Ginsberg,M.H. and Kahn,M.L.
  TITLE     Regulation of cardiovascular development and integrity by the heart
            of glass-cerebral cavernous malformation protein pathway
  JOURNAL   Nat Med 15 (2), 169-176 (2009)
   PUBMED   19151727
  REMARK    GeneRIF: Defects in the hearts of zebrafish lacking heg or ccm2, in
            the aortas of early mouse embryos lacking CCM2 and in the lymphatic
            vessels of neonatal mice lacking HEG1 were associated with abnormal
            endothelial cell junctions like those observed in human CCMs
            Erratum:[Nat Med. 2009 May;15(5):584. Sweeney, Shawn M [added]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB639887.1, BE862445.1 and BC076596.1.
            
            On Jul 25, 2007 this sequence version replaced NM_175256.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-670               BB639887.1         2-671
            671-985             BE862445.1         46-360              c
            986-4804            BC076596.1         265-4083
FEATURES             Location/Qualifiers
     source          1..4804
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 24.17 cM"
     gene            1..4804
                     /gene="Heg1"
                     /gene_synonym="4632417D23Rik; 5530401I02Rik;
                     9530025L16Rik; Gm629"
                     /note="heart development protein with EGF-like domains 1"
                     /db_xref="GeneID:77446"
                     /db_xref="MGI:MGI:1924696"
     exon            1..390
                     /gene="Heg1"
                     /gene_synonym="4632417D23Rik; 5530401I02Rik;
                     9530025L16Rik; Gm629"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..3395
                     /gene="Heg1"
                     /gene_synonym="4632417D23Rik; 5530401I02Rik;
                     9530025L16Rik; Gm629"
                     /note="protein HEG homolog 1"
                     /codon_start=1
                     /product="protein HEG homolog 1 precursor"
                     /protein_id="NP_780465.4"
                     /db_xref="GeneID:77446"
                     /db_xref="MGI:MGI:1924696"
                     /translation="MATPRAPRWPPPSLLLLLLLPLLLLPPAAPGARGSLPSPAHRTL
                     LPVAGPLSPPGAGHTAPGPGVATRRGRSGRVPRGVSAALESLPESPSSSRSQRRITPS
                     QTESGTSLGFLERTRELPEEGTVHTQVAGTWVSRQASHPALEPGEPTVLSQKRNSSGQ
                     EHSGPPFSWSQSHPPPSDHPSSPEDGAMLSDSSDLADSTSGARTPHTSAMSTRSGERT
                     LRSLDLSSAATRPARPTPRGNVTEHAGLLSGAPTLGVTGLSYTREHGSDAGQRTSSDH
                     TDHGYVPSTFTKGERTLLSITDNTSYSEASESSTSSVKISDSPSQAQPKQSSMSSDDD
                     EPAQSSTESPVLHTSNLPTYTSTVNMPNTLVLDTGTKPVEDPSDSRVPSTQPSPSQPQ
                     PFSSALPSTRSPGSTSETTTSSPSPSPISLLVSTLAPYSVSQTTFPHPSSTLVPHRPR
                     EPRVTSVQMSTAISAIALIPSNQTANPKNQSTPQQEKPITEAKSPSLVSPPTDSTKAV
                     TVSLPPGAPWSPALTGFSTGPALPATSTSLAQMSPALTSAMPQTTHSPVTSPSTLSHV
                     EALTSGAVVVHTTPKKPHLPTNPEILVPHISTEGAITTEGNREHTDPTTQPIPLTTST
                     TSAGERTTELGRAEESSPSHFLTPSSPQTTDVSTAEMLTSRYITFAAQSTSQSPTALP
                     PLTPVNSCTVNPCLHDGKCIVDLTGRGYRCVCPPAWQGENCSVDVNECLSSPCPPLAT
                     CNNTQGSFTCRCPVGYQLEKGICNLVRTFVTEFKLKKTFLNTTAENHSNTQELENEIA
                     QTLNVCFSTLPGYIRTTAHVSREPSTVFISLKTTFALASNVTLFDLADRIQKYVNSCR
                     SSAEVCQLLGSQRRVFRAGSLCKRKSPECDKETSICTDLDGVALCQCKSGYFQFNKMD
                     HSCRACEDGYRLENETCMSCPFGLGGLNCGNPYQLITVVIAAAGGGLLLILGVALIVT
                     CCRKSKNDISKLIFKSGDFQMSPYTDVPKNPRSQEWGREAIEMHENGSTKNLLQMTDV
                     YYSPTNVRNPELERNGLYPAYTGLPGSRHSCIFPGQYNPSFISDESRRRDYF"
     exon            391..690
                     /gene="Heg1"
                     /gene_synonym="4632417D23Rik; 5530401I02Rik;
                     9530025L16Rik; Gm629"
                     /inference="alignment:Splign:2.1.0"
     exon            691..909
                     /gene="Heg1"
                     /gene_synonym="4632417D23Rik; 5530401I02Rik;
                     9530025L16Rik; Gm629"
                     /inference="alignment:Splign:2.1.0"
     exon            910..2205
                     /gene="Heg1"
                     /gene_synonym="4632417D23Rik; 5530401I02Rik;
                     9530025L16Rik; Gm629"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2322
                     /gene="Heg1"
                     /gene_synonym="4632417D23Rik; 5530401I02Rik;
                     9530025L16Rik; Gm629"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2442
                     /gene="Heg1"
                     /gene_synonym="4632417D23Rik; 5530401I02Rik;
                     9530025L16Rik; Gm629"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2546
                     /gene="Heg1"
                     /gene_synonym="4632417D23Rik; 5530401I02Rik;
                     9530025L16Rik; Gm629"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2605
                     /gene="Heg1"
                     /gene_synonym="4632417D23Rik; 5530401I02Rik;
                     9530025L16Rik; Gm629"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..2766
                     /gene="Heg1"
                     /gene_synonym="4632417D23Rik; 5530401I02Rik;
                     9530025L16Rik; Gm629"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2901
                     /gene="Heg1"
                     /gene_synonym="4632417D23Rik; 5530401I02Rik;
                     9530025L16Rik; Gm629"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..2944
                     /gene="Heg1"
                     /gene_synonym="4632417D23Rik; 5530401I02Rik;
                     9530025L16Rik; Gm629"
                     /inference="alignment:Splign:2.1.0"
     exon            2945..2982
                     /gene="Heg1"
                     /gene_synonym="4632417D23Rik; 5530401I02Rik;
                     9530025L16Rik; Gm629"
                     /inference="alignment:Splign:2.1.0"
     exon            2983..3070
                     /gene="Heg1"
                     /gene_synonym="4632417D23Rik; 5530401I02Rik;
                     9530025L16Rik; Gm629"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3245
                     /gene="Heg1"
                     /gene_synonym="4632417D23Rik; 5530401I02Rik;
                     9530025L16Rik; Gm629"
                     /inference="alignment:Splign:2.1.0"
     exon            3246..4780
                     /gene="Heg1"
                     /gene_synonym="4632417D23Rik; 5530401I02Rik;
                     9530025L16Rik; Gm629"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3845..3850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Heg1"
                     /gene_synonym="4632417D23Rik; 5530401I02Rik;
                     9530025L16Rik; Gm629"
                     /note="hexamer: CATAAA"
     polyA_site      3883
                     /gene="Heg1"
                     /gene_synonym="4632417D23Rik; 5530401I02Rik;
                     9530025L16Rik; Gm629"
                     /note="major polyA site"
     polyA_site      3991
                     /gene="Heg1"
                     /gene_synonym="4632417D23Rik; 5530401I02Rik;
                     9530025L16Rik; Gm629"
     polyA_site      4711
                     /gene="Heg1"
                     /gene_synonym="4632417D23Rik; 5530401I02Rik;
                     9530025L16Rik; Gm629"
     polyA_site      4727
                     /gene="Heg1"
                     /gene_synonym="4632417D23Rik; 5530401I02Rik;
                     9530025L16Rik; Gm629"
ORIGIN      
        1 gattggcgtg tggcagcacc agggctgcct ccgccctccc gcggctccca caacttttgc
       61 ggctgagagc gcgctcgcac cccgctccgc tcgccgccgc cctcggcccg gcgcccggca
      121 tgtgagcgcg ggcggccgcc gccaccatgg ccacgccgcg cgccccgcgg tggccgccac
      181 cgtcgctgct gctgctgctg ctgctaccgc tgctgctgct gccgcccgct gcccccgggg
      241 cgcggggctc ccttccctcc ccggcccatc gaacactcct cccggtcgcg ggaccgcttt
      301 cgccgcctgg cgccggacat acggcccccg gacccggcgt cgcgacccgg cggggacgtt
      361 ccggccgtgt ccccagaggc gtgagcgcgg ccttggagag ccttcctgag tcacccagca
      421 gttccaggtc acaaagaaga atcacacctt ctcaaacaga gagtgggaca tccctaggct
      481 tcctggagag gacgagggag ctcccagaag aagggactgt gcacacgcaa gtggctggca
      541 cctgggtgtc ccgccaagcc tcccaccctg ctctggaacc tggggagcca actgtgctct
      601 cccagaagag aaattcatcc ggccaggaac actccgggcc accattctcc tggagtcaga
      661 gtcaccctcc tccctcagac cacccatcgt ctccggaaga tggtgcaatg ctgagtgaca
      721 gctctgatct ggcagacagc acttcggggg ctcgcacacc tcacacgtct gcaatgtcca
      781 cccggagcgg ggagcgcacg ctgcggtccc ttgacctctc gagtgcagca acccgccctg
      841 cgcgccccac tccacgaggg aacgtgacag agcacgctgg cctgctgtcc ggggcaccaa
      901 ctctcggagt caccggactt agctacactc gagaacatgg ctcagacgct gggcagagga
      961 cttccagtga ccacacagac cacggctatg ttccgtctac tttcaccaaa ggagaacgga
     1021 cgctactgtc tattacagat aacacctcct actcagaggc cagcgagagc tcaacctctt
     1081 ccgttaagat ctcagactct ccttctcagg ctcagcctaa acagagtagc atgtcctccg
     1141 acgatgacga gcctgctcag tcttccacag agtcaccggt tctgcatacg tccaacctgc
     1201 caacctacac gtccactgtt aatatgccaa acaccttggt tcttgatacc ggtaccaaac
     1261 ctgttgagga cccatctgat tcacgggtgc cttccactca accctcaccg tcacaacccc
     1321 agccattctc atcagcctta ccatcaacca ggtctcctgg gtctacctct gagacaacca
     1381 catcctcacc atcaccttca cccatctcct tactggtgtc aactcttgcc ccatattctg
     1441 tctcacaaac aaccttccca catccatctt ctaccctagt ccctcacagg ccaagggagc
     1501 cacgtgtgac ttcagtccaa atgtcgacgg caatatcagc cattgcattg atccccagca
     1561 atcaaacagc aaaccccaag aaccagagta ccccacaaca agagaaaccc atcacagaag
     1621 ctaagtcacc aagcttggtg tctccgccca cagactctac caaagcagta acagtgagcc
     1681 ttcctccagg ggccccttgg tccccagcct taacagggtt ctccacgggg ccagcccttc
     1741 cagccacaag caccagttta gcccagatgt ctccagcttt gacatctgcc atgccccaga
     1801 cgactcactc tcctgtgacc agtcccagta ctctgtcaca tgtagaagct ttgacttcag
     1861 gtgctgtagt tgtgcacact accccgaaga aaccacatct cccaaccaat cctgaaatcc
     1921 tagtgccaca catctcaact gagggggcca tcaccacaga agggaaccgg gagcatacgg
     1981 atcctaccac tcagccaatc cctctgacca cttcaaccac gtcagcagga gaaaggacca
     2041 cagagctggg ccgtgcggaa gagtccagtc catcccattt tcttacacca tcttcacctc
     2101 aaaccacaga tgtttctaca gctgaaatgt tgacttccag atatatcacc tttgctgctc
     2161 agagcacctc acagtcacca acagccttgc cacctctaac cccagtcaac agctgtaccg
     2221 tgaacccttg tcttcatgat ggcaaatgca ttgtggacct cactggccgt gggtatcgat
     2281 gtgtgtgccc gcctgcctgg cagggggaga actgcagtgt ggatgtgaac gaatgtctct
     2341 ccagcccctg tcctccccta gccacgtgca acaatactca gggatcgttc acctgcagat
     2401 gcccagtcgg gtatcagttg gagaaaggaa tatgcaatct ggttagaacc tttgtgaccg
     2461 agtttaagtt aaagaagact tttctcaata ctactgcaga aaaccattcc aacactcaag
     2521 agcttgaaaa cgagatcgct caaacactaa acgtgtgttt ttcaacattg cccggttata
     2581 tccgaactac agcccatgtg tctagggagc ccagtacagt tttcatctca ctgaaaacca
     2641 cctttgccct ggcctccaat gtgacactgt ttgacctggc agacaggatc cagaaatatg
     2701 tcaactcctg caggtcctct gctgaagtct gccagctctt ggggtctcag aggcgggtct
     2761 ttcgagcggg cagcttgtgt aagcggaaga gtccagaatg tgacaaagag acctccatct
     2821 gcaccgacct ggatggtgtc gcgctctgtc agtgcaagtc tggctacttc cagttcaaca
     2881 agatggatca ctcttgccga gcatgtgaag atggatatag gcttgaaaat gaaacctgta
     2941 tgagttgccc atttggcctc ggtggactca actgtggaaa cccctatcag ctcatcactg
     3001 tggtgatcgc agccgcagga ggtggcctct tgctcatcct gggcgtggca ctcattgtta
     3061 cctgttgcag aaagagtaaa aatgacataa gtaaactcat cttcaaaagt ggggacttcc
     3121 aaatgtcccc atacaccgat gtccccaaga atcctcgctc gcaagagtgg ggccgagaag
     3181 ccattgaaat gcacgagaac ggaagcacca aaaacctcct gcagatgaca gacgtgtact
     3241 actcgcccac aaacgtaagg aaccctgaac ttgaacgcaa cggactgtac ccagcctaca
     3301 ctggactgcc cggatcgaga cactcttgca tcttcccggg acagtataac ccatctttca
     3361 tcagcgacga gagcaggagg agagactact tctgagtcca ggagacagag ggaggccccc
     3421 gtttctctga gccacttccc cggacatctg gctcagagca ctacaccccc aaaagggagc
     3481 accatgcact agctgctcct gggactccgc agagccacgc ttgaggggcg tggccacagt
     3541 ggaagggaaa gacggaggcg gaactgcagg ccactcgttc agcactgttg ttactgtgaa
     3601 catggtcgtg ggccagtacc gagtctcaga atgcctgaca caacacgtag aacgtagaac
     3661 gggatgcctt ccataactga ccactaggct tcatttccag gacccagttt ccctttaatt
     3721 tgcactttaa tagattgggc tgggacactt ccacactgtg tcgtagaggc ctagcaggcg
     3781 ctgcagtcgg gtgcaaagta ttttaaggtt tctaggttgt ccgtgctcat ttccaagcca
     3841 atgccataaa tgagaccttg acatttgcaa ggctcaacac aaagcttttt tatgtcaaag
     3901 tgacacattt gcttacaatg tattagtttt actttcccaa gcaagtatga atcggggcaa
     3961 aacaacattc ctttgaattt ctttagaagc atccaggtgt cccttaatgt gtcccagcag
     4021 ggcagtatca gtcaggacct acatgtggtg aggtgttttt gacccatggg ggaattgcat
     4081 ggggcctgag gctctaacca tcaatgtgga gccagagtct gcagggtgta gttgaaaaag
     4141 gagaggcagt tgcaggtgtg tctgagctgg tgtctcacct ccagagggaa agcagccagc
     4201 tgtaggcccc acaattgggc agaggaatga acgagtaaac tgatacattc cccgaactcc
     4261 agtgcagaag ttggggagct aggaggaagc caccggcaag gatgcatgcc tgccaatctt
     4321 ccaaaccata atgttgccca ccaactcaac agaaactttt aaccacttaa aactacttat
     4381 tcactgagga gagaacttat ttactctcac ccagccattg atgcatgtgt gttcttgtgc
     4441 agtgtcacct caagactccg ctgtgacccg agtcagcttt ggagaactaa aggccagcta
     4501 agggtctgag ggcttgcttt gggggaagga cgttctgtgt tttgcttatt gtattgtgag
     4561 atcctgggca gtgggaggac tgtgtggtgt ttggtccccg gtggaactat catcttgtga
     4621 gatgtcctgg gtttggatga ggtgaagagg tcaaagcatt atccccaccc agatgatggg
     4681 gactccacag catatatttc tggaaatggg acagctgtta gaaatggttc tgtatgtgtt
     4741 tctttgatgt tctctgattc ctctaaaatt tatgaaggtc aaaaaaaaaa aaaaaaaaaa
     4801 aaaa
//
