LOCUS       XM_006530353           16479 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  PREDICTED: Mus musculus HECT domain E3 ubiquitin protein ligase 4
            (Hectd4), transcript variant X3, mRNA.
ACCESSION   XM_006530353
VERSION     XM_006530353.5
DBLINK      BioProject: PRJNA169
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000071.7) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Sep 21, 2020 this sequence version replaced XM_006530353.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001635.27-RS_2024_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/01/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16479
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6J"
                     /db_xref="taxon:10090"
                     /chromosome="5"
     gene            1..16479
                     /gene="Hectd4"
                     /gene_synonym="A130010L24; EG545802; Gm15800; mKIAA0614"
                     /note="HECT domain E3 ubiquitin protein ligase 4; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 6 mRNAs, 57 ESTs, 5795 long SRA reads, 3 Proteins, and
                     98% coverage of the annotated genomic feature by RNAseq
                     alignments, including 34 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:269700"
                     /db_xref="MGI:MGI:3647820"
     CDS             940..14514
                     /gene="Hectd4"
                     /gene_synonym="A130010L24; EG545802; Gm15800; mKIAA0614"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase HECTD4
                     isoform X3"
                     /protein_id="XP_006530416.1"
                     /db_xref="GeneID:269700"
                     /db_xref="MGI:MGI:3647820"
                     /translation="MPGTPPPRWRLTDSWLRSGRGGSCSSGRRRRRRRRGRGSPGPGL
                     ACGGGWRRGTPRAEPRGRGGRSRRGGRGGRPWVAEAAAAALQRLLLAMGSSAAAAAAA
                     AAAAAAADSAQWLSVKEETIFLHDGLIRVTDLAELPSEILGAPEAADTDLEILTFETK
                     NPTELAERLRSVCGNQSNAYARLLEYRLNALRGLWNAQRQLALEEQHEREGSGDEETL
                     ALLKRQGLLQQPEQAPFTSRVGLLLVFPLIQSQSRTDPSLCNITAEVLLNCLRDCQPL
                     SLTKEPADCLNGIETLLCSWLEETSDTGRHIPHKQKENAAAALVALACARGSLKTFVH
                     TVHLLQRQTELGSLPVADVLYRLLLLEGGPGSPSCLLGGKHIVSWGYEDMLPAPDSNT
                     GSSSENKDADLGRCLTADGHYLYTTNSAGRGVSKLGSGLHGTLRGFVYCRNEELEPGW
                     VAYGNGHLLHRPVSFDNKPHSLFQVIDQNTLQVCQTVPMPASPLPVGSTMSTVHLSSD
                     GTYFYWIWSPASLNEKTPKGHSVFMDIFELVVENGVFVANPLQERTILMRKEGESAKS
                     INEMLLSRLSRYRASPSATLAALTGSTISNTLKEDQAANTSCGLPLKMLRKTPMYTCG
                     TYLVMLVPPPGGSGSSATRSLFGGTSGLSSLKILASSLVYNISDGQFASRADLIDAAG
                     SSLGRGALVPGLGACYDTMNNMLWTCSNDYIDQWCNPGNQAFHYVCQRLGVSHIITEP
                     KEEAISTNEVINQLLHHVGAMCIHQLNLLATNPNLPITSVLGKQHPIEARHLSSICDI
                     MEKAMVNGDTCIVRCILVVFQVVFKFFFSPQTERNRDIIRRSGLLLWQLLMAPKDQIC
                     PEIQKEVCLAISSGLNILYPGETEINNLLKLVLTEGERNSGLSQLRDVILTNLAEQLQ
                     NNRFGSDEDDHYRLNDELLHYILKIVVRESCILITKCQTVSKDDFQKLLSTVPAASSC
                     LRYLMAVQNHLLSNTVLIKPDENEDSDSSLQGETLKVQELKTSILALATQILTGCDEV
                     LEMLQQVTTALINSDIPDREQRLKGLEQVTKATMLGHLLPVLLTSLMHPNLQTLTMAD
                     ALMPQLVQLVLYTSQTALLLKTQCPAFAEMSCSPCGTSDQKCRLFPDERMLEEKEEPG
                     FLTGLKIPAPWAAGKTVETVHPVRDNYKFKETVHIPGARCLYLRFDTRCSSQYDYDKS
                     NGLFSVLKLVIYAGPNTNSRKVAEYGGNTLGYGSRSVLGTGWPKDLVKVEGDTVTFSF
                     EMRSGREHNTPDKAMWGFACTVRAQESSEDVSGGLPFLVDLALGLSVLACSMLRILYN
                     GPEITKEEEACQDLLRSKLLQRCQWQVEANGVISPALTPSPSPLPLTIEEDREFTYPA
                     DVLVPPVGNYFDLPRIRLPPGIMIKLREISGRARPQFRPSIKEVIQPDVMEEMVVSCV
                     IKHLNLVDALQSLINFQYQEEHAEEYDLLCKIMGETFKKLNAMERQLQSVAELEQKWQ
                     SEAEDAMQGKLENNMPFFYDYHFNENKMKELELLCSMKEVSFDGNDLENMVLSLREKF
                     LQEVNSLAQKPSHPLAKTKTLVRSLMNRAELLLHVTIAAQAGLTRSISGTPAETPACK
                     SASETKVASHAVRQPVFLRSMSAPSDLEMIGNEDLEFTRANQSLVFCRRRHVTSHRSS
                     SFTLLQSLAIEDSRDKPTYSVLLGQLFAFIGTNPDQAVSSSSFLLAAQTRWRRGNTRK
                     QALVHMRELLTAAVRVGGVTHLVGPVTMVLQGGPRIEELTCGGMVEQVQEAFGETMTS
                     VVSLCARYPIACANSIGLLCTIPYTRSEEKCLVRSGLVQLMDRLCSLSSQTESSSSEK
                     QTKKQKVATMAWAAFQVLANRCVEWEKEEGGSTEAVHSGLARQVSSLLTNHLARATEC
                     CGNQAAGNDALQDVLSLLNDLSRSHIGKAILSQPACVSKLLSLLLDQRPSPKLVLIIL
                     QLCRAALPLMSVEDCGNVELPPWSYSVPSLNSEQEDPSDPASKIASLLLAKLADYVVP
                     GCQTVLSPTASEPDTTLTKTSPKNSLKGDKDPGEESEAVDGKLSIFIHKREDQSSHEV
                     LQPLLSSSEGRPFRLGTGANMEKVVKMDRDMTKGGCCEVITEEASAALRKATKWAQSG
                     LIVSVGPPVESINPETVSGLSTGDKKKTAQTSICRERNSELARTDPVRPFISGHVANS
                     MAAEVIALLHSLLMAPESNAAQIWTTTAEKVLSRALMYIPQLGKYAESILENGSSSGR
                     KLAKLQRIARQAVAALCALGGFKETIKIGSEVQVLGRGISGSIGVVASINEQEGIATV
                     RFPPVDCRRTSQAADTLTIPLSRLCVPRSEALPLHKLSITEKVVQAVQSMLLPQEGSL
                     SIHTSLPATGDGSAPVMAVVRLLAEIRTRACLVMAQLLEDSLFCEEFIQQCPAAVEVL
                     NLVAQECSAGERLAVVEMQCERLRMLYRDCARPPPPPLQADRRQPKEITWSPSRVFPP
                     VRACMFSSHLTSVTFLADPSAGGGLPRGTFIYATSPLPVQAPSFYWEIEIVSYGDTDD
                     DTGPIVSFGFATEAEKRDGAWTNPVGTCLFHNNGRAVHYNGSSLLQWKSVRLDVTLSP
                     GDVAGIGWERTEGTPPPPGQPAKGRVYFTYCGQRLTPYLEDVSGGMWPVVHIQKKNTK
                     TRANFGSRPFAYAEGQAHRNAADLCTDLAEEISANFEALPFAMASDSDNDAGTSIASD
                     PGTHGPPCRIAAVATAQQQYDSDTSCHYKVELSYENFITSGPDPHPPPIADDESDDDD
                     DDDIPQEDHYALLVKAWETKVFPTIRRRFRNEAERKSGLDQIKGALQLGMVDIARQTV
                     EFLYEENGGIPRDLYLPTIEDIKDEANKFTIDKVRKGLTVVTRSPDSSNVASSTVGTA
                     LPKFAIRGMLKTFSLHGVVLDVDSVNELVQVETYLRSEGVLVRYWYPIDMLERPPAGY
                     RRTATNGLVTLDNTNLQIHRELLRCEAALARLYCRMALLNIFAPKLPHLFTRLFHIPA
                     IRDITLEHLQLLSNQLLAPPLPDGTISSSSILLAQSLQHCIHSQSCSATDLFYQGSSQ
                     TLREWLSVAITRTLHQGEDSLLELTKQICAFLQTAPEQFPSEEFPVSESKVSMDVNFP
                     GAAFVVVSCKESQSGFRKDSSLYKAPWARVLVYGLGHKVKRTGQLNLIEAACYPRDAS
                     PANTGLAPPPTADQYPSVVLSTDKVHIKLGVSPPPGAVLVLHSLPLEFPLAMAFAEQL
                     LSWKSEDSDGKSEDEPDSIPASVLLHVVELLGNFLWTTDMAACVKELVFHLLAELLRT
                     VHTLEQRKHPAGLSSSIALQLNPCLAMLMALQSELHKLYDEETQSWVSSSACGGSGAA
                     AVGDQGRFSTYFHALMEGCLAVAEVTLPTNISVTASGVTSTTTPNLSDSSSSSSSSPG
                     QTPQSPSLLSKRKKVKMKREKASSSNKRQSSRASDADSTVLSIGGSKPEDMLWFHRAL
                     TLLIILRHLTKKDPQGLGVTSDAIADACQALVGPTAHSRLLVISGIPTHLDEAVVRGA
                     IRKACNAHGGVFKDEIYIPLQDEDPKKPKDKAEGSDSKVESEKLLGFPSVDSLEGSTS
                     SSLAPAMSISASASTSQASVCSSQCVSQTASDLSVDPLPSGLELPVPPVLLEPHVVSS
                     QESLDISLCSTGSLGSLGSLGEPLDNPETASVSDVGSMYTVTSLDTQPLATRPIKGFA
                     VVEIRSRAKIEKIRASLFNNNDLIGLSSLDGEDELMEMSTEEILTVSVVNQSLFDTQG
                     SPGLEDYFSDKSIKGEKLVPGAREVLTEIFKSCAHSEQTLSLTPAKPIRVSDIYLSKE
                     QINSQTPGNLLHLFFTNVRPPKKVLEDQLTQILRKYGVPKPKLDKSKYSKAGKEQHPV
                     KVVSTKRPVTKPPAKDKAVLSSLRTALSEKKPTVKPKSPEKSKPDEKDPEKSPTKKQE
                     VPEEKYLTLEGFHKFVIDRAKQDIRSVWRAILSCGYDLHFERCACIDVRHAQKASRKW
                     TLEMDVALVQYINRLCRHLAITPARLHPHEVYLDPADAADPRMACLSNVPIESLRLRF
                     ALLQSLNTTLETFFLPLVELRQTPMYAHSIAALLKEAKGLIFYDTKVTVMNRVLNATV
                     QRTADHAAPEITLDPLEIVGGEIRASENSYFCQAARQLASVPSSQLCVKLASGGDPTY
                     AFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLLLCPSSAVNKNKGKYILTPSP
                     ITYGEEQLLHFLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPDQDLQEADILTYN
                     YVKKFESINDESELEALCAEIASQHLATESPEGPKPCCRFTYLTMTGEEVELCSRGRH
                     IPVAWENKDIYAAAIRSLRLRELQNMECVTAVRAGLGSIIPLQLLTTLSPLEMELRTC
                     GLPYINLEFLKAHTMYQVGLMETDQHIELFWGALEMFTQEELCKFIKFACNQERIPFT
                     CPCKDGGPDTAHVPPYPMKIAPPDGTAGPPDSRYIRVETCMFMIKLPQYSSLETMLEK
                     LRCAIHYREDPLSG"
ORIGIN      
        1 tttttaattt ttaatttttt ttatgtgttt gactgtttcc tttatgtatg tctgtgtgcc
       61 acatctgtgt aatgatggag acggagacct gaagaggatg tgaggtccct tgggactgaa
      121 actcaggtcc cttgggactg aagttataaa aggtgtgagc tgccctctga gtgctgggaa
      181 ttgaacccca gccctctgga agagcaacca gtgtcaacct gtcaatcatt tctccagcct
      241 aacagcaatt gttgatagat actttatttt catcagatgt cagttgcttc tttgtactct
      301 ttttttcccc agtaaatatt aaccatctgc tgtgagtttt accaagttct catgaccaag
      361 cctattatat accagccttt agtattttat aaattttatg tattttttca gatacggagc
      421 ctacataggc ctgggtggcc tggagcatct tatgtagccc aggttggcct gaaacttgat
      481 atgtagacca ggctacctgc aacttgcaat ggtactccca cttctgtctt ccaagtactg
      541 gaacaactgg caacccccac caggtttgtt tacttatagt gctgtaaatg gaacatagga
      601 cctcaggcat tctaggctaa ccctctaaga ctgaactatt caagatctta gagaagacat
      661 ctgaacctat ctcatttaaa agataacagt gttgaccctc cataatcctt ccagaatgag
      721 ctctggcctg agcaaccggt gcacaccgga gtaaggagga aaggggacca gggtggtctt
      781 ctcccggagc cttagacttc ctcagatagc atgggaagca ggggtgccca agaggccatg
      841 cctctgagcg ccttgcagct gggttataaa gcctcgccgg gctgtgggcg gggctagacg
      901 gacaggaggg aggagcctgt attgtccacc ccgcggggca tgccgggaac cccgccccca
      961 agatggcgtc ttactgacag ttggctgcgg agcggcagag gcggatcctg ctcgtcaggg
     1021 cggcggcggc ggcggcggcg gcggggccgg gggtctcccg ggccggggtt ggcgtgcgga
     1081 gggggatggc ggcgcggaac gcctagggcg gagccgcgcg ggcgaggcgg gcgcagcagg
     1141 cgcggcgggc gcggcggtcg gccatgggtt gctgaggcgg cggcggcggc tctgcagcgc
     1201 cttctcttag ccatgggctc gtcggccgcg gcggcggcag ctgcagcggc ggcggcggcg
     1261 gcggcggact cggcgcagtg gctctcggtg aaggaggaga ccatctttct gcacgacgga
     1321 ctcatccggg tcaccgacct ggccgagctg cccagcgaga tcctcggcgc cccggaggcc
     1381 gccgacaccg acctggagat tttaacattc gagaccaaga acccaacaga attagcagaa
     1441 cgtttgcgct ctgtttgtgg gaaccagagc aatgcctatg cccgcctgct ggaataccgc
     1501 ctgaatgcct tgcgtggact atggaatgcc cagcgccagc tggccctgga ggagcaacat
     1561 gaaagggaag gctcaggtga cgaagagacc ttggccctgc tcaagcgcca gggcttgttg
     1621 cagcagcctg aacaagcccc cttcacgtcc cgggtgggcc tcctgttggt cttccccctt
     1681 attcagtccc agagtagaac agacccttcc ctctgtaaca taactgctga ggtgctatta
     1741 aactgcctgc gagactgtca gcctttgagc ttgaccaagg agcctgctga ttgtctcaat
     1801 gggatagaaa ccttgctgtg ctcttggcta gaggagacct cggacacagg ccgacacatc
     1861 ccacacaagc agaaggagaa cgctgctgct gccctggtgg ctttggcgtg tgccaggggg
     1921 tcactgaaga cctttgtcca cacagttcac ctgctgcaga gacagactga gctgggctcc
     1981 ctgcctgtcg ccgatgtttt atataggttg ctgcttttgg aagggggacc tggatcccca
     2041 tcctgtttgc ttgggggcaa acacatagta tcttggggat atgaggacat gctgccagca
     2101 ccagacagca acactggctc cagctctgaa aacaaagatg ctgacttggg ccgctgtctc
     2161 accgcagatg ggcattacct gtacactacc aactcagccg gaagaggagt gagcaagctg
     2221 ggctctggac tgcatggcac gctcagaggg tttgtgtact gtcgcaatga ggagctagag
     2281 ccagggtggg tggcgtacgg caatggccac ctactccatc ggcctgtgtc ttttgacaat
     2341 aaacctcact cccttttcca ggtcatagac cagaacaccc tgcaggtgtg ccagacagtg
     2401 cccatgcccg ccagccccct tcctgtgggc agcaccatga gcactgtgca cctttcctca
     2461 gatggcactt acttctactg gatctggtcc cctgccagtt taaatgagaa aaccccaaag
     2521 ggacactctg tcttcatgga catttttgaa cttgtggtgg aaaatggggt atttgtagcc
     2581 aacccgcttc aggaacgcac aatcctaatg agaaaagagg gtgagtctgc taaaagcatt
     2641 aatgagatgc tcctgagcag actgtctcgg tacagagcct ctccatcggc gactctcgcg
     2701 gccctgactg gctccaccat ctccaacacg ctgaaggagg atcaagcagc aaatactagc
     2761 tgtggccttc ctctgaaaat gctgcggaag acgcccatgt acacctgtgg cacgtacttg
     2821 gtgatgctgg tcccacctcc aggagggtca ggcagctctg ccacccgctc tctctttggt
     2881 ggaacaagtg gtctgtcgtc tttaaagatc ctggcctcca gtttggtgta taacatctca
     2941 gatggtcagt tcgcaagtcg tgcagatctc atagatgctg ctggaagctc gctggggcgt
     3001 ggtgctcttg taccaggatt gggtgcctgt tatgatacca tgaacaacat gctatggact
     3061 tgctcaaatg actacatcga ccagtggtgc aatcctggga accaggcctt ccattacgtg
     3121 tgccagagac tgggtgtcag ccatatcatc accgagccca aagaagaggc cattagcaca
     3181 aatgaagtca taaaccagtt actgcaccat gttggcgcca tgtgcattca ccagctcaac
     3241 cttctagcta cgaaccccaa ccttcccatc actagtgtcc tgggcaagca gcacccaatt
     3301 gaggcacgac atctgagcag catctgtgac atcatggaga aggccatggt taatggcgac
     3361 acctgcatcg tacgctgcat cctcgtcgtc tttcaggtgg tgtttaaatt tttcttcagc
     3421 ccacaaactg aaaggaaccg agacatcatt cggcggtcag gattgcttct ttggcagttg
     3481 ttgatggcac caaaagatca aatctgtcct gaaattcaga aggaggtctg tcttgccatc
     3541 agctctggtt taaatatttt atatcccggt gaaacagaaa ttaataactt acttaagctg
     3601 gtcttaacag aaggggagag aaacagtgga ctctcccagc tccgtgatgt gatcctcacc
     3661 aacctggccg agcagcttca gaacaaccga tttggcagtg atgaggacga tcactacaga
     3721 ctcaatgatg agctcttaca ctacatcctg aagattgtcg tgcgggaatc ctgtatccta
     3781 atcaccaagt gccaaacggt ctccaaggac gacttccaga agctcctctc gacggtgcct
     3841 gctgcatcct cctgcctgcg ctatctgatg gcggttcaga accacctcct cagtaacact
     3901 gttttgatta agcctgatga gaacgaggac agtgacagct ccttgcaggg agagacattg
     3961 aaggtacagg agttaaagac cagtatcttg gctcttgcca cccagatcct gactggctgt
     4021 gatgaggtcc tggaaatgct gcagcaggtc accacagccc tcataaacag tgacatacct
     4081 gaccgagagc agaggttaaa aggcttggag caagttacca aggccactat gcttggtcac
     4141 cttctcccag tgttgctgac ctccctgatg caccccaatc tacagaccct gaccatggcc
     4201 gacgccctga tgcctcagct tgtgcagctg gtgctgtaca ccagccagac ggccttgctg
     4261 cttaaaaccc agtgtccagc gtttgccgag atgagctgtt ccccatgtgg cacctcagac
     4321 cagaagtgca ggctttttcc tgatgagaga atgctagaag aaaaggaaga gccaggcttc
     4381 ctcactggct taaagatccc cgccccatgg gctgctggga agaccgtgga aacagtacac
     4441 cctgtcagag acaactataa gtttaaggag actgttcata tcccaggagc tcgctgcctg
     4501 tacctacgat ttgacaccag atgttcgtca cagtacgact atgacaaatc taacggtcta
     4561 ttttctgttt tgaagttggt gatttacgcg gggcctaaca caaacagtag gaaggttgct
     4621 gagtatggag gcaacactct gggatatggc agccggagtg tcttaggaac tggctggccg
     4681 aaggacttgg tgaaggttga aggcgataca gtcaccttct cctttgaaat gagaagtggc
     4741 cgtgaacaca acactcctga caaagccatg tggggttttg cttgcacagt ccgcgctcag
     4801 gagtcctcgg aggatgtctc gggaggcttg cccttcctgg tagacctggc cttagggctg
     4861 tctgtgttag cttgttccat gttaagaatc ctatacaacg gaccagaaat taccaaagaa
     4921 gaggaagctt gtcaggacct gttgcgatcc aaacttctac aaaggtgcca gtggcaggtg
     4981 gaggccaacg gtgttatctc ccctgccctt actccgagtc cctctccact gccgctgacc
     5041 atagaggaag acagagaatt cacctacccc gcggatgtcc ttgtgcctcc tgttgggaac
     5101 tacttcgacc tgcctcggat caggctgcct ccaggaatca tgataaagct cagggagatt
     5161 tctggccgtg cacgacctca gtttagacca agtataaaag aagtgatcca gcccgatgtc
     5221 atggaagaaa tggtggtgtc ctgtgttatt aagcacttga acttggttga cgcgctgcag
     5281 tccctgatca atttccagta tcaggaagaa catgctgagg aatatgactt attgtgtaaa
     5341 attatgggag agacctttaa gaagctcaat gccatggaga gacagctgca gagtgtggct
     5401 gagctggaac agaagtggca gagtgaggct gaggacgcca tgcaggggaa gctggagaat
     5461 aacatgcctt tcttttatga ctaccatttt aatgagaaca aaatgaaaga actagagctt
     5521 ttgtgttcca tgaaggaagt ctcctttgat gggaatgatc ttgagaacat ggtcctctca
     5581 ctgagggaga agttcctcca ggaagtgaat tctcttgctc agaagccctc ccacccactg
     5641 gccaaaacaa agaccctggt gaggagcctg atgaaccgag cagagctgct gctgcacgtc
     5701 accattgcgg cccaggctgg gctcaccagg agcatctcag ggacgccagc agagacgcct
     5761 gcatgcaaat cagcttcaga aacaaaggtg gcgtctcacg ctgtccggca gcctgttttc
     5821 cttcgaagca tgtctgctcc ttctgacctg gaaatgattg gtaatgaaga cttggaattt
     5881 actagagcaa atcaaagtct tgttttctgt aggcgtcggc acgtgaccag ccaccgcagc
     5941 agctccttta cacttctgca gtcactggcc atcgaagaca gcagggacaa gcccacttac
     6001 agtgtcctgc ttgggcagct gtttgctttc attggcacca accctgacca agcggtgtcc
     6061 agtagcagct tccttttggc tgcacagaca agatggaggc gggggaacac tcggaagcag
     6121 gccctggtgc atatgcggga gttgctgact gctgctgtgc gagttggggg agtcacacac
     6181 ctggtagggc cagtgacaat ggtccttcag gggggaccca gaattgaaga gctcacctgt
     6241 ggtgggatgg tggagcaggt ccaggaagcc tttggtgaga ccatgacctc tgtcgtgtct
     6301 ttgtgtgctc ggtaccccat tgcttgtgcg aacagcattg gactcctgtg taccatacct
     6361 tataccagga gtgaagagaa gtgcctggtc cgaagtggcc tcgtgcagct catggaccga
     6421 ctctgcagcc tgagcagcca gaccgagtcc agctccagtg agaagcagac aaagaagcag
     6481 aaggtggcca ccatggcctg ggctgccttc caggtgttgg ctaaccgctg tgtggagtgg
     6541 gagaaagagg aaggtggctc cacagaggct gtgcactcag ggctggcccg gcaggtgtcc
     6601 agtctcctca ccaaccacct tgcccgagcc actgagtgct gtggcaacca ggctgctggg
     6661 aacgacgccc tgcaggatgt cctgagcctt ctcaatgacc tctccaggag ccacataggg
     6721 aaagccatct tgagccagcc agcctgtgtt tctaagctcc tctcactact gctagatcag
     6781 cgtccatccc caaagctggt attgatcatt cttcaattgt gccgggctgc tttgcctttg
     6841 atgagcgtgg aggactgtgg gaatgtagag ctcccgccct ggagctactc cgtcccctcc
     6901 ctgaacagcg agcaagagga ccccagtgac cctgcctcca agattgcctc tctgctctta
     6961 gccaagctgg cagactatgt ggtcccagga tgtcagacgg ttctctctcc aactgcttct
     7021 gaacctgaca ccacactgac aaaaaccagt cctaagaatt ccttaaaagg agataaagat
     7081 cctggagaag agagtgaagc agtggatggc aagctctcca tatttatcca caagcgggaa
     7141 gaccagtcct cccatgaggt cctccagcca ctgctgagta gctcagaagg acggcccttt
     7201 cgactcggca ctggtgccaa catggaaaaa gttgtgaaga tggatcgaga catgaccaag
     7261 ggtggctgct gtgaagtgat cacagaagag gcctcagccg ccctcaggaa agcaaccaag
     7321 tgggcacagt cgggcctcat tgtcagtgtc ggaccaccag tggaatccat caacccagag
     7381 actgtgagtg ggctgtccac aggtgacaag aagaaaactg cccaaacctc catctgccga
     7441 gaaagaaact ctgaactggc cagaactgac cccgtgcgac ccttcatcag tggacatgtg
     7501 gcaaacagca tggctgcaga agtgatcgcc ttgcttcata gcctgctaat ggcgccagaa
     7561 tctaatgctg ctcaaatatg gaccacaacg gcagaaaagg ttctgtctcg agcattgatg
     7621 tacattccac aactagggaa gtatgcagaa agcatcctgg agaatgggag cagcagtggc
     7681 aggaaactgg ccaagcttca gaggattgca cgccaggcag ttgccgccct ctgtgcactc
     7741 ggaggcttta aagagacaat caagataggc tccgaggtcc aggttttagg tagaggaata
     7801 tcaggaagca ttggagttgt ggcttctatc aatgaacagg aaggtatagc tacagtccgg
     7861 ttccctcctg tggactgccg aaggacgtca caagcagcag acacgctgac tattccattg
     7921 tctagacttt gtgttccaag gtcagaggca ctgcctcttc ataagctgtc cattactgag
     7981 aaggtagtcc aggcagtgca gtccatgctg ctccctcagg aaggaagcct ctctatccac
     8041 acctctcttc ctgcaacagg agatggctca gcacctgtca tggcagttgt ccggcttctg
     8101 gctgaaatca gaaccagagc atgcctggtc atggcacagc ttttagaaga cagcctgttt
     8161 tgtgaagagt tcatacagca gtgtccagca gctgtggaag ttctgaacct cgtagcccag
     8221 gagtgcagtg cgggagagcg gctggcagtt gtagagatgc agtgtgagag gctcaggatg
     8281 ctctaccggg actgcgctcg gccccctcca cctccgctgc aggctgaccg gagacagccc
     8341 aaagagatca cctggagccc ttctcgagtg ttccctccag ttcgtgcctg catgttctca
     8401 tctcacctca cctctgtgac cttcctggct gaccccagcg ctggaggagg tcttccccgg
     8461 ggcacattca tctatgccac ctcgcccttg cctgttcagg ccccatcttt ctactgggaa
     8521 attgagattg tttcctatgg agacactgat gatgacactg gaccaatcgt ctcatttggc
     8581 ttcgctacag aagctgagaa gcgagatggg gcatggacca atccagtggg cacttgcctc
     8641 ttccacaaca atggccgagc tgtacactac aatggctcca gtctactgca gtggaagagc
     8701 gtccgcttag atgtcacact ctctcctggc gatgtggcag gaatcggctg ggagaggacc
     8761 gaggggactc cacctcctcc agggcagcca gccaaaggtc gggtgtactt cacatactgc
     8821 gggcagcgcc tcacaccata cctagaagat gtctctggtg gcatgtggcc tgtggttcac
     8881 attcagaaaa agaacacaaa aactcgagcc aattttggct cccgcccatt tgcgtatgct
     8941 gaaggacagg cccaccgaaa tgctgccgac ctgtgcactg acctggcaga agagatcagc
     9001 gctaactttg aggccttgcc attcgccatg gcatctgaca gtgacaacga tgctggcacc
     9061 agtattgcat cagacccagg cactcatggg ccgccatgcc ggattgcagc agtggccaca
     9121 gcccagcagc aatatgacag tgacacctcc tgccactata aagtagagct cagctatgag
     9181 aatttcatta cctcaggccc agacccccac ccacctccca ttgcggatga tgagagtgat
     9241 gatgacgacg atgatgacat ccctcaggag gaccactacg ccctgctggt gaaagcatgg
     9301 gagaccaagg ttttccctac catccggaga cgcttccgca atgaagccga gcgaaagtcg
     9361 ggcctagacc agatcaaggg tgctttacaa ctaggcatgg tggacatcgc ccggcagaca
     9421 gttgagttcc tctatgagga gaatggcggc atccccagag acctttatct tcctaccatt
     9481 gaggacatta aagatgaagc aaacaagttc acaatcgaca aagttcgaaa aggtctcacg
     9541 gttgtcaccc gctctccaga cagcagcaat gtagctagta gtaccgtggg aactgctctg
     9601 ccaaaatttg ccatccgagg gatgctaaaa accttcagcc ttcatggagt cgtcctagat
     9661 gttgattcag tgaatgaatt ggtgcaggtg gagacatacc tgcggagtga aggggtgttg
     9721 gtgcggtact ggtaccccat tgatatgcta gaaaggcccc ctgcaggcta ccggaggact
     9781 gccaccaatg gcctggtcac actggacaat accaaccttc aaattcacag agagctgctg
     9841 cgatgtgagg ctgcactggc ccgactgtac tgtcgcatgg ccctgcttaa catctttgcc
     9901 cccaagctac ctcatctatt cactcggctc ttccacatcc ctgccatccg agacatcacg
     9961 ttagagcacc tgcagctcct gtccaatcag ctccttgctc ctcccctccc agatggcacc
    10021 atcagctcca gctccatcct cctggcacag tctctgcagc actgcatcca ctcccagagc
    10081 tgctctgcca ccgacctctt ctaccagggc agctcgcaga cactgaggga gtggctcagc
    10141 gtggccatca cccgcaccct gcaccaaggc gaggacagcc tcctggagct gacaaagcag
    10201 atctgcgcct tcctgcagac agcaccagag cagttcccct ccgaggaatt cccagtgtct
    10261 gagtccaaag tcagtatgga tgtgaatttc cctggagcag cttttgttgt tgtgtcttgc
    10321 aaagaaagtc agtctggatt ccgcaaagac tcctctttgt acaaggctcc gtgggcacgc
    10381 gtgctcgtct atgggcttgg ccacaaagtg aagcgtaccg gccagctgaa cctcattgag
    10441 gctgcctgct accctcgaga cgcctcccca gccaacactg ggctcgcccc tccacccaca
    10501 gctgaccagt acccttctgt ggttctttcc acagacaaag tccacatcaa actaggagtg
    10561 tccccaccac ctggagcagt gctggtcttg cattctctgc ccctggagtt cccgctggcg
    10621 atggcctttg ccgagcagct gctgtcctgg aaatcagagg acagtgatgg gaagtcagag
    10681 gatgagcctg acagcatccc tgcctccgtc ctcctgcacg tggtggaact gctgggaaac
    10741 ttcctgtgga ctacagacat ggcggcctgt gtgaaggagt tggtcttcca cctcttggct
    10801 gagctcctac gcacagtaca caccctggag cagcggaagc acccagcagg cctgtcctcc
    10861 tccatcgccc tccagctcaa cccctgcctg gccatgctga tggccttaca gtcagagctg
    10921 cataagctgt atgacgagga gacgcagagt tgggtctcga gcagcgcctg tgggggctct
    10981 ggagcagcag ctgtgggcga ccagggcagg ttttccacct acttccacgc cctcatggaa
    11041 ggctgcctgg cagttgcgga agtaacccta cctaccaata tcagtgtcac agctagcggg
    11101 gtgacctcaa cgaccacccc aaatctcagc gactcgtcct cttcctcctc ctcctcccca
    11161 ggacagacac cacagagccc tagcctactg tccaagagaa agaaagtcaa gatgaagcgg
    11221 gagaaggcct cctcctccaa caagcgacag tcctcccgtg cctcagacgc agactccaca
    11281 gtgctcagca ttgggggaag caagcctgag gacatgctgt ggttccaccg tgccctcacc
    11341 ttgcttatca tccttcggca cctcaccaaa aaggacccac agggcctggg tgtaacgagc
    11401 gatgccattg ctgatgcctg ccaggccctg gtgggcccca ctgcccatag tcgcctgctt
    11461 gtgatctctg gcattcctac ccacctagat gaggctgttg tcagaggggc catccgcaag
    11521 gcctgcaatg cccatggcgg tgtcttcaaa gacgagatct acattccact gcaggacgag
    11581 gaccctaaga agccaaaaga caaggctgag ggcagcgaca gcaaggtgga atctgagaag
    11641 ctgctggggt tccccagtgt ggacagcctg gaggggagca cgtcgagcag cctggccccc
    11701 gccatgagca tcagcgcctc ggcctccacc agccaggcct cggtctgcag ttcacagtgt
    11761 gtctcacaga ctgccagtga cctctcagtg gacccactgc cctcaggcct ggagcttcct
    11821 gtccctcctg ttctgttgga accccatgta gtgtccagcc aggagagcct ggacatttcg
    11881 ttatgcagca ccggcagcct gggcagcctg ggcagcctgg gggagcctct agacaatcca
    11941 gagacggcat ctgtgtccga cgtgggctca atgtacacgg tcacatccct ggatacccag
    12001 cccctcgcaa cacgccctat caaaggcttt gcagtggtgg agatcaggtc ccgagccaaa
    12061 attgagaaaa tcagagcaag tttatttaac aataatgatt tgatcggtct gtcaagtctg
    12121 gatggtgaag acgagctgat ggaaatgtcg acagaggaga ttctgacagt gtcagtggtg
    12181 aaccagagtc tgtttgacac ccaagggagt ccagggctgg aagattactt cagtgacaag
    12241 tccattaaag gtgagaaact ggtgcctggg gccagagagg tcctgacaga aatatttaaa
    12301 agctgtgccc actcagagca gacgctgagc ctgacaccag ccaaacccat cagggtctct
    12361 gacatctatc ttagcaaaga gcagatcaac tcccagactc caggcaacct cctacacctc
    12421 ttcttcacca atgtccggcc tccaaagaaa gtgctggagg accagctcac acagatcctg
    12481 aggaaatacg gcgtgcccaa gcccaaactg gataagagca agtacagcaa ggctggcaag
    12541 gagcagcacc cggtgaaggt ggtgagcacc aagcggcccg tcaccaagcc gcctgccaag
    12601 gacaaagccg tgctcagcag cctcaggact gcactaagtg agaagaagcc gactgtgaag
    12661 ccaaaatcac ctgagaagag caaaccagac gaaaaggatc cagagaagtc acccaccaaa
    12721 aagcaagaag ttcctgagga aaagtaccta actctggaag gatttcacaa atttgtcatt
    12781 gaccgagcca agcaagacat ccgcagtgtc tggagggcaa tcctatcctg tggttatgat
    12841 cttcactttg agaggtgtgc ctgcattgat gttcgacatg cacagaaggc ctccaggaag
    12901 tggaccctgg agatggatgt ggctctcgtg caatacatca accggctgtg tcgccatctt
    12961 gctatcacac cagcacggct ccatcctcat gaggtgtacc ttgacccagc ggatgctgct
    13021 gaccccagga tggcctgcct ctcaaatgtg cctattgaga gcttacgcct gcgcttcgca
    13081 ctgctccagt ctctcaacac cacactggag accttcttct tgcccctggt agagctgcgt
    13141 cagacaccca tgtatgcaca cagcatcgcg gccctgctga aggaggccaa agggctgatc
    13201 ttctatgaca caaaggtgac tgtgatgaat cgggtgctaa atgcaactgt acagaggaca
    13261 gccgaccatg cagcacctga gatcacctta gacccactgg aaattgtggg aggggagatc
    13321 cgagcttctg aaaactccta cttctgccag gctgcccggc agctggcctc cgtgccatct
    13381 tctcagctct gtgtgaagtt ggccagtggc ggcgacccca catatgcctt caatatccgc
    13441 ttcaccgggg aggaggttca tggcaccagt ggctccttcc gtcacttcct gtggcaggtg
    13501 tgtaaagagc tgcagagttc ctcactgtcg ctgctcctgc tgtgtcccag ctctgcagtc
    13561 aacaagaaca agggcaagta catcctgaca ccaagcccca tcacctatgg ggaggagcag
    13621 ctgctacact tcttaggcca gctgctgggg atcgccattc gtgcagatgt gcctctcccc
    13681 ctggacctgc tgccctcctt ctggaagacg ctggttggcg agcctctcga ccctgaccag
    13741 gacctgcagg aagcagacat cctcacctac aattatgtca agaagtttga gagtatcaat
    13801 gatgagagcg agctggaggc cttgtgtgcc gagattgcct cccagcacct ggccaccgag
    13861 agccctgaag gtcccaagcc ctgctgccgg ttcacctacc tgaccatgac tggcgaggag
    13921 gtggagctat gcagccgtgg ccggcacatc cctgtggctt gggagaacaa ggatatctac
    13981 gccgcagcca tccggagcct gcggctgcgt gagctacaga acatggagtg cgtgacagcc
    14041 gtgcgtgctg gcctgggctc catcatcccc ctgcagttgc tcaccaccct cagcccactg
    14101 gagatggaat tgcgtacctg tggcctccca tacatcaacc tggagttcct gaaggcccac
    14161 accatgtacc aggtggggct gatggagaca gaccagcaca tcgagctttt ctggggggca
    14221 ctggagatgt tcacccagga ggaactgtgc aagttcatca agttcgcctg caaccaggag
    14281 cgcatcccct tcacctgccc ttgtaaggac gggggccctg acacagccca tgtgccaccg
    14341 taccccatga agattgcccc tccagatggc acagcaggtc cccccgactc acgctacatc
    14401 cgagtggaga cctgcatgtt catgatcaag ctcccccagt actcctccct ggagaccatg
    14461 ctggagaagc tgcgctgtgc cattcactac cgcgaagacc ccctcagtgg ctgatgggcg
    14521 tgagccgaag gattaggctg tcaccaaggc accattctgc cagcttggga agcttgccag
    14581 ttgaggcaca tccctccagg gcccaagtga ggagctggcg acatttgctt tctgaacttt
    14641 cctccgtgtc ccagggccac ctggaagaca ctttttgtat gtgtccgttt tgtgagggtc
    14701 tgttcctttg ctgcctgttt gtggtacatt tgtaggatag tttagttccg tcaatttgat
    14761 cttcctggac actgtttgtt ggtggtggct tccagatgct ggtgccacag gttcaagtgg
    14821 ttcctcatca cagagccact cgtggaaagc tgaggatgag atgacctcag ccacacaaag
    14881 tatcctgttc tctctacaga gtgtctccac agatgtgtga gagtcctcag tcctgccctc
    14941 ctgccctgag ctggcatctc tcccagaggc agcttccgca gggcccctcc ttccatcttg
    15001 aagtggttga gccagtgctc aaacgttcaa gagacacaag ggaactcatg tgttaatctt
    15061 cctgctttac cgtgtgttcc tggccttggt tttgtttttg tttttttttt tttttttaga
    15121 agtcccacag aggccccccc tgtctcctcc catcaggcag ccctatctgc cacctgtctc
    15181 ttctgggccc ctgggctgag tcatctgcgg acacctcagg agcagacacc caggggctac
    15241 tccaggcctt agctcacaga caggttgggt acggcctgat ggctggagtt gacagacagt
    15301 ggagctcaag gggtagcgct gagtgggcct ctctacagct gactgcacag gaaagcacat
    15361 gactcaagcc taccccactc tgtgctcaga gcctggccct cctcactaca gtgctgtaag
    15421 gagcccaggg aagggttaca acccgtgtct aaagactgtc tgaggtgctc tgcccaatca
    15481 gggctgcatc agtgacccag gcagagactg caggggagtc ctctgtgccc tggctggcct
    15541 gcccaacacc ctttacaccc aatgtgtgtg tgtgccaggg ctgagcttcc ttgcaggctc
    15601 gcccactacc ccagtgcatt tgtgccccaa ataagtcttt gtccaagaac agcacatgcc
    15661 aactgtcgga cactgtcact tgggcctccc cagttgtcac agaatggcaa cgctgtagct
    15721 attgtatgat attgtgtaca cagaagttct gaggagcgtg aggagggtac gctcctctct
    15781 ccacggcacc tggcctgctt ggaaggcgcg caagctttag ggctggcacg ccagcaccca
    15841 tctcctccct gttacgctta ggaaatgcat tgaggaccat tacagaaaac accccaccca
    15901 accccacctg aggaagtgat acaccccagc tcagtgtgcc agccacacca gtcactgggc
    15961 tgtatggaag tggtgcccag agcaagccct gctctcactg aagatggtgg ccgctgcttg
    16021 ggaccacccc agcggcctca agaatcctga ctccgttcgt tctccagaag gcaggagcct
    16081 ctgaatttta aagtgggttt tcattccagt accttcaaat ccgtggttcc cctcaattct
    16141 ctgcccttga gaggacttgg gattctgtca gctacctccc caggagggtt ctggaagcat
    16201 ctgttggccc attccttgat tagatgacag ctgtgagtga gatatctgct gctaactcag
    16261 ctgcttctcc tagagagcac actgaggtcc agacagatcc caaccttggc cctgaacaat
    16321 gtgtgctgta aagttacttg atgtatattt attataatta tttatgattg cattaacaga
    16381 cttcccattc agtctgatgc tatttacact atgctgtgta aaggaagctc actacaggaa
    16441 aaagtcacac caataaataa ccttcatctg actgactga
//
