LOCUS       NM_175244               4596 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus HECT domain E3 ubiquitin protein ligase 3 (Hectd3),
            mRNA.
ACCESSION   NM_175244
VERSION     NM_175244.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4596)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4596)
  AUTHORS   Li,F., Liang,H., You,H., Xiao,J., Xia,H., Chen,X., Huang,M.,
            Cheng,Z., Yang,C., Liu,W., Zhang,H., Zeng,L., Wu,Y., Ge,F., Li,Z.,
            Zhou,W., Wen,Y., Zhou,Z., Liu,R., Jiang,D., Xie,N., Liang,B.,
            Liu,Z., Kong,Y. and Chen,C.
  TITLE     Targeting HECTD3-IKKalpha axis inhibits inflammation-related
            metastasis
  JOURNAL   Signal Transduct Target Ther 7 (1), 264 (2022)
   PUBMED   35918322
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4596)
  AUTHORS   Gao,P., Ma,X., Yuan,M., Yi,Y., Liu,G., Wen,M., Jiang,W., Ji,R.,
            Zhu,L., Tang,Z., Yu,Q., Xu,J., Yang,R., Xia,S., Yang,M., Pan,J.,
            Yuan,H. and An,H.
  TITLE     E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing
            K29-linked cysteine ubiquitination of TRAF3
  JOURNAL   Nat Commun 12 (1), 1194 (2021)
   PUBMED   33608556
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4596)
  AUTHORS   Rangrez,A.Y., Borlepawar,A., Schmiedel,N., Deshpande,A., Remes,A.,
            Kumari,M., Bernt,A., Christen,L., Helbig,A., Jungmann,A.,
            Sossalla,S., Tholey,A., Muller,O.J., Frank,D. and Frey,N.
  TITLE     The E3 ubiquitin ligase HectD3 attenuates cardiac hypertrophy and
            inflammation in mice
  JOURNAL   Commun Biol 3 (1), 562 (2020)
   PUBMED   33037313
  REMARK    GeneRIF: The E3 ubiquitin ligase HectD3 attenuates cardiac
            hypertrophy and inflammation in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4596)
  AUTHORS   Cho,J.J., Xu,Z., Parthasarathy,U., Drashansky,T.T., Helm,E.Y.,
            Zuniga,A.N., Lorentsen,K.J., Mansouri,S., Cho,J.Y., Edelmann,M.J.,
            Duong,D.M., Gehring,T., Seeholzer,T., Krappmann,D., Uddin,M.N.,
            Califano,D., Wang,R.L., Jin,L., Li,H., Lv,D., Zhou,D., Zhou,L. and
            Avram,D.
  TITLE     Hectd3 promotes pathogenic Th17 lineage through Stat3 activation
            and Malt1 signaling in neuroinflammation
  JOURNAL   Nat Commun 10 (1), 701 (2019)
   PUBMED   30741923
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4596)
  AUTHORS   Li,F., Li,Y., Liang,H., Xu,T., Kong,Y., Huang,M., Xiao,J., Chen,X.,
            Xia,H., Wu,Y., Zhou,Z., Guo,X., Hu,C., Yang,C., Cheng,X., Chen,C.
            and Qi,X.
  TITLE     HECTD3 mediates TRAF3 polyubiquitination and type I interferon
            induction during bacterial infection
  JOURNAL   J Clin Invest 128 (9), 4148-4162 (2018)
   PUBMED   29920190
  REMARK    GeneRIF: Deficiency of the E3 ligase gene Hectd3 remarkably
            increased host defense against infection by intracellular bacteria
            Francisella novicida, Mycobacterium, and Listeria by limiting
            bacterial dissemination. In the absence of HECTD3, type I IFN
            response was impaired during bacterial infection both in vivo and
            in vitro.
REFERENCE   7  (bases 1 to 4596)
  AUTHORS   Zhang,L., Kang,L., Bond,W. and Zhang,N.
  TITLE     Interaction between syntaxin 8 and HECTd3, a HECT domain ligase
  JOURNAL   Cell Mol Neurobiol 29 (1), 115-121 (2009)
   PUBMED   18821010
  REMARK    GeneRIF: Syntaxin 8 and HECTd3 have similar subcellular
            localization.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671671.5 and BC070411.1.
            
            On May 4, 2018 this sequence version replaced NM_175244.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070411.1, AK155290.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AL671671.5         79472-79485
            15-4596             BC070411.1         1-4582
FEATURES             Location/Qualifiers
     source          1..4596
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.41 cM"
     gene            1..4596
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /note="HECT domain E3 ubiquitin protein ligase 3"
                     /db_xref="GeneID:76608"
                     /db_xref="MGI:MGI:1923858"
     exon            1..438
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            439..599
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            600..692
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            693..828
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            829..944
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1058
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1141
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1307
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1389
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1572
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1625
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1690
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1794
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1914
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2004
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2211
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2341
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2416
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2498
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2570
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..4566
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3452..3457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3469
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /note="major polyA site"
     regulatory      4543..4548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4566
                     /gene="Hectd3"
                     /gene_synonym="1700064K09Rik"
ORIGIN      
        1 ctgcttgctg tcccctggct gcggccggcc agggtttccc tggacgagtc tcacttcagc
       61 ggcttcgcta tggccggccc tggccccggc gcggcgcttg agtccccgcg gcagctcctg
      121 ggtcgcgtgc gcttcctggc ggaggcggcg cggagcctcc gggccgggct gccactgcct
      181 gcggcgctag ctttcgtgcc gcgggaagtg ctctacaagc tgtacaagga cccggcggga
      241 ccctcgcgcg tgctgctgcc cgtgtgggaa gcagagggcc tggggctgcg tgtgggagcc
      301 gtgggcgctg ccccgggcac aggctctgga cccctgcgcg ccgcccgtga cagtatcgag
      361 ctccggcgcg gcgcctgtgt gcgcaccact ggcgaggagc tgtgcaacgg ccacgggctc
      421 tgggtgaagt tgaccaagga gcagctggcc gaacacctga gtgactgtag tctggacgaa
      481 ggctggcttc tagtgtgtcg accagcagag ggcggagccc gccttgtacc tattgacact
      541 cccgaccacc tgcagcggca gcagcagcta tttggcgtgg actaccggcc ggtgctcaga
      601 tgggaacagg tagtggacct gacctattca catcgcctgg gatccaggcc tcagccagca
      661 gaggcatata cagaagctat acaaaggcta ctctatgtgc ccccaacatg gacatatgag
      721 tgcgacgagg acctgatcca cttcttatat gaccacctgg gcaaagaaga tgagaacctg
      781 ggtagtgtga agcagtatgt ggagagcata gatgtttctt cctatacgga ggagttcaat
      841 gtgtcctgcc tgacagatag caacgcagat acctactggg agagtgatgg gtcccagtgc
      901 caacactggg tacggcttac catgaagaaa ggcacaattg tcaagaagct gctactcaca
      961 gtggatacca cagatgacaa cttcatgccg aaacgggtag tagtctatgg gggtgaaggg
     1021 gacaacctga agaagctgag tgacgtgaac attgatgaga ccctgatcgg ggatgtctgt
     1081 gtattagagg acatgaccgt ccaccttcca atcattgaga tccgaatcgt tgagtgtcga
     1141 gatgatggga tcgatgtccg tcttcgaggg gtaaagatca agtcatctag acagcgggag
     1201 ctggggctga atgcagacct gttccagccg gccagtctgg tgcgatatcc acgcctggaa
     1261 ggcactgacc cagaagtact ataccgcaga gctgtccttc tgcagagatt catcaaaatt
     1321 ctggacagtg tcctgcacca cctagtacct gcatgggacc acaccctggg cacctttagt
     1381 gagattaagc aagtgaaaca gttcctactg ttgtcacgcc agcggcccag cctggtagca
     1441 cagtgcctgc gtgattcaga aagcagcaag cccagcttca tgccgaggct gtacatcaac
     1501 cgccgccttg ccatggaaca ccgtgcctgc ccttctcggg accctgcctg caagaatgca
     1561 gtcttcaccc aggtttatga aggtctcaag ccttctgaca agtatgagaa gcccttggac
     1621 tacaggtggc ccatgcgcta tgaccagtgg tgggaatgta aattcattgc ggaagggatc
     1681 attgaccaag gaggtggctt ccgtgacagc ctggcagata tgtcagaaga actgtgcccc
     1741 agctcagctg acacccctgt gcctctgccc ttctttgtgc gcacagcgaa ccagggcaat
     1801 ggcactggtg aggcccggga catgtatgtg ccaaatccct cttgccgaga ctttgccaag
     1861 tatgagtgga ttggacagtt gatgggggct gcccttcggg gtaaggagtt cctggtcctg
     1921 gccctgcctg ggtttgtgtg gaagcagctg tctggagagg aagtgagctg gagcaaggac
     1981 ttcccagctg tggactccgt gctggtgaag ctcctggaag tgatggaagg agtggacaag
     2041 gagacgtttg agttcaagtt tgggaaggag ctgacattca ccaccgtcct gagtgaccaa
     2101 caggtcgtgg agctgattcc tgggggcacg ggcatcgtgg tggaatatga ggatcgctcc
     2161 cgtttcatcc agctggtgcg gaaggcgcgg ctagaggaga gcaaggagca ggtggcagcc
     2221 atgcaggcag gtctgctgaa ggtggtacca caggctgtgc tggacttgct gacctggcaa
     2281 gagttggaaa agaaggtgtg tggggaccca gaggtcactg tggatgctct gcgcaagctc
     2341 actcggtttg aggacttcga accatctgac acacgcgtgc agtacttttg ggaggctctg
     2401 aacaatttca ccaatgagga ccggagccgt ttcctgcgct ttgtcaccgg ccgcagccgc
     2461 ctccctgctc ggatctacat ttacccagac aaactgggct atgagaccac agacgccctg
     2521 cctgagtctt ctacctgctc cagcacgctc ttcctcccac actatgccag tgccaaggta
     2581 tgcgaggaga agctccgcta cgccgcgtac aactgtgtgg ccatcgacac ggacatgagt
     2641 ccctgggagg agtgaggccg tgccctaagc gtgtacgctg ccctcaccca caccagcccg
     2701 gtttgggtct caacagaggt gatgggttca gaaatgtcag cacagtgggc cctgtacctg
     2761 agtatggtct ggtcgcagtg ggaggcgtga attgacacag acgctccagt ccccacagac
     2821 ccacgaaccc tactgtgctg gggcttgctt ccctaggtat ttagccttgg tgagagggaa
     2881 tcgtccacaa gcccagcaca cgctgccagg cctgagctac ttgaaggggg caatctagct
     2941 ccccaaacaa tggactatgt tttggtttcc cccattcctc tttttttcta gcttcagcca
     3001 tggctcaaaa tgtttaaaaa ctggtagaat ggtactttga gcaaggggcc aatgacagag
     3061 taaggtcatc ctccttggtc acgggtccct aagaaagaag ccccagttga gacccatccc
     3121 ttgcatacta gccttcttct ttccatagca gaggtgtgtg agctttgttc ttccagaggc
     3181 ttggcatgga catccgctca atacccaggc tttaccagca gccaaactac tgtcttctgg
     3241 atcatatcca gcccaactcc attgctcctt cacccccaag agttcacagc tgagggacct
     3301 tctgtcctct ctgaaatttc agtggttgct gtttccacac tctaaaataa ggcctagacg
     3361 ttaaacttcc tctaagggtg gtgcacaccc ttccattacc ctcaagagcc tccatggcac
     3421 tcctgtagga cgtcttacat tggggaaatt gaataaatgg agaaattcat ttttttagaa
     3481 tgtgcttttg ggatccctgc taaactcatg gcactcctag aaaatcgctg tgtcctagaa
     3541 ggagctccgg ggctgccacc ctactgatag caggggatgt gcgcctgatg ggagaggtgg
     3601 gcttcacagt gacacagtgg ggcatctgta gcacagcctg ggaatgagag ctcagaccag
     3661 aggacagaag gctgggcttt tgagatgatt gtgggattca gagtctggaa gctcacctcc
     3721 agcagcaagt gagcagaatg acggcacatg gagggtgaag ctggggtagc tgatgagcac
     3781 ccggatcctg atacacttgg gagcacctgt ctgcccccaa atgccacata tctaaggtcc
     3841 agagactcta gccctgtctt accccaagta cttccaccct gaagctcaat gcactagacg
     3901 ccatcttggt gtcctggtac agtgtaaaca gtcagttacc catcaaagca gactgagccc
     3961 taaaaatctt tcctaatgtg tcgtcttcag ctcacggtgc cattgagaaa gcctcttcac
     4021 atggctgtgt gcacgcccag acctatcttt cccacacact gagcctcctg gggcagcccc
     4081 atccgcccat gtgctttggg ggacccacag gagacaaaca tgaacaccct ccctcccagg
     4141 gagccccagc acctgcacac acacccacca aactctgctt ctcagaaagc tcccctggct
     4201 ctgttgggga aggagtgctt ccatagtgtc tgggaagggc cttccctgca gaagctgtgg
     4261 ggtgcagttt gtctctatgc ccccacacat gcccttaata actcttttac accatatttt
     4321 tcaggctgct ttgcatttac ttattcattt agagatgaag tgtggagtac agatgtcagg
     4381 caccagctgc aaagcaccaa ggctaagtcg gtgtttgctc cagagcacac actccccaca
     4441 gaagcttgct acatctttct cattaagtag cagtgtagag caagtgtctt cttggtgatg
     4501 aattatactt ctaaggggat ccactgaaat attttattct ctattaaaat tttattttta
     4561 aaatcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
