LOCUS       NM_001033432            5061 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus hdc homolog, cell cycle regulator (Heca), mRNA.
ACCESSION   NM_001033432 XM_354533 XM_897065 XM_897082 XM_897091 XM_912937
VERSION     NM_001033432.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5061)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153896.10.
            
            On Jan 5, 2023 this sequence version replaced NM_001033432.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132340.1, SRR14777534.617699.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-529               AC153896.10        81584-82112
            530-1570            AC153896.10        113589-114629
            1571-1725           AC153896.10        121433-121587
            1726-5061           AC153896.10        127244-130579
FEATURES             Location/Qualifiers
     source          1..5061
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 7.31 cM"
     gene            1..5061
                     /gene="Heca"
                     /gene_synonym="Gm869; HDC; HDCL"
                     /note="hdc homolog, cell cycle regulator"
                     /db_xref="GeneID:380629"
                     /db_xref="MGI:MGI:2685715"
     exon            1..529
                     /gene="Heca"
                     /gene_synonym="Gm869; HDC; HDCL"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..1890
                     /gene="Heca"
                     /gene_synonym="Gm869; HDC; HDCL"
                     /note="headcase homolog"
                     /codon_start=1
                     /product="headcase protein homolog"
                     /protein_id="NP_001028604.1"
                     /db_xref="CCDS:CCDS23709.1"
                     /db_xref="GeneID:380629"
                     /db_xref="MGI:MGI:2685715"
                     /translation="MPNPKNSKGGRKNKRANSSGDEQENGAGALAAAGATGAAAGGAL
                     AAAAAGCGAASPGAVGTGGAAGPGGAGTGAANATVAAGAAAAGDAKNGAPCATPLICS
                     FGRPVDLEKDDYQKVVCNNEHCPCSTWMHLQCFYEWESSILVQFNCIGRARSWNEKQC
                     RQNMWTKKGYDLAFRFCSCRCGQGHLKKDTDWYQVKRMQDEKKKKSGSEKNTARPPGE
                     AGEEAKKGRALNKPQKGLNHDLPRRHSMDRQNSQEKTVGSAAYGARSPCGSPGQSPPT
                     GYSILSPAHFSGPRSSRYLGEFLKNAIHLEPHKKAVPGGHVFRNAHFDYSSAGLSVHR
                     AGHFDTPVQFLRRLDLSELLTHIPRHKLNTFHVRMEDDAQVGQGEDLRKFILAALSAS
                     HRNVVNCALCHRALPVFEQFPLVDGTLFLSPSRHDEIEYDVPCHLQGRLMHLYAVCVD
                     CLEGVHKIICIKCKSRWDGSWHQLGTMYTYDILAASPCCQARLNCKHCGKPVIDVRIG
                     MQYFSEYSNVQQCPHCGNLDYHFVKPFSSFKVLEAY"
     exon            530..1570
                     /gene="Heca"
                     /gene_synonym="Gm869; HDC; HDCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1725
                     /gene="Heca"
                     /gene_synonym="Gm869; HDC; HDCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..5061
                     /gene="Heca"
                     /gene_synonym="Gm869; HDC; HDCL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3619..3624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Heca"
                     /gene_synonym="Gm869; HDC; HDCL"
                     /note="hexamer: AATAAA"
     polyA_site      3638
                     /gene="Heca"
                     /gene_synonym="Gm869; HDC; HDCL"
     regulatory      5042..5047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Heca"
                     /gene_synonym="Gm869; HDC; HDCL"
                     /note="hexamer: AATAAA"
     polyA_site      5061
                     /gene="Heca"
                     /gene_synonym="Gm869; HDC; HDCL"
                     /note="major polyA site"
ORIGIN      
        1 gggctcctcc gcgtctcgct ctgctcgggg gcccgttgcg cccgcgcggc tgcgagcctc
       61 gggtggccgc gcgtggccgc gccggcttct gccgcggagg gcgcggcggc cggaatgtcg
      121 cggcgagggc cgcgcggcgg ggcgggcgcc tgaggaagag cggccggccc gcgctctccg
      181 tggccgcccc ggtgcggcgg gggagccgcc ttcgtgggcg ccggggaccg ggacacccgc
      241 gagcgggccg gggagatgcc caaccccaag aacagcaaag gcggccgcaa aaacaagcgc
      301 gccaacagca gcggggacga gcaggaaaat ggagccgggg ccttggcggc ggcgggtgcg
      361 acaggcgcgg cggccggagg ggccctggcg gcggcggcgg cgggctgcgg ggcggcgtcg
      421 cccggcgcgg tgggcaccgg cggcgcggcg ggcccgggag gtgcgggcac gggcgccgcc
      481 aacgccaccg tcgctgcggg ggctgcagcc gcgggagacg ctaagaatgg agctccttgt
      541 gccacgcctc tgatctgcag ctttgggaga ccagtggacc tggagaagga tgactatcag
      601 aaggtggtgt gcaacaatga gcactgtccc tgcagcacct ggatgcatct tcagtgcttc
      661 tacgagtggg agagcagcat cttggtacag ttcaactgca tcggcagggc ccgcagctgg
      721 aatgagaagc agtgccgcca aaacatgtgg accaagaagg gctatgacct ggctttccgc
      781 ttctgttcct gccgctgtgg gcagggccac ttaaaaaagg acacagactg gtaccaggta
      841 aagcgaatgc aagatgaaaa gaagaagaag tctgggtcag agaagaacac agcaaggcct
      901 ccaggggagg ctggggagga ggcaaaaaaa ggcagggccc tgaacaagcc ccagaagggc
      961 ctgaaccatg accttcctcg gcggcactcc atggacaggc agaactccca ggaaaagaca
     1021 gtcggttctg cagcctatgg cgcccgctcc ccttgtggct cccctggcca gtccccaccc
     1081 acaggctact ctatcctctc cccagcccac tttagtggtc cccgatcctc cagatacctt
     1141 ggggaattct taaagaatgc cattcatctt gagcctcaca aaaaggccgt gccaggaggc
     1201 cacgtgttca gaaatgccca ctttgattac agttcggctg gtctgtctgt acacagggca
     1261 ggacactttg acacccctgt ccagttcctg cggcggctgg acctctctga acttctcact
     1321 cacatcccca ggcataagct aaacactttc catgttcgga tggaagacga tgcccaagta
     1381 ggccaaggcg aagatctgcg gaagttcatt cttgcagccc tcagtgccag ccacagaaac
     1441 gtcgtaaact gtgctttgtg ccaccgggcg ctccccgtgt ttgaacagtt ccctctggtg
     1501 gatggaactc tgttcttaag cccctcaaga cacgatgaga ttgaatatga tgttccttgt
     1561 caccttcaag ggagactcat gcatctgtat gcagtgtgtg tggactgcct ggaaggggtt
     1621 cacaagatta tctgcatcaa atgcaagtca cgatgggacg gcagctggca ccagctgggc
     1681 accatgtata cctacgacat cctggctgcc tctccctgct gtcaggcccg tctgaattgc
     1741 aagcattgtg gcaagcctgt gatcgacgta cggatcggga tgcagtactt ctctgagtac
     1801 agcaatgtcc agcagtgtcc acactgtggg aacctggact accatttcgt gaagccattc
     1861 tcttccttca aagttctcga agcttattga tgaaagcttt gctttagtaa tagctatttt
     1921 attgatatta ttactttact acatatcttt tataggggaa cattctgtga cattaatttc
     1981 ttttctaatt tgaagcagag tttactttgt atatttgtgc cactaaaatg gggacttcct
     2041 cttgcccttt cctgattccc aaatgtcaat gtgtgggtaa gactggaggc cagatgggga
     2101 attgtgcagg tttggtaggg ttttagtctc atgcagagtg tctgatggag ttctaaggta
     2161 gtaggaagaa tgggtgccat ttaggggtgg gaatctggct aaactagagg tgtggtagga
     2221 gttgggaggg agcttttact aaatgttagc tttcttgaga ctcactgtta gttctctggg
     2281 ccttggggaa ataaatgaca agtgaatgta cacctgagcc tggacagcca gtactgtatt
     2341 aggctgtctg gactctgttt ttcagcacag gttgaggtgc aattttctcc cactgataga
     2401 tgatttgaga gtagaactga gtgctctttc tttgactatt tgtctaattt aacagttttc
     2461 atactggaaa taatatccaa attatatgac acgtgaaagc tgttgctgtg taggtgagct
     2521 gaatctagca ggtcttgtga agcaaatttg gaaatgatgc acactgaatc aggcaggcag
     2581 aaagacacac tttggttatt tgaactgtat ctctagaggt ggtcagagag tctacagaaa
     2641 atctgtatac tcggtggttt tgatgggcag catttacagg ttgcattgct gaagtgctgc
     2701 ctggtatcca gagctccttg caggtaaacc tctggcctgc ctgctgtgct gcagaaccac
     2761 ctgtgccaca cttccttttc agtatatcta gtgccacata gtcagagcca atctgaagaa
     2821 ggaaggcgac agttagaatg atgaatagtt tttattcttt taaaagtaag ttcagttttg
     2881 ggagcagtaa tgcaaaagag catatctgaa aatagatcat cctaaagatt cccatgatcc
     2941 ctcactgttg gttaaagcaa aagtagcata cagaccaagt attccaaacc aacctctgtg
     3001 caggagaatg tggaaacttc aatatgctga agacatggcc tgtacagtta gaattagaga
     3061 cttacttctt atgaagcaat ttggtatttt caagtatgat atagaagtac atattaaaag
     3121 aatactaaat cttacccatt tatgactagg caaatttgaa gtttatgtaa atatttatat
     3181 catttttttg gtttatgccc cctacacata cagtgggtgt ttctcttcaa aattgtctaa
     3241 gcattattgc cagtgagttt taaattctac tgcttggtga tttgatggaa tcagcattaa
     3301 ggaacccaac taaaactctt catctttgga tgaatattct tcatcagttg gtttgttact
     3361 catagtttga tgatctgaag tttcacatct gtaaaaactt gcctaggaca agcagaaatc
     3421 attattggtc aggtggtgtt taatgcaatt acatgaggtc tacataacat aatacttaca
     3481 aatttgtctc cgaagcacaa agctgtaatt aggaattagc tgtttcccta tgagtctgtt
     3541 gtacactcaa gtttaaaatt ttggtaagtt tctattcaaa ttcatatttg tcttcgtgtt
     3601 tctgattctt ttaaaataaa taaaatactt gtaatgcagt tctttaacct ggtgacgttt
     3661 tctagtaaaa tttcactgtg ttattgttcc gaagtcaatc tattcactgt accacgtgag
     3721 ttctttaggt taaaagacac tgtggagctg taagccacat tccgttcttg ttccttagat
     3781 tgatttctgc ccctaaaagg aagaggtctt atttcagttg gataacattt gcatttgatg
     3841 ctatgttgat gataaagtga ggactatgta tatggtctta caaaagaagc atgagccctg
     3901 cattccaata cttacctttt gccttttagt gcattaattt cacttttgtc tggaagggaa
     3961 aatttggctg gttggagaaa aaaaaaaata caactaagca tacaatactt gctataaagg
     4021 taaattttac tttggaaatc ttctgacctt aatgttttca ccagtctttg cctgaacacg
     4081 ttgattagaa ttggtctatg tcaagaagga ttatcatttc tattgtagtt gggacagtaa
     4141 agggtatcag tcacctagga gatctaactt ctgtttctga tgagtaactc atagattcag
     4201 taactcatag attgactaat aatttaaagt gatttttatc tactttaata tctttagtca
     4261 tttattttta aagtgttcca tactttgagc aagtaaaatt gcttcagttt tgagacaagc
     4321 taatttctga tcgtattttc ttcaggccat ctcagctctc tgctgtttct gattacctga
     4381 tcacatggga agcccttaca gaggggcttc tccaacatcc tttaatttcc agtttttgaa
     4441 aaagggattc atttttctaa gtaaaagaaa ttttcatacc tttttgggaa aaattagctc
     4501 atgaagaaag agttttatat gtttaaatga taaaacttaa cagattgagt cataacatgc
     4561 tagactacca agactacctt tctgagttcc tcgtgtcgtc ctacaatacc agtgcttttt
     4621 ctgtgcagtc tgctttgtgc ctgttttcta accttgttga tttttttgtt caagtccttg
     4681 aagcagttgt tgaataattt tagttgggag attggggaag aggtgaggaa aaagcacttt
     4741 tctttagggt gtggttccca tgacaggatg ctgcctaacc tagttcatct tcataccttg
     4801 ttgactttat tattttttca gataattgaa agagaatata atgaatggac accatgaaaa
     4861 ccagctcaaa aatatgttgt tgtctacaaa gatttcttgt caagatgtct tggattgcac
     4921 ttttgttgag ggaagccagt gtaaatactt aaagaatgtt gataaaaatt gaagcatttg
     4981 ggttatggaa tcatgtgtga tgttagaggg tttctgtatg tgaaaggtgt gtattaagaa
     5041 taataaaatt ttagaaacaa a
//
