LOCUS       NM_013546               1065 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus heme binding protein 1 (Hebp1), mRNA.
ACCESSION   NM_013546
VERSION     NM_013546.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1065)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1065)
  AUTHORS   Ock,J., Wu,J., Liu,F.Y., Fridayana,F.R., Niloofar,L., Vo,M.N.,
            Hong,S.S., Kang,J.H., Suh,J.K., Yin,G.N., Jin,H.R. and Ryu,J.K.
  TITLE     Heme-binding protein 1 delivered via pericyte-derived extracellular
            vesicles improves neurovascular regeneration in a mouse model of
            cavernous nerve injury
  JOURNAL   Int J Biol Sci 19 (9), 2663-2677 (2023)
   PUBMED   37324943
  REMARK    GeneRIF: Heme-binding protein 1 delivered via pericyte-derived
            extracellular vesicles improves neurovascular regeneration in a
            mouse model of cavernous nerve injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1065)
  AUTHORS   Yin,G.N.
  TITLE     Pericyte-derived heme-binding protein 1 promotes angiogenesis and
            improves erectile function in diabetic mice
  JOURNAL   Investig Clin Urol 63 (4), 464-474 (2022)
   PUBMED   35796141
  REMARK    GeneRIF: Pericyte-derived heme-binding protein 1 promotes
            angiogenesis and improves erectile function in diabetic mice.
REFERENCE   4  (bases 1 to 1065)
  AUTHORS   Yin,G.N., Wu,J., Cui,Y., Lin,C., Shi,L., Gao,Z.L., Suh,J.K.,
            Ryu,J.K. and Jin,H.R.
  TITLE     Transcriptional profiling of mouse cavernous pericytes under
            high-glucose conditions: Implications for diabetic angiopathy
  JOURNAL   Investig Clin Urol 62 (1), 100-110 (2021)
   PUBMED   33258327
  REMARK    GeneRIF: Transcriptional profiling of mouse cavernous pericytes
            under high-glucose conditions: Implications for diabetic
            angiopathy.
REFERENCE   5  (bases 1 to 1065)
  AUTHORS   Micaelo,N.M., Macedo,A.L., Goodfellow,B.J. and Felix,V.
  TITLE     Tetrapyrrole binding affinity of the murine and human p22HBP
            heme-binding proteins
  JOURNAL   J Mol Graph Model 29 (3), 396-405 (2010)
   PUBMED   20800521
  REMARK    GeneRIF: Results present a systematic molecular modeling study of
            the binding properties of murine and human p22HBP protein
            (heme-binding protein) with four tetrapyrrole ring systems
            belonging to the heme biosynthetic pathway.
REFERENCE   6  (bases 1 to 1065)
  AUTHORS   Sato,E., Sagami,I., Uchida,T., Sato,A., Kitagawa,T., Igarashi,J.
            and Shimizu,T.
  TITLE     SOUL in mouse eyes is a new hexameric heme-binding protein with
            characteristic optical absorption, resonance Raman spectral, and
            heme-binding properties
  JOURNAL   Biochemistry 43 (44), 14189-14198 (2004)
   PUBMED   15518569
  REMARK    GeneRIF: The heme-binding properties and coordination structure of
            mouse liver p22HBP are distinct from those of SOUL protein, despite
            high sequence homology.
REFERENCE   7  (bases 1 to 1065)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1065)
  AUTHORS   Jacob Blackmon,B., Dailey,T.A., Lianchun,X. and Dailey,H.A.
  TITLE     Characterization of a human and mouse tetrapyrrole-binding protein
  JOURNAL   Arch Biochem Biophys 407 (2), 196-201 (2002)
   PUBMED   12413491
  REMARK    GeneRIF: Characterization as a tetrapyrrole-binding protein
REFERENCE   9  (bases 1 to 1065)
  AUTHORS   Zylka,M.J. and Reppert,S.M.
  TITLE     Discovery of a putative heme-binding protein family (SOUL/HBP) by
            two-tissue suppression subtractive hybridization and database
            searches
  JOURNAL   Brain Res Mol Brain Res 74 (1-2), 175-181 (1999)
   PUBMED   10640688
REFERENCE   10 (bases 1 to 1065)
  AUTHORS   Taketani,S., Adachi,Y., Kohno,H., Ikehara,S., Tokunaga,R. and
            Ishii,T.
  TITLE     Molecular characterization of a newly identified heme-binding
            protein induced during differentiation of urine erythroleukemia
            cells
  JOURNAL   J Biol Chem 273 (47), 31388-31394 (1998)
   PUBMED   9813049
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY242687.1, AC131718.5, AK008919.1 and AI527209.1.
            
            On Nov 17, 2015 this sequence version replaced NM_013546.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF117613.1, BC012654.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BY242687.1         2-25
            25-25               AC131718.5         43365-43365
            26-139              BY242687.1         27-140
            140-882             AK008919.1         61-803
            883-1065            AI527209.1         1-183               c
FEATURES             Location/Qualifiers
     source          1..1065
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 65.93 cM"
     gene            1..1065
                     /gene="Hebp1"
                     /gene_synonym="Hebp; p22HBP"
                     /note="heme binding protein 1"
                     /db_xref="GeneID:15199"
                     /db_xref="MGI:MGI:1333880"
     exon            1..196
                     /gene="Hebp1"
                     /gene_synonym="Hebp; p22HBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..691
                     /gene="Hebp1"
                     /gene_synonym="Hebp; p22HBP"
                     /note="p22 HBP"
                     /codon_start=1
                     /product="heme-binding protein 1"
                     /protein_id="NP_038574.3"
                     /db_xref="CCDS:CCDS20645.1"
                     /db_xref="GeneID:15199"
                     /db_xref="MGI:MGI:1333880"
                     /translation="MLGMIRNSLFGSVETWPWQVLSTGGKEDVSYEERACEGGKFATV
                     EVTDKPVDEALREAMPKIMKYVGGTNDKGVGMGMTVPVSFAVFPNEDGSLQKKLKVWF
                     RIPNQFQGSPPAPSDESVKIEEREGITVYSTQFGGYAKEADYVAHATQLRTTLEGTPA
                     TYQGDVYYCAGYDPPMKPYGRRNEVWLVKA"
     exon            197..335
                     /gene="Hebp1"
                     /gene_synonym="Hebp; p22HBP"
                     /inference="alignment:Splign:2.1.0"
     exon            336..516
                     /gene="Hebp1"
                     /gene_synonym="Hebp; p22HBP"
                     /inference="alignment:Splign:2.1.0"
     exon            517..1061
                     /gene="Hebp1"
                     /gene_synonym="Hebp; p22HBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1034..1039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hebp1"
                     /gene_synonym="Hebp; p22HBP"
                     /note="hexamer: AATACA"
     polyA_site      1052
                     /gene="Hebp1"
                     /gene_synonym="Hebp; p22HBP"
                     /note="major polyA site"
ORIGIN      
        1 ggagaccgcc gcagccccgc cccaatcgcc tgtctactca cgcgcttact gcccctcgcc
       61 ctgtggacct tactgccagt gagtgtacgc tcgatcggcc agaccccacg gcgtcaccat
      121 gttgggcatg atcaggaact cactgttcgg gagcgtggaa acgtggcctt ggcaggttct
      181 aagcaccggg ggcaaggaag atgtctccta tgaggaaaga gcctgtgaag ggggcaagtt
      241 tgctactgtg gaagtgacag acaagccagt ggatgaggct ctccgggaag cgatgcccaa
      301 gatcatgaag tatgtgggtg gcaccaatga caaaggagtc ggcatgggta tgacagtccc
      361 tgtctctttt gccgtgtttc ccaatgaaga tggctcccta cagaagaaac tgaaagtctg
      421 gttccggatt ccgaaccaat ttcaaggcag cccaccggcc cccagtgatg agagtgtgaa
      481 gatcgaggaa cgggagggca tcactgtcta ttccacgcaa tttggaggct atgccaagga
      541 agcagactat gttgctcatg ccacccagct acggaccaca ctggagggca caccagcgac
      601 ctaccagggt gatgtctatt actgtgccgg atatgaccct cccatgaagc cctatggacg
      661 ccgtaacgag gtctggcttg tgaaggcatg agtcacttga tgaactgaga acgtcctgga
      721 agggtgccac tgtgtcccct gacttagggt caaggggcgg gagggtgggg ggaggtactt
      781 cttcagctcc aatgttcctt caaaatccct cactgctgat tttctgaaat aagccaagat
      841 tggcagcatc attcttgagt tagaaagttc tggggcagac cagaaaaaaa atcccagtgg
      901 catttcctct gccactaaaa actgattttt aataattatc gaatttgtat ttttgttagt
      961 gaggaaatat gtgacttatg catgaacttt cttctgtgat tcttttaaga actttgtcta
     1021 gaaagaaacc aaaaatacaa atctttgacg tatgcagtgg aaaaa
//
