LOCUS       NM_145432               5677 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus HEAT repeat containing 6 (Heatr6), mRNA.
ACCESSION   NM_145432 XM_001004581 XM_001004585 XM_001004587 XM_001004594
            XM_001004600 XM_001004601 XM_354634 XM_902903 XM_902906 XM_902915
            XM_902919 XM_902921 XM_907748 XM_920525 XM_920537 XM_920567
            XM_920586 XM_920593
VERSION     NM_145432.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5677)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   2  (bases 1 to 5677)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV657360.1, AK132494.1, BC065092.1, AK138219.1 and AA183118.1.
            
            On Mar 1, 2007 this sequence version replaced NM_145432.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.57827.1, AK132494.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-670               DV657360.1         1-670
            671-1818            AK132494.1         606-1753
            1819-4125           BC065092.1         1745-4051
            4126-5243           AK138219.1         1384-2501
            5244-5677           AA183118.1         1-434
FEATURES             Location/Qualifiers
     source          1..5677
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.23 cM"
     gene            1..5677
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /note="HEAT repeat containing 6"
                     /db_xref="GeneID:217026"
                     /db_xref="MGI:MGI:1919790"
     exon            1..305
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..3641
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /codon_start=1
                     /product="HEAT repeat-containing protein 6"
                     /protein_id="NP_663407.2"
                     /db_xref="CCDS:CCDS36259.1"
                     /db_xref="GeneID:217026"
                     /db_xref="MGI:MGI:1919790"
                     /translation="MAAVQVAASLPCGQPREAPRELSPEQDDGFRRLSARLRALQPDD
                     STVSRMEIHLLFDQLISENYSEGGGVAPEDVSALLVRACQLVPLNQNHLVSKVCQLIH
                     RLLNRLQVVVDEPNLDFLLTYTISALQQCSSWTHMEILQALAALVYCNGSKCQKHLPD
                     LLGKSGLLMKLSDLSHSDPEVRRAAVHCMANLCLSVPGQPYLEEPYQHVCFQAFLTIL
                     QSPKSSDMDDITFCMLLQNALKGIQSLLNGGKMRLTQTEHLGALLAVLKKAMFHGLPG
                     LNIEMPAVLYPTPLPQYDGRSPVKPQQPESTTARSSANKKKKHKVKTKKTQQGEKAEE
                     EEEEPCGEVEAAPGLSMDQANVSGESAWCSSPWGSQGLPVDGGRAAGREQASLPFASS
                     SWKRVSSSESDYSDAEGGMQGKMRSYQAKVRQGALACFLSTIKSIEKKVLYGYWSAFV
                     PDTPELGSPQSVSLMTLTLKDPSPKTRACALQVLSAILEGSKQFLSVAEDTSDHKRAF
                     TPFSVTIASSIRELHRCLLLALVAESSSQTLTQIIKCLANLVSNAPYNRLKLSLLTKV
                     WNHIKPYIRHKDVNVRVSSLTLLGAIVSTHAPLPEVQLLLQQPCSSGLSSSSSATPHL
                     STPDGWKTFPAGSSLEEASLSSPKGSSEPCWLIRLCISTVVLPKEDSCSGSDAGSALG
                     STYEPSPMRLEALQVLAHLARGYFSTAQLYLMELGEVICKCMCEANPSIQLHGVKLLE
                     ELGAGLIQQYKPDSNIAPEQRVPVHLVVVFWTAMLSGPLPRALQSAEHPTLQASACDA
                     LSSILPEAFSSLPNDKQILCITVLLGLNDSKNHLVKAATSRALGVYVLFPCLRQDVIF
                     VADTANAILMSLQDKSLNVRAKAAWSLGNLTDTLIVNMDTPDPSFQDEFSGLLLLKML
                     QCAIQASTDKDKVKSNAVRALGNLLHFLQPSHVERPRFAEIIEESIQALISTVVNEAA
                     MKVRWNACYAMGNVFKNPALPLGTAPWTSQAYKALTSVVMSCKNFKVRIRSAAALSVP
                     SKRGQYGSLEQFIQIWSALVTALQKSEDTTDFLEFKYCASLRTHICQALLHLLSLASA
                     SDLPGIQETLKLHGDMIRSYILQFLKSGAEGDDPGAVHTPQERVQMVRVALKHIHRVQ
                     TLAGDTARGAIMGFLEDILTVHCDSSGEQVMLRGPSDQ"
     exon            306..413
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            414..554
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            555..670
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            671..785
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            786..887
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1025
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1333
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1511
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1718
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1818
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..2174
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2297
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2384
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2519
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2642
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2767
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2864
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..3069
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3070..5673
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4517..4522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4538
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /note="major polyA site"
     regulatory      5649..5654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5673
                     /gene="Heatr6"
                     /gene_synonym="2700008B19Rik"
                     /note="major polyA site"
ORIGIN      
        1 tggctttccg gaactggagc acacacccag gccctgcccc aagcggtgcc ccggaagtat
       61 ttcccaggct ttctcacgga ggaaaaatgg cggcggtgca ggtcgccgcc tctcttcctt
      121 gtgggcagcc gcgagaggcc ccgcgggaac tgtcgccgga gcaggacgat gggttccgcc
      181 gcttgtctgc caggctccgc gcgctgcagc cggatgacag caccgtgtcc cgcatggaga
      241 ttcacctgct cttcgaccag ctcatctccg agaactacag cgagggcggc ggcgtggccc
      301 ccgaggatgt cagtgctctt cttgtgcgag cttgtcagct ggtgcctctt aaccagaatc
      361 accttgtgag caaagtgtgt caactgatcc atcgtttgct taacagatta caggtggttg
      421 tggatgagcc aaacttagat ttcctgttga cctacacgat ctccgctctt caacagtgta
      481 gctcttggac acacatggaa attcttcaag ccctggcagc tctggtttac tgcaatggct
      541 caaaatgtca aaagcatctc ccagacttgc tgggcaagag tggcctcttg atgaaattga
      601 gtgatttatc tcactctgac cctgaagtca ggagagctgc agtacactgt atggcaaact
      661 tatgtctcag tgtgccagga cagccatact tggaggagcc ctaccagcat gtctgcttcc
      721 aagctttctt gaccatttta cagtctccaa aatcgtctga tatggatgat ataacatttt
      781 gcatgctgtt acagaatgca ctgaaaggca tacagtcgct tctcaatggt gggaagatga
      841 ggctgacgca gaccgagcac ctgggagcgc ttctcgctgt gctgaagaaa gccatgtttc
      901 acggactccc tggattaaac atagagatgc ccgcagtgct atacccaact ccacttcctc
      961 agtatgatgg gcgatctcct gttaaacccc agcagccaga atccactact gctcgatcat
     1021 ctgcgaataa aaagaaaaaa cacaaagtaa aaacaaagaa aactcaacaa ggagagaaag
     1081 cggaggagga agaggaggag ccctgtggtg aagtggaagc agcaccaggg ctcagcatgg
     1141 accaggcgaa tgtgagtggc gagagcgcct ggtgctcctc cccgtggggc tcccagggtt
     1201 tgcctgtgga tggaggcaga gctgccggaa gagagcaggc ctccttgccc ttcgcctcct
     1261 ccagctggaa gagagtcagc agcagtgagt cagactattc ggatgcagaa ggaggcatgc
     1321 agggtaaaat gaggtcatac caggccaagg ttcgccaagg ggcactagct tgttttcttt
     1381 ctactatcaa atcaatagaa aagaaagttc tatacggcta ctggtctgcc tttgttcctg
     1441 acacgccgga gctcggaagc ccacagtcag tgtccttaat gacgctcaca ttaaaggacc
     1501 cgtctccaaa gacccgtgcc tgtgctcttc aagtcctgtc tgccatcttg gaaggctcaa
     1561 agcagttcct ttctgttgct gaagacacta gtgaccacaa acgggctttc acgcccttct
     1621 cagtcacaat tgcatccagc attagagagt tgcacagatg tcttttgtta gctttggtgg
     1681 cagagtcctc gtcccagacc cttactcaga taattaagtg ccttgcaaac ctagtatcaa
     1741 acgcccccta caaccgtctg aaactcagct tgctaaccaa agtctggaac cacataaagc
     1801 cttacatccg ccacaaagat gttaatgtcc gagtgtcaag tctcacgctc ctaggagcta
     1861 tagtgtccac tcacgctcct ttgccggaag tccagctgct tcttcaacag ccctgctcct
     1921 ctggactcag cagcagcagc tcagcaaccc ctcacctcag cactcctgat ggctggaaga
     1981 cattccctgc agggtcctct ctggaagaag catcgctcag ctcaccaaag gggtcatcgg
     2041 agccctgctg gctcatccga ctctgcattt ccactgtggt gctgcccaag gaggactcct
     2101 gctcaggtag cgatgctggc tccgccctgg gaagcaccta tgaaccatcc cccatgcggc
     2161 tggaggctct acaggttttg gctcacctgg cgaggggcta tttttcaacg gctcagttgt
     2221 acttgatgga gctgggcgag gtgatctgta agtgcatgtg tgaggcaaac ccatccattc
     2281 agctccacgg cgtgaagctc ctggaagaac tgggtgcagg cttgatacag cagtacaagc
     2341 cagattccaa catagcgcct gaacagagag tgccagtcca cctggtggtg gtgttctgga
     2401 ctgcgatgct gagtggtcct ttgccccgag ccctgcagtc tgcagagcac ccgactctcc
     2461 aggcgagcgc ctgtgatgcc ctgtcctcca tcttgccaga ggccttcagc agtctgccga
     2521 acgacaagca gattttgtgc attacagtgt tgctcggcct gaatgacagc aagaaccatc
     2581 tagtgaaagc cgccacctcc agggcccttg gagtctacgt gcttttcccg tgcctcagac
     2641 aggacgtcat atttgttgca gacacagcaa atgctatatt gatgtcactt caagataagt
     2701 cactaaacgt gcgcgccaaa gcagcctggt ccctgggcaa cctgacagat actctgattg
     2761 tcaacatgga cacaccagac ccaagtttcc aggatgagtt ctctggactc ctgctcttga
     2821 aaatgttgca gtgtgcaata caagcctcca cagacaaaga caaggtcaaa agcaatgcgg
     2881 tccgggccct ggggaacctg cttcattttc tccagccctc tcacgtagaa aggcccaggt
     2941 tcgctgaaat cattgaggag tccatacagg ctctgatctc cactgttgta aacgaggccg
     3001 ccatgaaagt gcgatggaat gcctgttacg cgatgggaaa tgtttttaaa aaccctgctc
     3061 ttccacttgg gacagctccg tggacctccc aggcctacaa agccctgaca tcagttgtga
     3121 tgtcatgcaa aaacttcaaa gtgcgcatca gatctgccgc agccctctcc gttccgagca
     3181 agagaggaca gtacgggtcc ctagaacagt tcatccagat ctggagtgcg ctggtcactg
     3241 ccctgcagaa gagcgaagac accacagact tcctggagtt caagtactgt gccagcctgc
     3301 ggactcacat ctgccaggcg ctgcttcacc tcctgagcct agccagtgcc tcagacctgc
     3361 ccggcattca agaaactctt aagctgcatg gggatatgat tcggtcctac atcctacagt
     3421 tcttaaaatc aggagcagag ggagatgacc ccggagcagt ccacacccca caggaaagag
     3481 tccagatggt ccgagtggcc ctgaagcaca tacacagagt gcagacactg gctggagaca
     3541 cagccagagg ggccatcatg ggattcttag aggacatcct gaccgttcac tgtgactcct
     3601 caggagaaca ggtgatgctt cgtgggccct cagatcagtg actttcccac cctcccctca
     3661 caggtcacga gtggcaatca gacaccaagc ctgtgcattt gatacatgga gtttcattct
     3721 agggcaggag catccggcag cgtttattta gaacgggtta gtggctattt aactttttct
     3781 caaagggctt cgccactttg gagagtggtt ccattactgg ccattctaac ccagacaacc
     3841 aagaaacaag gaatcaggat ctatgtagcc tgggcccaaa caactggagg tcttttagtc
     3901 tcagaaagaa aaaataaata aatttagaaa ttagaatctt attagaattg tgttttcaag
     3961 agtgtttttt aaaaagccta gcaccgccag gcgcagtggc gcactccttt aatcccagca
     4021 tttgggaggt agaggcaggt agatttctga gttcgaggcc agcctagtct acaaagtgag
     4081 ttccaggaca gccagggcta tacagagaaa ccctgtctcg aaaaagaaaa aaaaaaagcc
     4141 cagcaccaat cggagcaaag gtctcatgca gtgtctgctg gcacagctgc agcagctgca
     4201 gacccctgca agagcccccc ttgatgaatg tgcagctgct cgcctgcacc tgcgtgcacc
     4261 ccagggctcc tcccctcccc acagtccagg atcctgcgcc acagcagcac caacttttgt
     4321 ctaaatttac aaatgacatt taggatgaca tggtcccgta cattaaatat gctgtttggc
     4381 cagccacctt ttaatttgtg tattttgggt tattcatgta acttaaatgg ttattaatgt
     4441 caaacacttg ttaaagtaat ttctggccaa tcagttgttt acatttagat tttgtacttt
     4501 tgaccacaat caatttaata aagttatttc catccaaagt gtagggttat ataagaaaga
     4561 aagtacttca cacttatatt tgctgtggga taaattaaaa gatgcaaaga ttggttctag
     4621 tgatatttgt ttaattgtga gatttaagct aggcatggtt aacatttctg ttatcccagt
     4681 accctgtagg ccgagataga agagcgagca atgggtaata tagcaaaacc cagtctcaga
     4741 aaactgaagt aatgctaggc gtggcagtcc acacctgaaa tccctgctct gaggagtcaa
     4801 ggcacgaggg ccaggagttt gtaagtctct cctttgctgt gtagttccag gcaaacctga
     4861 gctacataag gagagtctat ctcaaacaaa tgcccagcag acactgggga gatagcacag
     4921 tgggaaaggt acttgtgcaa gcctgagaac tgtaatttga atcaccagaa gctgccaaaa
     4981 agccagatgg gcactgtatg agcaaatata gcacgctctg ggttcagttg agagaccctg
     5041 cctcagcgaa tataagatgg agaacaatgg agactgaatc ctgacaacca cctcagacac
     5101 acacacacac gcacacacga gaaatacaac agaaaccaaa attgtcactt gaagtacaca
     5161 gtacacagtt aaaggcatgc atagatcttc aggttttccc ctttgcccct aatttccttc
     5221 ttcttttttt tttttttttt cttttctatc atggtggttc agaaactgct gtgtagacag
     5281 tgactggtga acacgcactc acactgacta aagtcttcat gttccaatgg tagagggctc
     5341 gcctgtccaa aggggtccgc ctacacagtg aggggtccac acagaacatt gtgtgagctt
     5401 gcattccttc agggtgattc tgaaatggag ggcccaggca tcgagctgac cctgccctga
     5461 ccctgcatgg cttccacacc ctcctctgca tcctcagcta cggcttcttt cacacacttc
     5521 cctaggccag aggatctgac aggctctggt tctttgaatt ttcgccagtt tgtatcttgg
     5581 tgaaaatact tgcaaaaccg gatctgatgg ttcatttgcc gatctgctcc tgtcctttgc
     5641 ttaccttgaa taaaacctgg catttctttg taaaaaa
//
