LOCUS       NM_001081179            6437 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus HEAT repeat containing 5B (Heatr5b), mRNA.
ACCESSION   NM_001081179 XM_283480
VERSION     NM_001081179.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6437)
  AUTHORS   Ghosh,S.G., Breuss,M.W., Schlachetzki,Z., Chai,G., Ross,D.,
            Stanley,V., Sonmez,F.M., Topaloglu,H., Zaki,M.S., Hosny,H., Gad,S.
            and Gleeson,J.G.
  TITLE     Biallelic hypomorphic mutations in HEATR5B, encoding HEAT
            repeat-containing protein 5B, in a neurological syndrome with
            pontocerebellar hypoplasia
  JOURNAL   Eur J Hum Genet 29 (6), 957-964 (2021)
   PUBMED   33824466
REFERENCE   2  (bases 1 to 6437)
  AUTHORS   Lamberti,A., Sanges,C., Chambery,A., Migliaccio,N., Rosso,F., Di
            Maro,A., Papale,F., Marra,M., Parente,A., Caraglia,M.,
            Abbruzzese,A. and Arcari,P.
  TITLE     Analysis of interaction partners for eukaryotic translation
            elongation factor 1A M-domain by functional proteomics
  JOURNAL   Biochimie 93 (10), 1738-1746 (2011)
   PUBMED   21689717
REFERENCE   3  (bases 1 to 6437)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC151264.2 and
            AC151284.3.
            
            On Feb 6, 2007 this sequence version replaced XM_283480.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.229391.1,
                                           SRR10223969.18132.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC151264.2         10080-10155
            77-224              AC151264.2         11218-11365
            225-436             AC151264.2         13876-14087
            437-545             AC151264.2         14794-14902
            546-695             AC151264.2         15819-15968
            696-867             AC151264.2         17358-17529
            868-1025            AC151264.2         19072-19229
            1026-1275           AC151264.2         20716-20965
            1276-1431           AC151264.2         23891-24046
            1432-1682           AC151264.2         24590-24840
            1683-1794           AC151264.2         26544-26655
            1795-1947           AC151264.2         27836-27988
            1948-2047           AC151264.2         29130-29229
            2048-2157           AC151264.2         29862-29971
            2158-2321           AC151264.2         31226-31389
            2322-2497           AC151264.2         32191-32366
            2498-2603           AC151264.2         34848-34953
            2604-2794           AC151264.2         36941-37131
            2795-2954           AC151264.2         39355-39514
            2955-3144           AC151264.2         41900-42089
            3145-3314           AC151264.2         43679-43848
            3315-3459           AC151264.2         48933-49077
            3460-3699           AC151264.2         49400-49639
            3700-3951           AC151264.2         50115-50366
            3952-4133           AC151264.2         53845-54026
            4134-4202           AC151264.2         57188-57256
            4203-4382           AC151264.2         71744-71923
            4383-4620           AC151284.3         2700-2937
            4621-4875           AC151284.3         4169-4423
            4876-5003           AC151284.3         5848-5975
            5004-5148           AC151284.3         8226-8370
            5149-5415           AC151284.3         9037-9303
            5416-5640           AC151284.3         10663-10887
            5641-5792           AC151284.3         14289-14440
            5793-6006           AC151284.3         15879-16092
            6007-6437           AC151284.3         17967-18397
FEATURES             Location/Qualifiers
     source          1..6437
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 49.54 cM"
     gene            1..6437
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /note="HEAT repeat containing 5B"
                     /db_xref="GeneID:320473"
                     /db_xref="MGI:MGI:2444098"
     exon            1..76
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            77..224
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..6311
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /codon_start=1
                     /product="HEAT repeat-containing protein 5B"
                     /protein_id="NP_001074648.1"
                     /db_xref="CCDS:CCDS37697.1"
                     /db_xref="GeneID:320473"
                     /db_xref="MGI:MGI:2444098"
                     /translation="MELAHSLLLNEEALAQITEAKRPVFIFEWLRFLDKVLVAANKTD
                     VKEKQKKLVEQLTGLISSSPGPPTRKLLAKNLAALYSIGDTYTVFQTLDKCNDIIRSK
                     DDTAAYLPTKLAAVACVGAFYEKMGRMLGSAFPETVNNLLKSLKSAESQGRSEILMSL
                     QKVLTGLGGAAASSHRDIYKNARSLLTDRSMAVRCAVAKCLLELQNEAVFMWTAELEN
                     VATLCFKALENSNYGVRVAVSKLLGTVMATALMPKQATVMRQNVKRATFDEVLELMAT
                     GFLRGGSGFLKSGGEMLKVGGSVNREVRVGVTQAYVVFVTTLGGQWLERSFATFLSHV
                     LDLVSHPRATQTHVDAVYSRRCVSFMLRATVGSLLGEKAQIAAAKEICQAIGKQMKAV
                     EAVVNDTSSENKSGTADIAASQHVMVCALQELGSLVQSLNATASPLIQEASIGLLEIV
                     TSVLLHPSMAARLAAAWCLRCVAVALPFQLTPFLDRCAERLNNLKTSPEAVSGYSFAM
                     AALLGGVHQCPLGIPHAKGKMVVSIAEDLLRTAAQNSRLSLQRTQAGWLLLGALMTLG
                     PSVVRYHLPKMLLLWRNVFPRSLKELEAEKARGDSFTWQVTLEGRAGALCAMRSFVAH
                     CPELLTEDAIRKLMTPIECAMTMMSHIPSVIKAHGAHLKASAAMVRLRLYDILALLPP
                     KTYEGSFNALLRELVAEFTLTDNSANTTTSLLRSLCHYDDSVLLGSWLQETDHKSIED
                     QLQPNSASGSGALEHDPSSIYLRIPAGEAVPGPLPLGVSVIDASVALFGVVFPHVSYK
                     HRLQMLDHFAECVKQAKGVRQQAVQLNIFTAVLSALKGLAENKSTLGPEEVRKSALTL
                     VMGALDNPNPILRCAAGEALGRMAQVVGEASFIARMAQYSFDKLKSARDVVSRTGHSL
                     ALGCLHRYVGGIGSGQHLKTSVSILLALAQDGTSPEVQTWSLHSLALIVDSSGPMYRG
                     YVEPTLSLVLTLLLTVPPSHTEVHQCLGRCLGAIITTVGPELQGNAATISTIRSSCLV
                     GCAITQDHSDSLVQAAAISCLQQLHMFAPRHVNLSSLVPSLCVHLCSSHLLLRRAAVA
                     CLRQLAQREAAEVCEYAMSLAKNAGDKEISGGNVNPFTPGVSSRSDVHCRHQGVNITD
                     TGLEGLLFGMLDRETDRKLCSDIHDTLGHMLSSLAVEKLSHWLMLCKDVLAASSDMSA
                     ATLLSSGKDEESEKKDEMDDDAMFTTLGEEDKSKPFVAPRWATRVFAADCLCRIINLC
                     ENSDQAHFDLALARSAKLRNPKNDLLVLHLSDLIRMAFMAATDHSNQLRMAGLQALED
                     IIKKFASVPEPEFPGHVILEQYQANVGAALRPAFSQDTPSDIIAKACQVCSTWIGSGV
                     VSDLNDLRRVHNLLVSSLDTVQAGKGSSSQLYRESATTMEKLAVLKAWAEVYVVAMNI
                     KKEAESKPKRAMNNPDDDDDDYGTIDELPPDSLITLVQPELPTLSRLWLAALKDYALL
                     TLPAEFSSQLPPDGGAFYTPETIDTARLHYRNSWAPILHAVALWLNSTGFISQESTEA
                     TTVSGVQKRSPAVSLNQVPGAMASAKPLPEVNKDRMHLILGVSIQFLCSPRPEEPIEH
                     VTACLQALHTLLGSPYARIHIAEDQLIGVELLSVLHRLLLTWNPPSIQLLVTGVVQQI
                     VRAAQDYLQEKRNALNEEDMEKESCPTLGEGGDTGGLIPGKSLVFATMELLMFILVRH
                     MPHLSTKMLDSPSHTAMKTQLSEESARLVAATVAILSDLPSLCSPAGCMTILPTILFL
                     IARILKDTAIKSADNQVPPPVSAALQGIKSIVTLSMAKTEDTQKQWTTLIRSTLACIL
                     EYSQPDDCMPAPDEVSTLTAIALFLWSASSEIIGVQSLQNGCMNRFKSALNSCDPWVQ
                     AKCYQLLLSVFQHSNRALSTPYIHSLAPLVVGKLKAVERHRPASSTELLAVQEGIKVL
                     ETLVALGEEQNRVQLLALLVPTLISYLLDENSFASASSISKDLHEFALQNLMHIGPLY
                     PHAFKTVMGAAPELKARLETAVRASQASKAKAAARQPAPTTHSTPTIKLKTSFF"
     exon            225..436
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            437..545
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            546..695
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            696..867
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1025
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1275
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1431
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1682
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1794
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1947
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2047
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2157
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2321
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2497
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2603
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2794
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..2954
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3144
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            3145..3314
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            3315..3459
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            3460..3699
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            3700..3951
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            3952..4133
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            4134..4202
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            4203..4382
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            4383..4620
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            4621..4875
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            4876..5003
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            5004..5148
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            5149..5415
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            5416..5640
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            5641..5792
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            5793..6006
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     exon            6007..6437
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6417..6422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /note="hexamer: AATAAA"
     polyA_site      6437
                     /gene="Heatr5b"
                     /gene_synonym="2010013B10Rik; A230048G03Rik;
                     D330050P16Rik; mKIAA1414"
                     /note="major polyA site"
ORIGIN      
        1 cggagtttgg gaggcggggc atccgggtcc ctcggcagag cggagcttgg ctgctcggct
       61 cggactagac caggaggtgt gaattaagaa catcaataat ggagctagct cacagtttat
      121 tgctaaatga ggaagctttg gctcagatca cggaggcaaa gagacccgtg ttcatctttg
      181 aatggttgag atttcttgat aaagtcctag ttgctgccaa caagacagat gtaaaagaaa
      241 aacagaaaaa acttgttgaa caattaactg gattaataag cagctcacct ggaccaccta
      301 ctcgaaaatt gttagctaaa aaccttgcag ccctttatag cattggggat acttacacag
      361 tttttcaaac actagataaa tgtaatgaca ttatcagaag taaggacgac actgcagcct
      421 acttaccaac aaaattggca gcagtggctt gtgttggagc cttctatgag aagatgggaa
      481 ggatgttggg cagtgcattt ccagaaacag tgaacaatct gttgaaatct ctgaaaagtg
      541 cagagtctca agggcgaagt gagatcttaa tgagtctgca gaaagtgctg actggactgg
      601 gcggcgcagc agcttcctct caccgcgaca tttacaagaa tgctcgatcc ctcctgaccg
      661 acaggtcgat ggctgtccga tgtgcagtgg ccaagtgcct tctggaacta cagaatgaag
      721 ctgtgttcat gtggactgcc gaactagaaa atgtagctac cctctgcttt aaggctctgg
      781 aaaactcaaa ttatggggta cgagtcgcag tatctaagct actaggaaca gtcatggcta
      841 cagcattgat gccgaaacag gcaacagtca tgcggcaaaa tgtgaagcga gcaaccttcg
      901 atgaagtctt agaactcatg gccacgggat ttctgcgcgg agggtcgggt ttcctaaaga
      961 gtggcggaga aatgttgaaa gttggagggt ctgttaatcg ggaagtgaga gttggtgtga
     1021 cacaggccta tgttgtcttt gtgacaactc tgggtggcca gtggctggag cgtagctttg
     1081 ccacattctt gtcccacgta cttgatctgg tttcccatcc tcgagcaaca caaacacacg
     1141 tggacgctgt gtactccagg cgatgtgtgt ccttcatgct gagagctacc gtgggcagtc
     1201 tgttaggtga gaaagcccag atagcagctg ccaaggagat ctgccaggca atcggaaagc
     1261 agatgaaagc tgtggaagca gtagtgaatg atacgagcag tgaaaacaaa tcggggacag
     1321 cagacattgc agccagccag cacgtcatgg tctgtgccct gcaggagctt gggagcctgg
     1381 tgcagagcct gaatgccacc gcctctcctc ttattcagga agcgtccata ggacttttgg
     1441 agattgtgac gtcagtgctt cttcacccaa gcatggctgc tcggcttgct gctgcctggt
     1501 gtctgcgttg tgtagctgtg gcgctgccct tccagttgac accatttctg gataggtgtg
     1561 cagaacggct caacaacctc aagacatccc cagaagctgt tagtggatac agttttgcaa
     1621 tggccgcctt gttgggtgga gtgcatcagt gtcctttggg cattcctcat gccaaaggaa
     1681 agatggtggt cagcattgct gaagatctgc tacgaactgc tgcccaaaac agcaggctgt
     1741 ccctgcagcg cacccaggct ggctggcttc ttctgggagc cctcatgact ttaggaccgt
     1801 ctgttgttcg ttaccatcta cccaagatgt tgctgctgtg gcggaacgtg ttccctcgct
     1861 ctttaaagga actggaggct gagaaggccc ggggggattc attcacctgg caggtcactc
     1921 tggaaggtcg cgctggggct ctgtgtgcca tgaggagttt tgttgcacat tgtcctgagc
     1981 tgctaacaga ggatgcaatt aggaaattaa tgactcctat cgaatgtgcc atgaccatga
     2041 tgtcgcacat tccatccgtc atcaaggccc atggagccca tctgaaagct agtgccgcaa
     2101 tggtccgctt aagactttat gatatcttgg ctttattacc tccaaaaact tatgaagggt
     2161 ctttcaatgc acttcttaga gagctggtgg cagagttcac tctgactgac aactcggcca
     2221 acacaactac ctccctcctt cgctccctct gccactatga cgacagcgtt ctcctgggct
     2281 cctggcttca agagactgat cataaatcca ttgaagacca gctccagcca aacagtgcat
     2341 ctggcagtgg ggctctggaa cacgaccctt cttccattta cctacggata cctgcaggtg
     2401 aagccgtgcc gggtccgctc cctctcggag tctcagtgat tgacgcatct gtggctctgt
     2461 tcggggttgt gtttccacat gtttcctata aacacaggtt acaaatgctg gatcactttg
     2521 ctgaatgtgt taagcaagcc aaaggtgtcc gccagcaggc tgtgcagctt aatatattta
     2581 ctgctgttct tagtgcactg aagggcttag ctgaaaacaa gagtactttg ggacctgagg
     2641 aagtccgcaa gtctgctctg acactggtta tgggagccct cgacaaccca aaccccatct
     2701 tacggtgtgc ggcaggggaa gcccttggaa gaatggctca ggtggtggga gaagcctctt
     2761 tcattgcccg aatggcccaa tacagctttg acaagttgaa gtcagctcga gatgtcgtgt
     2821 ccaggactgg tcactcactg gccctcggtt gtttacatcg ttatgttggt ggcataggat
     2881 caggacaaca cctaaagacc agtgtcagca ttttactggc tctagctcaa gatgggacat
     2941 cccctgaagt tcagacgtgg tctcttcatt cactcgccct gatagtggat tccagcggcc
     3001 caatgtaccg tgggtacgtg gagcccacgt tgtccctggt actcaccttg ctgctgacag
     3061 ttccaccttc acacacagaa gttcaccagt gcctgggcag atgcttgggg gcgatcataa
     3121 ctactgttgg accagagctg cagggaaatg cagcgaccat atccaccatc cgctcctcct
     3181 gcttggtggg ctgtgccatt acccaggacc actctgactc ccttgttcag gcagctgcca
     3241 tctcttgcct tcagcagctt cacatgtttg ccccacgaca cgtcaatctg tccagccttg
     3301 ttcctagcct ctgtgttcac ctgtgcagct cccacctgct gctccgacga gcggctgtgg
     3361 cctgtctccg gcaactcgca cagagagaag cagccgaagt gtgtgaatac gccatgagcc
     3421 tggcgaagaa tgcaggggac aaggagatca gcggtggtaa tgtcaaccct ttcacgcctg
     3481 gagttagctc tcgcagtgac gtccattgcc ggcaccaggg tgttaacata acagacacgg
     3541 ggcttgaggg acttctcttt ggaatgctag atcgagagac agaccggaaa ctctgctctg
     3601 atattcacga cacgttgggg cacatgctct cttcactggc cgttgaaaag ctttcccact
     3661 ggctaatgct ttgtaaagat gtcttagcag cttctagtga tatgagtgca gccacactct
     3721 taagcagtgg aaaagatgaa gaatctgaga agaaagatga gatggatgac gacgccatgt
     3781 tcacgacact aggcgaggag gacaaatcaa agcctttcgt ggctcctcgc tgggccactc
     3841 gggtgtttgc tgcagactgc ctgtgccgaa tcatcaacct gtgtgagaac tcagaccagg
     3901 ctcacttcga ccttgccttg gcacggtctg ctaaactacg aaacccaaaa aatgacctcc
     3961 tagtattgca tctctctgac ctgattcgaa tggcattcat ggctgcaact gatcatagca
     4021 accaactgcg aatggctggg ctccaggcac ttgaagacat tatcaagaaa tttgcatctg
     4081 tgcctgagcc agaatttcca ggtcatgtga tcctggagca gtatcaagct aatgtgggag
     4141 ctgccctaag accagccttt tcacaagata cgccatcaga cataatagcg aaagcttgcc
     4201 aggtgtgcag cacgtggatt ggaagcggcg ttgtcagcga cctcaatgat ctccgccggg
     4261 tgcataatct actggtttcc tctctggaca cagttcaggc tggaaaggga tcttctagtc
     4321 agctgtaccg agagagcgcc accaccatgg agaagctggc cgttcttaag gcatgggcag
     4381 aggtatatgt ggttgctatg aatattaaga aagaagcaga gtcaaaacca aagagagcaa
     4441 tgaacaatcc tgatgatgat gatgacgact atggcaccat cgacgagctg cctccagaca
     4501 gcttaataac cctggtgcag cctgagctgc cgacgctcag ccgcctgtgg ttggcagcac
     4561 tgaaagacta cgcgcttttg actttaccag ctgaattttc tagtcagctt cccccagatg
     4621 ggggggcatt ttatactcca gagaccatcg atacagcaag acttcactac aggaactcct
     4681 gggccccaat tctccatgca gtggcactct ggttaaacag cacaggattt ataagtcaag
     4741 agtccacaga agcaacaact gtgtctggtg tccagaaacg ctccccagct gtcagtttaa
     4801 accaagttcc aggagcaatg gctagtgcta aacccttgcc agaagttaac aaagacagga
     4861 tgcacctgat cctaggtgtg agtatacagt ttctttgttc ccctcgacca gaggagccca
     4921 ttgaacatgt tacagcatgc ctgcaggcct tgcacacctt actgggatct ccttatgcac
     4981 ggatccacat cgcagaagat cagctgattg gcgttgagtt gctaagtgtc ctgcaccgcc
     5041 tgctactgac atggaaccca ccctctatcc agctgctggt cactggagtt gtgcagcaga
     5101 tcgtcagggc tgctcaggac tatctacagg aaaagagaaa cgctctaaat gaagaggata
     5161 tggaaaaaga gtcctgtcct acattaggag aagggggtga taccggtggc ctcattcctg
     5221 gaaagtccct tgtgtttgca accatggagc tgctgatgtt cattttagta cggcacatgc
     5281 cacacctgag taccaagatg ttagactctc ctagtcacac ggccatgaaa actcagctgt
     5341 cagaagaaag cgcccgcttg gtggcagcca cggtggccat tctctcggat ctgccgtccc
     5401 tttgttcacc ggctggatgt atgacaatcc tacccacaat ccttttctta attgcaagaa
     5461 tattgaaaga cacagcaata aagtctgcgg acaaccaggt tcctccccca gtcagtgcag
     5521 ctcttcaggg gataaaaagt attgtgacac tttccatggc caaaactgag gacacacaga
     5581 aacagtggac gactctaatc cggagcaccc ttgcctgcat cctggaatat tctcaaccag
     5641 atgactgtat gcccgcacct gacgaagtga gcacactcac agccattgcg ctcttcctgt
     5701 ggtctgccag cagtgaaata ataggagtgc agtccctaca gaacggctgc atgaacagat
     5761 ttaagagtgc cctgaactcg tgtgacccat gggttcaagc caaatgctac cagcttctcc
     5821 tctccgtctt ccagcattcc aaccgtgcac tctccactcc ctacatccac tccttagccc
     5881 cgctggtggt tgggaagctg aaagctgtgg agagacacag accggccagt agcacggaac
     5941 ttttggctgt ccaagaagga attaaagttc ttgaaacatt ggttgctctt ggggaagaac
     6001 agaacagagt ccagttactc gctcttctag tgcccacttt gatctcttac ctgctggatg
     6061 aaaattcttt tgcctcagca agttcgatct ccaaagatct tcatgagttt gcactgcaga
     6121 acttaatgca tattggacct ctgtacccac atgctttcaa gacggtaatg ggggctgctc
     6181 ctgaactgaa agcacgacta gaaactgctg tccgagcaag ccaggcgagc aaagctaaag
     6241 ccgctgccag gcagcccgcc cccaccacac attccacacc gacaattaag ctgaaaacaa
     6301 gcttttttta gtgtgctttt ccgctcatct gtatttattt attttctcaa acatttacca
     6361 ctttttagaa taataccaac attcacatac tgtattacaa tggtaccaca atataaaata
     6421 aaatatgtat aaactga
//
