LOCUS       NM_013886               5868 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus HDGF like 3 (Hdgfl3), mRNA.
ACCESSION   NM_013886
VERSION     NM_013886.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5868)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5868)
  AUTHORS   Kerman,B.E., Genoud,S., Kurt Vatandaslar,B., Denli,A.M., Georges
            Ghosh,S., Xu,X., Yeo,G.W., Aimone,J.B. and Gage,F.H.
  TITLE     Motoneuron expression profiling identifies an association between
            an axonal splice variant of HDGF-related protein 3 and peripheral
            myelination
  JOURNAL   J Biol Chem 295 (34), 12233-12246 (2020)
   PUBMED   32647008
  REMARK    GeneRIF: Motoneuron expression profiling identifies an association
            between an axonal splice variant of HDGF-related protein 3 and
            peripheral myelination.
REFERENCE   3  (bases 1 to 5868)
  AUTHORS   Abouzied,M.M., El-Tahir,H.M., Gieselmann,V. and Franken,S.
  TITLE     Hepatoma-derived growth factor-related protein-3: a new
            neurotrophic and neurite outgrowth-promoting factor for cortical
            neurons
  JOURNAL   J Neurosci Res 88 (16), 3610-3620 (2010)
   PUBMED   20890995
  REMARK    GeneRIF: Antibody-mediated neutralization of HRP-3 function results
            in neuronal degeneration; this protein also exerts a neurite
            outgrowth-promoting effect when it is presented as a coated
            substrate but not as a soluble factor.
REFERENCE   4  (bases 1 to 5868)
  AUTHORS   Georgas,K., Rumballe,B., Valerius,M.T., Chiu,H.S.,
            Thiagarajan,R.D., Lesieur,E., Aronow,B.J., Brunskill,E.W.,
            Combes,A.N., Tang,D., Taylor,D., Grimmond,S.M., Potter,S.S.,
            McMahon,A.P. and Little,M.H.
  TITLE     Analysis of early nephron patterning reveals a role for distal RV
            proliferation in fusion to the ureteric tip via a cap
            mesenchyme-derived connecting segment
  JOURNAL   Dev Biol 332 (2), 273-286 (2009)
   PUBMED   19501082
REFERENCE   5  (bases 1 to 5868)
  AUTHORS   El-Tahir,H.M., Abouzied,M.M., Gallitzendoerfer,R., Gieselmann,V.
            and Franken,S.
  TITLE     Hepatoma-derived growth factor-related protein-3 interacts with
            microtubules and promotes neurite outgrowth in mouse cortical
            neurons
  JOURNAL   J Biol Chem 284 (17), 11637-11651 (2009)
   PUBMED   19237540
REFERENCE   6  (bases 1 to 5868)
  AUTHORS   Nameki,N., Tochio,N., Koshiba,S., Inoue,M., Yabuki,T., Aoki,M.,
            Seki,E., Matsuda,T., Fujikura,Y., Saito,M., Ikari,M., Watanabe,M.,
            Terada,T., Shirouzu,M., Yoshida,M., Hirota,H., Tanaka,A.,
            Hayashizaki,Y., Guntert,P., Kigawa,T. and Yokoyama,S.
  TITLE     Solution structure of the PWWP domain of the hepatoma-derived
            growth factor family
  JOURNAL   Protein Sci 14 (3), 756-764 (2005)
   PUBMED   15689505
REFERENCE   7  (bases 1 to 5868)
  AUTHORS   Abouzied,M.M., Baader,S.L., Dietz,F., Kappler,J., Gieselmann,V. and
            Franken,S.
  TITLE     Expression patterns and different subcellular localization of the
            growth factors HDGF (hepatoma-derived growth factor) and HRP-3
            (HDGF-related protein-3) suggest functions in addition to their
            mitogenic activity
  JOURNAL   Biochem J 378 (Pt 1), 169-176 (2004)
   PUBMED   14572309
REFERENCE   8  (bases 1 to 5868)
  AUTHORS   Ikegame,K., Yamamoto,M., Kishima,Y., Enomoto,H., Yoshida,K.,
            Suemura,M., Kishimoto,T. and Nakamura,H.
  TITLE     A new member of a hepatoma-derived growth factor gene family can
            translocate to the nucleus
  JOURNAL   Biochem Biophys Res Commun 266 (1), 81-87 (1999)
   PUBMED   10581169
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK045542.1, AK162418.1 and AK012267.1.
            
            On Jan 12, 2006 this sequence version replaced NM_013886.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045542.1, AK162418.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-921               AK045542.1         1-921
            922-5088            AK162418.1         565-4731
            5089-5868           AK012267.1         90-869
FEATURES             Location/Qualifiers
     source          1..5868
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.71 cM"
     gene            1..5868
                     /gene="Hdgfl3"
                     /gene_synonym="2700022B06Rik; Hdgfrp3; HRP-3"
                     /note="HDGF like 3"
                     /db_xref="GeneID:29877"
                     /db_xref="MGI:MGI:1352760"
     exon            1..521
                     /gene="Hdgfl3"
                     /gene_synonym="2700022B06Rik; Hdgfrp3; HRP-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             438..1046
                     /gene="Hdgfl3"
                     /gene_synonym="2700022B06Rik; Hdgfrp3; HRP-3"
                     /note="hepatoma-derived growth factor, related protein 3"
                     /codon_start=1
                     /product="hepatoma-derived growth factor-related protein
                     3"
                     /protein_id="NP_038914.2"
                     /db_xref="CCDS:CCDS40011.1"
                     /db_xref="GeneID:29877"
                     /db_xref="MGI:MGI:1352760"
                     /translation="MARPRPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKY
                     PIFFFGTHETAFLGPKDLFPYKEYKDKFGKSNKRKGFNEGLWEIENNPGVKFTGYQTI
                     QQQSSSETEGEGGNTADASSEEEGDRVEDGKGKRKNEKGGSKRKKSYTSKKSSKQSRK
                     SPGDEDDKDCKEEENKSSSEGGDAGNDTRNTTADLQKAGEGT"
     exon            522..598
                     /gene="Hdgfl3"
                     /gene_synonym="2700022B06Rik; Hdgfrp3; HRP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            599..737
                     /gene="Hdgfl3"
                     /gene_synonym="2700022B06Rik; Hdgfrp3; HRP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            738..893
                     /gene="Hdgfl3"
                     /gene_synonym="2700022B06Rik; Hdgfrp3; HRP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1040
                     /gene="Hdgfl3"
                     /gene_synonym="2700022B06Rik; Hdgfrp3; HRP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..5868
                     /gene="Hdgfl3"
                     /gene_synonym="2700022B06Rik; Hdgfrp3; HRP-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggggaatgc tgagcgcgcg cgagaacaat aataagatcg tgtttgcggt cgctgcccga
       61 ggaggaattc ggaggaggcg cgaggcccgg agctcgcacg gaacccagaa gctcggcggg
      121 gaggcggcgg ctgcatgagg ctggcgacgc ggctcctgtg agcagcgcgc ggcggtagcg
      181 gcggcgtcgg gactcggcgc ggccggacgc gggctcccat cccccgcagc cgggcgggga
      241 tctgcggggc ctgcggtgcc ccccgcccac cgctcgcctc ggccactgcc tcgccgctct
      301 ccctcgtcgg agcggccgct cgagcgttcg gctcgaggcc ccgcggggag cgcggcgcgg
      361 ttccgtcgtc ccgcggaggg gcggcctccc agcatcttcg cggcggccaa ggaccggcga
      421 gcaggagaac gaccgggatg gcgcgtccgc ggccccgcga gtacaaagcg ggagacctgg
      481 tcttcgccaa gatgaagggc tacccgcact ggcccgcccg gattgatgaa ctcccagagg
      541 gagctgtgaa gcctccagca aacaagtacc ctatcttctt ttttggtacc catgaaactg
      601 catttctagg tcctaaagac cttttcccat ataaggaata caaagacaag tttggaaagt
      661 caaacaaacg gaaaggattt aatgaaggat tatgggaaat tgaaaataat ccaggagtga
      721 aatttactgg gtaccagaca attcagcaac agagctcttc agaaactgag ggagaaggtg
      781 gaaatactgc agatgcaagc agtgaggaag aaggtgatag agtagaagat ggaaaaggca
      841 aaagaaagaa tgaaaaagga ggctcaaaac ggaaaaagtc ctacacgtca aagaagtctt
      901 ctaaacagtc ccggaaatct ccaggagacg aagatgataa agactgcaaa gaagaggaga
      961 acaaaagcag ctctgagggc ggagacgctg gcaatgacac gagaaacacg actgcagact
     1021 tgcagaaagc cggtgaaggg acctaactac cgtaatgaat gctgcatatt gagagacacc
     1081 acaagaaggt taactgtttg attgtctaat tcttggattt ggatttgata tgaaccaacg
     1141 gtctttgttg tcattgacag agccccagta tgtgtgtgca ttagtcacat tcctctctgt
     1201 tctgttgaag gaaaaagaga cattttaacc cttttaaggt tgactttatt ttatgttatt
     1261 tggttgcatg aagttgccct taatcactaa gaatgatgaa gattttgcag acttctctgt
     1321 gtctaggctc cttttccaag tcatcagctt cctgcctctc tcccaccatc atcagatact
     1381 cagctaaaca gtaattcata ttgttaggtg actgctcaac ataatacttc aggatgggat
     1441 tttctttgta gcagaaccca agaaccaact cctagataca tactgttggt gtattggaga
     1501 tgaagttaga gtcatctttc agttttaagg ccatgtgtaa agtttaacca tatgtacaat
     1561 acctattctg tattagaaat agctagttga aacttaatac ttctcaaaac tcatgttcct
     1621 gtgtccacaa actaagttta tatgtgaact tactgagtct ttttgtgtca taccaaaata
     1681 aagcaaggac ttattttttt tcccaaagcc aatacaattt gagccaatcc ctcaagatgg
     1741 tcactttaca ctgaaagctg agctcagcag gagcactgtg ggaaacaaag cattgactct
     1801 tgagtacaga gtttaaaata gacttttctt ttagaactag aattagagta gttaacgttc
     1861 atccgccaac cattgttacg tgtgcattac tgtcgctctt gtggtgatag agtcttattt
     1921 atttttatgc cagcttatac tgtgagaact cattagtcag tttgggtctc atcaaccctg
     1981 ctatgcttgt ccttggaaga tcttttgtgt gtgtttgagg tttgtagctg agaagtttac
     2041 tgtaaaaaaa aaaaatcaaa aacaaaaaaa tgtattgttt ttacagaata aatttattgg
     2101 aatgtgtact gggagtaagg tttgaggtta taaacagccg agttagtgtt atttggcttc
     2161 atatgtgtaa tgtgaagtat taatgtgttt cttgtattat agcaaagatt gacagcaaat
     2221 tgacattaga attaagtgca ggtgaaaatt ttattttttc tatcatgttt ctttttaagt
     2281 attctggatg ttaggttaag tgaaagccgt ggggggacag gagggagcaa cagcaggagc
     2341 tgcagcagca ggggctgtct gcacgtctgc gacagcccag ctcaggggac cctgcattta
     2401 cacacagcct tccgtgcatc cagtttgctt ttggtgttct tactgtgttg aagaactaat
     2461 gaacgtgaag agaaaataga agaagaccta agagcccagt gtcgttgtga agatggaggt
     2521 gatgtggggc tctggatgca ctggtctact cacccctccc tccaggacat cactgtcctt
     2581 tgggcttgct cctgccggtt agcaatcagt ggtcccctgt tgtgctcacg cagttccatg
     2641 tatggaaaat tcattaagag acaggctgtt aagtcagggt tttttcttta aaaggtactt
     2701 tttaatttta aatattttag tttaaaataa tgaaatttga caaaagatct cttcattatc
     2761 atgcaaaaca tatggagaat gtagatagca tttttaaatt ggaacatata acaaaggttt
     2821 ttttgtttgt ttgtttgttt gaggcagggt ttctctgtgt agccctgatt atcctggaac
     2881 tcactctgta gaccaggcta gcctggaact caaaagatca gcctgtctct gaatcccaag
     2941 tgcaaggatt aaaggcgtgt gctaccacta cctggcacag atttcttaaa taaaaagttc
     3001 aaaatttgtc atgaaaatgt atatataaaa tgcttcaaaa ttaataaagt ttatcttcat
     3061 aaacaccaaa aataatttta ttgaaggtat acacagtatt gaaggtatac acagaaacac
     3121 aagagaaata ttatcaacca ataaaacaag tgttcattaa ggcaactaat aaagttgatt
     3181 tgtgtcatct tagctattca aattcacaat agaagttttg acagcaattt ttaaaatggc
     3241 aataaataat atgctttcct tgtgaaaaca cttgaatcaa tttaaaaata ttgtgatgat
     3301 ctggcattta tattaagatt gtcaacaact catacatttc atatgaagcc atttctccaa
     3361 cctgcaattg ctgttttgaa ttatttctta tgcatagtat ggttagttac ttctgaatag
     3421 tttcattttt atgctttttg taggcactag agttgtaatt ttcacacata ctatgtgcaa
     3481 acaatgctaa aatcaatggt cacattcata gacaaatggt gatatatttc cttaaaaaag
     3541 ctgtttctca actttaattt tctttcaaaa ctgagaatat acccagatac tacccttagt
     3601 ttcactcaca tgtatgctgc agaacaagtg tgttcttgtg agtattcctg tatggagggg
     3661 ataaaggaga gcgccagtcc cattaacagg tcagagagaa ctgtgaggta tgtttgttta
     3721 ttccaacttc tcatctgcct tagttcttag gaagaactcg ggattgtagg tacaacggta
     3781 ggccaagagc tgaggaagaa ctccatatgc tatgtttagt gctagaaaaa agattttcgc
     3841 ttcttcgggg actctgtaga cataagcagt tctagcatga agggacgcac caatgtgaga
     3901 aaactgagcc tgtttatatt aaaacaaaac aaaaaaacag taaggatgag ctctgttcac
     3961 ttggattaat gatgaattct gagtgtctca ttcagaccat gtgccctcaa aacctgtctt
     4021 aaaggcaaaa tacctttagg taatccagtc ttaatatata atctttcact aaatttaagg
     4081 ttgttcttga tataagtatt caaataatgt atccttctta aagtgtgatt ttattattcc
     4141 agttgtgtat ttttaaccta tcctgtgcca aataacaaac aatactggct caattcaaca
     4201 acaacaacaa caaaatctcc ccctctttct aatttgaatc ttaggaacac taactatata
     4261 gacactcagc aaggtctcac aaattgggtt tgaattacaa atgaagttgg gttttaacat
     4321 ttaagctgta attagtatga ggagctactt tagagagaag cactaagggt ctcagaccaa
     4381 ccactggatg ccagagctca gagaccatca catgtactgc ttattcatcc gtgtgtttgg
     4441 ttttatgtaa cttaatagca ctatgattgt ttgtaaggta agcttgttaa tagcttggct
     4501 gtggatagca atatgattat aaaatggcaa atatatacac aggcagcctt tccaaatcag
     4561 actgaaatct acttagaatt gtgactggtc agcatgtttg aagtttcaga acagaacagc
     4621 aagggctccc tctgtttaca tgggatagtt tataaactat tcagaatgtg ccagttgaat
     4681 tttgcttggc tcatttgttt tttgtacttt tcataagcac agagaaaaac tattagaaaa
     4741 gtaatacagg ccatagcaga attgaaaacc gacagagtat ttttctcaga aaacttgtta
     4801 ttataaaatg caaaccccaa gtctgcactt ttatgtttgc ctgaaattca agatacacag
     4861 aaataaagac taaagattta aatgtagtta aatggcagat tatcagtata ctatgatcaa
     4921 agtgagacga taaaggatcc tgcaatctaa agagacagaa gtaacagtga atcactagag
     4981 agtgtgttct taatgtattg ttaccttata tgtccttcca tatgatcaat tgagagtgct
     5041 aagtgctaac agataaaagt gctacttggc atttgatgtg accttggcaa agaaaagagc
     5101 atgtttagga atttgtataa atggcagata ttttaatggg ctacaattta taaattactg
     5161 atatattccg gatactttta ctactctgga aataaaaatt aaattcctga tgtgtgttga
     5221 caaggaccaa caagtggctt acccacactg tgattctcct cgggcactga gaaggttctg
     5281 cccgcagaca cactccctag ggcacaaagc caaaggccca gcaaatgagt gcatctcaag
     5341 gctacacaga cagagtcctt gagaataaag ggcactttgg aagctgccca gaagagacac
     5401 tgctgtgaac agtctgggga ctctggcaga agccttgact cctgacactt gttctctggg
     5461 ccctgcttta gctgtttttt tgaacataca acaattttct tctggactag aggccagttt
     5521 tgaaccctgg ttttgtcaga cttgtgggtt tagtgattct atccttagag attattgtgc
     5581 tcatcataaa atgacagaaa aatactaccc acaattccca agaataagta acatgagcag
     5641 ctgggtgtac ctatataggt aaacctgtat gaaaggtcag tgattgtgtg ggcccttctc
     5701 tgcactgaac agtgcagtta atacctcatt ctcgtgaaca ggaaggtcat gacaacattc
     5761 aaaaaaatga tgcgtcctta gattagattg tacgcccact gggcagatac tgtgtctaat
     5821 gttttgtgtg gcacctatca cgttgttaga gttcaataaa cattcaac
//
